Cited by 325Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersFolate and B Vitamins Research

The DOI matches its Crossref record; 128 of the 132 references it cites were found in a registry or an index.

How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis

Deth, Richard, Muratore, Christina, Benzecry, Jorge, Power-Charnitsky, Verna-Ann, Waly, Mostafa·2008·NeuroToxicology

DOI 10.1016/j.neuro.2007.09.010

Open this paper in CoChat — free account

Abstract

Recently higher rates of autism diagnosis suggest involvement of environmental factors in causing this developmental disorder, in concert with genetic risk factors. Autistic children exhibit evidence of oxidative stress and impaired methylation, which may reflect effects of toxic exposure on sulfur metabolism. We review the metabolic relationship between oxidative stress and methylation, with particular emphasis on adaptive responses that limit activity of cobalamin and folate-dependent methionine synthase. Methionine synthase activity is required for dopamine-stimulated phospholipid methylation, a unique membrane-delimited signaling process mediated by the D4 dopamine receptor that promotes neuronal synchronization and attention, and synchrony is impaired in autism. Genetic polymorphisms adversely affecting sulfur metabolism, methylation, detoxification, dopamine signaling and the formation of neuronal networks occur more frequently in autistic subjects. On the basis of these observations, a "redox/methylation hypothesis of autism" is described, in which oxidative stress, initiated by environment factors in genetically vulnerable individuals, leads to impaired methylation and neurological deficits secondary to reductions in the capacity for synchronizing neural networks.

