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White matter pathology isolates the hippocampal formation in Alzheimer's disease
Open accessAbstract
Prior work has demonstrated that the memory dysfunction of Alzheimer's disease (AD) is accompanied by marked cortical pathology in medial temporal lobe (MTL) gray matter. In contrast, changes in white matter (WM) of pathways associated with the MTL have rarely been studied. We used diffusion tensor imaging (DTI) to examine regional patterns of WM tissue changes in individuals with AD. Alterations of diffusion properties with AD were found in several regions including parahippocampal WM, and in regions with direct and secondary connections to the MTL. A portion of the changes measured, including effects in the parahippocampal WM, were independent of gray matter degeneration as measured by hippocampal volume. Examination of regional changes in unique diffusion parameters including anisotropy and axial and radial diffusivity demonstrated distinct zones of alterations, potentially stemming from differences in underlying pathology, with a potential myelin specific pathology in the parahippocampal WM. These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways.
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“Effects of tauopathy on DTI metrics in the grey and white matter are complex and may involve axonal damage, myelin injury, neuronal degeneration, and gliosis, which all have been found in tauopathies [17,18,23,25,28,29,33,38,57].”
From Diffusion tensor imaging reveals whole-brain microstructural changes in the P301L mouse model of tauopathy. (2020) · cites this paper as [17]
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“…the cingulum bundle and the uncinate fasciculus, consistent with previous studies showing reduced FA and increased MD in the cingulum bundle (Bozzali et al., 2002; Fellgiebel et al., 2005; Zhang et al., 2007; Salat et al., 2010) or the uncinate fasciculus (Taoka et al., 2006; Kiuchi et al., 2009).”
A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease
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Metadata
- Authors
- Salat, D. H., Tuch, D. S., van der Kouwe, A. J. W., Greve, D. N., Pappu, V., Lee, S. Y., Hevelone, N. D., Zaleta, A. K., Growdon, J. H., Corkin, S., Fischl, B., & Rosas, H. D.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- Salat, D.H.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 31
- Issue
- 2
- Pages
- 244-256
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC3038572
- OpenAlex
- W2168247374
- Cited by
- 279
- References
- 92
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 6 · 2020: 13 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 20 · 2015: 23 · 2014: 17 · 2013: 26 · 2012: 32
- FWCI
- 17.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (F32AG005886, K01AG024898, AG 05886)
- National Institute of Nursing Research (R01NR010827)
- National Institute of Biomedical Imaging and Bioengineering (U54 EB05149, U54EB005149)
- National Center for Research Resources (P41-RR-14075, P41RR014075)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, white matter pathology, hippocampal formation, medial temporal lobe, diffusion tensor imaging, fractional anisotropy, axial and radial diffusivity, myelin degeneration, memory impairment, hippocampal volume
- MeSH terms
- Aged, Alzheimer Disease, Brain, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Male, Nerve Fibers, Myelinated, Neural Pathways, Organ Size, Anisotropy, Parahippocampal Gyrus, Nerve Fibers, Unmyelinated, Diffusion Tensor Imaging
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