Assessment of CSF Aβ42 as an aid to discriminating Alzheimer's disease from other dementias and mild cognitive impairment: A meta-analysis of 50 studies
Abstract
Mild Alzheimer's disease (AD) is usually difficult to differentiate from other dementias or mild cognitive impairment (MCI). The aim of our study is to evaluate the clinical importance of cerebrospinal fluid (CSF) β-amyloid 42 (Aβ42) in MCI, AD and other dementias, more specifically: frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), Parkinson's disease (PD) with dementia (PDD) and vascular dementia (VaD). Fifty eligible articles were identified by search of databases including PubMed, EMBASE, Elsevier, Springer Link and the Cochrane Library, from January 1990 to May 2014. The random effects model was used to calculate the standardized mean difference (SMD) with corresponding 95% CI by STATA 9.0 software. The subgroup analyses were made on the method (ELISA, xMAP). We found that CSF Aβ42 concentrations were significantly lower in AD compared to MCI (SMD: -0.68, 95% CI: [-0.80, -0.56], z=11.34, P<0.001), FTD (SMD: -1.09, 95% CI: [-1.41, -0.76], z=6.62, P<0.001), PDD (SMD: -0.75, 95% CI: [-1.39, -0.10], z=2.27, P=0.023), VaD (SMD: -0.95, 95% CI: [-1.30, -0.61], z=5.43, P<0.001). In addition, compared to DLB, Aβ42 concentrations are moderately lower in AD (SMD: -0.27, 95% CI: [-0.51, -0.03], z=2.20, P=0.028). Results from this meta-analysis hinted that CSF Aβ42 is a good biomarker for discriminating Alzheimer's disease from other dementias and MCI.
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CSF levels of Aβ38, Aβ42, and the Aβ42/Aβ38 ratio can distinguish AD from other dementias.
“In addition, it has been shown that the levels of Aβ38, Aβ42 and the Aβ42/Aβ38 ratio in cerebral spinal fluid (CSF) can be used to distinguish AD from other dementias [32–34].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [33]
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- Authors
- Tang, W., Huang, Q., Wang, Y., Wang, Z.-Y., & Yao, Y.-Y.
- Affiliations
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 345
- Issue
- 1-2
- Pages
- 26-36
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2068072654
- Cited by
- 38
- References
- 73
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Anhui Province (1208085MH145)
- Department of Anhui Province Education (KJ2011Z161)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- cerebrospinal fluid, amyloid-beta 42, Alzheimer's disease, mild cognitive impairment, dementia, frontotemporal dementia, dementia with Lewy bodies, Parkinson's disease dementia, vascular dementia, biomarkers, differential diagnosis
- MeSH terms
- Alzheimer Disease, Dementia, Humans, Peptide Fragments, Amyloid beta-Peptides, Cognitive Dysfunction
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