Integrity signals

Registry

Crossref · 10.1016/j.neuro.2007.09.010

Cites

128 of 128 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Attention-Deficit Hyperactivity Disorder and Blood Mercury Level: a Case-Control Study in Chinese Children
Cheuk, D. K., & Wong, V. (2006) · Neuropediatrics · doi:10.1055/s-2006-924577 · Cited by 69
Retracted
Metals, Toxicity and Oxidative Stress
Valko, M., Morris, H., & Cronin, M. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053764635 · Cited by 5,018
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587
Low-Level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis
Lanphear, B. P., Hornung, R., Khoury, J., Yolton, K., Baghurst, P., Bellinger, D. C., Canfield, R. L., Dietrich, K. N., Bornschein, R., Greene, T., et al. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7688 · Cited by 2,205
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
Bartos, M., Vida, I., & Jonas, P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2044 · Cited by 2,070
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788
Methionine metabolism in mammals
Finkelstein, J. D. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90070-2 · Cited by 1,495
Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking
Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E. R., Nemanov, L., Katz, M., & Belmaker, R. H. (1996) · Nature Genetics · doi:10.1038/ng0196-78 · Cited by 1,475
Biologic and pharmacologic regulation of mammalian glutathione synthesis
Griffith, O. W. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00176-8 · Cited by 1,210
Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking
Benjamin, J., Li, L., Patterson, C. A., Greenberg, B. D., Murphy, D. L., & Hamer, D. H. (1996) · Nature Genetics · doi:10.1038/ng0196-81 · Cited by 1,191
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1611 · Cited by 955
The Cognitive Neuroscience of Attention
Melara, R. D. (2004) · Sage eBooks · doi:10.4135/9781483328768.n11 · Cited by 797
X-Linked Mental Retardation and Autism Are Associated with a Mutation in the NLGN4 Gene, a Member of the Neuroligin Family
Laumonnier, F., Bonnet-Brilhault, F., Gomot, M., Blanc, R., David, A., Moizard, M.-P., Raynaud, M., Ronce, N., Lemonnier, E., Calvas, P., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/382137 · Cited by 768
Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder.
LaHoste, G. J., Swanson, J. M., Wigal, S. B., Glabe, C. G., Wigal, T. L., King, N., & Kennedy, J. L. (1996) · PubMed · Cited by 678
Oxidative stress in autism
Chauhan, A., & Chauhan, V. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.007 · Cited by 656
The Cognitive Neuroscience of Attention
(2020) · Routledge eBooks · doi:10.4324/9781003048916 · Cited by 653
Dendritic Spine Structural Anomalies in Fragile-X Mental Retardation Syndrome
Irwin, S. A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.1038 · Cited by 626
A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition
Malhotra, A. K., Kestler, L. J., Mazzanti, C. M., Bates, J. A., Goldberg, T. E., & Goldman, D. A. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.652 · Cited by 623
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
James, S. J., Melnyk, S., Jernigan, S., Cleves, M. A., Halsted, C. H., Wong, D. H., Cutler, P., Bock, K., Boris, M., Bradstreet, J., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30366 · Cited by 618
Searching for ways out of the autism maze: genetic, epigenetic and environmental clues
Persico, A. M., & Bourgeron, T. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.05.010 · Cited by 575
Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children
Braun, J. M., Kahn, R. S., Froehlich, T., Auinger, P., & Lanphear, B. P. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9478 · Cited by 573
The Effect of Oxygen on Biochemical Networks and the Evolution of Complex Life
Raymond, J., & Segrè, D. (2006) · Science · doi:10.1126/science.1118439 · Cited by 510
Localization of dopamine D4 receptors in GABAergic neurons of the primate brain
Mrzljak, L., Bergson, C., Pappy, M., Huff, R., Levenson, R., & Goldman-Rakic, P. S. (1996) · Nature · doi:10.1038/381245a0 · Cited by 494
Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse
Aoyama, K., Suh, S. W., Hamby, A. M., Liu, J., Chan, W. Y., Chen, Y., & Swanson, R. A. (2006) · Nature Neuroscience · doi:10.1038/nn1609 · Cited by 484
Public Health and Economic Consequences of Methyl Mercury Toxicity to the Developing Brain
Trasande, L., Landrigan, P. J., & Schechter, C. B. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7743 · Cited by 466
