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Cited by 291

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Alzheimer's β-Amyloid Peptides Compete for Insulin Binding to the Insulin Receptor

Xie, Ling, Helmerhorst, Erik, Taddei, Kevin, Plewright, Brian, van Bronswijk, Wilhelm, Martins, Ralph·2002·The Journal of Neuroscience
DOI 10.1523/jneurosci.22-10-j0001.2002
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Registry

Crossref · 10.1523/jneurosci.22-10-j0001.2002

Cites

5 of 5 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • Insulin and Aβ have a similar tertiary structure and both bind to IR, making Aβ a competitive inhibitor able to reduce cellular insulin sensitivity.

    “Insulin and Aβ have a similar tertiary structure and both bind to IR, making Aβ a competitive inhibitor able to reduce cellular insulin sensitivity”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [94]

    The Discussion reports that Aβ competes with insulin for receptor binding and inhibits insulin-promoted receptor autophosphorylation in vitro. It describes a shared sequence motif, not a demonstrated similarity in tertiary structure. Reduced cellular insulin sensitivity is a possible consequence, not a cellular effect established by these experiments. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

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Citations

Cites

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Research works printed but not linked: 1

  1. Small GW, Ercoli LM, Silverman DH, Huang SC, Komo S, Bookheimer SY, Lavretsky H, Miller K, Siddarth P, Rasgon NL, Mazziotta JC, Saxena S, Wu HM, Mega MS, Cummings JL, Saunders AM, Pericak- Vance MA, Roses AD, Barrio JR, Phelps ME (2000) Cerebral met- abolic and cognitive decline in persons at genetic risk for Alzheimer's disease. Proc Natl Acad Sci USA 97:6037-6042.

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Metadata

Authors
Xie, L., Helmerhorst, E., Taddei, K., Plewright, B., van Bronswijk, W., & Martins, R.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2002-05-15
Volume
22
Issue
10
Pages
RC221-RC221
ISSN
  • 0270-6474
  • 1529-2401
DOI
10.1523/jneurosci.22-10-j0001.2002
Cited by
291
References
5
Language
en
Licence
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)

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