White matter damage in Alzheimer’s disease assessed in vivo using diffusion tensor magnetic resonance imaging
Open accessAbstract
OBJECTIVE: To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging (DT-MRI). BACKGROUND: Although Alzheimer's disease pathology mainly affects cortical grey matter, previous pathological and MRI studies showed that also the brain white matter of patients is damaged. However, the nature of Alzheimer's disease associated white matter damage is still unclear. METHODS: Conventional and DT-MRI scans were obtained from 16 patients with Alzheimer's disease and 10 sex and age matched healthy volunteers. The mean diffusivity (D), fractional anisotropy (FA), and inter-voxel coherence (C) of several white matter regions were measured. RESULTS: D was higher and FA lower in the corpus callosum, as well as in the white matter of the frontal, temporal, and parietal lobes from patients with Alzheimer's disease than in the corresponding regions from healthy controls. D and FA of the white matter of the occipital lobe and internal capsule were not different between patients and controls. C values were also not different between patients and controls for any of the regions studied. Strong correlations were found between the mini mental state examination score and the average overall white matter D (r=0.92, p<0.001) and FA (r=0.78; p<0.001). CONCLUSIONS: White matter changes in patients with Alzheimer's disease are likely to be secondary to wallerian degeneration of fibre tracts due to neuronal loss in cortical associative areas.
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Results from DTI show that fibre tract alterations are widespread in the brain at the stage of mild cognitive impairment and Alzheimer's disease dementia.
“Results from DTI showed that fibre tract alterations are widespread in the brain at the stage of mild cognitive impairment and Alzheimer’s disease dementia (Bozzali et al., 2002; Medina et al., 2006; Acosta-Cabronero et al., 2010, 2012; Sexton et al., 2011; Bosch et al., 2012; for reviews see Acosta-Cabronero and Nestor, 2014; Teipel et al., 2015).”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Bozzali et al., 2002
The Abstract and Results report DTI abnormalities across several white-matter regions in patients with Alzheimer’s disease, supporting the claim’s breadth for that group, although other regions were spared. The study examined patients with Alzheimer’s disease and healthy controls; it does not establish that these alterations are widespread at the mild cognitive impairment stage. (LLM, conf=0.88)
Experimental — accuracy not yet measuredDiffusion MRI is more sensitive to brain microstructural changes than conventional volumetric MRI and has been widely used for evaluation of white matter integrity.
“Compared to the conventional volumetric MRI methods, diffusion MRI (dMRI) is more sensitive to the brain microstructural changes and has been widely used for the evaluation of white matter integrity (Bozzali et al., 2002; Mielke et al., 2009; Stebbins and Murphy, 2009; Wang et al., 2019b; Harrison et al., 2020; Veale et al., 2021).”
From Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging (2022) · cites this paper as Bozzali et al., 2002
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- Authors
- Bozzali, M.
- Affiliations
- IRCCS Ospedale San Raffaele (IT)
- Corresponding author
- Bozzali, M
- ORCID
- Bozzali, M
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2002-06-01
- Volume
- 72
- Issue
- 6
- Pages
- 742-746
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1737921
- OpenAlex
- W2115424422
- Cited by
- 568
- References
- 41
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 15 · 2023: 10 · 2022: 17 · 2021: 19 · 2020: 19 · 2019: 18 · 2018: 20 · 2017: 24 · 2016: 20 · 2015: 28 · 2014: 20 · 2013: 43 · 2012: 38
- FWCI
- 17.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Ministero della Salute
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, white matter injury, diffusion tensor imaging, mean diffusivity, fractional anisotropy, corpus callosum, Wallerian degeneration, cognitive impairment
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Corpus Callosum, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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