Cited by 530Neuroinflammation and Neurodegeneration MechanismsRedox biology and oxidative stressMitochondrial Function and Pathology

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways

Park, Junghyung, Min, Ju-Sik, Kim, Bokyung, Chae, Un-Bin, Yun, Jong Won, Choi, Myung-Sook, Kong, Il-Keun, Chang, Kyu-Tae, Lee, Dong-Seok·2015·Neuroscience Letters

DOI 10.1016/j.neulet.2014.10.016

Open this paper in CoChat — free account

Abstract

Activation of microglia cells in the brain contributes to neurodegenerative processes promoted by many neurotoxic factors such as pro-inflammatory cytokines and nitric oxide (NO). Reactive oxygen species (ROS) actively affect microglia-associated neurodegenerative diseases through their role as pro-inflammatory molecules and modulators of pro-inflammatory processes. Although the ROS which involved in microglia activation are thought to be generated primarily by NADPH oxidase (NOX) and involved in the immune response, mitochondrial ROS have also been proposed as important regulators of the inflammatory response in the innate immune system. However, the role of mitochondrial ROS in microglial activation has yet to be fully elucidated. In this study, we demonstrate that inhibition of mitochondrial ROS by treatment with Mito-TEMPO effectively suppressed the level of mitochondrial and intracellular ROS. Mito-TEMPO treatment also significantly prevented LPS-induced increase in the TNF-α, IL-1β, IL-6, iNOS and Cox-2 in BV-2 and primary microglia cells. Furthermore, LPS-induced suppression of mitochondrial ROS generation not only affected LPS-stimulated activation of MAPKs, including ERK, JNK, and p38, but also regulated IκB activation and NF-κB nuclear localization. These results indicate that mitochondria constitute a major source of ROS generation in LPS-mediated activated microglia cells. Additionally, suppression of LPS-induced mitochondrial ROS plays a role in modulating the production of pro-inflammatory mediators by preventing MAPK and NF-κB activation in microglia cells. Our findings suggest that a potential strategy in the development of therapy for inflammation-associated degenerative neurological diseases involves targeting the regulation of mitochondrial ROS in microglial cells.

Integrity signals

Registry

Crossref · 10.1016/j.neulet.2014.10.016

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049
Tlr signalling augments macrophage bactericidal activity through mitochondrial ros
West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659
Microglia in neurodegenerative disease
Perry, V. H., Nicoll, J. A. R., & Holmes, C. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.17 · Cited by 1,543
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
Bulua, A. C., Simon, A., Maddipati, R., Pelletier, M., Park, H., Kim, K.-Y., Sack, M. N., Kastner, D. L., & Siegel, R. M. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102049 · Cited by 860
Mitochondrial reactive oxygen species drive proinflammatory cytokine production
Naik, E., & Dixit, V. M. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110367 · Cited by 783
Redox regulation of glial inflammatory response to lipopolysaccharide and interferonγ
Pawate, S., Shen, Q., Fan, F., & Bhat, N. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20180 · Cited by 428
The non-provitamin A carotenoid, lutein, inhibits NF-κB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-κB-inducing kinase pathways: Role of H2O2 in NF-κB activation
Kim, J.-H., Na, H.-J., Kim, C.-K., Kim, J.-Y., Ha, K.-S., Lee, H., Chung, H.-T., Kwon, H. J., Kwon, Y.-G., & Kim, Y.-M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.06.019 · Cited by 273