The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus
Chang, F., Kídd, K. K., Livak, K. J., PAKSTIS, A. J., & Kídd, K. K. (1996) · Human Genetics · doi:10.1007/s004390050166 · Cited by 438
Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3
Samaco, R. C., Hogart, A., & LaSalle, J. M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi045 · Cited by 424
Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin—the antioxidant proteins
Chauhan, A., Chauhan, V., Brown, W. T., & Cohen, I. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.038 · Cited by 424
The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus
Wang, E., Ding, Y.-C., Flodman, P. L., Kidd, J. R., Kídd, K. K., Grady, D. L., Ryder, O. A., Spence, M. A., Swanson, J. M., & Moyzis, R. K. (2004) · The American Journal of Human Genetics · doi:10.1086/420854 · Cited by 406
A genetic variant that disrupts MET transcription is associated with autism
Campbell, D. B., Sutcliffe, J. S., Ebert, P. J., Militerni, R., Bravaccio, C., Trillo, S., Elia, M., Schneider, C., Melmed, R., Sacco, R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605296103 · Cited by 401
Pervasive Developmental Disorders in Montreal, Quebec, Canada: Prevalence and Links With Immunizations
Fombonne, E., Zakarian, R., Bennett, A., Meng, L., & McLean-Heywood, D. (2006) · Pediatrics · doi:10.1542/peds.2005-2993 · Cited by 399
Induction of Cytoprotective Genes Through Nrf2 / Antioxidant Response Element Pathway: A New Therapeutic Approach for the Treatment of Inflammatory Diseases
Chen, X., & KUNSCH, C. A. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043452901 · Cited by 387
Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site
Wright, R. O., Amarasiriwardena, C. J., Woolf, A. D., Jim, R., & Bellinger, D. C. (2005) · NeuroToxicology · doi:10.1016/j.neuro.2005.10.001 · Cited by 387
Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase.
Ueland, P. M. (1982) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00053-5 · Cited by 375
Autism and Genetics
Smalley, S. L. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800340081013 · Cited by 351
Children and adolescents with autism exhibit reduced MEG steady-state gamma responses
Wilson, T. W., Rojas, D. C., Reite, M. L., Teale, P. D., & Rogers, S. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.002 · Cited by 350
Thermolabile variant of 5, 10-methylenetetrahydrofolate reductaseassociated with low red-cell folates: implications for folate intake recommendations
Molloy, A. M., Daly, S., Mills, J. L., Kirke, P. N., Whitehead, A. S., Ramsbottom, D., Conley, M. R., Weir, D. G., & Scott, J. M. (1997) · The Lancet · doi:10.1016/s0140-6736(96)12049-3 · Cited by 341
The relationship of biliary glutathione disulfide efflux and intracellular glutathione disulfide content in perfused rat liver.
Akerboom, T. P. M., Bilzer, M., & Sies, H. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34713-6 · Cited by 339
Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder
Persico, A. M., D'Agruma, L., Maiorano, N., Totaro, A., Militerni, R., Bravaccio, C., Wassink, T. H., Schneider, C., Melmed, R., Trillo, S., et al. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000850 · Cited by 337
STRUCTURE-BASED PERSPECTIVES ON B12-DEPENDENT ENZYMES
Ludwig, M. L., & Matthews, R. G. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.269 · Cited by 328
Stress-Induced Protein S-Glutathionylation in Arabidopsis
Dixon, D. P., Skipsey, M., Grundy, N. M., & Edwards, R. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.058917 · Cited by 313
Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals.
Thomas, D. J., Li, J., Waters, S. B., Xing, W., Adair, B. M., Drobná, Z., Devesa, V., & Stýblo, M. (2007) · PubMed · Cited by 306
A Polymorphism (80G->A) in the Reduced Folate Carrier Gene and Its Associations with Folate Status and Homocysteinemia
Chango, A., Fillon-Emery, N., de Courcy, G. P., Lambert, D., Pfister, M., Rosenblatt, D. S., & Nicolas, J. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3034 · Cited by 295
On the epigenetic regulation of the human reelin promoter
Chen, Y. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf401 · Cited by 276
Evidence of Toxicity, Oxidative Stress, and Neuronal Insult in Autism
Kern, J. K., & Jones, A. M. (2006) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400600882079 · Cited by 265
A Common Mutation A1298C in Human Methylenetetrahydrofolate Reductase Gene: Association with Plasma Total Homocysteine and Folate Concentrations
Friedman, G., Goldschmidt, N., Friedlander, Y., Ben‐Yehuda, A., Selhub, J., Babaey, S., Mendel, M., Kidron, M., & Bar-On, H. (1999) · Journal of Nutrition · doi:10.1093/jn/129.9.1656 · Cited by 263
