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Cited by 138Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Inter- and intra-laminar connections of pyramidal cells in the neocortex.

Bannister, A. Peter·2005·Neuroscience Research
DOI 10.1016/j.neures.2005.06.019
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Abstract

The flow of excitation through cortical columns has long since been predicted by studying the axonal projection patterns of excitatory neurones situated within different laminae. In grossly simplified terms and assuming random connectivity, such studies predict that input from the thalamus terminates primarily in layer 4, is relayed 'forward' to layer 3, then to layers 5 and 6 from where the modified signal may exit the cortex. Projection patterns also indicate 'back' projections from layer 5 to 3 and layer 6 to 4. More recently it has become clear that the interconnections between these layers are not random; forward projections primarily contact specific pyramidal subclasses and intracortical back projections innervate interneurones. This indicates that presynaptic axons or postsynaptic dendrites are capable of selecting their synaptic partners and that this selectivity is layer dependent. For the past decade, we and others have studied pyramidal cell targeting in circuits both within, and between laminae using paired intracellular recordings with biocytin filling and have begun to identify further levels of selectivity through the preferential targeting of electrophysiologically and/or morphologically distinct pyramidal subtypes. Presented here, therefore, is a brief overview of current thinking on the layer and subclass specific connectivity of neocortical principle excitatory cells.

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Crossref · 10.1016/j.neures.2005.06.019

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48 of 48 references verified0 citation errors · 0 not checkable

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  • Axons of the layer 2/3 pyramidal neurons travel several millimeters parallel to the layer 2/3 - layer 4 boundary and re-enter layer 2/3 to make excitatory connections to pyramidal cells there.

    “In biology, it is found that axons of the layer 2/3 pyramidal neurons travel several millimeters parallel to the layer 2/3 – layer 4 boundary and re-enter layer 2/3 to make excitatory connections to pyramidal cells there [43],[48].”

    From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [43]

  • The layer 2/3 neurons receive excitatory inputs from other layer 2/3 neurons via extensive lateral connections.

    “In addition, the layer 2/3 neurons receive excitatory inputs from other layer 2/3 neurons via extensive lateral connections [43].”

    From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [43]

  • RS cells are mostly pre-synaptic to IB cells.

    “It is also known that the RS cells are mostly pre-synaptic to the IB cells [43].”

    From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [43]

  • The output of the RS cell goes to the IB cell.

    “The output of the RS cell goes to the IB cell.”

    From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [43]

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Authors
Bannister, A. P.
Affiliations
University of London (GB)
Corresponding author
Bannister, A. Peter
Venue
Neuroscience Research
Publisher
Elsevier BV
Published
2005-10
Volume
53
Issue
2
Pages
95-103
ISSN
0168-0102 (ISSN-L)
DOI
10.1016/j.neures.2005.06.019
OpenAlex
W2039265322
Cited by
138
References
49
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 10 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 14 · 2014: 8 · 2013: 5 · 2012: 5
FWCI
0.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
pyramidal neurons, neocortex, intracortical connections, cortical columns, axonal projection patterns, thalamocortical connections, back-projection, interneurons
MeSH terms
Animals, Humans, Neural Pathways, Pyramidal Cells, Neocortex

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