Cited by 396Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease

Grudzien, Aneta, Shaw, Pamela, Weintraub, Sandra, Bigio, Eileen, Mash, Deborah C., Mesulam, M. Marsel·2007·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2006.02.007

Open this paper in CoChat — free account

Abstract

Neurofibrillary degeneration in the nucleus basalis and a loss of its cortical cholinergic projections are prominent components of the neuropathology in Alzheimer's disease (AD). The AD brain is also associated with a degeneration of the noradrenergic projections arising from the nucleus locus coeruleus (LC), but the time course of this lesion is poorly understood. To determine whether the LC displays neurofibrillary abnormalities early in the course of events leading to AD, we examined tissue specimens from seven cognitively normal controls and five subjects at the stages of mild cognitively impairment (MCI) or early AD. Tyrosine hydroxylase immunochemistry was used as a marker of LC neurons while AT8 immunolabeling visualized abnormal tau associated with neurofibrillary tangles and their precursors. Thioflavine-S was used as a marker for fully developed tangles. We found that AT8-positive labeling and thioflavine-S positive tangles were present in both groups of specimens. However, the percentage of neurons containing each of these markers was significantly higher in the cognitively impaired group. The MMSE scores displayed a negative correlation with both markers of cytopathology. These results indicate that cytopathology in the LC is an early event in the age-MCI-AD continuum and that it may be listed among the numerous factors that mediate the emergence of the cognitive changes leading to dementia.

Integrity signals

Registry

Crossref · 10.1016/j.neurobiolaging.2006.02.007

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease
Moms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
Population-Based Norms for the Mini-Mental State Examination by Age and Educational Level
Crum, R. M. (1993) · JAMA · doi:10.1001/jama.1993.03500180078038 · Cited by 2,958
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859
A Compendium of Neuropsychological Tests
Selnes, O. A. (1991) · Neurology · doi:10.1212/wnl.41.11.1856-a · Cited by 2,278
Psychopharmacology: The Fourth Generation of Progress
Green, A. I. (1996) · Psychiatric Services · doi:10.1176/ps.47.3.312 · Cited by 1,147

Show all 45 references

Research works printed but not linked: 1

Knight, 1970, Histochemical demonstration of the catecholamines and acetylcholine esterase in the same cell bodies in the locus ceruleus (rat hind brain), Proc R Microsc Soc, 6, 26