Show all 26 references

Sorted by citations

Items 201–300 of 530

Carboxylic Acid Fullerene (C60) Derivatives Attenuated Neuroinflammatory Responses by Modulating Mitochondrial Dynamics
Ye, S., Zhou, T., Cheng, K., Chen, M., Wang, Y., Jiang, Y., & Yang, P. (2015) · Nanoscale Research Letters · doi:10.1186/s11671-015-0953-9 · Cited by 28
Experimental immunology Rhamnetin attenuates cognitive deficit and inhibits hippocampal inflammatory response and oxidative stress in rats with traumatic brain injury
Zhang, W., Liu, K., Li, B., Bai, Y., Wang, T., Fu, K., & Sun, G. (2015) · Central European Journal of Immunology · doi:10.5114/ceji.2015.50831 · Cited by 28
Neuroimmunomodulatory properties of DPSCs in an in vitro model of Parkinson's disease
Gnanasegaran, N., Govindasamy, V., Mani, V., & Kasim, N. H. A. (2017) · IUBMB Life · doi:10.1002/iub.1655 · Cited by 28
Epinecidin-1 protects mice from LPS-induced endotoxemia and cecal ligation and puncture-induced polymicrobial sepsis
Su, B., Huang, H.-N., Lin, T.-W., Hsiao, C., & Chen, J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.08.032 · Cited by 28
YY1 promotes IL-6 expression in LPS-stimulated BV2 microglial cells by interacting with p65 to promote transcriptional activation of IL-6
Zhang, X., Liang, H., Luo, X., Wang, H., Gu, A.-P., Zheng, C.-Y., Su, Q., & Cai, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.159 · Cited by 28
Elamipretide (SS-31) Improves Functional Connectivity in Hippocampus and Other Related Regions Following Prolonged Neuroinflammation Induced by Lipopolysaccharide in Aged Rats
Liu, Y., Fu, H., Wu, Y., Nie, B., Liu, F., Wang, T., Xiao, W. L., Yang, S., Kan, M., & Fan, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.600484 · Cited by 28
Biogenic silver NPs alleviate LPS-induced neuroinflammation in a human fetal brain-derived cell line: Molecular switch to the M2 phenotype, modulation of TLR4/MyD88 and Nrf2/HO-1 signaling pathways, and molecular docking analysis
Sharma, A., Sanjay, S., Jaiswal, V., Park, M., & Lee, H. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213363 · Cited by 28
Anti-inflammatory, antioxidant effects, and antimicrobial effect of Bacillus subtilis P223
Jung, H.-S., Lee, H. W., Kim, K., Lee, N., & Paik, H. (2023) · Food Science and Biotechnology · doi:10.1007/s10068-023-01445-4 · Cited by 27
Novel Insights into Parkin–Mediated Mitochondrial Dysfunction and “Mito-Inflammation” in α-Synuclein Toxicity. The Role of the cGAS–STING Signalling Pathway
Gąssowska-Dobrowolska, M., Olech-Kochańczyk, G., Culmsee, C., & Adamczyk, A. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s468609 · Cited by 29
Edible fungus-derived bioactive components as innovative and sustainable options in health promotion
Wang, X., Han, Y., Li, S., Li, M., Li, M., & Gao, Z. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104215 · Cited by 27
Milk Fat Globule-Epidermal Growth Factor-Factor 8 Reverses Lipopolysaccharide-Induced Microglial Oxidative Stress
Li, J., Xu, X., Cai, X., Weng, Y., Wang, Y., Shen, Q., & Shi, X. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2601394 · Cited by 27
The inhibitory effect of (−)-Epicatechin gallate on the proliferation and migration of vascular smooth muscle cells weakens and stabilizes atherosclerosis
Li, W., Yu, J., Xiao, X., Li, W., Zang, L., Han, T., Zhang, D., & Niu, X. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173761 · Cited by 27
MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy
Zhao, T., Ma, J., Li, L., Teng, W., Tian, Y., Ma, Y., Wang, W., Yan, W., & Jiao, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197161 · Cited by 26
Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by structures-based virtual screening and in vitro bioassays
Zhang, Y., Xu, L., Zhang, Y., Pan, J., Wang, P., Tian, S., Li, H., Gao, B., Hou, T., Zhen, X.-C., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00753-x · Cited by 26
Microglial activation in Alzheimer's disease: The role of flavonoids and microRNAs
Medrano-Jiménez, E., Meza‐Sosa, K. F., Aragon, J. A. U., Secundino, I., Pedraza-Alva, G., & Pérez-Martínez, L. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr1021-531r · Cited by 28
Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation
Novi, S., Vestuto, V., Campiglia, P., Tecce, N., Bertamino, A., & Tecce, M. F. (2023) · Nutrients · doi:10.3390/nu15122748 · Cited by 26
Succinate dehydrogenase inhibitor dimethyl malonate alleviates LPS/ d -galactosamine-induced acute hepatic damage in mice
