The DOI matches its Crossref record; 128 of the 132 references it cites were found in a registry or an index.
How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis
Abstract
Recently higher rates of autism diagnosis suggest involvement of environmental factors in causing this developmental disorder, in concert with genetic risk factors. Autistic children exhibit evidence of oxidative stress and impaired methylation, which may reflect effects of toxic exposure on sulfur metabolism. We review the metabolic relationship between oxidative stress and methylation, with particular emphasis on adaptive responses that limit activity of cobalamin and folate-dependent methionine synthase. Methionine synthase activity is required for dopamine-stimulated phospholipid methylation, a unique membrane-delimited signaling process mediated by the D4 dopamine receptor that promotes neuronal synchronization and attention, and synchrony is impaired in autism. Genetic polymorphisms adversely affecting sulfur metabolism, methylation, detoxification, dopamine signaling and the formation of neuronal networks occur more frequently in autistic subjects. On the basis of these observations, a "redox/methylation hypothesis of autism" is described, in which oxidative stress, initiated by environment factors in genetically vulnerable individuals, leads to impaired methylation and neurological deficits secondary to reductions in the capacity for synchronizing neural networks.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Accumulating evidence suggests that a common feature in autism cases may be oxidative stress, the mechanism through which environmental factors exert their deleterious effects, which may be further exacerbated by the interaction of genetically susceptible alleles [96–100].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [97]
Citations
Cites
1 retracted
Cheuk, D. K., & Wong, V. (2006) · Neuropediatrics · doi:10.1055/s-2006-924577 · Cited by 69
RetractedMetals, Toxicity and Oxidative Stress
Valko, M., Morris, H., & Cronin, M. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053764635 · Cited by 5,018
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587
Lanphear, B. P., Hornung, R., Khoury, J., Yolton, K., Baghurst, P., Bellinger, D. C., Canfield, R. L., Dietrich, K. N., Bornschein, R., Greene, T., et al. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7688 · Cited by 2,205
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
Bartos, M., Vida, I., & Jonas, P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2044 · Cited by 2,070
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788
Methionine metabolism in mammals
Finkelstein, J. D. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90070-2 · Cited by 1,495
Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E. R., Nemanov, L., Katz, M., & Belmaker, R. H. (1996) · Nature Genetics · doi:10.1038/ng0196-78 · Cited by 1,475
Research works printed but not linked: 2
- Boris, 2004, Association of MTHFR gene variants with autism, J Am Phys Surg, 9, 106
- Rice, 2007, Prevalence of autism spectrum disorders—autism and developmental disabilities monitoring network, CDC Surv Rep, 56, 12
Cited by
Sorted by citations
Items 201–300 of 323
Jaureguiberry, S., & Venturino, A. (2020) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000630 · Cited by 9
Soltani, Z., Shariatpanahi, M., Aghsami, M., Owliaey, H., & Kheradmand, A. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114464 · Cited by 10
Díaz‐Anzaldúa, A., & Martínez, A. D. (2013) · Revista de Neurología · doi:10.33588/rn.5712.2013072 · Cited by 11
Vitamins B 9 and B 12 in children with attention deficit hyperactivity disorder (ADHD)
Razavinia, F., Ebrahimian, A., Siahkal, S. F., Ghazinezhad, N., & Abedi, P. (2024) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000809 · Cited by 8
Morrow, W. P., Sardar, S., Thapa, P., Hossain, M. S., Foss, F. W., & Pierce, B. S. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.08.013 · Cited by 8
Michelassi, G. C., Bortoletti, H. S., Pinheiro, T. D., Nobayashi, T., de Barros, F. R. D., Testa, R. L., Silva, A., Revers, M. C., Portolese, J., Pedrini, H., et al. (2023) · Lecture notes in computer science · doi:10.1007/978-3-031-45389-2_18 · Cited by 8
Mansoor, S. S., Shafi, S. S., & Ahmed, S. (2011) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2011.06.026 · Cited by 8
Choi, J. W., Oh, J., Bennett, D. H., Kannan, K., Tancredi, D. J., Miller, M. R., Schmidt, R. J., & Shin, H. (2024) · Environmental Research · doi:10.1016/j.envres.2024.120141 · Cited by 8
Autism, heparan sulfate and potential interventions
Alexander, J. S., Keles, G., Killingsworth, J., Bronson, R., Pérez, C., Sawmiller, D. R., & Shytle, R. D. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114050 · Cited by 7
Semprún-Hernández, N., Bohórquez-Visier, A. P., Henríquez, A. R. B., Rogelio, C., Medina, F. H., Maury-Sintjago, E., & Ocando, N. M. (2011) · Trace Elements and Electrolytes · doi:10.5414/tex01188 · Cited by 7
The Redox/Methylation Hypothesis of Autism
Deth, R. C., & Muratore, C. (2009) · CRC Press eBooks · doi:10.1201/9781420068870-c7 · Cited by 7
Self-citationIncreased Vulnerability to Oxidative Stress and Mitochondrial Dysfunction in Autism
Chauhan, A., & Chauhan, V. P. S. (2015) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-2190-4_20 · Cited by 7
Chauhan, V. P. S., & Chauhan, A. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_4 · Cited by 7
Classification of Facial Images to Assist in the Diagnosis of Autism Spectrum DisorderPreprint
Michelassi, G. C., Bortoletti, H. S., Pinheiro, T. D., Nobayashi, T., de Barros, F. R. D., Testa, R. L., Silva, A., Revers, M. C., Portolese, J., Pedrini, H., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-448184/v1 · Cited by 7
Jiao, Y., Wang, M., Li, H., Jia, Q., Xu, L., Zhong, L., Huang, J., Li, L., Xiang, W., & Yao, P. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15935 · Cited by 6
Advances in Causes and Treatment of Autism
XiaoLi, W. U., Jin, F., & Duan, Y. (2015) · Scientia Sinica Vitae · doi:10.1360/n052015-0108 · Cited by 5
Serum vitamin B12 and folic acid status in Autism spectrum disorder children
Mahruba, S. N., Begum, S., Shahjadi, S., Afroz, S., Siddiqi, U. R., & Parvin, J. (2020) · Journal of Bangladesh Society of Physiologist · doi:10.3329/jbsp.v14i2.44783 · Cited by 6
Oxidative Stress and Mitochondrial Dysfunction in ASDs
Gu, F., Chauhan, V. P. S., & Chauhan, A. (2014) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814602167_0016 · Cited by 6
Reeda, V. S. J., Divya, P., Manikandan, A., Suja, R., Siddiqui, N., Aljohani, M., Althubeiti, K., Zaid, M., Sharma, M. K., Murtuza, M. W., et al. (2025) · ChemistrySelect · doi:10.1002/slct.202502748 · Cited by 5
Asakura, J., Nagao, M., Shinohara, M., Nishimori, M., Yoshikawa, S., Iino, T., Seto, Y., Tanaka, H., Satomi‐Kobayashi, S., Ishida, T., et al. (2023) · Heart and Vessels · doi:10.1007/s00380-023-02302-4 · Cited by 5
Neurodevelopmental Disorders (NDDs) in Children: Role of Maternal Factors
Banu, L. A. M., Haque, F. A., & Tasnim, S. (2023) · Bangladesh Journal of Obstetrics & Gynaecology · doi:10.3329/bjog.v37i2.69033 · Cited by 6
Papaya epicarp extract protects against aluminum-induced neurotoxicity
Waly, M. I., Guizani, N., Ali, A., & Rahman, M. S. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012168 · Cited by 5
Self-citationRedox/Methylation Theory and Autism
Deth, R. C., Trivedi, M. S., Hodgson, N., Muratore, C., & Waly, M. I. (2013) · Springer eBooks · doi:10.1007/978-1-4614-4788-7_78 · Cited by 4
Self-citationCould autism with mental retardation result from digenism and frequent de novo mutations?
Moraine, C., Bonnet‐Brilhault, F., Laumonnier, F., & Gomot, M. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970802627455 · Cited by 7
Vitamin D deficiency and autism; a review on recent findings
Sotodehasl, N., Tamadon, M. R., & Malek, F. (2017) · Journal of Parathyroid Disease · doi:10.15171/jpd.2018.04 · Cited by 5
Pierce, B. S., Schmittou, A. N., York, N. J., Madigan, R. P., Nino, P. F., Foss, F. W., & Lockart, M. M. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.105777 · Cited by 4
D’Adamo, C. R., Nelson, J. L., Miller, S. N., Hong, M. R., Lambert, E., & Ruhm, H. T. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14060641 · Cited by 5
Cannon, M. L., Toma, R., Ganeshan, S., Varela, E. Á., Vuyisich, M., & Banavar, G. S. (2024) · NeuroSci · doi:10.3390/neurosci5030022 · Cited by 4
Environmental Influences on Biochemistry in Autism Spectrum Disorder
Wormwood, K. L. (2014) · Autism - Open Access · doi:10.4172/2165-7890.1000e123 · Cited by 4
Fiorezi, J. N., Franke, S. I. R., Prá, D., Garcia, E. L., & Renner, J. D. P. (2017) · Cinergis · doi:10.17058/cinergis.v18i0.11174 · Cited by 4
A Novel Link between Early Life Allergen Exposure and Neuroimmune Development in Children
Kushnir‐Sukhov, N. M. (2020) · Journal of Clinical & Experimental Immunology · doi:10.33140/jcei.05.04.06 · Cited by 4
Oxidative Stress: A Potential Link Between Pesticide Exposure and Early-Life Neurological Disorders
Mani, S., Jain, A., Gulati, A., Tyagi, S., Pal, K. V., Jaiswal, H., & Singh, M. (2021) · Molecular and integrative toxicology · doi:10.1007/978-3-030-83446-3_10 · Cited by 3
Jin, F., Duan, Y., & XiaoLi, W. U. (2015) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972015-00355 · Cited by 3
Setiawati, Y., Mukono, H. J., Wahyuhadi, J., & Warsiki, E. (2018) · Health Notions · doi:10.33846/hn.v2i4.168 · Cited by 4
(2015) · Apple Academic Press eBooks · doi:10.1201/b18030-3 · Cited by 6
Mammalian Cysteine Dioxygenase
Driggers, C., Stipanuk, M. H., & Karplus, P. A. (2015) · Wiley eBooks · doi:10.1002/9781119951438.eibc2326 · Cited by 4
Remoção de mercúrio e arsênio em cação-azul, Prionace glauca
Macedo, L. F. L. (2011) · doi:10.11606/d.9.2011.tde-19012011-102635 · Cited by 4
Review of Potential Indicators of Adequacy and Selection of Indicators: Calcium and Vitamin D
Ross, A. C., Taylor, C. L., Yaktine, A. L., & Valle, H. B. D. (2011) · Cited by 3
Familiarity of evidence based practices in Chinese caregivers of autistic children
Bak, M. Y. S., Reilly, A. M., Yang, Y., Abas, H., Pan, Q., & Hugh, M. L. (2022) · International Journal of Developmental Disabilities · doi:10.1080/20473869.2022.2142374 · Cited by 4
Role of oxidative stress in the pathogenesis of autism spectrum disorders
Belokoskova, S. G., & Tsikunov, S. G. (2023) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf567781 · Cited by 5
Autism and Pediatric Dentistry: A Literature Review
Ashiry, E. A. E. (2020) · Egyptian Dental Journal /Egyptian Dental Journal · doi:10.21608/edj.2020.24022.1018 · Cited by 3
York, N. J., Lockart, M. M., Schmittou, A. N., & Pierce, B. S. (2023) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-023-01990-7 · Cited by 2
Indika, N.-L. R., Jasinge, E. A., Wijetunge, S., Peiris, H., ENGELEN, M. P. K. J., Deutz, N. E. P., & Perera, R. (2024) · Research in Autism · doi:10.1016/j.rasd.2024.102411 · Cited by 3
Oxidative Stress and Dynamic Thiol/Disulfide Homeostasis in Autism: A Focus on Early Childhood
Teke, H., Balcı, Ş., Neşeli̇oğlu, S., Teke, S., Erel, Ö., Tamer, L., & Toros, F. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02358-z · Cited by 2
Indika, N.-L. R., Senarathne, U. D., Anandavadivel, S., Senevirathne, B. S., Karunathilaka, S., Dushmantha, W. K. T., Abeysundara, P. D. A., & Ekanayake, S. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106788 · Cited by 4
Autism Spectrum Disorders (ASD): From Diagnosis to Management
Marriam, A. A. S. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.1000154 · Cited by 2
Kane, P., Cartaxo, A., & Deth, R. C. (2009) · CRC Press eBooks · doi:10.1201/9781420067637.sec6 · Cited by 2
Self-citationWhat are the Sociodemographic and Clinical Risk Factors for Autism Spectrum Disorder?
Beşenek, M. (2020) · Çocuk ve Gençlik Ruh Sağlığı Dergisi / Turkish Journal of Child and Adolescent Mental Health · doi:10.4274/tjcamh.galenos.2020.88597 · Cited by 2
Theoharides, T. C., & Tsilioni, I. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_40 · Cited by 3
Effects of thymoquinone on valproic acid-induced oxidative stress in perinatal rat brain
Tunçak, S., ESMERCE, B., Aydin, B., & Gören, B. (2023) · Anatolian Journal of Botany · doi:10.30616/ajb.1254803 · Cited by 2
Neuroinflammation and neuroprotection in schizophrenia and autism spectrum disorder
Mekori‐Domachevsky, E., Segal‐Gavish, H., & Gross, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814037-6.00011-2 · Cited by 2
Aggernæs, B. (2020) · AIMS molecular science · doi:10.3934/molsci.2020008 · Cited by 3
Classificação de imagens faciais para o auxílio ao diagnóstico do transtorno do espectro autista
Pinheiro, T. D. (2018) · doi:10.11606/d.100.2018.tde-23052018-140406 · Cited by 2
Disrupted functional connectome in a rodent model of autism during social isolation
Kemecsei, R., Dániel-Papp, S., Balázs, D., Tewelde, E. G., Csillag, A., & Zachár, G. (2025) · Frontiers in Neural Circuits · doi:10.3389/fncir.2025.1525130 · Cited by 1
Metwally, A. M., Omar, T. M. Y., Raouf, E. R. A., Ashaat, E. A., Elsaeid, A., El‐Saied, M. M., Elkhouly, A. E., Hassan, N. A.-M., Helmy, M. A., Goda, A. A., et al. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04877-7 · Cited by 1
Liu, H., Zhang, Z., Zheng, K., Liang, Z., Chen, C.-S., Carothers, C., & Hahn, J. (2026) · Annals of Biomedical Engineering · doi:10.1007/s10439-026-04204-8 · Cited by 2
Perinatal Immune Activation and Risk of Autism
Theoharides, T. C., Angelidou, A., Alysandratos, K., Asadi, S., Francis, K., Lykouras, L., & Kalogeromitros, D. C. (2011) · InTech eBooks · doi:10.5772/17436 · Cited by 1
Environmental Toxicants and Autism Spectrum Disorders
Ming, X. (2012) · Autism - Open Access · doi:10.4172/2165-7890.1000e108 · Cited by 1
Possible Impact of Innate Immunity on Autism
Jyonouchi, H. (2009) · CRC Press eBooks · doi:10.1201/9781420068870-c13 · Cited by 1
Trastornos del espectro autista
Fitzgerald, K. N., Hyman, M. A., & Swift, K. M. (2012) · Cited by 1
HEAVY METAL OVERLOAD IN AUTISTIC CHILDREN
El Safty, K. (2012) · Egyptian Journal of Occupational Medicine · doi:10.21608/ejom.2012.753 · Cited by 1
García, M., & BUWA, V. (2022) · Innovare Journal of Medical Sciences · doi:10.22159/ijms.2022.v10i4.45114 · Cited by 1
An Analysis of Glycolytic Enzymes in the Cellular Response to Metal Toxicity
Shanmuganathan, A. (2022) · UPT. Syiah Kuala University Library (Syiah Kuala University) · doi:10.57709/1063900 · Cited by 1
Genetic Polymorphism Related to Oxidative Stress in Autism
Yoo, H. J. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_20 · Cited by 1
Clinical Evaluations on the Diagnosis of Autism
Dobre, M., & Stoic, I. (2011) · InTech eBooks · doi:10.5772/17912 · Cited by 1
Consumo de ácido fólico en el embarazo y reducción del riesgo de trastornos del espectro autista
de Santander, E. D. X. N. D. M. U. I., Rangel-Rivera, D. A., Zambrano, S. E. O., & de Santander, U. I. (2015) · Revista Médicas UIS · doi:10.18273/revmed.v28n3-2015007 · Cited by 1
Autism Spectrum Disorder, Fear Response, and Environmental Exposures
Theoharides, T. C., Sant, J., & Giota, M.-E. (2019) · Advances in human services and public health (AHSPH) book series · doi:10.4018/978-1-5225-7635-8.ch002 · Cited by 1
Redox Imbalance and the Metabolic Pathology of Autism
Deth, R. C., Waly, M. I., Muratore, C., & Hodgson, N. (2010) · doi:10.1002/9780470917060.ch22 · Cited by 1
Self-citationBiochemical Biomarkers for Autism Spectrum Disorder
Anderson, G. M. (2014) · Wiley eBooks · doi:10.1002/9781118911389.hautc19 · Cited by 1
Feeding difficulties in young children with and without autism.
Pugh, A. N. (2009) · doi:10.18297/etd/1163 · Cited by 1
Prenatal and Perinatal Factors Associated with Pediatric Autism Spectrum Disorder in East ChinaPreprint
Li, Y., Han, L., Ding, N., Zhang, Z., Lin, Y., & Ke, X. (2021) · Research Square · doi:10.21203/rs.3.rs-1105841/v1 · Cited by 1
CHARACTERIZATION AND TREATMENT OF A NOVEL MOUSE MODEL OF TSC-ASSOCIATED AUTISM
Reith, R. M. (2012) · Digital Commons-TMC (Texas Medical Center)
A Perspective on Systemic Nutrition and Nutritional Genomics
Escott-Stump, S. A. (2009) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)
Possible Endophenotypes in the Search for Genetic Risk Factors in Autism Spectrum Disorders
Díaz‐Anzaldúa, A., Gutiérrez, R. R., Díaz‐Anzaldúa, A., & Lagunas, J. O. H. (2015) · InTech eBooks · doi:10.5772/60039
Complementary Medicine Products Used in Autism - Evidence for Rationale
Semple, S. J., Hewton, C., Paterson, F., & Angley, M. T. (2011) · InTech eBooks · doi:10.5772/17357
Oxidative Stress in Egyptian Children with Autism: Relation to Autoimmunity
Hewedi, D. H., Mostafa, G. A., & Hadidi, E. M. A. N. E. (2015) · European Psychiatry · doi:10.1016/s0924-9338(15)30628-3
A perspective on nutritional genomics.
Escott-Stump, S. (2009) · Topics in Clinical Nutrition · doi:10.1097/tin.0b013e3181a6b8f5
Epigenetics and autism: Insights for future research
Samtani, R. (2014)
Potential Biomarkers for Diagnosis and Screening of Autism Spectrum Disorders
Meiliana, A., & Wijaya, A. (2014) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v6i3.27
Neuhaus, D. (2015) · Common Library Network (Der Gemeinsame Bibliotheksverbund)
Structural connectivity of the brain in autism spectrum disorder
Gibbard, C. R. (2016) · UCL Discovery (University College London)
Crowell, J. K. (2015) · UTA ResearchCommons (University of Texas Arlington)
Mechanistic study of cysteine dioxygenase, a non-heme mononuclear iron enzyme
Li, W. (2014) · UTA ResearchCommons (University of Texas Arlington)
Biochemical, kinetic and spectroscopic characterizations of non-heme iron oxygenase enzymes
Subedi, B. P. (2015) · UTA ResearchCommons (University of Texas Arlington)
Gallagher, C. M. (2012) · SUNY Digital Repository Support (State University of New York System)
Αιτιολογικοί παράγοντες των διαταραχών αυτιστικού φάσματος(ΔΑΦ)
Αντωνίου, Α. Σ., & Daliana, N. (2017) · Πανελλήνιο Συνέδριο Επιστημών Εκπαίδευσης · doi:10.12681/edusc.836
The Role of Endocrine Disruptors in Autism Spectrum Disorder
Şahin, G. A. (2018) · Turkiye Klinikleri Journal of Health Sciences · doi:10.5336/healthsci.2018-61638
Biología, patobiología y bioclínica de la homocisteína eh la especie humana
García, G. A. (2010) · Revista Repertorio de Medicina y Cirugía · doi:10.31260/repertmedcir.v19.n2.2010.586
Nonessential metals and their brain pathology
Grabrucker, A. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821132-8.00005-7
Cavalcante, F. P., Barboza, A. D., & de Souza, H. C. (2021) · doi:10.22533/at.ed.8082108097
(2009) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32832ad5c0
Gunawan, R., & Bagheri, N. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-434-5
Shwe, T. T. W., Kyi‐Tha‐Thu, C., Fujitani, Y., Tsukahara, S., & Hirano, S. (2020) · Research Square · doi:10.21203/rs.3.rs-41390/v2
Metadata
- Authors
- Deth, R., Muratore, C., Benzecry, J., Power-Charnitsky, V.-A., & Waly, M.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Deth, Richard
- Venue
- NeuroToxicology
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 29
- Issue
- 1
- Pages
- 190-201
- ISSN
- 0161-813X (ISSN-L)
- OpenAlex
- W2167943688
- Cited by
- 325
- References
- 132
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 12 · 2023: 13 · 2022: 12 · 2021: 16 · 2020: 17 · 2019: 11 · 2018: 17 · 2017: 16 · 2016: 15 · 2015: 28 · 2014: 27 · 2013: 20 · 2012: 34
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroToxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Keywords
- autism spectrum disorder, oxidative stress, DNA methylation, sulfur metabolism, methionine synthase, vitamin B12, folic acid, dopamine signaling, dopamine D4 receptor, phospholipid methylation, neural network synchronization, genetic polymorphism, environmental toxic exposure
- MeSH terms
- Animals, Autistic Disorder, Environment, Humans, Methylation, Models, Biological, Oxidation-Reduction, Sulfur, Oxidative Stress, Receptors, Dopamine D4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
