Degradation of α-Synuclein by Proteasome

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836 · see citing works

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., & Goedert, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6469 · Cited by 3,151 · see citing works

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

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Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

Conway, K. A., Harper, J. D., & Lansbury, P. T. (1998) · Nature Medicine · doi:10.1038/3311 · Cited by 1,501 · see citing works

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

Uéda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A., Kondo, J. D. M., Ihara, Y., & Saitoh, T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11282 · Cited by 1,469 · see citing works

α-Synuclein Fibrillogenesis Is Nucleation-dependent

Wood, S. J., Wypych, J., Steavenson, S., Louis, J., Citron, M., & Biere, A. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19509 · Cited by 719 · see citing works

Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease

Lowe, J., Blanchard, A., Morrell, K., Lennox, G., Reynolds, L., Billett, M., Landon, M., & Mayer, R. J. (1988) · The Journal of Pathology · doi:10.1002/path.1711550105 · Cited by 539 · see citing works

Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro

Giasson, B. I., Uryu, K., Trojanowski, J. Q., & Lee, V. M. ‐. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7619 · Cited by 505 · see citing works

Synthetic filaments assembled from C‐terminally truncated α‐synuclein

Crowther, R. A., Jakes, R., Spillantini, M. G., & Goedert, M. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01146-6 · Cited by 417 · see citing works

Lewy bodies are ubiquitinated

Kuzuhara, S., Mori, H., Izumiyama, N., Yoshimura, M., & Ihara, Y. (1988) · Acta Neuropathologica · doi:10.1007/bf00687787 · Cited by 409 · see citing works

Aggregation of Neurofilament and α-Synuclein Proteins in Lewy Bodies

Trojanowski, J. Q., & Lee, V. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.2.151 · Cited by 255 · see citing works

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin in Cultured Cells

Dick, L. R., Cruikshank, A. A., Destree, A. T., Grenier, L., McCormack, T. A., Melandri, F. D., Nunes, S. L., Palombella, V. J., Parent, L. A., Plamondon, L., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.182 · Cited by 229 · see citing works

Immunocytochemical Co-localization of the Proteasome in Ubiquitinated Structures in Neurodegenerative Diseases and the Elderly

Ii, K., Ito, H., Tanaka, K., & Hirano, A. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199702000-00002 · Cited by 215 · see citing works

Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease.

Lennox, G. G., Lowe, J. S., Morrell, K., Landon, M., & Mayer, R. J. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.1.67 · Cited by 192 · see citing works

Regulating protein degradation by ubiquitination

Weissman, A. M. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)84666-x · Cited by 169 · see citing works

Factors Involved in the Establishment of Specific Interconnections between Thalamus and Cerebral CortexPreprint

Blakemore, C. B., & Molnár, Z. (1990) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1990.055.01.048 · Cited by 112 · see citing works

Regulation of proteasome structure and function

Rivett, A. J., MASON, G. G. F., Murray, R. Z., et al. (1997) · Molecular Biology Reports · doi:10.1023/a:1006814306401 · Cited by 34 · see citing works

The Ubiquitin-mediated Proteolytic System: Involvement of Molecular Chaperones, Degradation of Oncoproteins, and Activation of Transcriptional RegulatorsPreprint

Ciechanover, A. J., Laszlo, A., Bercovich, B., Stancovski, I., Alkalay, I., Ben‐Neriah, Y., & Orian, A. (1995) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1995.060.01.053 · Cited by 30 · see citing works

Protein degradation by the proteasome and dissection of its in vivo importance with synthetic inhibitors

Goldberg, A. L., Akopian, T. N., Kisselev, A. F., et al. (1997) · Molecular Biology Reports · doi:10.1023/a:1006860828265 · Cited by 28 · see citing works

Intracellular protein degradation in Neurospora crassa.

Martegani, E., & Alberghina, L. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50282-9 · Cited by 18 · see citing works

Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy

Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., & Sulzer, D. (2004) · Science · doi:10.1126/science.1101738 · Cited by 2,024 · see citing works

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Shimura, H., Hattori, N., Kubo, S.-I., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., et al. (2000) · Nature Genetics · doi:10.1038/77060 · Cited by 2,024 · see citing works

The Role of Oxidative Stress in Parkinson's Disease

Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845 · see citing works

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

Webb, J. L., Ravikumar, B., Atkins, J., Skepper, J. N., & Rubinsztein, D. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300227200 · Cited by 1,429 · see citing works

Degradation of misfolded proteins in neurodegenerative diseases: Therapeutic targets and strategies

Ciechanover, A., & Kwon, Y. T. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.117 · Cited by 898 · see citing works

The function of α-synuclein

Bendor, J. T., Logan, T. P., & Edwards, R. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.004 · Cited by 825 · see citing works

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

Vogiatzi, T., Xilouri, M., Vekrellis, K., & Stefanis, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801992200 · Cited by 683 · see citing works

Proteasomal function is impaired in substantia nigra in Parkinson’s disease

McNaught, K. S. P., & Jenner, P. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01701-8 · Cited by 653 · see citing works

Altered proteasomal function in sporadic Parkinson’s disease

St. P. McNaught, K., Belizaire, R., Isacson, O., Jenner, P., & Olanow, C. W. (2003) · Experimental Neurology · doi:10.1006/exnr.2002.8050 · Cited by 573 · see citing works

Failure of the ubiquitin-proteasome system in Parkinson’s disease

McNaught, K. S. P., Olanow, C. W., Halliwell, B., Isacson, O., & Jenner, P. (2001) · Nature Reviews Neuroscience · doi:10.1038/35086067 · Cited by 519 · see citing works

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

Gorman, A. M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00402.x · Cited by 362 · see citing works

Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection

Nedelsky, N. B., Todd, P. K., & Taylor, J. P. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.002 · Cited by 351 · see citing works

Small Ubiquitin-like Modifier (SUMO) Modification of Natively Unfolded Proteins Tau and α-Synuclein

Dorval, V., & Fraser, P. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510127200 · Cited by 319 · see citing works

In Situ and in Vitro Study of Colocalization and Segregation of α-Synuclein, Ubiquitin, and Lipids in Lewy Bodies

Gai, W. P., Yuan, H. X., Li, X. Q., Power, J. T. H., Blumbergs, P. C., & Jensen, P. H. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7527 · Cited by 272 · see citing works

Role of α-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease

Allen Reish, H. E., & Standaert, D. G. (2015) · Journal of Parkinson’s Disease · doi:10.3233/jpd-140491 · Cited by 244 · see citing works

Interaction between Aβ Peptide and α Synuclein: Molecular Mechanisms in Overlapping Pathology of Alzheimer’s and Parkinson’s in Dementia with Lewy Body Disease

Mandal, P. K., Pettegrew, J. W., Masliah, E., Hamilton, R. L., & Mandal, R. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9140-9 · Cited by 219 · see citing works

Proteolytic stress: A unifying concept for the etiopathogenesis of Parkinson’s disease

McNaught, K. S. P., & Olanow, C. W. (2003) · Annals of Neurology · doi:10.1002/ana.10512 · Cited by 203 · see citing works

17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy

Riedel, M., Goldbaum, O., Schwarz, L., Schmitt, S., & Richter-Landsberg, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008753 · Cited by 87 · see citing works

Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive Dystonia

Kawahata, I., & Fukunaga, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113779 · Cited by 71 · see citing works

Vulnerability of mesostriatal dopaminergic neurons in Parkinson’s disease

González-Hernández, T. (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00140 · Cited by 65 · see citing works

Upregulation of α‐synuclein by lipopolysaccharide and interleukin‐1 in human macrophages

Tanji, K., Mori, F., Imaizumi, T., Yoshida, H., Matsumiya, T., Tamo, W., Yoshimoto, M., Odagiri, H., Sasaki, M., Takahashi, H., et al. (2002) · Pathology International · doi:10.1046/j.1440-1827.2002.01385.x · Cited by 55 · see citing works

Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson’s disease.

Bortolozzi, A., Manashirov, S., Chen, A., & Artigas, F. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107873 · Cited by 37 · see citing works

The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology

Manecka, D.-L., Vanderperre, B., Fon, E. A., & Durcan, T. M. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00311 · Cited by 21 · see citing works

P1‐150: Proteasome inhibition increases Aβ load and the underlying mechanisms in rat brain

Liu, Y. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.155

IC‐P‐097: Proteasome inhibition increases Aβ load and the underlying mechanisms in rat brain

Liu, Y. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.05.651 · Cited by 7 · see citing works

The Leishmania mexicana proteasome

Robertson, C. D. (1999) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(99)00110-3 · Cited by 73 · see citing works

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin in Cultured Cells

Dick, L. R., Cruikshank, A. A., Destree, A. T., Grenier, L., McCormack, T. A., Melandri, F. D., Nunes, S. L., Palombella, V. J., Parent, L. A., Plamondon, L., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.182 · Cited by 229 · see citing works

Degradation of BACE by the ubiquitin‐proteasome pathway

Qing, H., Zhou, W., Christensen, M. A., Sun, X., Tong, Y., & Song, W. (2004) · The FASEB Journal · doi:10.1096/fj.04-1994fje · Cited by 149 · see citing works