Yang, Y., Shao, R., Tang, L. P., Li, L., Zhu, M. P., Huang, J., Shen, Y., & Zhang, L. (2019) · Innate Immunity · doi:10.1177/1753425919873042 · Cited by 26
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure
Xu, B., Lang, L., Li, S., Guo, J., Wang, J., Yang, H.-M., & Lian, S. (2019) · Biomolecules · doi:10.3390/biom9090426 · Cited by 25
Tert-butylhydroquinone attenuates osteoarthritis by protecting chondrocytes and inhibiting macrophage polarization
Zhang, H., Li, J., Xiang, X., Zhou, B., Zhao, C., Wei, Q., Sun, Y., Chen, J., Lai, B., Luo, Z., et al. (2021) · Bone and Joint Research · doi:10.1302/2046-3758.1011.bjr-2020-0242.r4 · Cited by 25
Muscone and (+)-Borneol Cooperatively Strengthen CREB Induction of Claudin 5 in IL-1β-Induced Endothelium Injury
Li, Y., Li, Y., Zhang, Y.-N., Zhao, Q., Zhang, Y., Sun, M., Liu, B., Yang, H., & Liu, B. (2022) · Antioxidants · doi:10.3390/antiox11081455 · Cited by 25
Melatonin protects against lipopolysaccharide-induced epididymitis in sheep epididymal epithelial cells in vitro
Ge, W., Xiao, L., Duan, H., Li, Z.-S., Jiang, Y., Yang, S., Hu, J., Zhang, Y., & Zhao, X. (2019) · Immunology Letters · doi:10.1016/j.imlet.2019.09.001 · Cited by 25
Cold Atmospheric Plasma as a Novel Therapeutic Tool for the Treatment of Brain Cancer
Adhikari, M., Adhikari, B., Adhikari, A., Yan, D., Soni, V., Sherman, J. H., & Keidar, M. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200302105715 · Cited by 24
Delphinidin prevents high glucose-induced cell proliferation and collagen synthesis by inhibition of NOX-1 and mitochondrial superoxide in mesangial cells
Song, S. E., Jo, H. J., Kim, Y., Cho, Y., Kim, J.-R., & Park, S. (2016) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2016.03.005 · Cited by 24
Remote Limb Ischemic Postconditioning Protects against Ischemic Stroke via Modulating Microglia/Macrophage Polarization in Mice
Han, D., Wang, J., Wen, L., Sun, M., Liu, H., & Gao, Y. (2021) · Journal of Immunology Research · doi:10.1155/2021/6688053 · Cited by 24
Sumoylation Modulates the Susceptibility to Type 1 Diabetes
Zhang, J., Chen, Z., Zhou, Z., Yang, P. C., & Wang, C. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-50044-7_18 · Cited by 24
Dexmedetomidine post-conditioning protects blood-brain barrier integrity by modulating microglia/macrophage polarization via inhibiting NF-κB signaling pathway in intracerebral hemorrhage
Guo, H., Zhang, W., Wang, Z., Li, Z., Zhou, J., & Yang, Z. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.977941 · Cited by 23
Quercetin alleviates DEHP exposure-induced pyroptosis and cytokine expression changes in grass carp L8824 cell line by inhibiting ROS/MAPK/NF-κB pathway
Cai, H., Li, K., Yin, Y., Ni, X., & Xu, S. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.109223 · Cited by 24
Direct and indirect pro-inflammatory cytokine response resulting from TC-83 infection of glial cells
Keck, F., Kortchak, S., Bakovic, A., Roberts, B., Agrawal, N., & Narayanan, A. (2018) · Virulence · doi:10.1080/21505594.2018.1509668 · Cited by 23
G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses
Ho, D. H., Lee, H., Son, I., & Seol, W. (2019) · Animal Cells and Systems · doi:10.1080/19768354.2019.1585948 · Cited by 23
The Silent Epidemic - Frailty and Aging with HIV.
Willig, A. L., Overton, E. T., & Saag, M. S. (2016) · PubMed · Cited by 22
Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes
Tawbeh, A., Gondcaille, C., Saih, F.-E., Raas, Q., Loichot, D., Hamon, Y., Keime, C., Benani, A., Di Cara, F., Cherkaoui-Malki, M., et al. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1542938 · Cited by 21
From small‐scale studies to an encompassing view: Inhibiting inflammation and clinically relevant enzymes with various extracts of Primula vulgaris using in vitro and in silico techniques
Celep, İ. K., Nilofar, N., Çetiz, M. V., Zheleva‐Dimitrova, D., Gevrenova, R., Celep, E., Sinan, K. I., Yıldıztugay, E., Ferrante, C., & Zengin, G. (2024) · Food Frontiers · doi:10.1002/fft2.473 · Cited by 21
Decoding paradoxical links of cytokine markers in cognition: Cross talk between physiology, inflammaging, and Alzheimer’s disease- related cognitive decline
Khan, H., Naseem, T., Kaushik, P., Narang, J., Khan, R., Panwar, S., & Parvez, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102535 · Cited by 21
Activation of spinal PGC-1α regulates microglial polarization through a feedback loop between ROS-mediated mitochondrial dysfunction and the NLRP3 inflammasome in neuropathic pain
