CoChat
Sign Up
Cited by 320

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

RETRACTED: Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

Safdar, Adeel, Bourgeois, Jacqueline M., Ogborn, Daniel I., Little, Jonathan P., Hettinga, Bart P., Akhtar, Mahmood, Thompson, James E., Melov, Simon, Mocellin, Nicholas J., Kujoth, Gregory C., Prolla, Tomas A., Tarnopolsky, Mark A.·2011·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1019581108
Open this paper in CoChat — free account

Abstract

A causal role for mitochondrial DNA (mtDNA) mutagenesis in mammalian aging is supported by recent studies demonstrating that the mtDNA mutator mouse, harboring a defect in the proofreading-exonuclease activity of mitochondrial polymerase gamma, exhibits accelerated aging phenotypes characteristic of human aging, systemic mitochondrial dysfunction, multisystem pathology, and reduced lifespan. Epidemiologic studies in humans have demonstrated that endurance training reduces the risk of chronic diseases and extends life expectancy. Whether endurance exercise can attenuate the cumulative systemic decline observed in aging remains elusive. Here we show that 5 mo of endurance exercise induced systemic mitochondrial biogenesis, prevented mtDNA depletion and mutations, increased mitochondrial oxidative capacity and respiratory chain assembly, restored mitochondrial morphology, and blunted pathological levels of apoptosis in multiple tissues of mtDNA mutator mice. These adaptations conferred complete phenotypic protection, reduced multisystem pathology, and prevented premature mortality in these mice. The systemic mitochondrial rejuvenation through endurance exercise promises to be an effective therapeutic approach to mitigating mitochondrial dysfunction in aging and related comorbidities.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.1019581108This paper is marked retracted.

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Endurance training and alternate-day-fasting may improve healthspan through their capacity to avoid mitochondrial degeneration.

    “endurance training and alternate-day-fasting may improve healthspan through their capacity to avoid mitochondrial degeneration”

    From The Hallmarks of Aging (2013) · cites this paper as Safdar et al., 2011

    The Abstract reports that endurance exercise prevented mitochondrial dysfunction and premature-aging effects in mtDNA mutator mice, supporting the endurance-training part of the claim. The paper does not report a comparable finding for alternate-day fasting (searched: “alternate-day fasting” and “fasting caloric restriction intermittent alternate day”). (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 48

  1. 10.1111/j.1532-5415.1972.tb00787.x · DOI
  2. 10.1146/annurev-biochem-060408-093701 · DOI
  3. 10.1016/0047-6374(95)01611-3 · DOI
  4. 10.1016/S0027-5107(03)00010-1 · DOI
  5. 10.1146/annurev.genet.39.110304.095751 · DOI · Paper page
  6. 10.1016/j.coph.2009.09.002 · DOI
  7. 10.1186/1479-5868-7-39 · DOI · Paper page
  8. 10.1016/j.freeradbiomed.2010.08.010 · DOI
  9. 10.1007/s10540-007-9041-4 · DOI
  10. 10.1001/archinternmed.2009.530 · DOI · Paper page
  11. 10.1097/BOR.0b013e3283319d53 · DOI
  12. 10.3810/psm.2009.12.1746 · DOI
  13. 10.1016/S1353-8020(09)70812-0 · DOI
  14. 10.2217/fon.09.65 · DOI
  15. 10.1016/j.cger.2009.08.002 · DOI
  16. 10.1001/archinternmed.2009.248 · DOI
  17. 10.1513/pats.200907-070DP · DOI
  18. 10.1113/jphysiol.2008.165464 · DOI
  19. 10.1016/j.freeradbiomed.2007.08.015 · DOI
  20. 10.1111/j.1753-4887.2009.00185.x · DOI
  21. 10.1126/science.1112125 · DOI · Paper page
  22. 10.1016/0022-510X(88)90132-3 · DOI
  23. 10.1259/0007-1285-54-641-384 · DOI
  24. 10.1371/journal.pone.0011468 · DOI · Paper page
  25. 10.1046/j.1532-5415.51.3s.4.x · DOI
  26. 10.1182/blood-2008-08-169474 · DOI
  27. 10.1016/j.cmet.2009.06.010 · DOI · Paper page
  28. 10.1093/hmg/ddl477 · DOI · Paper page
  29. 10.1371/journal.pbio.0060010 · DOI
  30. 10.1093/hmg/ddn150 · DOI
  31. 10.1093/hmg/ddp093 · DOI
  32. 10.1152/japplphysiol.91571.2008 · DOI · Paper page
  33. 10.1016/j.tips.2009.03.006 · DOI · Paper page
  34. 10.1101/gad.1525107 · DOI
  35. 10.1073/pnas.0911570106 · DOI · Paper page
  36. 10.1093/hmg/ddp243 · DOI
  37. 10.1016/j.cmet.2007.08.004 · DOI
  38. 10.1038/ng0398-231 · DOI · Paper page
  39. 10.1093/geronj/31.2.129 · DOI
  40. 10.3109/01913129209061355 · DOI
  41. 10.1016/j.exger.2009.11.002 · DOI · Paper page
  42. 10.1016/j.tem.2009.03.007 · DOI
  43. 10.1016/j.bbrc.2004.05.104 · DOI
  44. 10.1089/rej.2005.8.216 · DOI
  45. 10.1016/j.neurobiolaging.2004.11.008 · DOI
  46. 10.1016/S0960-8966(01)00332-7 · DOI · Paper page
  47. 10.1126/science.286.5440.774 · DOI
  48. 10.1073/pnas.072670199 · DOI

Cited by

Sorted by citations

Metadata

Authors
Safdar, A., Bourgeois, J. M., Ogborn, D. I., Little, J. P., Hettinga, B. P., Akhtar, M., Thompson, J. E., Melov, S., Mocellin, N. J., Kujoth, G. C., Prolla, T. A., & Tarnopolsky, M. A.
Affiliations
  • Departments of aKinesiology,
  • Pathology and Molecular Medicine, and
  • McMaster University
  • Pediatrics,
  • Roswell Park Cancer Institute
  • Buck Institute for Age Research
  • University of Wisconsin
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2011-02-22
Volume
108
Issue
10
Pages
4135-4140
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1019581108
Cited by
320
References
8
Language
en
Status
Retracted
Update notices

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review