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Cited by 226

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium

Open access
Murray, Carol, Sanderson, David J., Barkus, Chris, Deacon, Robert M.J., Rawlins, J. Nicholas P., Bannerman, David M., Cunningham, Colm·2012·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2010.04.002
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Abstract

Delirium is an acute, severe neuropsychiatric syndrome, characterized by cognitive deficits, that is highly prevalent in aging and dementia and is frequently precipitated by peripheral infections. Delirium is poorly understood and the lack of biologically relevant animal models has limited basic research. Here we hypothesized that synaptic loss and accompanying microglial priming during chronic neurodegeneration in the ME7 mouse model of prion disease predisposes these animals to acute dysfunction in the region of prior pathology upon systemic inflammatory activation. Lipopolysaccharide (LPS; 100 μg/kg) induced acute and transient working memory deficits in ME7 animals on a novel T-maze task, but did not do so in normal animals. LPS-treated ME7 animals showed heightened and prolonged transcription of inflammatory mediators in the central nervous system (CNS), compared with LPS-treated normal animals, despite having equivalent levels of circulating cytokines. The demonstration that prior synaptic loss and microglial priming are predisposing factors for acute cognitive impairments induced by systemic inflammation suggests an important animal model with which to study aspects of delirium during dementia.

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Metadata

Authors
Murray, C., Sanderson, D. J., Barkus, C., Deacon, R. M. J., Rawlins, J. N. P., Bannerman, D. M., & Cunningham, C.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2012-03
Volume
33
Issue
3
Pages
603-616.e3
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2010.04.002
OpenAlex
W1999691215
Cited by
226
References
10
FWCI
7.17
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. https://app.cochat.ai/papers/10.1016/j.neurobiolaging.2010.04.002
The paper
Murray, C., Sanderson, D. J., Barkus, C., Deacon, R. M. J., Rawlins, J. N. P., Bannerman, D. M., & Cunningham, C. (2012). Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2010.04.002

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.