Chen, Y., Ling, G., Xu, Q., Zhu, Q., Huang, T., Su, T., Xie, Y., & Zhong, Y. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111365 · Cited by 21
3ʹ,4ʹ-Dihydroxyflavone mitigates inflammatory responses by inhibiting LPS and TLR4/MD2 interaction
Lee, H., Shin, J., Chung, K., Kim, J., Jung, S.-H., Yoo, H., Hassan, A. H. E., Lee, J. K., Inn, K., Lee, S., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154553 · Cited by 21
Liensinine, a alkaloid from lotus plumule, mitigates lipopolysaccharide-induced sepsis-associated encephalopathy through modulation of nuclear factor erythroid 2-related factor-mediated inflammatory biomarkers and mitochondria apoptosis
Wang, G., Sun, Y., Yang, Q., Dai, D., Zhang, L., Fan, H., Zhang, W., Dong, J., & Zhao, P. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113813 · Cited by 21
Laminin‐Augmented Decellularized Extracellular Matrix Ameliorating Neural Differentiation and Neuroinflammation in Human Mini‐Brains
Bae, M., Ngo, H., Kang, Y. J., Lee, S., Park, W., Jo, Y., Choi, Y., Kim, J. J., Yi, H., Kim, H., et al. (2023) · Small · doi:10.1002/smll.202308815 · Cited by 21
Gene-metabolite profile integration to understand the cause of spaceflight induced immunodeficiency
Chakraborty, N., Cheema, A. K., Gautam, A., Donohue, D. E., Hoke, A. V., Conley, C., Jett, M., & Hammamieh, R. (2018) · npj Microgravity · doi:10.1038/s41526-017-0038-4 · Cited by 22
Mechanisms of Inhibition of Excessive Microglial Activation by Melatonin
Gao, J., Su, G., Liu, J., Zhang, J., Zhou, J., Liu, X., Tian, Y., & Zhang, Z. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01531-w · Cited by 22
Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation
Song, Q., Zhao, Y., Yang, Y., Han, X., & Duan, J. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115361 · Cited by 21
Caloric restriction ameliorates high-fat diet induced cognitive deficits through attenuating neuroinflammation via the TREM2-PI3K/AKT signaling pathway
Wang, R., Zhou, Z., Wang, D., Zhao, Q., Zhang, C., Liu, C., Zhao, H., Yuan, C., Yuan, D., & Wang, T. (2021) · Food & Function · doi:10.1039/d0fo02946g · Cited by 22
Therapeutics effect of mesenchymal stromal cells in reactive oxygen species-induced damages
Kumar, S., Verma, R., Tyagi, N., Gangenahalli, G. U., & Verma, Y. K. (2021) · Human Cell · doi:10.1007/s13577-021-00646-5 · Cited by 21
Harmful and Beneficial Role of ROS 2020
Meo, S. D., Venditti, P., Víctor, V. M., & Napolitano, G. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9873652 · Cited by 21
Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity
Wickstead, E. S., Elliott, B., Pokorny, S., Biggs, C. S., Getting, S. J., & McArthur, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115996 · Cited by 20
The Inflammation-Energy Metabolism Axis: A Central Driver of Sarcopenia-Osteoporosis: A Narrative Review
Jiang, Y., Qi, X., Cui, H., Huang, Y., Lv, Y., Yang, Y., Yao, X., & Yang, D. (2026) · Calcified Tissue International · doi:10.1007/s00223-025-01473-8 · Cited by 20
Andrographolide inhibits IL-1β release in bone marrow-derived macrophages and monocyte infiltration in mouse knee joints induced by monosodium urate
Lo, C., Lii, C., Hong, J.-J., Chuang, W.-T., Yang, Y., Huang, C., & Chen, H. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115341 · Cited by 19
Bisdemethoxycurcumin Protects Small Intestine from Lipopolysaccharide‐Induced Mitochondrial Dysfunction via Activating Mitochondrial Antioxidant Systems and Mitochondrial Biogenesis in Broiler Chickens
Zhang, J., Yang, Y., Han, H., Zhang, L., & Wang, T. Z. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9927864 · Cited by 19
The Role of Oxidative Stress and Inflammation in X-Link Adrenoleukodystrophy
Yu, J., Chen, T., Guo, X., Zafar, M. I., Li, H., Wang, Z., & Zheng, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.864358 · Cited by 22
The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke
Ma, W.-Y., Wang, S., Wu, Q.-L., Zhou, X., Chu, S., & Chen, N. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108733 · Cited by 20
Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2‐mediated antioxidant signalling
Sun, J., Wang, X., Song, F., Li, D., Gao, S., Zhang, L., Wu, J., Liu, D.-Q., Wang, L., Zhou, Y., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16195 · Cited by 19
Mitochondria-targeted cerium vanadate nanozyme suppressed hypoxia-ischemia injury in neonatal mice via intranasal administration
Jiang, Z., Wang, W., Zhao, Y., Li, T., Xin, D., Gai, C., Liu, D., & Wang, Z. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.016 · Cited by 19
