Cited by 5,265Medical Image Segmentation TechniquesAdvanced Radiotherapy TechniquesMRI in cancer diagnosis

Nonrigid registration using free-form deformations: application to breast mr images

Rueckert, D., Sonoda, L.I., Hayes, C., Hill, D.L.G., Leach, M.O., Hawkes, D.J.·1999·IEEE Transactions on Medical Imaging

Abstract

In this paper we present a new approach for the nonrigid registration of contrast-enhanced breast MRI. A hierarchical transformation model of the motion of the breast has been developed. The global motion of the breast is modeled by an affine transformation while the local breast motion is described by a free-form deformation (FFD) based on B-splines. Normalized mutual information is used as a voxel-based similarity measure which is insensitive to intensity changes as a result of the contrast enhancement. Registration is achieved by minimizing a cost function, which represents a combination of the cost associated with the smoothness of the transformation and the cost associated with the image similarity. The algorithm has been applied to the fully automated registration of three-dimensional (3-D) breast MRI in volunteers and patients. In particular, we have compared the results of the proposed nonrigid registration algorithm to those obtained using rigid and affine registration techniques. The results clearly indicate that the nonrigid registration algorithm is much better able to recover the motion and deformation of the breast than rigid or affine registration algorithms.

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Crossref · 10.1109/42.796284

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  • Traditional registration algorithms are constructed as continuous optimization problems or discrete optimization problems.

    “The traditional registration algorithms are constructed as continuous optimization problems (15, 16) or discrete optimization problems (17).”

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Authors
Rueckert, D., Sonoda, L. I., Hayes, C., Hill, D. L. G., Leach, M. O., & Hawkes, D. J.
Affiliations
  • Guy's Hospital (GB)
  • Institute of Cancer Research (GB)
Venue
IEEE Transactions on Medical Imaging
Published
1999
Volume
18
Issue
8
Pages
712-721
ISSN
0278-0062 (ISSN-L)
OpenAlex
W2113576511
Cited by
5,265
References
2
Citations by year
2026: 100 · 2025: 151 · 2024: 155 · 2023: 156 · 2022: 159 · 2021: 194 · 2020: 216 · 2019: 204 · 2018: 238 · 2017: 267 · 2016: 283 · 2015: 315 · 2014: 317 · 2013: 345 · 2012: 337
FWCI
35.11
Type
journal article
Language
en
Open access
closed
Locations
  • IEEE Transactions on Medical Imaging (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
  • Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
Keywords
non-rigid registration, free-form deformation, breast MRI, contrast-enhanced MRI, B-splines, normalized mutual information, affine transformation, automatic image registration
MeSH terms
Breast, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging

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