The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T
Open accessAbstract
Background Details of the internal hippocampal structure visible at 4 T allow for in vivo volumetry of subfields. The aims of this study were: 1. To determine if Apo e4 has subfield specific effects in controls. 2. To study the influence of Apo e4 on hippocampal subfields in AD.Methods 81 subjects (66 controls, mean age 60.8+/-13.6, range: 28-85 years), and 15 AD (mean age 67.5+/-9.3) were studied. Entorhinal cortex, subiculum, CA1, CA1-CA2 transition zone, CA3-4 and dentate gyrus (CA3&DG) and total hippocampal volume were determined using a manual marking strategy.Results Significant effects for Apo e4 on the CA3&DG were found in the total control population (p=0.042) and in older controls (61-85 years) (p=0.036) but not in younger (28-60 years) controls. Significant effects for Apo e4 (p=0.0035) on CA3&DG were also found in a subgroup of older subjects and AD subjects. AD with Apo e4 had smaller CA3&DG than AD without Apo e4 (p=0.027).Conclusions These findings suggest that Apo e4 exerts a regionally selective effect on CA3&DG in normal aging and AD.
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“all studies agree that the subiculum and the presubiculum show atrophic changes”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [34]
In the citing paper
“the CA1 subfield was found significantly atrophic in a study that used the same automated method as ours and included patients with similar dementia severity [33] and in studies that used a procedure involving manual segmentation of hippocampal subfields [34], [35] or based on 3D surface reconstruction and shape analysis of the hippocampi [36], [37]”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [34]
In the citing paper
“differ as to the pattern of the volume reduction in Ammon's horn subfields”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [34]
In the citing paper
“Conversely, the volume of the CA3 and CA4 subfields was found in the normal range in most of the studies that used manual segmentation [34], [35] and 3D surface reconstruction and shape analysis [36] but was invariably atrophic in studies based on automated segmentation procedures [31], [33].”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [34]
In the citing paper
“Previous neuroimaging studies obtained contrasting data regarding the pattern of hippocampal subfield atrophy in AD patients.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [34]
In the citing paper
“Indeed, there were differences in defining the CA1 and subiculum in previous studies.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [34]
In the citing paper
“as acknowledged by Mueller et al. [34], the border used in that study was chosen “because it could be easily and reliably identified although by doing so, parts of the presubiculum and subiculum proper were counted towards CA1” (p. 45).”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [34]
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“Based on histological studies (West et al., 1994), we expected to find a more pronounced volume loss in CA1 in AD with the Apo e4 allele than in AD without it.”
BackgroundInfluentialIncreased hippocampal neurogenesis in Alzheimer's disease
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1 of the 45 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
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Metadata
- Authors
- Mueller, S. G., Schuff, N., Raptentsetsang, S., Elman, J., & Weiner, M. W.
- Affiliations
- San Francisco VA Medical Center (US)
- Corresponding author
- Mueller, S.G.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 42
- Issue
- 1
- Pages
- 42-48
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC2597377
- OpenAlex
- W2124461703
- Cited by
- 116
- References
- 45
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 8 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 11 · 2013: 9 · 2012: 9
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute on Aging (R01AG010897, P01AG012435)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- APOE ε4, Alzheimer's disease, hippocampal subfields, CA3, dentate gyrus, normal aging, entorhinal cortex, subiculum, CA1, regional selectivity
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Female, Hippocampus, Humans, Image Enhancement, Magnetic Resonance Imaging, Male, Middle Aged, Dentate Gyrus, Genetic Predisposition to Disease, Apolipoprotein E4
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