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Cited by 14Neuropeptides and Animal PhysiologyPain Mechanisms and TreatmentsRegulation of Appetite and Obesity

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PACAP up-regulates the expression of apolipoprotein D in 3T3-L1 adipocytes. DRG/3T3-L1 co-cultures study

Kosacka, Joanna, Schröder, Thomas, Bechmann, Ingo, Klöting, Nora, Nowicki, Marcin, Mittag, Anja, Gericke, Martin, Spanel-Borowski, Katharina, Blüher, Matthias·2011·Neuroscience Research
DOI 10.1016/j.neures.2010.09.009
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Abstract

The existence of a cross-talk between nerves and fatty tissue is increasingly recognized. Using co-cultures of dorsal root ganglion (DRG)-derived cells and 3T3-L1 adipocytes, we have previously shown that the presence of fat cells enhances neurite outgrowth and number of synapses. Vice versa, neural cells induced expression of neurotrophic adipokines apolipoprotein D and E (ApoD, ApoE) and angiopoietin-1 (Ang-1) by adipocytes. Here, we tested whether pituitary adenylate cyclase-activating peptide (PACAP), which is released by sensory fibres and causes Ca(2+) influx into fat cells, is involved in ApoD induction. Using 3T3-L1 cell cultures, we found that PACAP at a dose of 1 nM up-regulated the expression of ApoD protein and mRNA approx. 2.5 fold. This effect was driven by ERK1/2 acting upon PAC1/VPAC2 receptors. In turn, PACAP-treated 3T3-L1 adipocytes in co-cultures with DRG cells enhanced neurite ramification of neurofilament 200 (NF200)-positive neurons (measured using fluorescence microscopy) and neurofilament 68 protein levels (measured using Western blot analysis). This effect could be blocked using the PAC1/VPAC2 antagonist PACAP(6-38). Scanning cytometry revealed PACAP/ApoD induced low density lipoprotein receptors (LDLR) and ApoE receptor 2 (apoER2) in NF200-positive cells. Thus, a bidirectional loop seems to exist regulating the innervation of fatty tissues: PACAP released from sensory fibres might stimulate fat cells to synthesize neurotrophic adipokines, which, in…

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Metadata

Authors
Kosacka, J., Schröder, T., Bechmann, I., Klöting, N., Nowicki, M., Mittag, A., Gericke, M., Spanel-Borowski, K., & Blüher, M.
Affiliations
Leipzig University (DE)
Corresponding author
Kosacka, Joanna
ORCID
Venue
Neuroscience Research
Publisher
Elsevier BV
Published
2011-01
Volume
69
Issue
1
Pages
8-16
ISSN
0168-0102 (ISSN-L)
DOI
10.1016/j.neures.2010.09.009
OpenAlex
W2004320859
Cited by
14
References
2
Citations by year
2024: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2016: 2 · 2015: 1 · 2013: 3 · 2012: 2
FWCI
0.85
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
pituitary adenylate cyclase-activating peptide, apolipoprotein D, adipocytes, dorsal root ganglia, neurite outgrowth, ERK signaling, PAC1 receptor, VPAC2 receptor, PACAP(6-38), LDL receptor, peripheral innervation, adipose tissue innervation
MeSH terms
Animals, Apolipoproteins E, Ganglia, Spinal, Rats, Inbred WF, Synapses, Up-Regulation, Neurites, Neurofilament Proteins, Adipocytes, Coculture Techniques, 3T3-L1 Cells, Angiopoietin-1, Mitogen-Activated Protein Kinase 3, Pituitary Adenylate Cyclase-Activating Polypeptide, Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I, Receptors, Vasoactive Intestinal Peptide, Type II, Mice, Rats, Apolipoproteins D, Adipokines

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