Sorted by citations

Items 201–300 of 392

Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis
Sakakibara, Y., Hirota, Y., Ibaraki, K., Takei, K., Chikamatsu, S., Tsubokawa, Y., Saito, T., Saido, T. C., Sekiya, M., & Iijima, K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210385 · Cited by 26
Steps Towards Developing Effective Treatments for Neuropsychiatric Disturbances in Alzheimer’s Disease: Insights From Preclinical Models, Clinical Data, and Future Directions
Clement, A., Wiborg, O., & Asuni, A. A. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00056 · Cited by 28
Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice
Evans, A. K., Park, H. H., Saw, N. L., Singhal, K., Ogawa, G., Leib, R. D., & Shamloo, M. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.06.012 · Cited by 25
Associations between MRI-assessed locus coeruleus integrity and cortical gray matter microstructure
Elman, J. A., Puckett, O. K., Hagler, D. J., Pearce, R. C., Fennema‐Notestine, C., Hatton, S. N., Lyons, M. J., McEvoy, L. K., Panizzon, M. S., Reas, E. T., et al. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab475 · Cited by 25
It is the Locus Coeruleus! Or… is it? : A proposition for analyses and reporting standards for structural and functional magnetic resonance imaging of the noradrenergic Locus Coeruleus
Yi, Y., Lüsebrink, F., Ludwig, M., Maaß, A., Ziegler, G., Yakupov, R., Kreissl, M. C., Betts, M. J., Speck, O., Düzel, E., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.04.007 · Cited by 29
Inferior frontal gyrus preserves working memory and emotional learning under conditions of impaired noradrenergic signaling
Becker, B., Androsch, L., Jahn, R. T., Alich, T. C., Striepens, N., Markett, S. A., Maier, W., & Hurlemann, R. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00197 · Cited by 25
Exposure to acrylamide decreases noradrenergic axons in rat brain
Zhang, L., Hara, S., Ichinose, H., Nagashima, D., Morita, K., Sakurai, T., Ichihara, S., & Ichihara, G. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.03.001 · Cited by 25
Selective neuronal vulnerability in Alzheimer’s disease
Wang, Z.-T., Zhang, C. M., Wang, Y., Dong, Q., Tan, L., & Yu, J. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101114 · Cited by 24
New frontiers in Alzheimer's disease diagnostic: Monoamines and their derivatives in biological fluids
Gallo, A., Pillet, L., & Verpillot, R. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111452 · Cited by 25
Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease
Daulatzai, M. A. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9643-3 · Cited by 27
High‐resolution and high‐sensitivity PET for quantitative molecular imaging of the monoaminergic nuclei: A GATE simulation study
Wang, Z., Cao, X., LaBella, A., Zeng, X., Biegon, A. R., Franceschi, D., Petersen, E. W., Clayton, N., Ulaner, G. A., Zhao, W., et al. (2022) · Medical Physics · doi:10.1002/mp.15653 · Cited by 23
Ageing-Related Neurodegeneration and Cognitive Decline
Alafuzoff, I. I., & Libard, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074065 · Cited by 27
ApoE3 R136S binds to Tau and blocks its propagation, suppressing neurodegeneration in mice with Alzheimer’s disease
Chen, G., Wang, M., Zhang, Z., Hong, D. K., Ahn, E. H., Liu, X., Kang, S. S., & Ye, K. (2025) · Neuron · doi:10.1016/j.neuron.2024.12.015 · Cited by 21
Epigenetic dysregulation of brainstem nuclei in the pathogenesis of Alzheimer’s disease: looking in the correct place at the right time?
Iatrou, A., Kenis, G., Rutten, B. P. F., Lunnon, K., & van den Hove, D. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2361-4 · Cited by 22
Emerging Functions of Neuromodulation during Sleep
Sulaman, B. A., Zhang, Y., Matosevich, N., Kjærby, C., Foustoukos, G., Andersen, M., & Eban-Rothschild, A. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1277-24.2024 · Cited by 24
Acetylcholine and noradrenaline differentially regulate hippocampus-dependent spatial learning and memory
de Leo, G., Gulino, R., Coradazzi, M., & Leanza, G. (2022) · Brain Communications · doi:10.1093/braincomms/fcac338 · Cited by 20
Correction: Correlation between cognition and plasma noradrenaline level in Alzheimer’s disease: a potential new blood marker of disease evolution
Pillet, L., Taccola, C., Cotoni, J., Thiriez, H., André, K., & Verpillot, R. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01102-y · Cited by 20
Using Drosophila amyloid toxicity models to study Alzheimer's disease
Tsintzas, E., & Niccoli, T. (2024) · Annals of Human Genetics · doi:10.1111/ahg.12554 · Cited by 20
Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer’s pathology stages
Hary, A. T., Chadha, S., Mercaldo, N. D., Smith, E. N., van der Kouwe, A. J. W., Fischl, B. R., Mount, C., Kozanno, L. N., Frosch, M. P., & Augustinack, J. C. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-01957-6 · Cited by 24
Gender effect on the accumulation of hyperphosphorylated tau in the brain of locus-ceruleus-injured APP-transgenic mouse