Oxidative activation of antioxidant defence
Winyard, P. G., Moody, C. J., & Jacob, C. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.06.001 · Cited by 255
Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal
Burbacher, T. M., Shen, D. D., Liberato, N., Grant, K. S., Cernichiari, E., & Clarkson, T. W. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7712 · Cited by 246
A Functional Transsulfuration Pathway in the Brain Links to Glutathione Homeostasis
Vitvitsky, V., THOMAS, M. P., Ghorpade, A., Gendelman, H. E., & Banerjee, R. V. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602799200 · Cited by 243
Reelin glycoprotein: structure, biology and roles in health and disease
Fatemi, S. H. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001613 · Cited by 241
Increased excretion of a lipid peroxidation biomarker in autism
Ming, X., Stein, T. P., Brimacombe, M., Johnson, W. G., Lambert, G. H., & Wagner, G. C. (2005) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.06.002 · Cited by 236
Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism
Zoroğlu, S. S., Armutçu, F., Özen, Ş., Gürel, A., Sivaslı, E., Yetkin, O., & Meram, İ. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0456-7 · Cited by 235
A Subpopulation of Neurons in the Medial Prefrontal Cortex Encodes Emotional Learning with Burst and Frequency Codes through a Dopamine D4Receptor-Dependent Basolateral Amygdala Input
Laviolette, S. R., Lipski, W. J., & Grace, A. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1168-05.2005 · Cited by 235
Dysregulation of Reelin and Bcl-2 Proteins in Autistic Cerebellum
Fatemi, S. H., Stary, J. M., Halt, A. R., & Realmuto, G. R. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1013234708757 · Cited by 212
Redox regulation of ubiquitin‐conjugating enzymes: mechanistic insights using the thiol‐specific oxidant diamide
Obin, M. S., Shang, F., Gong, X., Handelman, G. J., Blumberg, J. B., & Taylor, A. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.7.561 · Cited by 205
What's Going on? The Question of Time Trends in Autism
Blaxill, M. F. (2004) · Public Health Reports · doi:10.1016/j.phr.2004.09.003 · Cited by 205
Neurotoxicity of organomercurial compounds
Sanfeliu, C., Sebastià, J., Cristòfol, R. M., & Rodrı́guez-Farré, E. (2003) · Neurotoxicity Research · doi:10.1007/bf03033386 · Cited by 201
GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high‐risk population
Hung, R. J., Boffetta, P., Brennan, P., MALAVEILLE, C., Hautefeuille, A. H., Donato, F., Gelatti, U., Spaliviero, M., Placidi, D., Carta, A., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20157 · Cited by 193
l-CYSTATHIONINE IN HUMAN BRAIN
Tallan, H. H., Moore, S., & Stein, W. H. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70493-6 · Cited by 180
Gene expression profiling reveals a signaling role of glutathione in redox regulation
Fratelli, M., Goodwin, L. O., Ørom, U. A., Lombardi, S., Tonelli, R., Mengozzi, M., & Ghezzi, P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504398102 · Cited by 180
Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome.
McConkie‐Rosell, A., Lachiewicz, A. M., Spiridigliozzi, G. A., Tarleton, J. C., Schoenwald, S., Phelan, M. C., Goonewardena, P., Ding, X., & Brown, W. T. (1993) · PubMed · Cited by 168
Autism and environmental genomics
Herbert, M. R., Russo, J. P., Yang, S., Roohi, J., Blaxill, M. F., Kahler, S. G., Cremer, L., & Hatchwell, E. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.03.017 · Cited by 167
Candidate gene studies of attention-deficit/hyperactivity disorder.
Faraone, S. V., & Khan, S. (2006) · PubMed · Cited by 165
Environmental Distribution, Analysis, and Toxicity of Organometal(loid) Compounds
Dopp, E., Hartmann, L. M., Florea, A., Rettenmeier, A. W., & Hirner, A. V. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490270160 · Cited by 165
Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal
Waly, M. I., Olteanu, H., Banerjee, R. V., Choi, S.-W., Mason, J. B., Parker, B. S., Sukumar, S. V., Shim, S., Sharma, A. K., Benzecry, J., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001476 · Cited by 165
Self-citation
Excretion of GSSG and Glutathione Conjugates Mediated by MRP1 and CM0AT/MRP2
Suzuki, H., & Sugiyama, Y. (1998) · Seminars in Liver Disease · doi:10.1055/s-2007-1007170 · Cited by 163
Oxidative Stress Inactivates Cobalamin-Independent Methionine Synthase (MetE) in Escherichia coli
Hondorp, E. R., & Matthews, R. G. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020336 · Cited by 152
Duplication of the 15q11‐13 Region in a Patient with Autism, Epilepsy and Ataxia
Bundey, S., Hardy, C., Vickers, S., Kilpatrick, M. W., & Corbett, J. A. (1994) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1994.tb11916.x · Cited by 151
High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism
Paşca, S. P., Nemeş, B., Vlase, L., Gagyi, C. E., Dronca, E., Miu, A. C., & Dronca, M. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.09.040 · Cited by 151
Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase
Evans, J. C., Huddler, D. P., Hilgers, M. T., Romanchuk, G. L., Matthews, R. G., & Ludwig, M. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308082100 · Cited by 146
Mean total arsenic concentrations in chicken 1989-2000 and estimated exposures for consumers of chicken.
Lasky, T., Sun, W., Kadry, A. M., & Hoffman, M. K. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6407 · Cited by 139
Rapid Trafficking of the Neuronal Glutamate Transporter, EAAC1
Fournier, K. M., González, M. I., & Robinson, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404032200 · Cited by 137
Oxidative stress in autism.
McGinnis, W. R. (2005) · PubMed · Cited by 134
Altered Vascular Phenotype in Autism
Yao, Y., Walsh, W. J., McGinnis, W. R., & Praticò, D. (2006) · Archives of Neurology · doi:10.1001/archneur.63.8.1161 · Cited by 131
Dopamine D4 and D2L Receptor Stimulation of the Mitogen-Activated Protein Kinase Pathway Is Dependent on trans- Activation of the Platelet-Derived Growth Factor Receptor
Oak, J. N., Lavine, N. E., & Tol, H. H. M. V. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.1.92 · Cited by 130
Reaction mechanism and regulation of cystathionine β-synthase
Banerjee, R. V., Evande, R., Kabil, Ö., Ojha, S., & Taoka, S. (2003) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/s1570-9639(03)00044-x · Cited by 125
Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene–environment interactions
D'Amelio, M., Ricci, I., Sacco, R., Liu, X., D'Agruma, L., Muscarella, L. A., Guarnieri, V, Militerni, R., Bravaccio, C., Elia, M., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001714 · Cited by 125
The role of mercury in the pathogenesis of autism
Bernard, S., Enayati, A., Roger, H., Binstock, T., & Redwood, L. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001177 · Cited by 124
A mutation in adenylosuccinate lyase associated with mental retardation and autistic features
Stone, R. L., Aimi, J., Barshop, B. A., Jaeken, J., Berghe, G., Zalkin, H., & Dixon, J. E. (1992) · Nature Genetics · doi:10.1038/ng0492-59 · Cited by 123
Functional Dissection of Reelin Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic Plasticity
Beffert, U., Durudas, A., Weeber, E. J., Stolt, P. C., Giehl, K. M., Sweatt, J. D., Hammer, R. E., & Herz, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4566-05.2006 · Cited by 121
Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults
Miller, J. W., Ramos, M. I., Garrod, M. G., Flynn, M. A., & Green, R. (2002) · Blood · doi:10.1182/blood-2002-01-0209 · Cited by 120
Association of paraoxonase 1 gene polymorphisms with risk of Parkinson’s disease: a meta-analysis
Zintzaras, E., & Hadjigeorgiou, G. M. (2004) · Journal of Human Genetics · doi:10.1007/s10038-004-0176-x · Cited by 114
A Clinical and Laboratory Evaluation of Methionine Cycle-Transsulfuration and Androgen Pathway Markers in Children with Autistic Disorders
Geier, D. A., & Geier, M. R. (2006) · Hormone Research in Paediatrics · doi:10.1159/000094467 · Cited by 107
Role of neuronal glutamate transporter in the cysteine uptake and intracellular glutathione levels in cultured cortical neurons
Himi, T., Ikeda, M., Yasuhara, T., Nishida, M., & Morita, I. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-003-0049-z · Cited by 107
Increases in the Number of Reactive Glia in the Visual Cortex of Macaca fascicularis Following Subclinical Long-Term Methyl Mercury Exposure
Charleston, J. S., Bolender, R. P., Mottet, N. K., Body, R. L., Vahter, M. E., & Burbacher, T. M. (1994) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1994.1244 · Cited by 107
Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody
Shashidharan, P., Huntley, G. W., Murray, J., Buku, A., Moran, T. M., Walsh, M. J., Morrison, J. H., & Plaitakis, A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00921-9 · Cited by 107
Homocysteine thiolactone inhibits insulin signaling, and glutathione has a protective effect
Najib, S., & Sánchez‐Margalet, V. (2001) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0270085 · Cited by 106
Brief report: Duplication of chromosome 15q11-13 in two individuals with autistic disorder
Baker, P., Piven, J., Schwartz, S., & Patil, S. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172133 · Cited by 106
DRD4 and DAT1 polymorphisms modulate human gamma band responses
Demiralp, T., Herrmann, C. S., Erdal, M. E., Ergenoglu, T., Keskin, Y. H., Ergen, M., & Beydagi, H. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl011 · Cited by 105
Prediction of Heterogeneity in Intelligence and Adult Prognosis by Genetic Polymorphisms in the Dopamine System Among Children With Attention-Deficit/Hyperactivity Disorder
Mill, J. S., Caspi, A., Williams, B. S., Craig, I., Taylor, A., Polo-Tomás, M., Berridge, C. W., Poulton, R., & Moffitt, T. E. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.462 · Cited by 104
Domain alternation switches B12-dependent methionine synthase to the activation conformation
Barian, V., Pattridge, K. A., Lennon, B. W., Huddler, D. P., Matthews, R. G., & Ludwig, M. L. (2001) · Nature Structural Biology · doi:10.1038/nsb738 · Cited by 104
The Human Aminophospholipid-Transporting ATPase Gene ATP10C Maps Adjacent to UBE3A and Exhibits Similar Imprinted Expression
Herzing, L. B. K., Kim, S., Cook, E. H., & Ledbetter, D. H. (2001) · The American Journal of Human Genetics · doi:10.1086/320616 · Cited by 101
SH3 Binding Domains in the Dopamine D4 Receptor
Oldenhof, J., Vickery, R. G., Anafi, M., Oak, J. N., Ray, A. P., Schoots, O., Pawson, T. J., von Zastrow, M., & Tol, H. H. M. V. (1998) · Biochemistry · doi:10.1021/bi981634+ · Cited by 100
Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes
Pezacka, E. H., Green, R., & Jacobsen, D. W. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90351-m · Cited by 97
Spectroscopic and Computational Studies of Co1+Cobalamin: Spectral and Electronic Properties of the “Superreduced” B12 Cofactor
Liptak, M. D., & Brunold, T. C. (2006) · Journal of the American Chemical Society · doi:10.1021/ja061433q · Cited by 94
Aluminum and other metals in Alzheimer's disease: A review of potential therapy with chelating agents
Domingo, J. L. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-102-315 · Cited by 91
Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors
Ahveninen, J., Kähkönen, S., Tiitinen, H., Pekkonen, E., Huttunen, J., Kaakkola, S., Ilmoniemi, R. J., & Jääskeläinen, I. P. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01429-4 · Cited by 87
Autometallographic Determination of Inorganic Mercury Distribution in the Cortex of the Calcarine Sulcus of the Monkey Macaca fascicularis Following Long-Term Subclinical Exposure to Methylmercury and Mercuric Chloride
Charleston, J. S., Body, R. L., Mottet, N. K., Vahter, M. E., & Burbacher, T. M. (1995) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1995.1114 · Cited by 86
Interactive Effects of a DRD4 Polymorphism, Lead, and Sex on Executive Functions in Children
Froehlich, T. E., Lanphear, B. P., Dietrich, K. N., Cory‐Slechta, D. A., Wang, N., & Kahn, R. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.039 · Cited by 84
Homologous pairing of 15q11–13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples
Thatcher, K. N., Peddada, S., Yasui, D. H., & LaSalle, J. M. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi073 · Cited by 83
Analysis of case-parent trios at a locus with a deletion allele: association of GSTM1 with autism
Buyske, S. G., Williams, T. A., Mars, A. E., Stenroos, E. S., Ming, S. X., Wang, R., Sreenath, M., Factura, M. F., Reddy, C., Lambert, G. H., et al. (2006) · BMC Genetics · doi:10.1186/1471-2156-7-8 · Cited by 75
Chromosome 15q11-13 abnormalities and other medical conditions in individuals with autism spectrum disorders
Bolton, P., Veltman, M. W. M., Weisblatt, E. J. L., Holmes, J. R., Thomas, N. S., Youings, S. A., Thompson, R. J., Roberts, S. E., Dennis, N. R., Browne, C. E., et al. (2004) · Psychiatric Genetics · doi:10.1097/00041444-200409000-00002 · Cited by 71
Redox control of the transsulfuration and glutathione biosynthesis pathways
Deplancke, B., & Gaskins, H. R. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200201000-00015 · Cited by 69
D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia
Sharma, A. K., Kramer, M. L., Wick, P. F., Liu, D., Chari, S., Shim, S., Tan, W., Ouellette, D., Nagata, M., DuRand, C. J., et al. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000522 · Cited by 60
Self-citation
The Fragile X Syndrome
Hagerman, R. J., McBogg, P., & Hagerman, P. J. (1983) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-198306000-00009 · Cited by 56
Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cells
Agrawal, A., Kaushal, P., Agrawal, S., Gollapudi, S. V. S., & Gupta, S. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0706467 · Cited by 55
The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver
Stipanuk, M. H., Hirschberger, L. L., Londono, M. P., Cresenzi, C. L., & Yu, A. F. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00336.2003 · Cited by 54
Adenosine Deaminase Activity Decreased in Autism
STUBBS, G., Litt, M. J., Lis, E. W., Jackson, R. H., Voth, W., LINDBERG, A., & Litt, R. M. (1982) · Journal of the American Academy of Child Psychiatry · doi:10.1097/00004583-198201000-00012 · Cited by 53
Testosterone Regulation of Homocysteine Metabolism Modulates Redox Status in Human Prostate Cancer Cells
Prudova, A., Albin, M. M., Bauman, Z. M., Lin, A., Vitvitsky, V., & Banerjee, R. V. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1712 · Cited by 50
The presence of a transsulfuration pathway in the lens: a new oxidative stress defense system
Persa, C., Pierce, A., Ma, Z., Kabil, Ö., & Lou, M. F. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2004.06.029 · Cited by 48
D(4) dopamine receptor differentially regulates Akt/nuclear factor-kappa b and extracellular signal-regulated kinase pathways in D(4)MN9D cells.
Zhen, X., Zhang, J., Johnson, G., & Friedman, E. (2001) · PubMed · Cited by 43
Sequence variants of theDRD4 gene in autism: Further evidence that rareDRD4 7R haplotypes are ADHD specific
Grady, D. L., Harxhi, A., Smith, M., Flodman, P. L., Spence, M. A., Swanson, J. M., & Moyzis, R. K. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30182 · Cited by 43
A model for modulation of neuronal synchronization by D4 dopamine receptor-mediated phospholipid methylation
Kuznetsova, A. Y., & Deth, R. C. (2007) · Journal of Computational Neuroscience · doi:10.1007/s10827-007-0057-3 · Cited by 41
Self-citation
Immunotoxic Effects of Mercuric Compounds on Human Lymphocytes and Monocytes. IV. Alterations in Cellular Glutathione Content
Shenker, B. J., Rooney, C., And, L. V., Mayro, J. S., & Shapiro, I. M. (1993) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979309025999 · Cited by 41
A study of the glutathione metaboloma peptides by energy‐resolved mass spectrometry as a tool to investigate into the interference of toxic heavy metals with their metabolic processes
Rubino, F. M., Pitton, M., Brambilla, G., & Colombi, A. (2006) · Journal of Mass Spectrometry · doi:10.1002/jms.1143 · Cited by 34
A New Role for Glutathione: Protection of Vitamin B12 from Depletion by Xenobiotics
Watson, W. P., Munter, T., & Golding, B. T. (2004) · Chemical Research in Toxicology · doi:10.1021/tx0497898 · Cited by 31
Preventive mechanism of cellular glutathione in monomethylarsonic acid-induced cytolethality
Sakurai, T., Ochiai, M., Kojima, C., Ohta, T., Sakurai, M. H., Takada, N. O., Qu, W., Waalkes, M. P., Himeno, S., & Fujiwara, K. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.11.008 · Cited by 31
CYP450, genetics and Parkinson’s disease: gene × environment interactions hold the key
Mellick, G. D. (2006) · Springer eBooks · doi:10.1007/978-3-211-45295-0_25 · Cited by 30
Relationship between dopamine‐stimulated phospholipid methylation and the single‐carbon folate pathway
Zhao, R., Chen, Y., Tan, W., Waly, M. I., Sharma, A. K., Stover, P. J., Rosowsky, A., Malewicz, B., & Deth, R. C. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00471.x · Cited by 24
Self-citation
D4 Dopamine Receptor Differentially Regulates Akt/Nuclear Factor-κB and Extracellular Signal-Regulated Kinase Pathways in D4MN9D Cells
Zhen, X., Zhang, J., Johnson, G. P., & Friedman, E. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12314-0 · Cited by 24
Endotoxin Induces Glutathione Reductase Activity in Lungs of Mice
Hamburg, D. C., Tonoki, H., Welty, S. E., Geske, R. S., Montgomery, C. A., & Hansen, T. N. (1994) · Pediatric Research · doi:10.1203/00006450-199403000-00006 · Cited by 14
Corrections
(2005) · Annals of Neurology · doi:10.1002/ana.20397 · Cited by 14
Two‐loci ADA haplotypes in autistic disorder
Lucarelli, P., Saccucci, P., Bottini, N., Luca, D. D., Fiumara, A., Elia, M., Bottini, N., Porfirio, M. C., & Curatolo, P. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10272 · Cited by 12
HOMOLOGOUS PAIRING AND
Kowalczykowski, C., & Eggleston, A. K. (1994) · Cited by 9
Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic β-cell glucose-sensing, cellular signal transduction and integrity
Patterson, S., Flatt, P. R., & McClenaghan, N. H. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.02.011 · Cited by 7
Untitled work
Jonnal (2000) · doi:10.1002/1096-8628(20001204)96:6

Flagged first, then by citations

4 of the 132 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Boris, 2004, Association of MTHFR gene variants with autism, J Am Phys Surg, 9, 106
Rice, 2007, Prevalence of autism spectrum disorders—autism and developmental disabilities monitoring network, CDC Surv Rep, 56, 12

Sorted by citations

Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses
Modabbernia, A., Velthorst, E., & Reichenberg, A. (2017) · Molecular Autism · doi:10.1186/s13229-017-0121-4 · Cited by 809
Consensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723
Environmental toxicants and autism spectrum disorders: a systematic review
Rossignol, D. A., Genuis, S. J., & Frye, R. E. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.4 · Cited by 458
Redox dysregulation, neurodevelopment, and schizophrenia
Do, K. Q., Cabungcal, J. H., Frank, A., Steullet, P., & Cuenod, M. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.001 · Cited by 384
Oxidative stress-related biomarkers in autism: Systematic review and meta-analyses
Frustaci, A., Neri, M., Cesario, A., Adams, J. B., Domenici, E., Bernardina, B. D., & Bonassi, S. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.011 · Cited by 383

See all 325

Authors: Deth, R., Muratore, C., Benzecry, J., Power-Charnitsky, V.-A., & Waly, M.
Affiliations: Northeastern University (US)
Corresponding author: Deth, Richard
ORCID: Deth, Richard
Waly, Mostafa
Venue: NeuroToxicology
Publisher: Elsevier BV
Published: 2008-01
Volume: 29
Issue: 1
Pages: 190-201
ISSN: 0161-813X (ISSN-L)
DOI: 10.1016/j.neuro.2007.09.010
OpenAlex: W2167943688
Cited by: 325
References: 132
Citations by year: 2026: 5 · 2025: 7 · 2024: 12 · 2023: 13 · 2022: 12 · 2021: 16 · 2020: 17 · 2019: 11 · 2018: 17 · 2017: 16 · 2016: 15 · 2015: 28 · 2014: 27 · 2013: 20 · 2012: 34
FWCI: 1.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroToxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Keywords: autism spectrum disorder, oxidative stress, DNA methylation, sulfur metabolism, methionine synthase, vitamin B12, folic acid, dopamine signaling, dopamine D4 receptor, phospholipid methylation, neural network synchronization, genetic polymorphism, environmental toxic exposure
MeSH terms: Animals, Autistic Disorder, Environment, Humans, Methylation, Models, Biological, Oxidation-Reduction, Sulfur, Oxidative Stress, Receptors, Dopamine D4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks