CoChat
Sign Up
Cited by 99

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Functional characterization of the brain-to-blood efflux clearance of human amyloid-β peptide (1–40) across the rat blood–brain barrier

Ito, Shingo, Ohtsuki, Sumio, Terasaki, Tetsuya·2006·Neuroscience Research
DOI 10.1016/j.neures.2006.07.006
Open this paper in CoChat — free account

Abstract

The present study sought to characterize the brain-to-blood efflux transport of human amyloid-beta peptide (hAbeta)(1-40) across the blood-brain barrier (BBB) in rats. We determined the apparent brain-to-blood [(125)I]hAbeta(1-40) efflux clearance in rats and found it to be 11.0 microL/(ming brain). There were no significant gender differences in the apparent brain-to-blood [(125)I]hAbeta(1-40) efflux clearance. The brain-to-blood [(125)I]hAbeta(1-40) efflux transport was significantly inhibited by unlabeled hAbeta(1-40) and hAbeta(1-42) by 79.1% and 36.4%, respectively, but was not inhibited by hAbeta(1-43) and hAbeta(40-1), and was significantly facilitated by hAbeta(17-40) by 16.0%, which is one of the major proteolytic fragments of hAbeta(1-40) generated by the action of Abeta degradation enzymes, such as endothelin-converting enzyme. Pre-administration of human receptor-associated protein, a low-density lipoprotein receptor-related protein (LRP) antagonist, reduced the elimination of [(125)I]hAbeta(1-40) by 20.3%, while quinidine or verapamil, P-glycoprotein (P-gp) inhibitors, did not significantly affect the elimination. Western blot analysis suggested that LRP-1 is expressed in rat brain capillary endothelial cells. In conclusion, the partial contribution of LRP-1 and the minor contribution of P-gp suggest that the hAbeta(1-40) elimination from rat brain is mediated by as yet unidentified molecules.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.neures.2006.07.006