Oikawa, N., Ogino, K., Masumoto, T., Yamaguchi, H., & Yanagisawa, K. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.005 · Cited by 19
Sex Differences in Locus Coeruleus: A Heuristic Approach That May Explain the Increased Risk of Alzheimer’s Disease in Females
Luckey, A. M., Robertson, I. H., LAWLOR, B. A., Mohan, A., & Vanneste, S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210404 · Cited by 24
Alpha1-Adrenergic Receptor Mediated Long-Term Depression at CA3-CA1 Synapses Can Be Induced via Accumulation of Endogenous Norepinephrine and Is Preserved Following Noradrenergic Denervation
Dyer-Reaves, K., Goodman, A. M., Nelson, A. R., & McMahon, L. L. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00027 · Cited by 17
Neuropathology of the Brainstem to Mechanistically Understand and to Treat Alzheimer’s Disease
Patthy, Á., Murai, J., Hanics, J., Pintér, A., Zahola, P., Hökfelt, T. G. M., Harkany, T., & Alpár, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081555 · Cited by 17
The β‐adrenergic hypothesis of synaptic and microglial impairment in Alzheimer's disease
Li, S. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15782 · Cited by 18
Inhibition of Pro-Inflammatory Microglia with Minocycline Improves Cognitive and Sleep-Wake Dysfunction Under Respiratory Stress in a Sporadic Model for Alzheimer’s Disease
Vicente, M. C., Paneghini, J. D. L., Stabile, A. M., Amorim, M. R., Silva, C. E. A., Patrone, L. G. A., Cunha, T. M., Bícego, K. C., Almeida, M. C., Carrettiero, D. C., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230151 · Cited by 21
Monoamine Oxidase-A Physically Interacts with Presenilin-1(M146V) in the Mouse Cortex
Wei, Z.-L., Gabriel, G. G., Rui, L., Cao, X., Pennington, P. R., Chlan‐Fourney, J., Nazarali, A., Baker, G., & Mousseau, D. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-111241 · Cited by 18
Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model
Martin, S. B., Dowling, A. L. S., & Head, E. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376217 · Cited by 19
Recent Advances in Imaging of Preclinical, Sporadic, and Autosomal Dominant Alzheimer's Disease
Buckley, R. F. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01026-5 · Cited by 18
Effects of Psychotropic Medication on Cognition, Caregiver Burden, and Neuropsychiatric Symptoms in Alzheimer’s Disease over 12 Months: Results from a Prospective Registry of Dementia in Austria (PRODEM)
Pirker-Kees, A., Dal-Bianco, P., & Schmidt, R. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181102 · Cited by 17
Early loss of locus coeruleus innervation promotes cognitive and neuropathological changes before amyloid plaque deposition in a transgenic rat model of Alzheimer's disease
Aguilar, L. F., Hall, H., Orciani, C., Foret, M. K., Kovecses, O., Ducatenzeiler, A., & Cuello, A. C. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12835 · Cited by 17
Neuronal hyperexcitability in the Tg2576 mouse model of Alzheimer's disease – the influence of sleep and noradrenergic transmission
Szabo, A. B., Cattaud, V., Bezzina, C., Dard, R. F., Sayegh, F. J. P., Gauzin, S., Lejards, C., Valton, L., Rampon, C., Verret, L., et al. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.11.017 · Cited by 18
Changes in the locus coeruleus during the course of Alzheimer's disease and their relationship to cortical pathology
Beardmore, R., Durkin, M., Zayee‐Mellick, F., Lau, L. C., Nicoll, J. A. R., Holmes, C., & Boche, D. (2024) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12965 · Cited by 17
Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-Related Metabolic Diseases
Clapcote, S. J. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-58811-7_5 · Cited by 18
Brainstem noradrenergic neurons: Identifying a hub at the intersection of cognition, motility, and skeletal muscle regulation
Delbono, O., Wang, Z., & Messi, M. L. (2022) · Acta Physiologica · doi:10.1111/apha.13887 · Cited by 17
Articulatory Agility in Cognitive Decline
Östberg, P., Bogdanović, N., & Wahlund, L. (2009) · Folia Phoniatrica et Logopaedica · doi:10.1159/000235649 · Cited by 17
The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
Weber, L. M., Divecha, H. R., Tran, M. N., Kwon, S., Spangler, A., Montgomery, K. D., Tippani, M., Bharadwaj, R. A., Kleinman, J. E., Page, S. C., et al. (2023) · eLife · doi:10.7554/elife.84628 · Cited by 33
Possible role of locus coeruleus neuronal loss in age-related memory and attention deficits
Gargano, A., Olabiyi, B. F., Palmisano, M., Zimmer, A., & Bilkei‐Gorzó, A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1264253 · Cited by 17
Rodent Models of Alzheimer’s Disease: Past Misconceptions and Future Prospects
Collins, H. M., & Greenfield, S. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116222 · Cited by 21
Hippocampal Network Alterations in Alzheimer's Disease and Down Syndrome: From Structure to Therapy
Sanchez, M. M., Moghadam, S., Naik, P. K., Martin, K. J., & Salehi, A. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0050 · Cited by 17
