Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 221

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome

Emmanouilidou, Evangelia, Stefanis, Leonidas, Vekrellis, Kostas·2010·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2008.07.008
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neurobiolaging.2008.07.008

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 11 references

Research works printed but not linked: 58

  1. Akaishi, 1995, Regulatory subunit complex dissociated from 26S proteasome, isolation and characterization, Biochim. Biophys. Acta, 1245, 331, 10.1016/0304-4165(95)00122-0 · DOI
  2. Ancolio, 2000, Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells, Neurosci. Lett., 285, 79, 10.1016/S0304-3940(00)01049-1 · DOI
  3. Auluck, 2005, Mechanisms of suppression of {alpha}-synuclein neurotoxicity by geldanamycin in Drosophila, J. Biol. Chem., 280, 2873, 10.1074/jbc.M412106200 · DOI · Paper page
  4. Baba, 1998, Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies, Am. J. Pathol., 152, 879
  5. Bence, 2001, Impairment of the ubiquitin–proteasome system by protein aggregation, Science, 292, 1552, 10.1126/science.292.5521.1552 · DOI · Paper page
  6. Carter, 1998, A model for structure-dependent binding of Congo red to Alzheimer beta-amyloid fibrils, Neurobiol. Aging, 19, 37, 10.1016/S0197-4580(97)00164-4 · DOI
  7. Chan, 2000, Mechanisms of chaperone suppression of polyglutamine disease, selectivity, synergy and modulation of protein solubility in Drosophila, Hum. Mol. Genet., 9, 2811, 10.1093/hmg/9.19.2811 · DOI · Paper page
  8. Chondrogianni, 2005, Overexpression of proteasome β5 subunit increases the amount of assembled proteasome and confers ameliorated response to oxidative stress and higher survival rates, J. Biol. Chem., 280, 11840, 10.1074/jbc.M413007200 · DOI · Paper page
  9. Conway, 2000, Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease, implications for pathogenesis and therapy, Proc. Natl. Acad. Sci. U.S.A., 97, 571, 10.1073/pnas.97.2.571 · DOI · Paper page
  10. Conway, 2001, Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct, Science, 294, 1346, 10.1126/science.1063522 · DOI · Paper page
  11. Cummings, 1998, Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1, Nat. Genet., 19, 148, 10.1038/502 · DOI · Paper page
  12. Dickson, 1999, Widespread alterations of alpha-synuclein in multiple system atrophy, Am. J. Pathol., 155, 1241, 10.1016/S0002-9440(10)65226-1 · DOI · Paper page
  13. Dixon, 2005, Alpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast, Genetics, 170, 47, 10.1534/genetics.104.035493 · DOI
  14. De Los Rios, 2006, Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling, PNAS, 103, 6166, 10.1073/pnas.0510496103 · DOI · Paper page
  15. Evans, 2006, Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro, J. Biol. Chem., 281, 33182, 10.1074/jbc.M606192200 · DOI · Paper page
  16. Farrer, 2004, Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications, Ann. Neurol., 55, 174, 10.1002/ana.10846 · DOI
  17. Ghee, 2000, Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex, J. Neurochem., 75, 2221, 10.1046/j.1471-4159.2000.0752221.x · DOI
  18. Ghee, 2005, PA700, the regulatory complex of the 26S proteasome, interferes with a-synuclein assembly, FEBS J., 272, 4023, 10.1111/j.1742-4658.2005.04776.x · DOI
  19. Giasson, 2002, Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein, Neuron, 34, 521, 10.1016/S0896-6273(02)00682-7 · DOI · Paper page
  20. Gosavi, 2002, Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion, J. Biol. Chem., 277, 48984, 10.1074/jbc.M208194200 · DOI · Paper page
  21. Heiser, 2000, Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules, implications for Huntington's disease therapy, Proc. Natl. Acad. Sci. U.S.A., 92, 6739, 10.1073/pnas.110138997 · DOI · Paper page
  22. Hendil, 1998, Simultaneous binding of PA28 and PA700 activators to 20S proteasomes, Biochem. J., 332, 749, 10.1042/bj3320749 · DOI · Paper page
  23. Hendil, 2002, 26S proteasomes function as stable entities, J. Mol. Biol., 315, 627, 10.1006/jmbi.2001.5285 · DOI
  24. Hoffman, 1994, Activation of the multicatalytic protease, J. Biol. Chem., 269, 16890, 10.1016/S0021-9258(19)89473-5 · DOI
  25. Hoglinger, 2003, Dysfunction of mitochondrial complex I and the proteasome, interactions between two biochemical deficits in a cellular model of Parkinson's disease, J. Neurochem., 86, 12097, 10.1046/j.1471-4159.2003.01952.x · DOI · Paper page
  26. Holmberg, 2004, Inefficient degradation of truncated polyglutamine proteins by the proteasome, EMBO J., 23, 4307, 10.1038/sj.emboj.7600426 · DOI · Paper page
  27. Jabado, 2004, RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons, Cell Death Diff., 11, 618, 10.1038/sj.cdd.4401397 · DOI
  28. Jariel-Encontre, 1995, Ubiquitinylation is not an absolute requirement for degradation of c-Jun protein by the 26 S proteasome, J. Biol. Chem., 270, 11623, 10.1074/jbc.270.19.11623 · DOI
  29. Kahle, 2001, Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model, Am. J. Pathol., 159, 2215, 10.1016/S0002-9440(10)63072-6 · DOI · Paper page
  30. Klucken, 2004, Hsp70 reduces alpha-synuclein aggregation and toxicity, J Biol Chem., 279, 25497, 10.1074/jbc.M400255200 · DOI · Paper page
  31. Kristiansen, 2007, Disease-associated prion protein oligomers inhibit the 26S proteasome, Mol. Cell., 26, 175, 10.1016/j.molcel.2007.04.001 · DOI · Paper page
  32. Lang-Rollin, 2003, Ubiquitinated inclusions and neuronal cell death, Histol. Histopathol., 18, 509
  33. Lashuel, 2002, a-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils, J. Mol. Biol., 322, 1089, 10.1016/S0022-2836(02)00735-0 · DOI · Paper page
  34. Lindersson, 2004, Proteasomal inhibition by alpha-synuclein filaments and oligomers, J. Biol. Chem., 279, 12924, 10.1074/jbc.M306390200 · DOI · Paper page
  35. Liu, 2002, The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility, Cell, 111, 209, 10.1016/S0092-8674(02)01012-7 · DOI · Paper page
  36. Martin-Clemente, 2004, α-Synuclein expresion levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines, J. Biol. Chem., 279, 52984, 10.1074/jbc.M409028200 · DOI
  37. McLean, 2004, Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro, Biochem. Biophys. Res. Commun., 321, 665, 10.1016/j.bbrc.2004.07.021 · DOI · Paper page
  38. Outeiro, 2008, Formation of toxic oligomeric α-synuclein species in living cells, PLOS One, 3, e1867, 10.1371/journal.pone.0001867 · DOI · Paper page
  39. Paxinou, 2001, Induction of alpha-synuclein aggregation by intracellular nitrative insult, J. Neurosci., 21, 8053, 10.1523/JNEUROSCI.21-20-08053.2001 · DOI · Paper page
  40. Petrucelli, 2002, Parkin protects against the toxicity associated with mutant alpha-synuclein, proteasome dysfunction selectively affects catecholaminergic neurons, Neuron, 36, 1007, 10.1016/S0896-6273(02)01125-X · DOI
  41. Pickart, 2004, Proteasomes and their kin, proteases in the machine age, Nat. Rev. Mol. Cell Biol., 5, 177, 10.1038/nrm1336 · DOI · Paper page
  42. Rideout, 2001, Proteasomal inhibition leads to formation of ubiquitin/α-synuclein immunoreactive inclusions in PC12 cells, J. Neurochem., 78, 899, 10.1046/j.1471-4159.2001.00474.x · DOI · Paper page
  43. Rideout, 2002, Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination, Mol. Cell Neurosci., 21, 223, 10.1006/mcne.2002.1173 · DOI
  44. Rivett, 2002, Assays of proteasome activity in relation to aging, Exp. Gerontol., 37, 1217, 10.1016/S0531-5565(02)00127-4 · DOI
  45. Rodgers, 2003, Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates, Int. J. Biochem. Cell Biol., 35, 716, 10.1016/S1357-2725(02)00391-6 · DOI
  46. Sanchez, 2003, Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders, Nature, 421, 373, 10.1038/nature01301 · DOI · Paper page
  47. Sawada, 2004, Proteasome mediates dopaminergic neuronal degeneration and its inhibition causes a-synuclein inclusions, J. Biol. Chem., 279, 10710, 10.1074/jbc.M308434200 · DOI
  48. Singleton, 2003, alpha-Synuclein locus triplication causes Parkinson's disease, Science, 302, 841, 10.1126/science.1090278 · DOI · Paper page
  49. Smith, 2005, Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutantalpha-synuclein-inducedtoxicity, Hum. Mol. Genet., 14, 3801, 10.1093/hmg/ddi396 · DOI · Paper page
  50. Snyder, 2003, Aggregated and monomeric alpha-synuclein bind to the S6’ proteasomal protein and inhibit proteasomal function, J. Biol. Chem., 278, 11753, 10.1074/jbc.M208641200 · DOI · Paper page
  51. Stefanis, 2001, Expression of A53T mutant but not wild-type a-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death, J. Neurosci., 21, 9549, 10.1523/JNEUROSCI.21-24-09549.2001 · DOI
  52. Stefanis, 2001, Synuclein-1 is selectively up-regulated in response to nerve growth factor treatment in PC12 cells, J. Neurochem., 76, 1165, 10.1046/j.1471-4159.2001.00114.x · DOI
  53. Tanaka, 2000, Isolation and characterization of a novel 530-kDa protein complex (PC530. capable of associating with the 20S proteasome from Starfish oocytes, Arch. Biochem. Biophys., 374, 181, 10.1006/abbi.1999.1584 · doi:10.1006/abbi.1999.1584
  54. Tanaka, 2001, Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis, Hum. Mol. Genet., 10, 919, 10.1093/hmg/10.9.919 · DOI · Paper page
  55. Tofaris, 2001, Alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome, FEBS Lett., 509, 22, 10.1016/S0014-5793(01)03115-5 · DOI · Paper page
  56. Treier, 1994, Ubiquitin-dependent c-jun degradation in vivo is mediated by the delta domain, Cell, 78, 787, 10.1016/S0092-8674(94)90502-9 · DOI · Paper page
  57. Vekrellis, 2004, Neurobiology of a-synuclein, Mol. Neurobiol., 30, 1, 10.1385/MN:30:1:001 · DOI
  58. Volles, 2003, Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease, Biochemistry, 42, 7871, 10.1021/bi030086j · DOI · Paper page

Cited by

See all 221

Metadata

Authors
Emmanouilidou, E., Stefanis, L., & Vekrellis, K.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2010-06
Volume
31
Issue
6
Pages
953-968
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2008.07.008
OpenAlex
W1977977555
Cited by
221
References
11
FWCI
6.09
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome. https://app.cochat.ai/papers/10.1016/j.neurobiolaging.2008.07.008
The paper
Emmanouilidou, E., Stefanis, L., & Vekrellis, K. (2010). Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2008.07.008

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.