1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons
Abstract
There is an accumulation of evidence implicating a role for vitamin D(3) in the developing brain. The receptor for this seco-steroid is expressed in both neurons and glial cells, it induces nerve growth factor (NGF) and it is a potent inhibitor of mitosis and promoter of differentiation in numerous cells. We have therefore assessed the direct effect of vitamin D(3) on mitosis, neurite outgrowth, as well as NGF production as a possible mediator of those effects, in developing neurons. Using cultured embryonic hippocampal cells and explants we found the addition of vitamin D(3) significantly decreases the percentage of cultured hippocampal cells undergoing mitosis in conjunction with increases in both neurite outgrowth and NGF production. The role of vitamin D(3) during brain development warrants closer scrutiny.
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Vitamin D analogues upregulate NGF in cultured glial cells and embryonic hippocampal cells.
“Vitamin D analogues have been shown to upregulate NGF in cultured glial cell and embryonic hippocampal cells [177,178], to decrease the percentage of cultured hippocampal cells undergoing mitosis [178], and to decrease BDNF and concommitantly to improve memory in postmenopausal women [179].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [178]
Vitamin D analogues decrease the percentage of cultured hippocampal cells undergoing mitosis.
“Vitamin D analogues have been shown to upregulate NGF in cultured glial cell and embryonic hippocampal cells [177,178], to decrease the percentage of cultured hippocampal cells undergoing mitosis [178], and to decrease BDNF and concommitantly to improve memory in postmenopausal women [179].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [178]
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- Authors
- Brown, J., Bianco, J. I., McGrath, J. J., & Eyles, D. W.
- Affiliations
- The University of Queensland (AU)
- Park Centre for Mental Health (AU)
- Corresponding author
- Eyles, Darryl W.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 343
- Issue
- 2
- Pages
- 139-143
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2111598959
- Cited by
- 377
- References
- 20
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 18 · 2023: 21 · 2022: 25 · 2021: 10 · 2020: 15 · 2019: 19 · 2018: 16 · 2017: 21 · 2016: 20 · 2015: 30 · 2014: 36 · 2013: 17 · 2012: 21
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- HAL AMU (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- 1,25-dihydroxyvitamin D3, vitamin D3, nerve growth factor, neurite outgrowth, mitosis inhibition, hippocampal neurons, embryonic brain development, neurotrophic factors, neuronal differentiation
- MeSH terms
- Animals, Bromodeoxyuridine, Cholecalciferol, Embryo, Mammalian, Female, Hippocampus, Immunohistochemistry, Mitosis, Neurons, Pregnancy, Time Factors, Neurites, Rats, Sprague-Dawley, Nerve Growth Factor, Culture Techniques, Rats
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