Mitochondrial reactive oxygen species drive proinflammatory cytokine production
Open accessAbstract
High levels of reactive oxygen species (ROS) are observed in chronic human diseases such as neurodegeneration, Crohn’s disease, and cancer. In addition to the presence of oxidative stress, these diseases are also characterized by deregulated inflammatory responses, including but not limited to proinflammatory cytokine production. New work exploring the mechanisms linking ROS and inflammation find that ROS derived from mitochondria act as signal-transducing molecules that provoke the up-regulation of inflammatory cytokine subsets via distinct molecular pathways.
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Under an imbalanced redox state, increased mitochondrial reactive oxygen species production may modify arterial walls and be followed by an inflammatory environment.
“Under conditions of an imbalanced redox state, increased mitochondrial ROS production might lead to modifications of the arterial walls180, followed by an inflammatory environment181.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [180]
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- Authors
- Naik, E., & Dixit, V. M.
- Affiliations
- Genentech (US)
- Corresponding author
- Dixit, Vishva M.
- ORCID
- Dixit, Vishva M.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2011-02-28
- Volume
- 208
- Issue
- 3
- Pages
- 417-420
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC3058577
- OpenAlex
- W2051930121
- Cited by
- 783
- References
- 19
- Citations by year
- 2026: 31 · 2025: 47 · 2024: 68 · 2023: 52 · 2022: 52 · 2021: 80 · 2020: 62 · 2019: 62 · 2018: 50 · 2017: 37 · 2016: 41 · 2015: 39 · 2014: 44 · 2013: 58 · 2012: 36
- FWCI
- 20.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial reactive oxygen species, inflammatory cytokines, inflammation, oxidative stress, neurodegeneration, Crohn's disease, cancer, chronic disease
- MeSH terms
- Humans, Inflammation, Mitochondria, Signal Transduction, Cytokines, Reactive Oxygen Species
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