Cited by 783Redox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative MechanismsMitochondrial Function and Pathology

Mitochondrial reactive oxygen species drive proinflammatory cytokine production

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Naik, Edwina, Dixit, Vishva M.·2011·Journal of Experimental Medicine

Abstract

High levels of reactive oxygen species (ROS) are observed in chronic human diseases such as neurodegeneration, Crohn’s disease, and cancer. In addition to the presence of oxidative stress, these diseases are also characterized by deregulated inflammatory responses, including but not limited to proinflammatory cytokine production. New work exploring the mechanisms linking ROS and inflammation find that ROS derived from mitochondria act as signal-transducing molecules that provoke the up-regulation of inflammatory cytokine subsets via distinct molecular pathways.

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  • Under an imbalanced redox state, increased mitochondrial reactive oxygen species production may modify arterial walls and be followed by an inflammatory environment.

    “Under conditions of an imbalanced redox state, increased mitochondrial ROS production might lead to modifications of the arterial walls180, followed by an inflammatory environment181.”

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Authors
Naik, E., & Dixit, V. M.
Affiliations
Genentech (US)
Corresponding author
Dixit, Vishva M.
Venue
Journal of Experimental Medicine
Published
2011-02-28
Volume
208
Issue
3
Pages
417-420
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
OpenAlex
W2051930121
Cited by
783
References
19
Citations by year
2026: 31 · 2025: 47 · 2024: 68 · 2023: 52 · 2022: 52 · 2021: 80 · 2020: 62 · 2019: 62 · 2018: 50 · 2017: 37 · 2016: 41 · 2015: 39 · 2014: 44 · 2013: 58 · 2012: 36
FWCI
20.92
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • The Journal of Experimental Medicine (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
mitochondrial reactive oxygen species, inflammatory cytokines, inflammation, oxidative stress, neurodegeneration, Crohn's disease, cancer, chronic disease
MeSH terms
Humans, Inflammation, Mitochondria, Signal Transduction, Cytokines, Reactive Oxygen Species

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