Cited by 149Vitamin D Research StudiesDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

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VDR gene variants associate with cognitive function and depressive symptoms in old age

Kuningas, Maris, Mooijaart, Simon P., Jolles, Jelle, Slagboom, P. Eline, Westendorp, Rudi G.J., van Heemst, Diana·2009·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2007.07.001

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Abstract

Vitamin D has been recently implicated in brain function. Our objective was to test whether genetic variance in the vitamin D receptor (VDR) gene is associated with cognitive functioning and depressive symptoms in old age. The study was carried out in the prospective population-based Leiden 85-plus Study. All 563 participants of the study were genotyped for Cdx-2, FokI, BsmI, ApaI and TaqI polymorphisms in the VDR gene. Our data revealed an overall worse performance on tests measuring cognitive functioning for carriers of BsmI (p=0.013) and TaqI (p=0.004) polymorphisms, and of haplotype 2 (BAt) (p=0.004). In contrast, carriers of ApaI variant-allele and of haplotype 1 (baT) had better cognitive functioning together with less depressive symptoms. These associations could not be explained by differences in calcium levels, and by selective survival, since no associations between the VDR gene variants and calcium levels and mortality were observed. In conclusion, our results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms.

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Authors: Kuningas, M., Mooijaart, S. P., Jolles, J., Slagboom, P. E., Westendorp, R. G. J., & van Heemst, D.
Affiliations: Leiden University Medical Center (NL)
Maastricht University Medical Centre (NL)
ORCID: Mooijaart, Simon P.
Slagboom, P. Eline
Westendorp, Rudi G.J.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2009-03
Volume: 30
Issue: 3
Pages: 466-473
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2007.07.001
OpenAlex: W2106494040
Cited by: 149
References: 47
Citations by year: 2026: 1 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 5 · 2016: 11 · 2015: 12 · 2014: 10 · 2013: 11 · 2012: 6
FWCI: 4.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
VU Research Portal (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: vitamin D receptor, VDR polymorphisms, cognitive function, depressive symptoms, old age, BsmI polymorphism, TaqI polymorphism, ApaI polymorphism, FokI polymorphism, haplotypes, age-related cognitive decline, Leiden 85-plus Study, genetic susceptibility
MeSH terms: Age Factors, Aged, 80 and over, Cognition, Depression, Female, Follow-Up Studies, Genotype, Haplotypes, Humans, Male, Prospective Studies, Risk Factors, Genetic Variation, Cohort Studies, Receptors, Calcitriol

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VDR gene variants associate with cognitive function and depressive symptoms in old age

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