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Association between the CETP polymorphisms and the risk of Alzheimer's disease, carotid atherosclerosis, longevity, and the efficacy of statin therapy

Li, Qing, Huang, Ping, He, Qian-Chao, Lin, Quan-Zhen, Wu, Jian, Yin, Rui-Xing·2014·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2013.12.032
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Abstract

The purpose of this meta-analysis was to detect the association between the cholesteryl ester transfer protein gene polymorphisms and the risk of Alzheimer's disease (AD), carotid atherosclerosis, longevity, and the efficacy of statin therapy. Databases of MEDLINE, EMBASE, BIOSIS, the Cochrane Library, and the Chinese National Knowledge Infrastructure were systematically searched. Thirty-two studies were included in this meta-analysis. There was no difference in the I405V, C629A, and Taq1B polymorphisms between AD and control groups. However, stratified analysis showed that AD group had higher B2B2 genotype frequency than control group in Asian populations with APOE4+ in Taq1B. I405V and Taq1B polymorphisms were not associated with the risk of carotid atherosclerosis and longevity. The efficacy of statin therapy was not associated with Taq1B polymorphism. In conclusion, there was no association between cholesteryl ester transfer protein gene polymorphisms and the risk of AD, carotid atherosclerosis, longevity, and the efficacy of statin therapy in the pooled effects of overall population. However, the B2B2 genotype of Taq1B was associated with increased risk of AD in the Asian populations with APOE4+.

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Metadata

Authors
Li, Q., Huang, P., He, Q.-C., Lin, Q.-Z., Wu, J., & Yin, R.-X.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2014-06
Volume
35
Issue
6
Pages
1513.e13-1513.e23
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2013.12.032
Cited by
16
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
National Natural Science Foundation of China (81200205, 30960130)

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