In vivo Brainstem Imaging in Alzheimer’s Disease: Potential for Biomarker Development
Braun, D. J., & Eldik, L. J. V. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00266 · Cited by 16
Alzheimer's disease-like pathology-triggered oxidative stress, alterations in monoamines levels, and structural damage of locus coeruleus neurons are partially recovered by a mix of proteoglycans of embryonic genesis
Aghajanov, M. I., Chavushyan, V. A., Matinyan, S., Danielyan, M., & Yenkoyan, K. B. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104531 · Cited by 16
Passive (Amyloid-β) Immunotherapy Attenuates Monoaminergic Axonal Degeneration in the AβPPswe/PS1dE9 Mice
Liu, Y. M., Lee, M. K., James, M. M., Price, D. L., Borchelt, D., Troncoso, J. C., & Oh, E. S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101602 · Cited by 16
Attention enhancing effects of methylphenidate are age-dependent
Bhattacharya, S. E., Shumsky, J. S., & Waterhouse, B. D. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.11.006 · Cited by 17
Late reaction times identify MCI
Fernaeus, S., Östberg, P., & Wahlund, L. (2013) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12053 · Cited by 16
Role of catalpol in ameliorating the pathogenesis of experimental autoimmune encephalomyelitis by increasing the level of noradrenaline in the locus coeruleus
Li, Q., Yang, T., Guo, A., & Fan, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8378 · Cited by 16
Age-related changes in the functional integrity of the phasic alerting system: a pupillometric investigation
He, M., Heindel, W. C., Nassar, M. R., Siefert, E. M., & Festa, E. K. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.02.025 · Cited by 16
Alzheimer disease-related presenilin-1 variants exert distinct effects on monoamine oxidase-A activity in vitro
Pennington, P. R., Wei, Z.-L., Rui, L., Doig, J., Graham, B., Kuski, K., Gabriel, G. G., & Mousseau, D. (2011) · Journal of neural transmission · doi:10.1007/s00702-011-0616-7 · Cited by 15
Essential role of hippocampal noradrenaline in the regulation of spatial working memory and TDP‐43 tissue pathology
Pintus, R., Riggi, M., Cannarozzo, C., Valeri, A., de Leo, G., Romano, M., Gulino, R., & Leanza, G. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24397 · Cited by 15
Noradrenergic pathways of locus coeruleus in Parkinson’s and Alzheimer’s pathology
Singh, S. (2019) · International Journal of Neuroscience · doi:10.1080/00207454.2019.1667799 · Cited by 17
FDG-PET assessment of the locus coeruleus in Alzheimer’s disease
Liu, K. Y., Acosta‐Cabronero, J., Hong, Y. T., Yi, Y., Hämmerer, D., & Howard, R. J. (2021) · Neuroimage Reports · doi:10.1016/j.ynirp.2020.100002 · Cited by 17
Pontine Arteriolosclerosis and Locus Coeruleus Oxidative Stress Differentiate Resilience from Mild Cognitive Impairment in a Clinical Pathologic Cohort
Kelly, S. C., Nelson, P. T., & Counts, S. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab017 · Cited by 15
Attentional network changes in subjective cognitive decline
Esmaeili, M., Nejati, V., Shati, M., Vatan, R. F., Chehrehnegar, N., & Foroughan, M. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-02005-8 · Cited by 15
Post-Stroke Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Attenuates Chronic Changes in Brain Metabolism, Increases Neurotransmitter Levels, and Improves Recovery
Nguyen, T. V., Crumpacker, R. H., Calderon, K., Garcia, F. G., Zbesko, J. C., Frye, J. B., Gonzalez, S., Becktel, D. A., Yang, T., Tavera-Garcia, M. A., et al. (2021) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.121.000711 · Cited by 15
Cognitive Impairment in Alzheimer’s and Metabolic Diseases: A Catecholaminergic Hypothesis
Guzmán-Ramos, K. R., Osorio‐Gómez, D., & Bermúdez‐Rattoni, F. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.05.031 · Cited by 15
Subcortical tau deposition and plasma glial fibrillary acidic protein as predictors of cognitive decline in mild cognitive impairment and Alzheimer’s disease
Chang, Y. Z., Liu, J., Xu, X., Sun, S., Zhang, J., Zhang, X., Lu, G., Xiao, S., Cao, Y., Wu, R., et al. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-07016-x · Cited by 14
Banhasasim-Tang Attenuates Lipopolysaccharide-Induced Cognitive Impairment by Suppressing Neuroinflammation in Mice
Oh, Y.-C., Jeong, Y. H., Pak, M. E., & Go, Y. (2020) · Nutrients · doi:10.3390/nu12072019 · Cited by 14
Diffusion MRI tractography of the locus coeruleus‐transentorhinal cortex connections using GO‐ESP
Solders, S. K., Galinsky, V. L., Clark, A. L., Sorg, S. F., Weigand, A. J., Bondi, M. W., & Frank, L. R. (2021) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29088 · Cited by 12
Glycosylation States of Pre- and Post-synaptic Markers of 5-HT Neurons Differ With Sex and 5-HTTLPR Genotype in Cortical Autopsy Samples
Nyarko, J. N. K., Quartey, M. O., Heistad, R. M., Pennington, P. R., Poon, L. J., Knudsen, K. J., Allonby, O., Zawily, A. M. E., Freywald, A., Rauw, G., et al. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00545 · Cited by 13
The Aging Brain
Magnusson, K. R., & Brim, B. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.00158-6 · Cited by 14
Noradrenergic denervation facilitates the release of acetylcholine and serotonin in the hippocampus: Towards a mechanism underlying upregulations described in MCI patients?
Jackisch, R., Gansser, S., & Cassel, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.06.011 · Cited by 14
Biology enters the scene—a new perspective on bilingualism, cognition, and dementia
Bak, T. H., & Robertson, I. H. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.10.020 · Cited by 14
Noradrenergic dysregulation in the locus coeruleus: Implications for neuropsychiatric disease pathophysiology- A systematic review
Mir, F. A., Jha, S. K., & Nehs, C. J. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106442 · Cited by 17
What Are Current Concepts on the Functional Organization of the Locus Coeruleus and Its Role in Cognition and Neurodegeneration?
Benarroch, E. E. (2023) · Neurology · doi:10.1212/wnl.0000000000206736 · Cited by 12
Association of Tooth Loss with Alzheimer’s Disease Tau Pathologies Assessed by Positron Emission Tomography
Matsumoto, H., Tagai, K., Endo, H., Matsuoka, K., Takado, Y., Kokubo, N., Shimada, H., Goto, T., Goto, T. K., & Higuchi, M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230581 · Cited by 15
Can Animal Models Inform on the Relationship between Depression and Alzheimer Disease?
Nyarko, J. N. K., Quartey, M. O., Baker, G. B., & Mousseau, D. D. (2018) · The Canadian Journal of Psychiatry · doi:10.1177/0706743718772514 · Cited by 12
Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-β Pathology in Female Rhesus Macaques (Macaca Mulatta)
Duffy, K. B., Ray, B., Lahiri, D. K., Tilmont, E. M., Tinkler, G. P., Herbert, R. L., Greig, N. H., Ingram, D. K., Ottinger, M. A., & Mattison, J. A. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180487 · Cited by 13
Hippocampal Noradrenaline Is a Positive Regulator of Spatial Working Memory and Neurogenesis in the Rat
Gulino, R., Nunziata, D., de Leo, G., Kostenko, A., Emmi, S. A., & Leanza, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065613 · Cited by 8
Disease‐specific neuropathological alterations of the locus coeruleus in Alzheimer's disease, Down syndrome, and Parkinson's disease
Fructuoso, M., Vermeiren, Y., Boluda, S., Stimmer, L., Crans, R. A. J., Xicota, L., Eisel, U., Ortí-Casañ, N., Bun, P., Duyckaerts, C. J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70262 · Cited by 14
Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of Alzheimer's disease
Ohm, D. T., Fought, A. J., RADEMAKER, A. W., Kım, G., Sridhar, J., Coventry, C., Gefen, T. D., Weıntraub, S., Bigio, E. H., Mesulam, M. M., et al. (2019) · Brain Pathology · doi:10.1111/bpa.12783 · Cited by 14
Self-citation
Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus
Baytaş, O., Kauer, J. A., & Morrow, E. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105831 · Cited by 11
Decreased Signal in the Locus Coeruleus Based on Neuromelanin-Sensitive MRI Technique as an Imaging Biomarker for Alzheimer's Disease
Li, M., Liu, S., Zhu, H., Guo, Z., Zhi, Y., Liu, R., Jiang, Z., Liang, X., Hu, H., & Zhu, J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1014485 · Cited by 11
Crosstalk between mitochondria, calcium channels and actin cytoskeleton modulates noradrenergic activity of locus coeruleus neurons
de Oliveira, R. B., Petiz, L. L., Lim, R., Lipski, J., Gravina, F. S., Brichta, A. M., Callister, R. J., Leão, R. N., & Helden, D. F. V. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14692 · Cited by 12
The Locus Coeruleus – Noradrenaline system: Looking into Alzheimer’s therapeutics with rose coloured glasses
Behl, T., Kaur, I., Sehgal, A., Singh, S., Makeen, H. A., Albratty, M., Alhazmi, H. A., Bhatia, S., & BUNGAU, S. G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113179 · Cited by 12
Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathy
Emmerson, J. T., Malcolm, J. C., Carmo, S. D., Nguyen, P., Breuillaud, L., Martínez-Trujillo, J., & Cuello, A. C. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106317 · Cited by 11
Assessing disease-modifying effects of norepinephrine in Down syndrome and Alzheimer’s disease
Ponnusamy, R., McNerney, M. W., Moghadam, S., & Salehi, A. (2017) · Brain Research · doi:10.1016/j.brainres.2017.09.035 · Cited by 11
Central Nervous System Circuitries Underlying Two Types of Peripheral Autonomic Nervous System Disorders~!2008-04-24~!2008-09-26~!2008-12-05~!
Lechín, F., & van der Dijs, B. (2008) · The Open Neuroscience Journal · doi:10.2174/1874082000802010041 · Cited by 9
Probing locus coeruleus functional network in healthy aging and its association with Alzheimer’s disease biomarkers using pupillometry
Wu, J., Toporek, A., Lin, Q., Goldstein, F. C., Loring, D. W., Kelberman, M. A., Weinshenker, D., Levey, A. I., Lah, J. J., & Qiu, D. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01701-1 · Cited by 10
Use of Light Therapy for Insomnia in the Elderly: Role of Circadian Rhythm Disorders
Cahan, J. G., & Abbott, S. M. (2020) · Current Sleep Medicine Reports · doi:10.1007/s40675-020-00181-z · Cited by 11
BAG2 prevents Tau hyperphosphorylation and increases p62/SQSTM1 in cell models of neurodegeneration
Lima, R. S., Carrettiero, D. C., & Ferrari, M. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07577-w · Cited by 10
Task-Evoked Pupillary Response as a Potential Biomarker of Dementia and Mild Cognitive Impairment: A Scoping Review
Zeeman, M., Figeys, M., Brimmo, T., Burnstad, C., Hao, J., & Kim, E. (2023) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175231160010 · Cited by 10
AUTONOMIC NERVOUS SYSTEM DISORDERS
Henderson, R. D., & Spies, J. (2014) · CRC Press eBooks · doi:10.1201/b16337-25 · Cited by 10
Cross Talk between the Autonomic and Central Nervous Systems: Mechanistic and Therapeutic Considerations for Neuronal, Immune, Vascular, and Somatic-Based Diseases
Lechín, F., & van der Dijs, B. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195326697.003.0005 · Cited by 10
Sex-Related Motor Deficits in the Tau-P301L Mouse Model
Camargo, L. C., Honold, D., Bauer, R., Shah, N. J., Langen, K., Willbold, D., Kutzsche, J., Willuweit, A., & Schemmert, S. (2021) · Biomedicines · doi:10.3390/biomedicines9091160 · Cited by 9
Acute and chronic effects of intravitreally injected β-amyloid on the neurotransmitter system in the retina
Aruoma, O. I., Jen, S. S. M., Watts, H. R., George, J., Gentleman, S. M., Anderson, P. J., & Jen, L. (2008) · Toxicology · doi:10.1016/j.tox.2008.11.007 · Cited by 9
The Aged Dog as a Natural Model of Alzheimer’s Disease Progression
Araujo, J. A., Baulk, J., & de Rivera, C. (2017) · Springer eBooks · doi:10.1007/978-3-319-53219-6_4 · Cited by 9
Locus coeruleus pathology is associated with cerebral microangiopathy at autopsy
Freeze, W. M., van Veluw, S. J., Jansen, W. J., Bennett, D. A., & Jacobs, H. I. L. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13096 · Cited by 8
The role of sex differences in depression in pathologically defined Alzheimer’s disease
Tremblay, C., Choudhury, P., Belden, C. M., Goldfarb, D., Lorenzini, I., Beach, T. G., & Serrano, G. E. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1156764 · Cited by 9
Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease
Matt, R. A., Martin, R. S., Evans, A. K., Gever, J. R., Vargas, G. A., Shamloo, M., & Ford, A. P. D. W. (2023) · Handbook of experimental pharmacology · doi:10.1007/164_2023_677 · Cited by 11
Neurobiological Mechanisms Involved in the Pathogenesis of Alzheimer’s Disease
Mir, F. A., & Rizvi, Z. A. (2019) · Springer eBooks · doi:10.1007/978-981-13-9636-6_13 · Cited by 8
Calbindin-D28K, parvalbumin, and calretinin in young and aged human locus coeruleus
Lamerand, S. R., Shahidehpour, R. K., Ayala, I. A. D. L., Gefen, T. D., Mesulam, M. M., Bigio, E. H., & Geula, C. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.06.006 · Cited by 8
Self-citation
Pathogenese und Prävention des M. Alzheimer
Braak, H., Feldengut, S., & Tredici, K. D. (2013) · Der Nervenarzt · doi:10.1007/s00115-012-3688-1 · Cited by 8
Neuropathology of dementia
Kim, E.-J., Vatsavayai, S., & Seeley, W. W. (2016) · The Behavioral Neurology of Dementia · doi:10.1017/9781139924771.008 · Cited by 7
Loss of Cholinergic and Monoaminergic Afferents in APPswe/PS1ΔE9 Transgenic Mouse Model of Cerebral Amyloidosis Preferentially Occurs Near Amyloid Plaques
Lee, M. K., & Chen, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25095004 · Cited by 6
Noradrenaline Regulation of Brain-Body Communication
Fernandes, G., Lam, R. M., Park, J. H., Drummond, G. T., & Sur, M. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-89525-8_2 · Cited by 8
Exercise may alleviate age-related spatial memory impairment by rescuing β-adrenergic receptor dysregulation via both G protein–dependent and β-arrestin–dependent mechanisms in rat hippocampus
Chodari, L., Derafshpour, L., Jafari, A., Ghasemi, M., & Mehranfard, N. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148250 · Cited by 7
Norepinephrine Drives Sleep Fragmentation Activation of Asparagine Endopeptidase, Locus Ceruleus Degeneration, and Hippocampal Amyloid-β42Accumulation
Zhang, K., Zhu, Y. W., Fenik, P., Fleysh, D., Ly, C., THOMAS, S. A., & Veasey, S. C. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1929-23.2024 · Cited by 8
Early β adrenoceptor dependent time window for fear memory persistence in APPswe/PS1dE9 mice
Karunakaran, S. (2021) · Scientific Reports · doi:10.1038/s41598-020-79487-5 · Cited by 7
Late-Life Depression as a Risk Factor for Dementia
Halperin, I. J. Y., & Korczyn, A. D. (2007) · Future Neurology · doi:10.2217/14796708.2.2.201 · Cited by 7
Chemoattractants and receptors in Alzheimer s disease
Le, Y. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s81 · Cited by 7
Neurotoxin-Induced DNA Damage is Persistent in SH-SY5Y Cells and LC Neurons
Wang, Y., Musich, P. R., Cui, K., Zou, Y., & Zhu, M. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9521-4 · Cited by 7

Authors: Grudzien, A., Shaw, P., Weintraub, S., Bigio, E., Mash, D. C., & Mesulam, M. M.
Affiliations: Northwestern University (US)
University of Miami (US)
Corresponding author: Mesulam, M. Marsel
ORCID: Shaw, Pamela
Bigio, Eileen
Mash, Deborah C.
Mesulam, M. Marsel
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2007-03
Volume: 28
Issue: 3
Pages: 327-335
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2006.02.007
OpenAlex: W2168697938
Cited by: 396
References: 45
Citations by year: 2026: 17 · 2025: 21 · 2024: 19 · 2023: 31 · 2022: 19 · 2021: 40 · 2020: 30 · 2019: 16 · 2018: 15 · 2017: 28 · 2016: 18 · 2015: 22 · 2014: 18 · 2013: 20 · 2012: 20
FWCI: 6.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: University of Miami
Northwestern University
National Institute on Aging (P30AG013854)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: locus coeruleus, neurofibrillary degeneration, Alzheimer's disease, mild cognitive impairment, aging, tau protein, neurofibrillary tangles, noradrenergic projections, AT8, thioflavine S, tyrosine hydroxylase, cognitive decline, dementia
MeSH terms: Acetylcholinesterase, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Cognition Disorders, Female, Humans, Immunohistochemistry, Locus Coeruleus, Male, Middle Aged, Postmortem Changes, Psychological Tests, Reference Values, Tyrosine 3-Monooxygenase, Neurofibrillary Tangles, tau Proteins, Statistics, Nonparametric

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks