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VDR gene variants associate with cognitive function and depressive symptoms in old age
Abstract
Vitamin D has been recently implicated in brain function. Our objective was to test whether genetic variance in the vitamin D receptor (VDR) gene is associated with cognitive functioning and depressive symptoms in old age. The study was carried out in the prospective population-based Leiden 85-plus Study. All 563 participants of the study were genotyped for Cdx-2, FokI, BsmI, ApaI and TaqI polymorphisms in the VDR gene. Our data revealed an overall worse performance on tests measuring cognitive functioning for carriers of BsmI (p=0.013) and TaqI (p=0.004) polymorphisms, and of haplotype 2 (BAt) (p=0.004). In contrast, carriers of ApaI variant-allele and of haplotype 1 (baT) had better cognitive functioning together with less depressive symptoms. These associations could not be explained by differences in calcium levels, and by selective survival, since no associations between the VDR gene variants and calcium levels and mortality were observed. In conclusion, our results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms.
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“findings by Kuningas et al. (2009) [32] and Lye et al. [33] that single nucleotide polymorphisms (SNPs) of vitamin D receptor (VDR) and zinc transporter-3 (SLC30A3) genes were respectively associated with MDD”
From Predictors of recurrence of major depressive disorder (2020) · cites this paper as [32]
In the citing paper
“Kuningas et al. (32) found that Dutch patients with the baT haplotype of the Vitamin D receptor (VDR) gene were less prone to depression compared with carriers of BAt.”
From Predictors of recurrence of major depressive disorder (2020) · cites this paper as [32]
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Metadata
- Authors
- Kuningas, M., Mooijaart, S. P., Jolles, J., Slagboom, P. E., Westendorp, R. G. J., & van Heemst, D.
- Affiliations
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 30
- Issue
- 3
- Pages
- 466-473
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2106494040
- Cited by
- 149
- References
- 47
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 5 · 2016: 11 · 2015: 12 · 2014: 10 · 2013: 11 · 2012: 6
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- vitamin D receptor, VDR polymorphisms, cognitive function, depressive symptoms, old age, BsmI polymorphism, TaqI polymorphism, ApaI polymorphism, FokI polymorphism, haplotypes, age-related cognitive decline, Leiden 85-plus Study, genetic susceptibility
- MeSH terms
- Age Factors, Aged, 80 and over, Cognition, Depression, Female, Follow-Up Studies, Genotype, Haplotypes, Humans, Male, Prospective Studies, Risk Factors, Genetic Variation, Cohort Studies, Receptors, Calcitriol
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