Cited by 508Dementia and Cognitive Impairment ResearchAging and Gerontology ResearchFunctional Brain Connectivity Studies

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Consistent neuroanatomical age-related volume differences across multiple samples

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Walhovd, Kristine B., Westlye, Lars T., Amlien, Inge, Espeseth, Thomas, Reinvang, Ivar, Raz, Naftali, Agartz, Ingrid, Salat, David H., Greve, Doug N., Fischl, Bruce, Dale, Anders M., Fjell, Anders M.·2011·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2009.05.013PMC PMC4040218

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Abstract

Magnetic resonance imaging (MRI) is the principal method for studying structural age-related brain changes in vivo. However, previous research has yielded inconsistent results, precluding understanding of structural changes of the aging brain. This inconsistency is due to methodological differences and/or different aging patterns across samples. To overcome these problems, we tested age effects on 17 different neuroanatomical structures and total brain volume across five samples, of which one was split to further investigate consistency (883 participants). Widespread age-related volume differences were seen consistently across samples. In four of the five samples, all structures, except the brainstem, showed age-related volume differences. The strongest and most consistent effects were found for cerebral cortex, pallidum, putamen and accumbens volume. Total brain volume, cerebral white matter, caudate, hippocampus and the ventricles consistently showed non-linear age functions. Healthy aging appears associated with more widespread and consistent age-related neuroanatomical volume differences than previously believed.

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Authors: Walhovd, K. B., Westlye, L. T., Amlien, I., Espeseth, T., Reinvang, I., Raz, N., Agartz, I., Salat, D. H., Greve, D. N., Fischl, B., Dale, A. M., & Fjell, A. M.
Affiliations: University of Oslo (NO)
Wayne State University (US)
Massachusetts General Hospital (US)
University of California San Diego (US)
Corresponding author: Walhovd, Kristine B.
ORCID: Walhovd, Kristine B.
Westlye, Lars T.
Amlien, Inge
Espeseth, Thomas
Raz, Naftali
Agartz, Ingrid
Salat, David H.
Fischl, Bruce
Dale, Anders M.
Fjell, Anders M.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2011-05
Volume: 32
Issue: 5
Pages: 916-932
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2009.05.013
PMC: PMC4040218
OpenAlex: W2120973488
Cited by: 506
References: 97
Citations by year: 2026: 22 · 2025: 13 · 2024: 22 · 2023: 23 · 2022: 31 · 2021: 43 · 2020: 39 · 2019: 44 · 2018: 31 · 2017: 25 · 2016: 28 · 2015: 28 · 2014: 37 · 2013: 32 · 2012: 42
FWCI: 18.14
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R37AG011230, R01-AG11230, R01AG011230)
National Institute of Neurological Disorders and Stroke (R01NS039581, R01-NS39581)
National Center for Research Resources (P41-RR-14075, R01RR013609, R01-RR13609, R01-RR16594, P41RR014075, R01RR016594)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: brain aging, total brain volume, cerebral cortex, globus pallidus, putamen, accumbens, hippocampus, caudate nucleus, ventricles, white matter, healthy aging
MeSH terms: Adult, Age Factors, Aged, Aged, 80 and over, Aging, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Young Adult

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Consistent neuroanatomical age-related volume differences across multiple samples

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