The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Critical ages in the life course of the adult brain: nonlinear subcortical aging
Open accessAbstract
Age-related changes in brain structure result from a complex interplay between various neurobiological processes, which may contribute to more complex trajectories than can be described by simple linear or quadratic models. We used a non-parametric smoothing spline approach to delineate cross-sectionally estimated age-trajectories of the volume of 17 neuroanatomical structures in 1100 healthy adults (18–94 years). Accelerated estimated decline in advanced age characterized some structures, e.g. hippocampus, but was not the norm. For most areas, one or two critical ages were identified, characterized by changes in the estimated rate of change. One year follow up data from 142 healthy older adults (60–91 years) confirmed the existence of estimated change from the cross-sectional analyses for all areas except one (caudate). The cross-sectional and the longitudinal analyses agreed well on the rank order of age effects on specific brain structures (Spearman’s ρ = .91). The main conclusions are that most brain structures do not follow a simple path throughout adult life, and that accelerated decline in high age is not the norm of healthy brain aging.
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Self-citationA Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
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Consistent neuroanatomical age-related volume differences across multiple samples
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Self-citationAtlas Renormalization for Improved Brain MR Image Segmentation Across Scanner Platforms
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A common brain network links development, aging, and vulnerability to disease
Douaud, G., Groves, A. R., Tamnes, C. K., Westlye, L. T., Duff, E. P., Engvig, A., Walhovd, K. B., James, A., Gass, A., Monsch, A. U., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410378111 · Cited by 317
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Metadata
- Authors
- Fjell, A. M., Westlye, L. T., Grydeland, H., Amlien, I., Espeseth, T., Reinvang, I., Raz, N., Holland, D., Dale, A. M., & Walhovd, K. B.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 34
- Issue
- 10
- Pages
- 2239-2247
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2085037176
- Cited by
- 390
- References
- 7
- FWCI
- 15.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Fjell, A. M., Westlye, L. T., Grydeland, H., Amlien, I., Espeseth, T., Reinvang, I., Raz, N., Holland, D., Dale, A. M., & Walhovd, K. B. (2013). Critical ages in the life course of the adult brain: nonlinear subcortical aging. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2013.04.006
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