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Transcriptome-wide piRNA profiling in human brains of Alzheimer's disease
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Discovered in the brains of multiple animal species, piRNAs may contribute to the pathogenesis of neuropsychiatric illnesses. The present study aimed to identify brain piRNAs across transcriptome that are associated with Alzheimer's disease (AD). Prefrontal cortical tissues of 6 AD cases and 6 controls were examined for piRNA expression levels using an Arraystar HG19 piRNA array (containing 23,677 piRNAs) and genotyped for 17 genome-wide significant and replicated risk SNPs. We examined whether piRNAs are expressed differently between AD cases and controls and explored the potential regulatory effects of risk SNPs on piRNA expression levels. We identified a total of 9453 piRNAs in human brains, with 103 nominally (p < 0.05) differentially (>1.5 fold) expressed in AD cases versus controls and most of the 103 piRNAs nominally correlated with genome-wide significant risk SNPs. We conclude that piRNAs are abundant in human brains and may represent risk biomarkers of AD.
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“Since flamenco is known to encode a major piRNA cluster3,26, and piRNAs have recently been reported to be differentially expressed in the human Alzheimer’s disease brain27,28, we next determined if piRNAs are involved in dysfunctional transposable element control in the tauopathy brain.”
From Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies (2018) · cites this paper as [28]
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Metadata
- Authors
- Qiu, W., Guo, X., Lin, X., Yang, Q., Zhang, W., Zhang, Y., Zuo, L., Zhu, Y., Li, C.-S. R., Ma, C., & Luo, X.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai Mental Health Center (CN)
- Fujian Medical University (CN)
- Tianjin Anding Hospital (CN)
- Yale University (US)
- Corresponding author
- Ma, Chao
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 57
- Pages
- 170-177
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC5542056
- OpenAlex
- W2620580060
- Cited by
- 105
- References
- 58
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 11 · 2023: 14 · 2022: 14 · 2021: 14 · 2020: 10 · 2019: 12 · 2018: 7 · 2017: 1
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- China Human Brain Bank Consortium
- National Natural Science Foundation of China (81373150, 81271239, 81202371, 81201057, 81171091, 91632113)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- piRNA, Alzheimer's disease, prefrontal cortex, risk biomarkers, gene expression profiling
- MeSH terms
- Alzheimer Disease, Brain, Humans, Risk, Biomarkers, Gene Expression, Polymorphism, Single Nucleotide, RNA, Small Interfering, Microarray Analysis, Genome-Wide Association Study, Transcriptome
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