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 32

  1. Bayer, 2003, Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice, Proc. Natl. Acad. Sci. U.S.A., 100, 14187, 10.1073/pnas.2332818100 · DOI
  2. Deane, 2004, LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms, Neuron, 43, 333, 10.1016/j.neuron.2004.07.017 · DOI · Paper page
  3. DeMattos, 2002, Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease, J. Neurochem., 81, 229, 10.1046/j.1471-4159.2002.00889.x · DOI
  4. Eckman, 2001, Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme, J. Biol. Chem., 276, 24540, 10.1074/jbc.M007579200 · DOI
  5. Eckman, 2003, Alzheimer's disease β-amyloid peptide is increased in mice deficient in endothelin-converting enzyme, J. Biol. Chem., 278, 2081, 10.1074/jbc.C200642200 · DOI
  6. Farris, 2003, Insulin-degrading enzyme regulates the levels of insulin, amyloid β protein, and the beta-amyloid precursor protein intracellular domain in vivo, Proc. Natl. Acad. Sci. U.S.A., 100, 4162, 10.1073/pnas.0230450100 · DOI
  7. Field, 2000, Decreased hepatic expression of the low-density lipoprotein (LDL) receptor and LDL receptor-related protein in aging rats is associated with delayed clearance of chylomicrons from the circulation, Metabolism, 49, 492, 10.1016/S0026-0495(00)80014-1 · DOI
  8. Fratiglioni, 1997, Very old women at highest risk of dementia and Alzheimer's disease: incidence data from the Kungsholmen Project, Stockholm, Neurology, 48, 132, 10.1212/WNL.48.1.132 · DOI · Paper page
  9. Hardy, 2002, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science, 297, 353, 10.1126/science.1072994 · DOI · Paper page
  10. Hosoya, 2000, Conditionally immortalized brain capillary endothelial cell lines established from a transgenic mouse harboring temperature-sensitive simian virus 40 large T-antigen gene, AAPS PharmSci., 2, E27, 10.1208/ps020328 · DOI
  11. Iwata, 2001, Metabolic regulation of brain Aβ by neprilysin, Science, 292, 1550, 10.1126/science.1059946 · DOI
  12. Joslin, 1991, Amyloid-β peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor, J. Biol. Chem., 266, 21897, 10.1016/S0021-9258(18)54721-9 · DOI
  13. Kakee, 1996, Brain efflux index as a novel method of analyzing efflux transport at the blood–brain barrier, J. Pharmacol. Exp. Ther., 277, 1550, 10.1016/S0022-3565(25)13107-8 · DOI
  14. Kandimalla, 2005, Pharmacokinetic analysis of the blood-brain barrier transport of 125I-amyloid beta protein 40 in wild-type and Alzheimer's disease transgenic mice (APP, PS1) and its implications for amyloid plaque formation, J. Pharmacol. Exp. Ther., 313, 1370, 10.1124/jpet.104.081901 · DOI
  15. Kang, 1997, Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease, Neurology, 49, 56, 10.1212/WNL.49.1.56 · DOI · Paper page
  16. Kurochkin, 1998, Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme, FEBS Lett., 427, 153, 10.1016/S0014-5793(98)00422-0 · DOI
  17. Kusuhara, 1997, P-glycoprotein mediates the efflux of quinidine across the blood–brain barrier, J. Pharmacol. Exp. Ther., 283, 574, 10.1016/S0022-3565(24)37075-2 · DOI
  18. Lam, 2001, β-Amyloid efflux mediated by p-glycoprotein, J. Neurochem., 76, 1121, 10.1046/j.1471-4159.2001.00113.x · DOI
  19. Matter, 1998, The α5β1 integrin mediates elimination of amyloid-β peptide and protects against apoptosis, J. Cell. Biol., 141, 1019, 10.1083/jcb.141.4.1019 · DOI
  20. Mori, 2004, Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs, J. Neurochem., 90, 931, 10.1111/j.1471-4159.2004.02552.x · DOI
  21. Poduslo, 2001, Permeability of proteins at the blood–brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease, Neurobiol. Dis., 8, 555, 10.1006/nbdi.2001.0402 · DOI
  22. Schuessel, 2005, Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice, Neurobiol. Dis., 18, 89, 10.1016/j.nbd.2004.09.003 · DOI
  23. Seeman, 1997, Psychopathology in women and men: focus on female hormones, Am. J. Psychiatr., 154, 1641, 10.1176/ajp.154.12.1641 · DOI
  24. Shiiki, 2004, Brain insulin impairs amyloid-β(1–40) clearance from the brain, J. Neurosci., 24, 9632, 10.1523/JNEUROSCI.2236-04.2004 · DOI
  25. Terasaki, 2005, Brain-to-blood transporters for endogenous substrates and xenobiotics at the blood-brain barrier: an overview of biology and methodology, NeuroRx, 2, 63, 10.1602/neurorx.2.1.63 · DOI
  26. Vogelgesang, 2002, Deposition of Alzheimer's β-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans, Pharmacogenetics, 12, 535, 10.1097/00008571-200210000-00005 · DOI
  27. Wang, 2003, Gender differences in the amount and deposition of amyloid β in APPswe and PS1 double transgenic mice, Neurobiol. Dis., 14, 318, 10.1016/j.nbd.2003.08.009 · DOI · Paper page
  28. Warshawsky, 1993, 39-kD protein inhibits tissue-type plasminogen activator clearance in vivo, J. Clin. Invest., 92, 937, 10.1172/JCI116669 · DOI
  29. Wengenack, 2000, Targeting Alzheimer amyloid plaques in vivo, Nat. Biotechnol., 18, 868, 10.1038/78482 · DOI
  30. Xie, 2002, Alzheimer's β-amyloid peptides compete for insulin binding to the insulin receptor, J. Neurosci., 22, RC221, 10.1523/JNEUROSCI.22-10-j0001.2002 · DOI · Paper page
  31. Yamaoka, 1981, A pharmacokinetic analysis program (multi) for microcomputer, J. Pharmacobiodyn., 4, 879, 10.1248/bpb1978.4.879 · DOI
  32. Zhang, 2001, Rapid transferrin efflux from brain to blood across the blood–brain barrier, J. Neurochem., 76, 1597, 10.1046/j.1471-4159.2001.00222.x · DOI

Cited by

Sorted by citations

See all 99

Metadata

Authors
Ito, S., Ohtsuki, S., & Terasaki, T.
Venue
Neuroscience Research
Publisher
Elsevier BV
Published
2006-11
Volume
56
Issue
3
Pages
246-252
ISSN
0168-0102
DOI
10.1016/j.neures.2006.07.006
Cited by
99
References
11
Language
en
Licence
Funders
  • Japan Society for the Promotion of Science
  • Ministry of Education, Culture, Sports, Science and Technology

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review