Cited by 106Neurogenesis and neuroplasticity mechanismsExercise and Physiological ResponsesNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation

Open access

E, Lezi, Burns, Jeffrey M., Swerdlow, Russell H.·2014·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2014.05.033PMC PMC4171347

Open this paper in CoChat — free account

Abstract

In aged mice, we assessed how intensive exercise affects brain bioenergetics, inflammation, and neurogenesis-relevant parameters. After 8 weeks of a supra-lactate threshold treadmill exercise intervention, 21-month-old C57BL/6 mice showed increased brain peroxisome proliferator-activated receptor gamma coactivator-1α protein, mammalian target of rapamycin and phospho-mammalian target of rapamycin protein, citrate synthase messenger RNA, and mitochondrial DNA copy number. Hippocampal vascular endothelial growth factor A (VEGF-A) gene expression trended higher, and a positive correlation between VEGF-A and PRC messenger RNA levels was observed. Brain doublecortin, brain-derived neurotrophic factor, tumor necrosis factor-α, and CCL11 gene expression, as well as plasma CCL11 protein levels, were unchanged. Despite these apparent negative findings, a negative correlation between plasma CCL11 protein levels and hippocampal doublecortin gene expression was observed; further analysis indicated exercise may mitigate this relationship. Overall, our data suggest supra-lactate threshold exercise activates a partial mitochondrial biogenesis in aged mice, and a gene (VEGF-A) known to support neurogenesis. Our data are consistent with another study that found systemic inflammation in general, and CCL11 protein specifically, suppresses hippocampal neurogenesis. Our study supports the view that intense exercise above the lactate threshold may benefit the aging brain; future studies to address the extent to which exercise-generated lactate mediates the observed effects are warranted.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neurobiolaging.2014.05.033

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice
Safdar, A., Bourgeois, J. M., Ogborn, D. I., Little, J. P., Hettinga, B. P., Akhtar, M., Thompson, J. E., Melov, S., Mocellin, N. J., Kujoth, G. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019581108 · Cited by 320
Retracted
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Mechanism of activation of protein kinase B by insulin and IGF‐1.
Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
Physiology of Sport and Exercise
Wilmore, J. H., COSTILL, D. L., & Gleim, G. W. (1995) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199505000-00024 · Cited by 2,240
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666
Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559

Show all 43 references

Sorted by citations

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690
Physical Activity and Brain Health
Liegro, C. M. D., Schiera, G., Proia, P., & Liegro, I. D. (2019) · Genes · doi:10.3390/genes10090720 · Cited by 451
Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance
Raefsky, S. M., & Mattson, M. P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.045 · Cited by 280
Physical exercise induces hippocampal neurogenesis and prevents cognitive decline
Ma, C., Ma, X., Wang, J., Liu, H., Chen, Y., & Yang, Y. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.067 · Cited by 207
Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate?
Ryan, S. M., & Nolan, Y. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.12.004 · Cited by 205
Physical exercise, reactive oxygen species and neuroprotection
Radak, Z., Suzuki, K., Higuchi, M., Balogh, L., Boldogh, I., & Koltai, E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.024 · Cited by 167
Aging, lifestyle and dementia
Wahl, D., Solon‐Biet, S. M., Cogger, V. C., Fontana, L., Simpson, S. J., Couteur, D. G. L., & Ribeiro, R. V. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104481 · Cited by 155
Long-Term Mild, rather than Intense, Exercise Enhances Adult Hippocampal Neurogenesis and Greatly Changes the Transcriptomic Profile of the Hippocampus
Inoue, K., Okamoto, M., Shibato, J., Lee, M. C., Matsui, T., Rakwal, R., & Soya, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128720 · Cited by 154
High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats
Freitas, D. A., Rocha‐Vieira, E., Soares, B. A., Nonato, L. F., da Fonseca, S. F., Martins, J. B., Mendonça, V. A., Lacerda, A. C. R., Massensini, A. R., Poortamns, J. R., et al. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.10.027 · Cited by 131
Mechanisms of Hippocampal Aging and the Potential for Rejuvenation
Fan, X., Wheatley, E., & Villeda, S. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031357 · Cited by 132
Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease
Wilkins, H., & Swerdlow, R. H. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150827095102 · Cited by 124
Self-citation
Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice
Gusdon, A. M., Callio, J., Distéfano, G., O'Doherty, R. M., Goodpaster, B. H., Coen, P. M., & Chu, C. T. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.013 · Cited by 112
Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
Parodi‐Rullán, R. M., Sone, J. Y., & Fossati, S. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190357 · Cited by 110
CCL‐11 or Eotaxin‐1: an immune marker for ageing and accelerated ageing in neuro‐psychiatric disorders
Ivanovska, M., Abdi, Z., Murdjeva, M., Macedo, D., Maes, A., & Maes, M. (2020) · Pharmaceuticals · doi:10.3390/ph13090230 · Cited by 83
Exercise increases mTOR signaling in brain regions involved in cognition and emotional behavior
Lloyd, B. A., Hake, H. S., Ishiwata, T., Farmer, C. E., Loetz, E. C., Fleshner, M., Bland, S. T., & Greenwood, B. N. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.033 · Cited by 105
Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management
Ellis, R. J., Marquine, M. J., Kaul, M., Fields, J. A., & Schlachetzki, J. C. M. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00879-y · Cited by 101
Exercise-stimulated FGF23 promotes exercise performance via controlling the excess reactive oxygen species production and enhancing mitochondrial function in skeletal muscle
Li, D.-J., Fu, H., Zhao, T., Ni, M., & Shen, F.-M. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.009 · Cited by 92
The Alzheimer’s Disease Mitochondrial Cascade Hypothesis: A Current Overview
Swerdlow, R. H. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221286 · Cited by 88
Self-citation
Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System
Hu, J., Cai, M., Shang, Q., Li, Z.-R., Feng, Y., Liu, B., Xue, X., & Lou, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.629914 · Cited by 79
Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke?
Hugues, N., Pellegrino, C., Rivera, C., Berton, É., Pin-Barre, C., & Laurin, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063003 · Cited by 68
Harnessing neuroplasticity: modern approaches and clinical future
Sasmita, A. O., Kuruvilla, J., & Ling, A. P. K. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1466781 · Cited by 69
Exercise effects on brain and behavior in healthy mice, Alzheimer’s disease and Parkinson’s disease model—A systematic review and meta-analysis
da Costa Daniele, T. M., de Bruin, P. F. C., de Matos, R. S., de Bruin, G. S., Maia Chaves, C., & de Bruin, V. M. S. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112488 · Cited by 59
Physical Exercise Improves Aging-Related Changes in Angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia Nigra
Muñoz, A., Corrêa, C. L., López-López, A., Costa-Besada, M. A., Díaz-Ruiz, C., & Labandeira-García, J. L. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly072 · Cited by 59
Pleiotropic and multi-systemic actions of physical exercise on PGC-1α signaling during the aging process
Neto, I. V. D. S., Pinto, A. P., Muñoz, V. R., Marqueti, R. D. C., Pauli, J. R., Ropelle, E. R., & da Silva, A. S. R. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101935 · Cited by 56
Immune-regulating effects of exercise on cigarette smoke-induced inflammation
Madani, A., Alack, K., Richter, M. J., & Krüger, K. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s141149 · Cited by 59
Lactate as Potential Mediators for Exercise-Induced Positive Effects on Neuroplasticity and Cerebrovascular Plasticity
Huang, Z., Zhang, Y., Zhou, R., Yang, L., & Pan, H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.656455 · Cited by 58
High-intensity interval training is superior to moderate intensity training on aerobic capacity in rats: Impact on hippocampal plasticity markers
Constans, A., Pin-Barre, C., Molinari, F., Temprado, J.-J., Brioche, T., Pellegrino, C., & Laurin, J. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112977 · Cited by 55
Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome
Zhang, T., Ding, S., & Wang, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910866 · Cited by 53
Irisin: An unveiled bridge between physical exercise and a healthy brain
Sadier, N. S., Hajjar, F. E., Sabouri, A. A. K. A., Abbas, L. A., Siomava, N., Almutary, A. G., & Tambuwala, M. M. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122393 · Cited by 49
Friend or foe: Lactate in neurodegenerative diseases
Wang, M., Zhou, Y., Li, W., Zhu, L., & Liu, D. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102452 · Cited by 48
Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression
Price, J. B., Bronars, C. A., Erhardt, S., Cullen, K., Schwieler, L., Berk, M., Walder, K. R., McGee, S. L., Frye, M. A., & Tye, S. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.002 · Cited by 47
Physical exercise protects against mitochondria alterations in the 6-hidroxydopamine rat model of Parkinson’s disease
Ferreira, A. F. F., Binda, K. H., Singulani, M. P., Pereira, C. P. M., Ferrari, G. D., Alberici, L. C., Real, C. C., & Britto, L. R. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112607 · Cited by 46
The Combination Effects of Resveratrol and Swimming HIIT Exercise on Novel Object Recognition and Open-field Tasks in Aged Rats
Amirazodi, F., Mehrabi, A., Amirazodi, M., Parsania, S., Rajizadeh, M. A., & Esmaeilpour, K. (2020) · Experimental Aging Research · doi:10.1080/0361073x.2020.1754015 · Cited by 45
The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body
Rosa, M. C. D., Zimbone, S., Saab, M. W., & Tomasello, M. F. (2021) · Life · doi:10.3390/life11111256 · Cited by 41
Can Exercise Make You Smarter, Happier, and Have More Neurons? A Hormetic Perspective
Gradari, S., Pallé, A., McGreevy, K. R., Fontán‐Lozano, Á., & Trejo, J. L. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00093 · Cited by 37
CCL11 promotes migration and proliferation of mouse neural progenitor cells
Wang, F., Baba, N., Shen, Y., Yamashita, T., Tsuru, E., Tsuda, M., Maeda, N., & Sagara, Y. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0474-9 · Cited by 34
Exercise-Induced Neuroplasticity: Adaptive Mechanisms and Preventive Potential in Neurodegenerative Disorders
Mansoor, M. A., Ibrahim, A., Hamide, A., Tran, T., Candreva, E., & Baltaji, J. (2025) · Physiologia · doi:10.3390/physiologia5020013 · Cited by 38
Static Stretching Reduces Motoneuron Excitability: The Potential Role of Neuromodulation
Trajano, G. S., & Blazevich, A. J. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000243 · Cited by 35
Swimming exercise enhances the hippocampal antioxidant status of female Wistar rats
Stone, V., Kudo, K. Y., Marcelino, T. B., August, P. M., & Matté, C. (2014) · Redox Report · doi:10.1179/1351000214y.0000000116 · Cited by 31
New insights into vascular aging: Emerging role of mitochondria function
Li, Y., Jin, X., Li, D. X., Lu, J. Z., Zhang, X., Yang, S., Zhao, Y., & Wu, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113954 · Cited by 30
Is the “lactormone” a key-factor for exercise-related neuroplasticity? A hypothesis based on an alternative lactate neurobiological pathway
Monteiro-Júnior, R. S., Maillot, P., Gatica-Rojas, V., Ávila, W. R. D. M. E., de Paula, A. M. B., Guimarães, A. L. S., Santos, S. H. S., Pupe, C., & Deslandes, A. C. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.12.013 · Cited by 30
Reduced ccl11/eotaxin mediates the beneficial effects of environmental stimulation on the aged hippocampus
Scabia, G., Testa, G., Scali, M., Turco, S. D., Desiato, G., Berardi, N., Sale, A., Matteoli, M., Maffei, L., Maffei, M., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.222 · Cited by 29
Effect of physical exercise on brain and lipid metabolism in mouse models of multiple sclerosis
Houdebine, L., Gallelli, C. A., Rastelli, M., Sampathkumar, N. K., & Grenier, J. (2017) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2017.06.002 · Cited by 29
Impact of Exercise on Immunometabolism in Multiple Sclerosis
Afzal, R., Dowling, J. K., & McCoy, C. E. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9093038 · Cited by 29
Mitochondrial Dynamics in Brain Cells During Normal and Pathological Aging
Sukhorukov, V. S., Baranich, T. I., Egorova, A. V., Akateva, A. V., Okulova, K. M., Ryabova, M. S., Skvortsova, K. A., Dmitriev, O. V., Mudzhiri, N. M., Воронков, Д. Н., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312855 · Cited by 27
Physical exercise and mitochondrial function: New therapeutic interventions for psychiatric and neurodegenerative disorders
Sun, L., Liu, T., Liu, J., Gao, C., & Zhang, X. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.929781 · Cited by 27
Exercise and mitochondrial remodeling to prevent age-related neurodegeneration
O’Reilly, C. L., Miller, B. F., & Lewis, T. L. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00611.2022 · Cited by 25
An exercise “sweet spot” reverses cognitive deficits of aging by growth-hormone-induced neurogenesis
Blackmore, D. G., Steyn, F. J., Carlisle, A., O’Keeffe, I., Vien, K.-Y., Zhou, X. A., Leiter, O., Jhaveri, D. J., Vukovic, J., Waters, M. J., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103275 · Cited by 26
CCL11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-psychiatric DisordersPreprint
Ivanovska, M., Abdi, Z., Murdjeva, M., Macêdo, D. S., Maes, A., & Maes, M. H. J. (2020) · Preprints.org · doi:10.20944/preprints202001.0370.v1 · Cited by 24
Novel Strategies for Healthy Brain Aging
Wahl, D., Cavalier, A. N., & LaRocca, T. J. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000242 · Cited by 26
Exercise reduces metabolic burden while altering the immune system in aged mice
Yoon, K. J., Ahn, A., Park, S. H., Kwak, S. H., Kwak, S. E., Lee, W., Yang, Y. R., Kim, M., Shin, H. M., Kim, H., et al. (2021) · Aging · doi:10.18632/aging.202312 · Cited by 23
From energy metabolism to mood regulation: The rise of lactate as a therapeutic target
Zhang, S., Xia, J., He, W., Zou, Y., Liu, W., Li, L., Huang, Z., Li, Q., Li, Q. X., & Liu, W. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.04.018 · Cited by 23
Acute Carnosine Administration Increases Respiratory Chain Complexes and Citric Acid Cycle Enzyme Activities in Cerebral Cortex of Young Rats
Macedo, L. W., Cararo, J. H., Maravai, S. G., Gonçalves, C. L., de Oliveira, G. M. T., Kist, L. W., Martinez, C. G., Kurtenbach, E., Bogo, M. R., Hipkiss, A. R., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9475-9 · Cited by 19
Emerging methods for and novel insights gained by absolute quantification of mitochondrial DNA copy number and its clinical applications
Li, B., Kalinowski, P., Kim, B., Pauls, A. D., & Poburko, D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107995 · Cited by 19
Pathways explaining racial/ethnic disparities in incident all‐cause and Alzheimer's disease dementia among older US men and women
Beydoun, M. A., Weiss, J., Beydoun, H. A., Kuczmarski, M. F., Hossain, S. A., El‐Hajj, Z. W., Evans, M. K., & Zonderman, A. B. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12275 · Cited by 19
Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model
Aoki, K., Konno, M., Honda, K., Abe, T., Nagata, T., Takehara, M., Sugasawa, T., Takekoshi, K., & Ohmori, H. (2020) · Geriatrics · doi:10.3390/geriatrics5030048 · Cited by 18
Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis
Karlsson, L., Alvarado, M. N. G., Motalleb, R., Wang, Y., Wang, Y., Börjesson, M., Zhu, C., & Kuhn, H. G. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02189-6 · Cited by 17
Effects of Treadmill Exercise on Neural Mitochondrial Functions in Parkinson’s Disease: A Systematic Review of Animal Studies
Nhu, N. T., Cheng, Y., & Lee, S. (2021) · Biomedicines · doi:10.3390/biomedicines9081011 · Cited by 17
Delineating the contribution of ageing and physical activity to changes in mitochondrial characteristics across the lifespan
Lee, M. J.-C., Saner, N. J., Ferri, A., García-Domínguez, E., Broatch, J. R., & Bishop, D. J. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101272 · Cited by 18
Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases
Ma, J., Gao, B., Zhang, K., Zhang, Q., Jia, G., Li, J., Li, C., Yan, L., & Cai, Z. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.08.004 · Cited by 15
The Impact of Physical Exercise on the Hippocampus in Physiological Condition and Ageing-Related Decline: Current Evidence from Animal and Human Studies
Lauretta, G., Ravalli, S., Maugeri, G., D’Agata, V., Rosa, M. D., & Musumeci, G. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210405142611 · Cited by 15
Interactive Effects of Swimming High‐Intensity Interval Training and Resveratrol Supplementation Improve Mitochondrial Protein Levels in the Hippocampus of Aged Rats
Amirazodi, M., Daryanoosh, F., Mehrabi, A., Gaeini, A. A., Jahromi, M. K., Salesi, M., & Zarifkar, A. H. (2022) · BioMed Research International · doi:10.1155/2022/8638714 · Cited by 13
Different exercises can modulate the differentiation/maturation of neural stem/progenitor cells after photochemically induced focal cerebral infarction
Morishita, S., Hokamura, K., Yoshikawa, A., Agata, N., Tsutsui, Y., Umemura, K., & Kumada, T. (2020) · Brain and Behavior · doi:10.1002/brb3.1535 · Cited by 13
Empowering mitochondrial metabolism: Exploring L-lactate supplementation as a promising therapeutic approach for metabolic syndrome
Cai, M., Li, S., Cai, K., Du, X., Han, J., & Hu, J. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155787 · Cited by 11
The mitochondrial quality control system: a new target for exercise therapeutic intervention in the treatment of brain insulin resistance-induced neurodegeneration in obesity
Cai, M., Wan, J., Cai, K., Li, S., Du, X., Song, H., Sun, W., & Hu, J. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01490-x · Cited by 11
The Role of Mitochondrial Energy Metabolism in the Mechanism of Exercise Improving Depression
Liu, Y., Zhong, C., Yang, Y., Hu, J., Yi, X., Huang, J., Li, H., Liu, X., Xue, K., & Chen, X. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47050382 · Cited by 12
Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging
Maclaine, K. D., Stebbings, K. A., Llano, D. A., & Rhodes, J. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0226860 · Cited by 10
Pindolol Rescues Anxiety-Like Behavior and Neurogenic Maladaptations of Long-Term Binge Alcohol Intake in Mice
Patkar, O. L., Belmer, A., Beecher, K., Jacques, A., & Bartlett, S. E. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00264 · Cited by 9
A balanced formula of essential amino acids promotes brain mitochondrial biogenesis and protects neurons from ischemic insult
Ragni, M., Fenaroli, F., Ruocco, C., Segala, A., D’Antona, G., Nisoli, E., & Valerio, A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1197208 · Cited by 7
Spatial Training Attenuates Long-Term Alzheimer’s Disease-Related Pathogenic Processes in APP/PS1 Mice
Zhao, Y., Bao, J., Liu, W., Gong, X., Liang, Z., Li, W., Wu, M., Xiao, Y., Sun, B., Wang, X., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215016 · Cited by 6
Initial Assessment of Lactate as Mediator of Exercise-Induced Retinal Protection
Sellers, J. T., Chrenek, M. A., Girardot, P. E., Nickerson, J. M., Pardue, M. T., & Boatright, J. H. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-27378-1_74 · Cited by 6
The Hormesis of Thinking: A Deeper Quantum Thermodynamic Perspective?
Nunn, A. V. W., Guy, G. W., & Bell, J. D. (2017) · International Journal of Neurorehabilitation · doi:10.4172/2376-0281.1000272 · Cited by 5
The comparison of AICAR and exercise on mitochondrial quality control in hippocampus and cognitive function of aged mice
Liao, B., Qin, Y., Pan, S.-Y., Wang, G., Jiang, Z., Li, B., Wang, Y., Wang, Y., Zhou, M., Zhang, Y., et al. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250325 · Cited by 4
PHYSIOLOGICAL RISK FACTORS CAUSED BY LOW PHYSICAL ACTIVITY
Sibiryakova, N. V. (2023) · Ulyanovsk Medico-biological Journal · doi:10.34014/2227-1848-2023-2-132-144 · Cited by 4
Effects of aerobic training and combination of resveratrol and fisetin on brain neurogenesis signaling pathways in Alzheimer’s mice
Jahanbakhsh, A., Dehkordi, K. J., & Taghian, F. (2024) · Journal of Shahrekord University of Medical Sciences · doi:10.34172/jsums.911 · Cited by 3
Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia
Zhang, Q., Xu, Y., Luo, H., Su, H., Zhong, J., Pan, L., Liu, Y., Yang, C., Yin, Y., & Tan, B. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04359-1 · Cited by 3
Proceedings from the Albert Charitable Trust Inaugural Workshop on ‘Understanding the Acute Effects of Exercise on the Brain’
Barnes, J. N., Burns, J. M., Bamman, M. M., Billinger, S. A., Bodine, S. C., Booth, F. W., Brassard, P., Clemons, T. A., Fadel, P. J., Geiger, P. C., et al. (2022) · Brain Plasticity · doi:10.3233/bpl-220146 · Cited by 4
Self-citation
The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body
Rosa, M. C. D., Zimbone, S., Saab, M. W., & Tomasello, M. F. (2022) · Vide Leaf, Hyderabad eBooks · doi:10.37247/pabsc.1.22.35 · Cited by 3
Exercised-enriched blood plasma rescues hippocampal impairments and cognitive deficits in an Alzheimer's disease model
Huang, T., Gong, X., Liang, Z., Yang, R., Wu, L., Yang, C., Wu, M., Wang, X., Shu, X., & Bao, J. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167197 · Cited by 2
Swimming exercise prevents hippocampal dendritic spine changes and memory loss caused by aging: An application of a new semi-automated spine analysis software
Li, J.-M., Yang, F.-H., Chao, M., & Tseng, C. (2022) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2022.103755 · Cited by 2
A new analytical model for the changes of vascular endothelial growth factor in ischemic diseases
Qiu, F., Cao, H., & Wu, Y. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.09.024 · Cited by 2
Exercise and Neuroplasticity: Benefits of High Intensity Interval Exercise
Hwang, J. S., Kim, T. Y., Hwang, M., & Lee, W. J. (2016) · Journal of Life Science · doi:10.5352/jls.2016.26.1.129 · Cited by 2
Nuclear Factor [Erythroid-derived 2]-like 2 and Mitochondrial Transcription Factor A Contribute to Moderate-intensity Swimming Effectiveness against Memory Impairment in Young Mice Induced by Concomitant Exposure to a High-calorie Diet during the Early Life Period
Jardim, N. S., Müller, S. G., Pase, F. M., & Nogueira, C. W. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.023 · Cited by 2
The Effect of Eight Weeks Resistance and Endurance training on Some Angiogenesis factors of Hippocampus Tissue in male Wistar rats
Ghomi, M. S., Kashef, M., & Salehpour, M. (2021) · Journal of Sport and Exercise Physiology · doi:10.52547/joeppa.14.2.45 · Cited by 2
Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats
Holst, C. M., Esperon‐Abril, I., Juhl, F. B., Jakobsgaard, J. E., Kristiansen, J. B., Vissing, K., & Stevnsner, T. (2025) · Experimental Physiology · doi:10.1113/ep092815 · Cited by 1
CoQ10-Supported HIIT Modulates Skeletal Muscle and Hippocampal Biomarkers in Rats: A Randomized, Repeated-Measures, Post-Test Controlled Design
Yılmaz, B., Şenel, Ö., Çalıkuşu, A., Topa, E., Yasul, Y., Anadol, E., Sarısoy, F., Atalar, K., Bahçelioğlu, M., & Yılmaz, C. (2025) · Antioxidants · doi:10.3390/antiox14111360 · Cited by 1
Biochemical Mechanisms Associated With Exercise-Induced Neuroprotection in Aging Brains and Related Neurological Diseases
Shanmugam, M. S., Tierney, W. M., Hernandez, R. A., Cruz, A., Uhlendorf, T. L., & Cohen, R. W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805094-1.00009-5 · Cited by 1
Lifestyle Factors, Mitochondrial Dynamics, and Neuroprotection
Broman, K., Davis, A. U., May, J., & Park, H. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.89416 · Cited by 1
Exercise-Mediated Autophagy and Brain Aging
Kou, X., Zhang, H., Guo, Y. L., Kirberger, M., & Chen, N. (2021) · Springer eBooks · doi:10.1007/978-981-16-4525-9_6 · Cited by 1
Differential Expression of the Brain Proteome in Physical Training
Ravikiran, T., Vani, R., & Anand, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805094-1.00003-4
Uma semana de treinamento intervalado de alta intensidade (HIIT) aumenta a plasticidade neuronal no hipocampo independentemente do estado redox
dos Santos, J. R. (2020) · doi:10.11606/d.17.2020.tde-19082020-223852
Efeitos do exercício físico na função e biogênese mitocondrial em modelo de doença de Parkinson induzido por 6-hidroxidopamina.
Ferreira, A. F. F. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2020.tde-23122020-200354
Effects of a moderate intensity aerobic exercise on serum levels of BDNF, DCX, and DBHB in triathlon male adolescents
Mohammadbeygi, S., & Dehnou, V. V. (2021) · یافته · doi:10.32592/yafteh.2021.23.4.7
SIRTUIN 6 GENE EXPRESSION AND TELOMERE LENGTH CHANGES IN OLD RAT HEPATOCYTES AFTER 6 WEEKS SWIMMING EXERCISE AND RESVERATROL SUPPLEMENTATION FEEDING
Shahhosseini, S., Ravasi, A., & Nouri, R. (2021) · Studies in Medical Sciences · doi:10.52547/umj.32.8.619
Exercise Reverses Immune-Related Genes in the Hippocampus of Multiple Sclerosis Patients
Qiu, J., Gu, J., Chang, S., Zhang, Z., Zhang, H., Liu, T., Jie, J., & Wei, J. (2024) · Neurology India · doi:10.4103/ni.ni_27_22
Flaxseed Oil Mitigates Stress-Induced Immunoreactivity Loss of Midbrain Tyrosine Hydroxylase-Positive neurons caused by High- intensity exercise trainingPreprint
Oliveira, R. F., Paiva, K. M., de Andrade, A. V. D., Melo, L. H. M. D. F., Freire, K. F., de Melo, A. M. D. M. F., Rocha, G. S., Matoso, L. Y. D. A., Tavares, É. A. F., Martins, D. G. D. S., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6564884/v1
The Significance of Prolonged Physical Activity in Neurogenesis and Neural Regeneration: Comparing Clinical Studies With Proposed AI‐Based Framework
Saadh, M. J., Abdulsahib, W. K., Saidkhodjaeva, S., Sanghvi, G. V., Ballal, S., Sharma, R. S. K., Pathak, P. K., Shankhyan, A., Kumar, A., Sead, F. F., et al. (2025) · Artificial Organs · doi:10.1111/aor.15059
Etude des effets de programmes d'endurance de haute intensité et de haut volume sur les performances physiques, cognitives ainsi que sur la plasticité musculaire et cérébrale chez le rat sain et ayant subi une ischémie cérébrale
Constans, A. (2019) · theses.fr (ABES) · doi:10.70675/93486891z6065z449cz992az7390677dca22
Étude des effets de programmes d’entrainement en endurance sur la performance, les fonctions cognitives et sensorimotrices ainsi que sur la plasticité cérébrale chez le rat sain et ayant subi une ischémie cérébrale
Hugues, N. (2023) · theses.fr (ABES) · doi:10.70675/3c52cc4bze9dfz499cza28az42945d38cbd6
The Effect of Saffron Extract Supplementation During Resistance Training on Hippocampal Doublecortin and Hepatic β ‐Hydroxybutyrate Levels in Rats With Type 2 Diabetes
Dehnou, V. V., Sarghaleh, A. J., Karimi, A., Hasanvand, B., & Pahlavani, H. A. (2026) · Journal of Diabetes Research · doi:10.1155/jdr/1914865

Authors: E, L., Burns, J. M., & Swerdlow, R. H.
Affiliations: University of Kansas (US)
University of Kansas Medical Center (US)
Corresponding author: Swerdlow, Russell H.
ORCID: Burns, Jeffrey M.
Swerdlow, Russell H.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2014-11
Volume: 35
Issue: 11
Pages: 2574-2583
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2014.05.033
PMC: PMC4171347
OpenAlex: W2036466453
Cited by: 106
References: 43
Citations by year: 2026: 7 · 2025: 8 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 18 · 2020: 14 · 2019: 8 · 2018: 6 · 2017: 10 · 2016: 6 · 2015: 4 · 2014: 1
FWCI: 2.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: University of Kansas Alzheimer's Disease Center (P30 AG035982)
Mabel Woodyard Fellowship Award
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: high-intensity exercise, brain aging, mitochondrial biogenesis, neurogenesis, systemic inflammation, eotaxin, VEGF-A, PGC-1α, mTOR, mitochondrial DNA copy number, citrate synthase, hippocampus, doublecortin, brain-derived neurotrophic factor, TNF-α, lactate threshold, treadmill exercise, aged mice
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Doublecortin Domain Proteins, Aging, Animals, Organelle Biogenesis, Brain, Citrate (si)-Synthase, DNA, Mitochondrial, Hippocampus, Humans, Inflammation, Lactates, Male, Mice, Inbred C57BL, Microtubule-Associated Proteins, Mitochondria, Neuropeptides, Physical Conditioning, Animal, RNA, Messenger, Transcription Factors, Gene Dosage, Vascular Endothelial Growth Factor A, Chemokine CCL11, Neurogenesis, TOR Serine-Threonine Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks