Whole-brain atrophy rate and CSF biomarker levels in MCI and AD: a longitudinal study
Abstract
Objectives To assess associations between cerebrospinal fluid (CSF) biomarker levels and MRI-based whole-brain atrophy rate in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Methods We included 99 patients (47 AD, 29 MCI, 23 controls) who underwent lumbar puncture at baseline and repeat MRI. A subgroup of 48 patients underwent a second lumbar puncture. CSF levels of beta-amyloid(1-42) (A beta(1-42)), tau and tau phosphorylated at threonine-181 (P-tau(181)), and whole-brain atrophy rate were measured. Results Across groups, baseline A beta(1-42) and tau were modestly associated with whole-brain atrophy rate. Adjusted for age, sex and diagnosis, we found no association between A beta(1-42) or tau, and whole-brain atrophy rate. By contrast, high CSF levels of P-tau(181) showed a mild association with a lower whole-brain atrophy rate in AD but not in controls or MCI patients. Finally, whole-brain atrophy rate was associated with change in MMSE, but change in CSF biomarker levels was not. Conclusions Whole-brain atrophy rate and CSF levels of A beta(1-42,) tau or P-tau(181) provide complementary information in patients with MCI and AD.
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Some studies observed no relation between CSF tau or Aβ1-42 and whole-brain atrophy, while others found a significant inverse relationship between CSF P-tau and hippocampal volume in MCI.
“Some observed no relation between CSF tau or Aβ1-42 and whole-brain atrophy (Sluimer et al., 2010), while others found a significant inverse relationship between CSF P-tau and hippocampal volume in MCI (Herukka et al., 2008).”
From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Sluimer et al., 2010
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T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease
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- Authors
- Sluimer, J. D., Bouwman, F. H., Vrenken, H., Blankenstein, M. A., Barkhof, F., van der Flier, W. M., & Scheltens, P.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Sluimer, Jasper D.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 31
- Issue
- 5
- Pages
- 758-764
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2171094273
- Cited by
- 106
- References
- 4
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 9 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 5
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Vanderbilt University Medical Center
- Internationale Stichting Alzheimer Onderzoek
- Stichting Dioraphte
- Alzheimer Nederland
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- cerebrospinal fluid biomarkers, mild cognitive impairment, Alzheimer's disease, amyloid-beta 42, tau protein, phosphorylated tau 181, brain atrophy, longitudinal MRI, cognitive decline
- MeSH terms
- Aged, Alzheimer Disease, Analysis of Variance, Atrophy, Brain, Cognition Disorders, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Phosphorylation, Biomarkers, Chi-Square Distribution, Amyloid beta-Peptides, tau Proteins
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