Insights into the ageing mind: a view from cognitive neuroscience

Hedden, Trey; Gabrieli, John D. E.

doi:10.1038/nrn1323

Cited by 2,223Dementia and Cognitive Impairment ResearchAging and Gerontology ResearchCognitive Functions and Memory

Insights into the ageing mind: a view from cognitive neuroscience

Hedden, Trey, Gabrieli, John D. E.·2004·Nature Reviews Neuroscience

DOI 10.1038/nrn1323

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Regional reductions in brain volumes occur during aging, and become more pervasive with MCI and AD.
“Regional reductions occur during aging, and become more pervasive with MCI and AD [195, 196].”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [195]
These cognitive changes typically manifest at ages younger than those at which plaque deposition typically begins.
“These changes typically manifest at ages younger than those at which plaque deposition typically begins.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [195]
At least some elements of cognitive decline evolve throughout adulthood.
“Lastly, it is worth noting that at least some elements of cognitive decline evolve throughout adulthood [195, 242-245].”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [195]
Cognitive speed and multitasking abilities become less robust with advancing age.
“Cognitive speed and multitasking abilities, for example, become less robust with advancing age.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [195]
Advancing age positively correlates with prefrontal cortical atrophy, while hippocampal volumes change to a lesser extent.
“These neuroimaging studies show advancing age and prefrontal cortical atrophy positively correlate, while hippocampal volumes change to a lesser extent.”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [15]

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Age-Related Changes in Regional Cerebral Blood Flow during Working Memory for Faces
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Imaging hippocampal function across the human life span: Is memory decline normal or not?
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Aging effects on memory encoding in the frontal lobes.
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Differential aging of the human striatum: a prospective MR imaging study.
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Sixteen-year longitudinal and time lag changes in memory and cognition in older adults.
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Material-dependent and material-independent selection processes in the frontal and parietal lobes: an event-related fMRI investigation of response competition
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Contributions of Processing Ability and Knowledge to Verbal Memory Tasks across the Adult Life-Span
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Functional Significance of Mild Cognitive Impairment in Elderly Patients Without a Dementia Diagnosis
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A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E ε4 allele
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Differential Associations Between Entorhinal and Hippocampal Volumes and Memory Performance in Older Adults.
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Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects
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Contributions of source and inhibitory mechanisms to age-related retroactive interference in verbal working memory.
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Terminal decline and cognitive performance in very old age: Does cause of death matter?
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Diffusion tensor trace mapping in normal adult brain using single-shot EPI technique. . A methodological study of the aging brain
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Executive-process interactive control: A unified computational theory for answering 20 questions (and more) about cognitive ageing
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An Examination of the Hofer and Sliwinski Evaluation
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Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers
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Can training in a real-time strategy video game attenuate cognitive decline in older adults?
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Authors: Hedden, T., & Gabrieli, J. D. E.
Affiliations: Stanford University (US)
Corresponding author: Hedden, Trey
ORCID: Hedden, Trey
Gabrieli, John D. E.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-02
Volume: 5
Issue: 2
Pages: 87-96
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1323
OpenAlex: W2171776652
Semantic Scholar: 3add9431310756b012e801809baba765dfdfcf68
Cited by: 2,223
References: 148
Citations by year: 2026: 68 · 2025: 79 · 2024: 111 · 2023: 121 · 2022: 128 · 2021: 142 · 2020: 133 · 2019: 141 · 2018: 124 · 2017: 134 · 2016: 132 · 2015: 127 · 2014: 118 · 2013: 123 · 2012: 114
FWCI: 5.75
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords: cognitive aging, age-related memory decline, cognitive slowing, prefrontal cortex, medial temporal lobe, white matter tracts
MeSH terms: Aging, Animals, Atrophy, Brain, Brain Mapping, Cognition Disorders, Humans, Memory Disorders, Nerve Fibers, Myelinated, Neural Pathways

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