Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism
Open accessAbstract
Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism.
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Several lines of evidence indicate oxidative stress and mitochondrial dysfunction are prevalent in individuals with ASD.
“There are presently several lines of evidence indicating oxidative stress and mitochondrial dysfunction are prevalent in individuals with ASD [3,10,11,12,13,14,15,16].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [14]
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The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615 · see citing works
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587 · see citing works
Strong association of de novo copy number mutations with autism
Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., Yamrom, B., Yoon, S., Krasnitz, A., Kendall, J., et al. (2007) · Science · doi:10.1126/science.1138659 · Cited by 2,795 · see citing works
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works
Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS)
Schopler, E., Reichler, R. J., DeVellis, R. F., & Daly, K. (1980) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02408436 · Cited by 2,432 · cited 3× · see citing works
“1989) and CARS (Schopler et al. 1980) are diagnostic tools used to confirm the diagnosis and severity of autism.”
InfluentialNeuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · see citing works
Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., & Schopler, E. (1989) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02211841 · Cited by 2,030 · see citing works
Stability and flexibility of epigenetic gene regulation in mammalian development
Reik, W. (2007) · Nature · doi:10.1038/nature05918 · Cited by 1,963 · cited 2× · see citing works
“Fetal DNA methylation patterns are established very early during embryogenesis and provide the basis for tissue-specific gene expression, allele-specific gene imprinting, X chromosome inactivation, and chromosome stability (Dean and FergusonSmith 2001; Reik 2007).”
DNA methylation in cancer: too much, but also too little
Ehrlich, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205651 · Cited by 1,540 · see citing works
Analysis of glutathione: implication in redox and detoxification
Pastore, A., Federici, G., Bertini, E., & Piemonte, F. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00200-6 · Cited by 1,185 · see citing works
Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer’s disease
Small, G. W., Ercoli, L. M., Silverman, D. H. S., Huang, S.-C., Komo, S., Bookheimer, S. Y., Lavretsky, H., Miller, K., Siddarth, P., Rasgon, N. L., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090106797 · Cited by 790 · see citing works
Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis
Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773 · see citing works
Helbock, H. J., Beckman, K. B., Shigenaga, M. K., Walter, P. B., Woodall, A., Yeo, H. C. H., & Ames, B. N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.288 · Cited by 688 · see citing works
Chauhan, A., & Chauhan, V. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.007 · Cited by 656 · see citing works
Bourgeron, T. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.06.003 · Cited by 637 · see citing works
Redox modifications of protein-thiols: emerging roles in cell signaling.
Biswas, S., Chida, A., & Rahman, I. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.10.044 · Cited by 631 · see citing works
James, S. J., Melnyk, S., Jernigan, S., Cleves, M. A., Halsted, C. H., Wong, D. H., Cutler, P., Bock, K., Boris, M., Bradstreet, J., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30366 · Cited by 607 · see citing works
Self-citationGenomic and epigenetic evidence for oxytocin receptor deficiency in autism
Gregory, S. G., Connelly, J. J., Towers, A. J., Johnson, J., Biscocho, D., Markunas, C. A., Lintas, C., Abramson, R. K., Wright, H. H., Ellis, P., et al. (2009) · BMC Medicine · doi:10.1186/1741-7015-7-62 · Cited by 576 · see citing works
Berk, M., Copolov, D., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., Judd, F., Katz, F., Katz, P., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.004 · Cited by 552 · see citing works
Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo
Do, K. Q., Trabesinger, A. H., Kirsten‐Krüger, M., Lauer, C. J., Dydak, U., Hell, D., Holsboer, F., Boesiger, P., & Cuénod, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00229.x · Cited by 540 · see citing works
Belmonte, M. K., Cook, E. H., Anderson, G. M., Rubenstein, J. L. R., Greenough, W. T., Beckel-Mitchener, A., Courchesne, E., Boulanger, L. M., Powell, S. B., Levitt, P. R., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001499 · Cited by 442 · see citing works
Samaco, R. C., Hogart, A., & LaSalle, J. M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi045 · Cited by 420 · see citing works
<i>N</i> -acetylcysteine for antioxidant therapy: pharmacology and clinical utility
Dodd, S., Dean, O., Copolov, D. L., Malhi, G. S., & Berk, M. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14728220802517901 · Cited by 413 · see citing works
Castro, R., Rivera, I. A., Struys, E. A., Jansen, E. E. W., Ravasco, P., Camilo, M., Blom, H. J., Jakobs, C., & de Almeida, I. T. (2003) · Clinical Chemistry · doi:10.1373/49.8.1292 · Cited by 409 · see citing works
Longitudinal changes in grey and white matter during adolescence
Giorgio, A., Watkins, K. E., Chadwick, M., James, S., Winmill, L., Douaud, G., De Stefano, N., Matthews, P. M., Smith, S. M., Johansen-Berg, H., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.08.003 · Cited by 394 · see citing works
The methylation, neurotransmitter, and antioxidant connections between folate and depression.
Miller, A. L. (2008) · PubMed · Cited by 393 · see citing works
Cell signalling and the glutathione redox system
Filomeni, G., Rotilio, G., & Ciriolo, M. R. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01176-0 · Cited by 357 · see citing works
Guerri, C., & Pascual, M. (2010) · Alcohol · doi:10.1016/j.alcohol.2009.10.003 · Cited by 344 · see citing works
Pilger, A., & Rüdiger, H. W. (2006) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-006-0106-7 · Cited by 341 · see citing works
Epigenetics of autism spectrum disorders
Schanen, N. C. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl213 · Cited by 341 · see citing works
Novel de novo SHANK3 mutation in autistic patients
Gauthier, J., Spiegelman, D., Piton, A., Lafrenière, R. G., Laurent, S., St‐Onge, J., Lapointe, L., Hamdan, F. F., Cossette, P., Mottron, L., et al. (2009) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30822 · Cited by 321 · see citing works
Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence
Gysin, R., Kraftsik, R., Sandell, J., Bovet, P., Chappuis, C., Conus, P., Deppen, P., Preisig, M., Ruiz, V., Steullet, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706778104 · Cited by 309 · see citing works
Jones, D. P., Go, Y., Anderson, C. L., Ziegler, T. R., Kinkade, J. M., & Kirlin, W. G. (2004) · The FASEB Journal · doi:10.1096/fj.03-0971fje · Cited by 302 · see citing works
Söğüt, S., Zoroğlu, S. S., Özyurt, H., Yilmaz, H. R., Özuğurlu, F., Sivaslı, E., Yetkin, Ö., Yanık, M., Tutkun, H., SAVAS, H. A., et al. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00119-0 · Cited by 275 · see citing works
Evidence of Toxicity, Oxidative Stress, and Neuronal Insult in Autism
Kern, J. K., & Jones, A. M. (2006) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400600882079 · Cited by 265 · see citing works
Importance of methyl donors during reproduction
Zeisel, S. H. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26811d · Cited by 251 · see citing works
James, S. J., Melnyk, S., Fuchs, G. J., Reid, T., Jernigan, S., Pavliv, O., Hubanks, A., & Gaylor, D. W. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26615 · Cited by 241 · see citing works
Self-citationIncreased excretion of a lipid peroxidation biomarker in autism
Ming, X., Stein, T. P., Brimacombe, M., Johnson, W. G., Lambert, G. H., & Wagner, G. C. (2005) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.06.002 · Cited by 236 · see citing works
Zoroğlu, S. S., Armutçu, F., Özen, Ş., Gürel, A., Sivaslı, E., Yetkin, O., & Meram, İ. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0456-7 · Cited by 235 · see citing works
Melnyk, S. (1999) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(99)00033-9 · Cited by 231 · see citing works
Self-citationThree hypotheses for developmental defects that may underlie some forms of autism spectrum disorder
Rubenstein, J. L. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328336eb13 · Cited by 230 · see citing works
Friso, S., Choi, S., Dolnikowski, G. G., & Selhub, J. (2002) · Analytical Chemistry · doi:10.1021/ac020050h · Cited by 225 · see citing works
James, S. J., Rose, S., Melnyk, S., Jernigan, S., Blossom, S. J., Pavliv, O., & Gaylor, D. W. (2009) · The FASEB Journal · doi:10.1096/fj.08-128926 · Cited by 223 · see citing works
Self-citationMelnyk, S., Pogribna, M., Pogribny, I. P., Yi, P., & James, S. J. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.2.265 · Cited by 221 · see citing works
Self-citationThe LEARn model: an epigenetic explanation for idiopathic neurobiological diseases
Lahiri, D. K., Maloney, B., & Zawia, N. H. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.82 · Cited by 211 · see citing works
Investigation of antioxidant enzymes in children with autistic disorder
Yorbık, Ö., Sayal, A., Akay, C., Akbiyik, D. I., & Söhmen, T. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2002.0439 · Cited by 207 · see citing works
Andreazza, A. C., Kapczinski, F. P., Kauer‐Sant’Anna, M., Walz, J. C., Bond, D. J., Gonçalves, C. A., Young, L. T., & Yatham, L. N. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0935 · Cited by 199 · see citing works
Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine
Finkelstein, J. D. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.341 · Cited by 196 · see citing works
Shigenaga, M. K., Park, J., Cundy, K. C., Gimeno, C. J., & Ames, B. N. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86146-m · Cited by 185 · see citing works
Glutathione: a novel treatment target in psychiatry
Berk, M., Ng, F., Dean, O., Dodd, S., & Bush, A. I. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.05.001 · Cited by 183 · see citing works
Gene expression profiling reveals a signaling role of glutathione in redox regulation
Fratelli, M., Goodwin, L. O., Ørom, U. A., Lombardi, S., Tonelli, R., Mengozzi, M., & Ghezzi, P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504398102 · Cited by 180 · see citing works
A mathematical model of glutathione metabolism
Reed, M. C., Thomas, R. L., Pavisic, J., James, S. J., Ulrich, C. M., & Nijhout, H. F. (2008) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-5-8 · Cited by 173 · see citing works
Epigenetic dysregulation in cognitive disorders
Gräff, J., & Mansuy, I. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06787.x · Cited by 163 · see citing works
Jiang, Y., Sahoo, T., Michaelis, R. C., Bercovich, D., Bressler, J., Kashork, C. D., Liu, Q., Shaffer, L. G., Schroer, R. J., Stockton, D. W., et al. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30297 · Cited by 159 · see citing works
Extracellular redox modulation by regulatory T cells
Yan, Z., Garg, S. K., Kipnis, J., & Banerjee, R. V. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.212 · Cited by 145 · see citing works
Altered Vascular Phenotype in Autism
Yao, Y., Walsh, W. J., McGinnis, W. R., & Praticò, D. (2006) · Archives of Neurology · doi:10.1001/archneur.63.8.1161 · Cited by 131 · see citing works
Increase in Cerebellar Neurotrophin-3 and Oxidative Stress Markers in Autism
Sajdel-Sulkowska, E. M., Xu, M., & Koibuchi, N. (2009) · The Cerebellum · doi:10.1007/s12311-009-0105-9 · Cited by 122 · see citing works
Redox regulation of homocysteine-dependent glutathione synthesis
Vitvitsky, V., Mosharov, E. V., Tritt, M., et al. (2003) · Redox Report · doi:10.1179/135100003125001260 · Cited by 121 · see citing works
The stress proteome of Enterococcus faecalis
Giárd, J.-C., Laplace, J., Rincé, A., Pichereau, V., Benachour, A., Leboeuf, C., Flahaut, S., Auffray, Y., & Hartke, A. (2001) · Electrophoresis · doi:10.1002/1522-2683(200108)22:14 · Cited by 120 · see citing works
Redox Regulation of Cell Growth and Cell Death
Kwon, Y., Masutani, H., Nakamura, H., Ishii, Y., & Yodoi, J. (2003) · Biological chemistry · doi:10.1515/bc.2003.111 · Cited by 117 · see citing works
Neurometabolic disorders and dysfunction in autism spectrum disorders
Zecavati, N., & Spence, S. J. (2009) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-009-0021-x · Cited by 110 · see citing works
MECP2 promoter methylation and X chromosome inactivation in autism
Nagarajan, R. P., Patzel, K. A., Martin, M. R., Yasui, D. H., Swanberg, S. E., Hertz‐Picciotto, I., Hansen, R. L., de Water, J. V., Pessah, I. N., Jiang, R., et al. (2008) · Autism Research · doi:10.1002/aur.24 · Cited by 108 · see citing works
Mohiuddin, I. T., Chai, H., Lin, P. H., Lumsden, A. B., Yao, Q., & Chen, C. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2005.10.008 · Cited by 106 · see citing works
Integrity of the methylation cycle is essential for mammalian neural tube closure
Dunlevy, L. P. E., Burren, K. A., Mills, K., et al. (2006) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20286 · Cited by 104 · see citing works
Redox State as a Central Modulator of Precursor Cell Function
Noble, M., Smith, J., Power, J., & Mayer-Pröschel, M. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07481.x · Cited by 104 · see citing works
Mechanisms for the involvement of DNA methylation in colon carcinogenesis.
Schmütte, C., Yang, A. S., Nguyen, T. T., Beart, R. W., & Jones, P. A. (1996) · PubMed · Cited by 104 · see citing works
Dean, O. M., van den Buuse, M., Bush, A. I., Copolov, D., Ng, F., Dodd, S., & Berk, M. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709788803060 · Cited by 101 · see citing works
The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits
Allan, A. M., Liang, X., Luo, Y., Pak, C., Li, X., Szulwach, K. E., Chen, D., Jin, P., & Zhao, X. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn102 · Cited by 101 · see citing works
The Role of One-Carbon Metabolism in Schizophrenia and Depression
Frankenburg, F. R. (2007) · Harvard Review of Psychiatry · doi:10.1080/10673220701551136 · Cited by 101 · see citing works
Li, Y., Liu, Y., Strickland, F. M., & Richardson, B. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.12.008 · Cited by 91 · see citing works
One-carbon metabolism and schizophrenia: current challenges and future directions
Krebs, M., Bellon, A., Mainguy, G., Jay, T. M., & Frieling, H. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.10.001 · Cited by 87 · see citing works
Chan, A., Tchantchou, F., Graves, V., Rozen, R., & Shea, T. B. (2008) · The Journal of Nutrition, Health & Aging · doi:10.1007/bf02982630 · Cited by 86 · see citing works
Redox remodeling as an immunoregulatory strategy
Yan, Z., & Banerjee, R. (2010) · Biochemistry · doi:10.1021/bi902022n · Cited by 82 · see citing works
Lenton, K. J., Therriault, H., & Wagner, J. R. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4258 · Cited by 80 · see citing works
Nuclear and Mitochondrial Genome Defects in Autisms
Smith, M., Spence, M. A., & Flodman, P. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03571.x · Cited by 67 · see citing works
Formation and efflux of glutathione disulfide studied in isolated rat hepatocytes
Eklöw, L., Thor, H., & Orrenius, S. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80357-2 · Cited by 66 · see citing works
Dahlmann, H. A., Vaidyanathan, V. G., & Sturla, S. J. (2009) · Biochemistry · doi:10.1021/bi901059k · Cited by 64 · see citing works
Costa, E., Chen, Y., Dong, E., Grayson, D. R., Kundaković, M., Maloku, E., Ruzicka, W. B., Satta, R., Veldić, M., Zhubi, A., et al. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.9.1.87 · Cited by 62 · see citing works
CpG methylation reduces genomic instability
Rizwana, R., & Hahn, P. J. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.24.4513 · Cited by 58 · see citing works
Grayson, D. R., Chen, Y., Dong, E., Kundaković, M., & Guidotti, A. (2009) · Epigenetics · doi:10.4161/epi.4.3.8534 · Cited by 54 · see citing works
Strous, R. D., Ritsner, M. S., Adler, S., Ratner, Y., Maayan, R., Kotler, M., Lachman, H. M., & Weizman, A. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.08.004 · Cited by 47 · see citing works
Tchantchou, F., Graves, M. V., Ashline, D. J., Morin, A., Pimenta, A., Ortiz, D., Rogers, E. J., & Shea, T. B. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.10867 · Cited by 42 · see citing works
Disturbances of one-carbon metabolism in neuropsychiatric disorders: A review
Smythies, J., Gottfries, C., & Regland, B. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00068-6 · Cited by 38 · see citing works
Genomic imprinting: Mother maintains methylation marks
Dean, W., & Ferguson‐Smith, A. C. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00311-6 · Cited by 30 · see citing works
Saudubray, J. (2009) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-009-9958-9 · Cited by 22 · see citing works
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Rose, S., Melnyk, S., Pavliv, O., Bai, S., Nick, T. G., Frye, R. E., & James, S. J. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.61 · Cited by 480 · see citing works
Self-citationClinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review
Deepmala, Slattery, J., Kumar, N., Delhey, L., Berk, M., Dean, O., Spielholz, C., & Frye, R. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.015 · Cited by 463 · see citing works
Jašarević, E., Howerton, C. L., Howard, C. D., & Bale, T. L. (2015) · Endocrinology · doi:10.1210/en.2015-1177 · Cited by 329 · see citing works
The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
Morris, G., & Berk, M. (2015) · BMC Medicine · doi:10.1186/s12916-015-0310-y · Cited by 245 · see citing works
Rose, S., Frye, R. E., Slattery, J., Wynne, R., Tippett, M., Pavliv, O., Melnyk, S., & James, S. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085436 · Cited by 168 · see citing works
Self-citationFrye, R. E., Rose, S., Chacko, J., Wynne, R., Bennuri, S. C., Slattery, J. C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S. G., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.189 · Cited by 130 · see citing works
Self-citationVitamin D and Autism Spectrum Disorder: A Literature Review
Mazahery, H., Camargo, C., Conlon, C., Beck, K., Kruger, M., & Von Hurst, P. (2016) · Nutrients · doi:10.3390/nu8040236 · Cited by 110 · see citing works
Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum
James, S. J., Shpyleva, S., Melnyk, S., Pavliv, O., & Pogribny, I. P. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.8 · Cited by 100 · see citing works
Self-citationFrye, R. E., & Rossignol, D. A. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s38337 · Cited by 96 · see citing works
Shortened telomeres in families with a propensity to autism
Nelson, C. A., Varcin, K. J., Coman, N. K., DeVivo, I., & Tager-Flusberg, H. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.04.006 · Cited by 27 · see citing works
Slattery, J., MacFabe, D., Kahler, S., & Frye, R. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160905123953 · Cited by 20 · see citing works
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- Authors
- Melnyk, S., Fuchs, G. J., Schulz, E., Lopez, M., Kahler, S. G., Fussell, J. J., Bellando, J., Pavliv, O., Rose, S., Seidel, L., Gaylor, D. W., & Jill James, S.
- Affiliations
- Arkansas Children's Hospital (US)
- University of Arkansas for Medical Sciences (US)
- ORCID
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2011-04-26
- Volume
- 42
- Issue
- 3
- Pages
- 367-377
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC3342663
- OpenAlex
- W2070592913
- Cited by
- 250
- References
- 85
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 11 · 2023: 11 · 2022: 13 · 2021: 15 · 2020: 26 · 2019: 13 · 2018: 24 · 2017: 16 · 2016: 25 · 2015: 17 · 2014: 23 · 2013: 23 · 2012: 13
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Arkansas Biosciences Institute
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD051873)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, oxidative stress, DNA methylation, DNA hypomethylation, oxidative protein damage, oxidative DNA damage, antioxidant capacity, metabolic pathways, epigenetic modifications, unaffected siblings, environmental stressors, genetic susceptibility
- MeSH terms
- Autistic Disorder, Child, Child, Preschool, Female, Glutathione, Humans, Male, Case-Control Studies, Reactive Oxygen Species, Oxidative Stress, DNA Methylation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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