Protective Effect of Colchicine on LPS-Induced Lung Injury in Rats via Inhibition of P-38, ERK1/2, and JNK Activation
Yue, Q., Liu, T., & Cheng, Z. (2020) · Pharmacology · doi:10.1159/000504759 · Cited by 19
Antineuroinflammatory Effects of 7,3’,4’-Trihydroxyisoflavone in Lipopolysaccharide-Stimulated BV2 Microglial Cells through MAPK and NF-κB Signaling Suppression
Kim, S., Ko, Y., Lee, Y., Lee, S., & Jang, C. (2020) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2020.093 · Cited by 19
Dilodendron bipinnatum Radlk. inhibits pro-inflammatory mediators through the induction of MKP-1 and the down-regulation of MAPKp38/JNK/NF-κB pathways and COX-2 in LPS-activated RAW 264.7 cells
de Oliveira, R. G., Castilho, G. R. D. C., da Cunha, A. L., Miyajima, F., & Martins, D. T. D. O. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.02.026 · Cited by 19
Agmatine suppresses glycolysis via the PI3K /Akt/ mTOR / HIF ‐1α signaling pathway and improves mitochondrial function in microglia exposed to lipopolysaccharide
Milosevic, K., Milosevic, A., Stevanović, I. D., Zivkovic, A., Laketa, D., Janjic, M. M., Bjelobaba, I. M., Lavrnja, I. C., & Savić, D. Z. (2025) · BioFactors · doi:10.1002/biof.2149 · Cited by 18
Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity
Hu, R., Zhang, W., Li, L., Zuo, Z.-Q., Ma, M., Ma, J.-F., Yin, T., Gao, C., Yang, S., Zhao, Z., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04308-0 · Cited by 18
Anti-inflammatory and anti-COVID-19 effect of a novel polyherbal formulation (Imusil) via modulating oxidative stress, inflammatory mediators and cytokine storm
Ratheesh, M., Sunil, S., Sheethal, S., Jose, S. P., Sandya, S., Ghosh, O. S. N., Rajan, S., Jagmag, T., & Tilwani, J. (2022) · Inflammopharmacology · doi:10.1007/s10787-021-00911-x · Cited by 18
Regulation of anti-inflammatory and antioxidant responses by methanol extract of Mikania cordata (Burm. f.) B. L. Rob. leaves via the inactivation of NF-κB and MAPK signaling pathways and activation of Nrf2 in LPS-induced RAW 264.7 macrophages
Kang, E., Lee, J., Seo, S., Uddin, M. S., Lee, S.-W., Han, S. B., & Cho, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115746 · Cited by 18
Zaluzanin C Alleviates Inflammation and Lipid Accumulation in Kupffer Cells and Hepatocytes by Regulating Mitochondrial ROS
Jung, J., Wang, F., Turk, A., Park, J.-S., Ma, H., Ma, Y., Noh, H.-R., Sui, G.-Y., Shin, D.-S., Lee, M. K., et al. (2023) · Molecules · doi:10.3390/molecules28227484 · Cited by 18
Self-citation
Curcumin loaded hydrogel with double ROS-scavenging effect regulates microglia polarization to promote poststroke rehabilitation
Zhang, S., Ran, Y., Tuolhen, Y., Wang, Y., Tian, G., Xi, J., Feng, Z., Su, W., Ye, L., & Liu, Z. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101177 · Cited by 18
Neuron-Glia Crosstalk in the Autonomic Nervous System and Its Possible Role in the Progression of Metabolic Syndrome: A New Hypothesis
Río, R. D., Quintanilla, R. A., Orellana, J. A., & Retamal, M. A. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00350 · Cited by 18
Anti-inflammatory Effect of AZD6244 on Acrolein-Induced Neuroinflammation
Ho, W.-C., Hsu, C., Huang, H.-J., Wang, H., & Lin, A. M.-Y. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01758-8 · Cited by 18
ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NF-κB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation
Zhang, S., Liu, M., Liu, D.-N., Shang, Y.-F., Wang, Y., & Du, G. (2022) · Molecules · doi:10.3390/molecules27092990 · Cited by 18
15-O-Acetyl-3-O-benzoylcharaciol and helioscopinolide A, two diterpenes isolated from Euphorbia helioscopia suppress microglia activation
Wang, H., Liu, Y., Zhang, J., Xu, J., Cui, C., Guo, Y., & Jin, D. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.12.010 · Cited by 18
Baicalin Decreases the LPS-Induced Intestine Inflammatory Responses by ROS/p-ERK/p-P38 Signal Pathways In Vivo and In Vitro
Sun, X., Guo, M., Su, H., Liang, M., Wu, H., Zhao, L., Zhang, J., He, J., Yong, Y., Yu, Z., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13020251 · Cited by 18
Mutual Activation of Two Radical Trapping Agents: Unusual “Win–Win Synergy” of Resveratrol and TEMPO during Scavenging of dpph • Radical in Methanol
Konopko, A., & Litwinienko, G. (2022) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.2c02080 · Cited by 17
Molecular mechanisms of the chemical constituents from anti-inflammatory and antioxidant active fractions of Ganoderma neo-japonicum Imazeki
Zhang, R., Zhang, J., Guo, X., Chen, Y., Sun, J., Miao, J.-L., Carpena, M., Prieto, M. A., Li, N., Zhou, Q., et al. (2023) · Current Research in Food Science · doi:10.1016/j.crfs.2023.100441 · Cited by 17
Characterization of Inflammatory Signals in BV-2 Microglia in Response to Wnt3a
Li, C., Wu, Y., Huang, M., & Song, X. (2023) · Biomedicines · doi:10.3390/biomedicines11041121 · Cited by 18
Heat-Killed Latilactobacillus sakei CNSC001WB and Lactobacillus pentosus WB693 Have an Anti-inflammatory Effect on LPS-Stimulated RAW 264.7 Cells
Jung, H.-S., Lee, N., & Paik, H. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10139-6 · Cited by 17
Therapeutic Potential of Kaempferol against Sleep Deprivation-Induced Cognitive Impairment: Modulation of Neuroinflammation and Synaptic Plasticity Disruption in Mice
Du, Y.-Y., Sun, T., Yang, Q., Liu, Q.-Q., Li, J., Yang, L., & Luo, L. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00226 · Cited by 17
2′O-galloylhyperin attenuates LPS-induced acute lung injury via up-regulation antioxidation and inhibition of inflammatory responses in vivo
Zhang, S.-D., Wang, P., Zhang, J., Wang, W., Yao, L., Gu, C., Efferth, T., & Fu, Y. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.02.029 · Cited by 17
CLG from Hemp Seed Inhibits LPS-Stimulated Neuroinflammation in BV2 Microglia by Regulating NF-κB and Nrf-2 Pathways
Wang, S., Luo, Q., Zhou, Y., & Fan, P. (2019) · ACS Omega · doi:10.1021/acsomega.9b02168 · Cited by 17
Ex vivo imaging and analysis of ROS generation correlated with microglial activation in rat model with acute neuroinflammation induced by intrastriatal injection of LPS
Shukuri, M., Uchino, M., Sakamaki, T., Onoe, S., Hosoi, R., Todoroki, K., Arano, Y., Sakai, T., Akizawa, H., & Inoue, O. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.11.008 · Cited by 17
Network pharmacology-based strategy to investigate pharmacological mechanisms of Andrographolide for treatment of vascular cognitive impairment
Zhao, Y., Zhang, J., Zhang, Y., Zhang, Y., Zhang, X., Zheng, Y., Wang, H., Wang, X., & Fu, J. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108756 · Cited by 17
Oligopeptide of RDPEER from watermelon seeds prevents heat stress-induced liver injury by suppressing oxidative stress and inflammation responses
Chen, S., Zhou, J., Igbokwe, C. J., Duan, Y., Cai, M., He, Y., & Zhang, H. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105563 · Cited by 16
Fusobacterium nucleatum facilitates proliferation and autophagy by activating miR-361-3p/NUDT1 axis through oxidative stress in hypopharyngeal squamous cell carcinoma
Lau, H., Yuan, X., Huang, H., Zhang, M., Hsueh, C., & Gong, H. (2023) · BMC Cancer · doi:10.1186/s12885-023-11439-4 · Cited by 16
Mycotoxicosis and oxidative stress in poultry: pathogenesis and therapeutic insights
Alam, M. S., Maowa, Z., Subarna, S. D., & Hoque, M. N. (2024) · World s Poultry Science Journal · doi:10.1080/00439339.2024.2347307 · Cited by 16
Inflammatory stimuli promote oxidative stress in pancreatic acinar cells via Toll-like receptor 4/nuclear factor-κB pathway
Pan, L., Yu, L., Wang, L., He, J., Sun, J., Wang, X., Wang, H., Bai, Z., Feng, H., & Pei, H. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3906 · Cited by 16
Paraquat mediates BV-2 microglia activation by raising intracellular ROS and inhibiting Akt1 phosphorylation
Xiao, H., Song, B., Li, Q., Shao, Y., Zhang, Y.-B., Chang, X., & Zhou, Z. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.11.017 · Cited by 16
Rivastigmine Reverses the Decrease in Synapsin and Memory Caused by Homocysteine: Is There Relation to Inflammation?
Júnior, O. V. R., dos Santos, T. M., Silveira, J. S., Leite-Aguiar, R., Coutinho‐Silva, R., Savio, L. E. B., & Wyse, Â. T. D. S. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02871-x · Cited by 16
Liver Kinase B1/AMP-Activated Protein Kinase Pathway Activation Attenuated the Progression of Endotoxemia in the Diabetic Mice
Yang, Y., Dong, R., Hu, D., Chen, Z., Fu, M., Wang, D. W., Xu, X., & Tu, L. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000478068 · Cited by 16
The therapeutic effects of edaravone on collagen‐induced arthritis in rats
Zhang, X., Ye, G., Wu, Z., Zou, K., He, X., Xu, X., Yao, J., & Wei, Q. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29382 · Cited by 16
Corticosterone potentiates ochratoxin A-induced microglial activation
Chansawhang, A., Phochantachinda, S., Temviriyanukul, P., & Chantong, B. (2022) · BioMolecular Concepts · doi:10.1515/bmc-2022-0017 · Cited by 15
Effect of quercetin-loaded poly (lactic-co-glycolic) acid nanoparticles on lipopolysaccharide-induced memory decline, oxidative stress, amyloidogenesis, neurotransmission, and Nrf2/HO-1 expression
Hussein, R. M., Kandeil, M. A., Soliman, H. M., & El‐Shahawy, A. A. G. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23527 · Cited by 18
Effects of 18β-Glycyrrhetinic Acid on Fungal Protease-Induced Airway Inflammatory Responses
Kim, Y. H., Kim, D. E., & Lee, S. (2018) · Mediators of Inflammation · doi:10.1155/2018/6461032 · Cited by 16
3α-Angeloyloxy-ent-kaur-16-en-19-oic Acid Isolated from Wedelia trilobata L. Alleviates Xylene-Induced Mouse Ear Edema and Inhibits NF-κB and MAPK Pathway in LPS-Stimulated Macrophages
Xu, J., Zhou, L., Sun, L., Wang, Z., Wang, Y., Wang, Y., & He, X. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c00990 · Cited by 15
The involvement of autophagy in the maintenance of endothelial homeostasis: The role of mitochondria
Dymkowska, D. (2021) · Mitochondrion · doi:10.1016/j.mito.2020.12.013 · Cited by 15
[18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 mice
Hsieh, C., Hou, C., Zhu, Y., Lee, J. Y., Kohli, N., Gallagher, E. P., Xu, K., Lee, H. S., Li, S., McManus, M. J., et al. (2022) · EJNMMI Research · doi:10.1186/s13550-022-00914-x · Cited by 16
Drp1-dependent mitochondrial fission regulates p62-mediated autophagy in LPS-induced activated microglial cells
Chae, U., Kim, H. S., Lee, H., Lee, S., & Lee, D. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1549933 · Cited by 15
Self-citation
Brain-Targeted Reactive Oxygen Species in Hypertension: Unveiling Subcellular Dynamics, Immune Cross-Talk, and Novel Therapeutic Pathways
Wang, R., Wang, M., Du, D., Shan, Z. J., Bi, L., & Chen, Q. (2025) · Antioxidants · doi:10.3390/antiox14040408 · Cited by 15
Chronic Mild Stress and Venlafaxine Treatment Were Associated with Altered Expression Level and Methylation Status of New Candidate Inflammatory Genes in PBMCs and Brain Structures of Wistar Rats
Białek, K. I., Czarny, P. L., Wigner, P., Synowiec, E., Barszczewska-Pietraszek, G., Bijak, M., Szemraj, J., Niemczyk, M., Tota-Glowczyk, K., Papp, M., et al. (2021) · Genes · doi:10.3390/genes12050667 · Cited by 14
ZNF667 Suppressed LPS-induced Macrophages Inflammation through mTOR-dependent Aerobic Glycolysis Regulation
Li, Y., Chao, R., Qu, S., Huang, L., & Zhang, C. (2023) · Current Pharmaceutical Design · doi:10.2174/1381612829666230530143129 · Cited by 14
NMDA receptor inhibitor MK801 alleviated pro-inflammatory polarization of BV-2 microglia cells
Wu, C.-C., Tzeng, C., Chang, C.-Y., Wang, J., Chen, Y., Chen, W.-Y., Kuan, Y., Liao, S., Wang, W., & Chen, C. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175927 · Cited by 14
Mycobacterium tuberculosis Rv0928 protein facilitates macrophage control of mycobacterium infection by promoting mitochondrial intrinsic apoptosis and ROS-mediated inflammation
Xu, C. A., Yue, Y., & Xiong, S. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1291358 · Cited by 14
Euonymus alatus Leaf Extract Attenuates Effects of Aging on Oxidative Stress, Neuroinflammation, and Cognitive Impairment
Gurung, P., Lim, J., Magar, T. B. T., Shrestha, R., & Kim, Y. (2024) · Antioxidants · doi:10.3390/antiox13040433 · Cited by 14
Reactive oxygen species and neurodegenerative diseases: insights into nanozyme therapeutics
Wang, L., Chen, F., Zhang, C., Cheng, Y. Y., Bu, W., & Liu, Y. (2024) · MedMat. · doi:10.1097/mm9.0000000000000009 · Cited by 14
Retracted : Green tea polyphenols attenuate LPS‐induced inflammation through upregulating microRNA‐9 in murine chondrogenic ATDC5 cells
Zhang, Q., Wang, Y., Zhang, M., & Ying, H. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28826 · Cited by 14
Retracted
TLR4 inhibition ameliorates mesencephalic substantia nigra injury in neonatal rats exposed to lipopolysaccharide via regulation of neuro-immunity
He, W., Jiang, M. L., Mao, P., & Yan, F. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.09.012 · Cited by 14
Crataegus laevigata Suppresses LPS-Induced Oxidative Stress during Inflammatory Response in Human Keratinocytes by Regulating the MAPKs/AP-1, NFκB, and NFAT Signaling Pathways
Nguyen, Q. T. N., Fang, M., Zhang, M., Quynh, N., Kim, M., Zheng, S., Hwang, E., & Yi, T. (2021) · Molecules · doi:10.3390/molecules26040869 · Cited by 14
Interleukin-34-CSF1R Signaling Axis Promotes Epithelial Cell Transformation and Breast Tumorigenesis
Poudel, M., Kim, G., Bhattarai, P. Y., Kim, J., & Choi, H. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052711 · Cited by 14

Authors: Park, J., Min, J.-S., Kim, B., Chae, U.-B., Yun, J. W., Choi, M.-S., Kong, I.-K., Chang, K.-T., & Lee, D.-S.
Affiliations: Kyungpook National University (KR)
Daegu University (KR)
Gyeongsang National University (KR)
Korea Research Institute of Bioscience and Biotechnology (KR)
Corresponding author: Lee, Dong-Seok
ORCID: Park, Junghyung
Min, Ju-Sik
Kim, Bokyung
Yun, Jong Won
Choi, Myung-Sook
Kong, Il-Keun
Chang, Kyu-Tae
Lee, Dong-Seok
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 2015-01
Volume: 584
Pages: 191-196
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/j.neulet.2014.10.016
OpenAlex: W2042183116
Cited by: 529
References: 26
Citations by year: 2026: 53 · 2025: 37 · 2024: 59 · 2023: 64 · 2022: 64 · 2021: 47 · 2020: 51 · 2019: 54 · 2018: 43 · 2017: 23 · 2016: 18 · 2015: 15
FWCI: 9.69
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
KRIBB Repository (submittedVersion)
Funders: National Research Foundation of Korea (NRF-2012R1A1A2008880, 112020-03-2-SB020)
Korea Institute of Planning & Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (2008-0062618)
Korea Research Institute of Bioscience and Biotechnology (KGM4611411)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitochondrial reactive oxygen species, microglial activation, lipopolysaccharide, pro-inflammatory response, MAPK signaling, NF-κB signaling, MitoTEMPO, ERK, JNK, p38 MAPK, TNF-α, IL-1β, interleukin-6, inducible nitric oxide synthase, cyclooxygenase-2, neuroinflammation, neurodegenerative diseases
MeSH terms: Animals, Cell Line, Inflammation, Lipopolysaccharides, Mitochondria, Organophosphorus Compounds, Piperidines, Signal Transduction, NF-kappa B, Reactive Oxygen Species, Microglia, Mitogen-Activated Protein Kinases, Extracellular Signal-Regulated MAP Kinases, p38 Mitogen-Activated Protein Kinases, MAP Kinase Kinase 4, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks