Cited by 116Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMemory and Neural Mechanisms

The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.

Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T

Open access

Mueller, S.G., Schuff, N., Raptentsetsang, S., Elman, J., Weiner, M.W.·2008·NeuroImage

DOI 10.1016/j.neuroimage.2008.04.174PMC PMC2597377

Open this paper in CoChat — free account

Abstract

Background Details of the internal hippocampal structure visible at 4 T allow for in vivo volumetry of subfields. The aims of this study were: 1. To determine if Apo e4 has subfield specific effects in controls. 2. To study the influence of Apo e4 on hippocampal subfields in AD.Methods 81 subjects (66 controls, mean age 60.8+/-13.6, range: 28-85 years), and 15 AD (mean age 67.5+/-9.3) were studied. Entorhinal cortex, subiculum, CA1, CA1-CA2 transition zone, CA3-4 and dentate gyrus (CA3&DG) and total hippocampal volume were determined using a manual marking strategy.Results Significant effects for Apo e4 on the CA3&DG were found in the total control population (p=0.042) and in older controls (61-85 years) (p=0.036) but not in younger (28-60 years) controls. Significant effects for Apo e4 (p=0.0035) on CA3&DG were also found in a subgroup of older subjects and AD subjects. AD with Apo e4 had smaller CA3&DG than AD without Apo e4 (p=0.027).Conclusions These findings suggest that Apo e4 exerts a regionally selective effect on CA3&DG in normal aging and AD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuroimage.2008.04.174

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Whole Brain Segmentation
Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · cited 5×
“Based on histological studies (West et al., 1994), we expected to find a more pronounced volume loss in CA1 in AD with the Apo e4 allele than in AD without it.”
BackgroundInfluential
Increased hippocampal neurogenesis in Alzheimer's disease
Jin, K., Peel, A. L., Mao, X. O., Xie, L., Cottrell, B. A., Henshall, D. C., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2634794100 · Cited by 971
Adult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease
Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600549103 · Cited by 912
Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals.
Velakoulis, D., Wood, S., Wong, M., McGorry, P., Yung, A., Phillips, L., Smith, D., Brewer, W., Proffitt, T., Desmond, P., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.139 · Cited by 630
A computational theory of hippocampal function, and empirical tests of the theory
Rolls, E. T., & Kesner, R. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.04.005 · Cited by 608
Neuron Number in the Entorhinal Cortex and CA1 in Preclinical Alzheimer Disease
Price, J. L., Ko, A. I., Wade, M. J., Tsou, S. K., McKeel, D. W., & Morris, J. C. (2001) · Archives of Neurology · doi:10.1001/archneur.58.9.1395 · Cited by 596
The Human Hippocampus
Duvernoy, H. M., Cattin, F., & Risold, P. (2013) · Springer eBooks · doi:10.1007/978-3-642-33603-4 · Cited by 569

Show all 45 references

Research works printed but not linked: 1

Mattson, 1989, Intrinsic vulnerability of hippocampal pyramidal neurons, Prog. Clin. Res., 317, 333

Sorted by citations

Structural Brain Changes in Aging: Courses, Causes and Cognitive Consequences
Fjell, A. M., & Walhovd, K. B. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.3.187 · Cited by 1,158
High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment
Yassa, M. A., Stark, S. M., Bakker, A., Albert, M. S., Gallagher, M., & Stark, C. E. L. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.03.040 · Cited by 523
Structural imaging of hippocampal subfields in healthy aging and Alzheimer’s disease
de Florès, R., Joie, R. L., & Chételat, G. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.033 · Cited by 387
Magnetic Resonance Imaging of Hippocampal Subfields in Posttraumatic Stress Disorder
Wang, Z., Neylan, T. C., Mueller, S. G., Lenoci, M., Truran, D., Marmar, C. R., Weiner, M. W., & Schuff, N. W. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.205 · Cited by 307
Self-citation
Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields
Mueller, S. G., & Weiner, M. W. (2009) · Hippocampus · doi:10.1002/hipo.20614 · Cited by 248
Self-citation
Brain imaging of neurovascular dysfunction in Alzheimer’s disease
Montagne, A., Nation, D. A., Pa, J., Sweeney, M. D., Toga, A. W., & Zlokovic, B. V. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1570-0 · Cited by 239
Hippocampal Subfield Volumes: Age, Vascular Risk, and Correlation with Associative Memory
Shing, Y. L., Rodrigue, K. M., Kennedy, K. M., Fandakova, Y., Bodammer, N., Werkle‐Bergner, M., Lindenberger, U., & Raz, N. (2011) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2011.00002 · Cited by 200
Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI
Kerchner, G. A., Hess, C. P., Hammond-Rosenbluth, K. E., Xu, D., Rabinovici, G. D., Kelley, D. A. C., Vigneron, D. B., Nelson, S. J., & Miller, B. L. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f736a1 · Cited by 193
Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence
Joie, R. L., Fouquet, M., Mézenge, F., Landeau, B., Villain, N., Mevel, K., Pèlerin, A., Eustache, F., Desgranges, B., & Chételat, G. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.024 · Cited by 179
A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals?
Wisse, L. E. M., Daugherty, A. M., Olsen, R. K., Berron, D., Carr, V. A., Stark, C. E. L., Amaral, R. S. C., Amunts, K., Augustinack, J. C., Bender, A. R., et al. (2016) · Hippocampus · doi:10.1002/hipo.22671 · Cited by 159
Self-citation
Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease
Carlesimo, G. A., Piras, F., Orfei, M. D., Iorio, M., Caltagirone, C., & Spalletta, G. (2015) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2014.12.001 · Cited by 159
Which Memory System is Impaired First in Alzheimer's Disease?
Didic, M., Barbeau, E. J., Félician, O., Tramoni, E., Guedj, É., Poncet, M., & Ceccaldi, M. P. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110557 · Cited by 172
Episodic memory on the path to Alzheimer's disease
Gallagher, M., & Koh, M. T. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.021 · Cited by 168
Age differences in hippocampal subfield volumes from childhood to late adulthood
Daugherty, A. M., Bender, A. R., Raz, N., & Ofen, N. (2015) · Hippocampus · doi:10.1002/hipo.22517 · Cited by 149
Evidence for functional specialization of hippocampal subfields detected by MR subfield volumetry on high resolution images at 4T
Mueller, S. G., Chao, L. L., Berman, B. D., & Weiner, M. W. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.03.028 · Cited by 156
Self-citation
In vivo quantification of hippocampal subfields using 4.7 T fast spin echo imaging
Malykhin, N. V., Lebel, R. M., Coupland, N. J., Wilman, A. H., & Carter, R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.09.042 · Cited by 145
3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects
Apostolova, L. G., Hwang, K., Andrawis, J. P., Green, A. E., Babakchanian, S., Morra, J. H., Cummings, J. L., Toga, A. W., Trojanowski, J. Q., Shaw, L. M. J., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.003 · Cited by 144
Self-citation
Insomnia Severity Is Associated with a Decreased Volume of the CA3/Dentate Gyrus Hippocampal Subfield
Neylan, T. C., Mueller, S. G., Wang, Z., Metzler, T. J., Lenoci, M., Truran, D., Marmar, C. R., Weiner, M. W., & Schuff, N. W. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.035 · Cited by 131
Self-citation
Exercise, APOE genotype, and the evolution of the human lifespan
Raichlen, D. A., & Alexander, G. E. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.001 · Cited by 132
Hippocampal maturity promotes memory distinctiveness in childhood and adolescence
Keresztes, A., Bender, A. R., Bodammer, N., Lindenberger, U., Shing, Y. L., & Werkle‐Bergner, M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710654114 · Cited by 142
In vivo Analysis of Hippocampal Subfield Atrophy in Mild Cognitive Impairment via Semi-Automatic Segmentation of T2-Weighted MRI
Pluta, J., Yushkevich, P., Das, S., & Wolk, D. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-111931 · Cited by 107
11β-Hydroxysteroid Dehydrogenase Type 1 Expression Is Increased in the Aged Mouse Hippocampus and Parietal Cortex and Causes Memory Impairments
Holmes, M. C., Carter, R. N., Noble, J., Chitnis, S., Dutia, A., Paterson, J. M., Mullins, J. J., Seckl, J. R., & Yau, J. L. W. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0731-10.2010 · Cited by 103
Cardiac Disorders as Risk Factors for Alzheimer's Disease
Alves, T. C. T. F., Ferreira, L. K., Wajngarten, M., & Busatto, G. F. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091561 · Cited by 107
Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism
Donix, M., Burggren, A. C., Suthana, N., Siddarth, P., Ekstrom, A. D., Krupa, A. K., Jones, M., Rao, A., Martin‐Harris, L., Ercoli, L. M., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.009 · Cited by 96
Medial temporal lobe subregional morphometry using high resolution MRI in Alzheimer's disease
Wolk, D. A., Das, S. R., Mueller, S. G., Weiner, M. W., & Yushkevich, P. A. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.09.011 · Cited by 92
Self-citation
Subfield atrophy pattern in temporal lobe epilepsy with and without mesial sclerosis detected by high‐resolution MRI at 4 Tesla: Preliminary results
Mueller, S. G., Laxer, K. D., Barakos, J. A., Cheong, I., Garcia, P. A., & Weiner, M. W. (2009) · Epilepsia · doi:10.1111/j.1528-1167.2009.02010.x · Cited by 91
Self-citation
Prominent hippocampal CA3 gene expression profile in neurocognitive aging
Haberman, R. P., Colantuoni, C., Stocker, A. M., Schmidt, A. C., Pedersen, J. T., & Gallagher, M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.10.005 · Cited by 91
Differential vulnerability of hippocampal subfields and anteroposterior hippocampal subregions in healthy cognitive aging
Malykhin, N. V., Huang, Y., Hrybouski, S., & Olsen, F. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.001 · Cited by 88
APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory
Kerchner, G. A., Berdnik, D., Shen, J. C., Bernstein, J. D., Fenesy, M. C., Deutsch, G. K., Wyss-Coray, T., & Rutt, B. K. (2014) · Neurology · doi:10.1212/wnl.0000000000000154 · Cited by 86
Regional vulnerability of hippocampal subfields to aging measured by structural and diffusion MRI
Pereira, J. B., Valls‐Pedret, C., Ros, E., Palacios, E. M., Falcón, C., Bargalló, N., Bartrés‐Faz, D., Wahlund, L., Westman, E., & Junqué, C. (2013) · Hippocampus · doi:10.1002/hipo.22234 · Cited by 81
Imaging Brain Effects of APOE4 in Cognitively Normal Individuals Across the Lifespan
Fouquet, M., Besson, F. L., Gonneaud, J., Joie, R. L., & Chételat, G. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9263-8 · Cited by 89
Gray matter network associated with risk for Alzheimer's disease in young to middle-aged adults
Alexander, G. E., Bergfield, K. L., Chen, K., Reiman, E. M., Hanson, K. D., Lin, L., Bandy, D. J., Caselli, R. J., & Moeller, J. R. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.01.014 · Cited by 91
Presence of ApoE ε4 Allele Associated with Thinner Frontal Cortex in Middle Age
Fennema‐Notestine, C., Panizzon, M. S., Thompson, W., Chen, C., Eyler, L. T., Fischl, B. R., Franz, C. E., Grant, M. D., Jak, A. J., Jernigan, T. L., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0002 · Cited by 79
From perception to memory: Changes in memory systems across the lifespan
Ofen, N., & Shing, Y. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.006 · Cited by 79
Systematic comparison of different techniques to measure hippocampal subfield volumes in ADNI2
Mueller, S. G., Yushkevich, P. A., Das, S. R., Wang, L., Leemput, K. V., Iglesias, J. E., Alpert, K., Mezher, A. F., Ng, P., Paz, K., et al. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.12.036 · Cited by 73
Self-citation
Family History and APOE-4 Genetic Risk in Alzheimer’s Disease
Donix, M., Small, G. W., & Bookheimer, S. Y. (2012) · Neuropsychology Review · doi:10.1007/s11065-012-9193-2 · Cited by 78
Vascular Risk Moderates Associations between Hippocampal Subfield Volumes and Memory
Bender, A. R., Daugherty, A. M., & Raz, N. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00435 · Cited by 69
An Alzheimer’s Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults
Harrison, T. M., Mahmood, Z., Lau, E. P., Karacozoff, A. M., Burggren, A. C., Small, G. W., & Bookheimer, S. Y. (2016) · eNeuro · doi:10.1523/eneuro.0098-16.2016 · Cited by 67
Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Epigenetics
Kosik, K. S., Rapp, P. R., Raz, N., Small, S. A., Sweatt, J. D., & Tsai, L. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls110 · Cited by 67
Brain Plasticity and Genetic Factors
Pearson‐Fuhrhop, K. M., Kleim, J. A., & Cramer, S. C. (2009) · Topics in Stroke Rehabilitation · doi:10.1310/tsr1604-282 · Cited by 65
Relative effect of APOE ε4 on neuroimaging biomarker changes across the lifespan
Gonneaud, J., Arenaza‐Urquijo, E. M., Fouquet, M., Perrotin, A., Fradin, S., Sayette, V. D. L., Eustache, F., & Chételat, G. (2016) · Neurology · doi:10.1212/wnl.0000000000003234 · Cited by 65
Neurotoxic Saboteurs: Straws that Break the Hippo’s (Hippocampus) Back Drive Cognitive Impairment and Alzheimer’s Disease
Daulatzai, M. A. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9407-2 · Cited by 56
Genetic Influences on Neural Plasticity
Pearson‐Fuhrhop, K. M., & Cramer, S. C. (2010) · PM&R · doi:10.1016/j.pmrj.2010.09.011 · Cited by 59
Aberrant Hippocampal Subregion Networks Associated with the Classifications of aMCI Subjects: A Longitudinal Resting-State Study
Bai, F., Xie, C., Watson, D. R., Shi, Y., Yuan, Y., Wang, Y., Yue, C., Teng, Y., Wu, D., & Zhang, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029288 · Cited by 56
Effects of ApoE4 and maternal history of dementia on hippocampal atrophy
Andrawis, J. P., Hwang, K. S., Green, A. E., Kotlerman, J., Elashoff, D., Morra, J. H., Cummings, J. L., Toga, A. W., Thompson, P. M., & Apostolova, L. G. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.07.020 · Cited by 54
Five-Year Longitudinal Brain Volume Change in Healthy Elders at Genetic Risk for Alzheimer’s Disease
Reiter, K. E., Nielson, K. A., Durgerian, S., Woodard, J. L., Smith, J. C., Seidenberg, M., Kelly, D. A., & Rao, S. M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160504 · Cited by 52
APOE ε4 is associated with longer telomeres, and longer telomeres among ε4 carriers predicts worse episodic memory
Wikgren, M., Karlsson, T., Nilbrink, T., Nordfjäll, K., Hultdin, J., Sleegers, K., Broeckhoven, C. V., Nyberg, L. H., Roos, G., Nilsson, L., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.004 · Cited by 53
Differential associations of age with volume and microstructure of hippocampal subfields in healthy older adults
Wolf, D. G. F., Fischer, F. U., de Florès, R., Chételat, G., & Fellgiebel, A. (2015) · Human Brain Mapping · doi:10.1002/hbm.22880 · Cited by 45
Comparing Hippocampal Atrophy in Alzheimer’s Dementia and Dementia with Lewy Bodies
Chow, N., Aarsland, D., Honarpisheh, H., Beyer, M. K., Somme, J. H., Elashoff, D. A., Rongve, A., Tysnes, O., Thompson, P. M., & Apostolova, L. G. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000339727 · Cited by 50
Measuring longitudinal change in the hippocampal formation from in vivo high-resolution T2-weighted MRI
Das, S. R., Avants, B., Pluta, J. B., Wang, H., Suh, J. W., Weiner, M. W., Mueller, S. G., & Yushkevich, P. A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.098 · Cited by 47
Self-citation
Investigating brain connectivity heritability in a twin study using diffusion imaging data
Shen, K., Rose, S., Fripp, J., McMahon, K. L., de Zubicaray, G. I., Martin, N. G., Thompson, P. M., Wright, M. J., & Salvado, O. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.041 · Cited by 50
APOE-epsilon4 and aging of medial temporal lobe gray matter in healthy adults older than 50 years
Taylor, J. L., Scanlon, B. K., Farrell, M. E., Hernandez, B., Adamson, M. M., Ashford, J. W., Noda, A. M., Murphy, G. M., & Weiner, M. W. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.011 · Cited by 48
Self-citation
Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans
Chao, L. L., Kriger, S., Buckley, S. T., Ng, P., & Mueller, S. G. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.07.003 · Cited by 43
Self-citation
High Resolution Imaging of the Medial Temporal Lobe in Alzheimer's Disease and Dementia with Lewy Bodies
Firbank, M., Blamire, A. M., Teodorczuk, A., Teper, E. L., Burton, E. J., Mitra, D., & O'Brien, J. T. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100138 · Cited by 42
Role of Stress, Depression, and Aging in Cognitive Decline and Alzheimer’s Disease
Daulatzai, M. A. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_350 · Cited by 42
Impact of APOE-ɛ4 and family history of dementia on gray matter atrophy in cognitively healthy middle-aged adults
ten Kate, M., Sanz‐Arigita, E., Tijms, B. M., Wink, A. M., Clerigué, M., García‐Sebastián, M., Izagirre, A., Ecay‐Torres, M., Estanga, A., Villanúa, J., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.10.018 · Cited by 41
Changes in Search Path Complexity and Length During Learning of a Virtual Water Maze: Age Differences and Differential Associations with Hippocampal Subfield Volumes
Daugherty, A. M., Bender, A. R., Yuan, P., & Raz, N. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv061 · Cited by 37
Changes in the Hippocampal Volume and Shape in Early-Onset Mild Cognitive Impairment
Moon, S. W., Lee, B., & Choi, Y. C. (2018) · Psychiatry Investigation · doi:10.30773/pi.2018.02.12 · Cited by 35
Neuroimaging biomarkers for Alzheimer's disease in asymptomatic APOE4 carriers
Chételat, G., & Fouquet, M. (2013) · Revue Neurologique · doi:10.1016/j.neurol.2013.07.025 · Cited by 32
Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study
Dounavi, M., Newton, C., Jenkins, N. D., Mak, E., Low, A., Terrera, G. M., Williams, G. B., LAWLOR, B. A., Naçi, L., Malhotra, P., et al. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11061-7 · Cited by 31
Characterization of white matter degeneration in elderly subjects by magnetic resonance diffusion and FLAIR imaging correlation
Zhan, W., Zhang, Y., Mueller, S. G., Lorenzen, P., Hadjidemetriou, S., Schuff, N. W., & Weiner, M. W. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.02.004 · Cited by 30
Self-citation
Reduced hippocampal CA2, CA3, and dentate gyrus activity in asymptomatic people at genetic risk for Alzheimer's disease
Suthana, N., Krupa, A. K., Donix, M., Burggren, A. C., Ekstrom, A. D., Jones, M., Ercoli, L. M., Miller, K. J., Siddarth, P., Small, G. W., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.014 · Cited by 30
APOE genotype and verbal memory recovery during and after emergence from post-traumatic amnesia
Noé, E., Ferri, J., Colomer, C., Moliner, B., & Chirivella, J. (2010) · Brain Injury · doi:10.3109/02699051003724952 · Cited by 27
Heterogeneity of functional activation during memory encoding across hippocampal subfields in temporal lobe epilepsy
Das, S. R., Mechanic-Hamilton, D. J., Pluta, J. B., Korczykowski, M., Detre, J. A., & Yushkevich, P. A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.085 · Cited by 24
Subtle Gray Matter Changes in Temporo-Parietal Cortex Associated with Cardiovascular Risk Factors
Alves, T. C. T. F., Scazufca, M., Squarzoni, P., Duran, F., Tamashiro-Duran, J. H., Vallada, H., Andrei, A. M., Wajngarten, M., Menezes, P. R., & Busatto, G. F. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110827 · Cited by 23
Spatial pattern separation differences in older adult carriers and non-carriers for the apolipoprotein E epsilon 4 allele
Sheppard, D. P., Graves, L. V., Holden, H. M., Delano‐Wood, L., Bondi, M. W., & Gilbert, P. E. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.04.011 · Cited by 22
Prognostic value of CA4/DG volumetry with 3 T magnetic resonance imaging on postoperative outcome of epilepsy patients with dentate gyrus pathology
Meng, N., Liu, Y., Chen, S., Gao, W., Ge, H., Wang, Y., Wang, H., Long, Y., Shen, H., Shi, C., et al. (2014) · Epilepsy Research · doi:10.1016/j.eplepsyres.2014.06.005 · Cited by 20
Evidence of Hippocampal Structural Alterations in Gulf War Veterans With Predicted Exposure to the Khamisiyah Plume
Chao, L. L., Raymond, M. R., Leo, C. K., & Abadjian, L. R. (2017) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000001082 · Cited by 19
Episodic memory of APOE ε4 carriers is correlated with fractional anisotropy, but not cortical thickness, in the medial temporal lobe
Westlye, E. T., Hodneland, E., Haász, J., Espeseth, T., Lundervold, A., & Lundervold, A. J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.072 · Cited by 20
Age‐related differences in hippocampal subfield volumes across the human lifespan: A meta‐analysis
Homayouni, R., Canada, K. L., Saifullah, S., Foster, D. J., Thill, C., Raz, N., Daugherty, A. M., & Ofen, N. (2023) · Hippocampus · doi:10.1002/hipo.23582 · Cited by 22
The Hippocampal Subfield Volume Reduction and Plasma Biomarker Changes in Mild Cognitive Impairment and Alzheimer’s Disease
Cao, J., Tang, Y., Chen, S., Yu, S., Wan, K., Yin, W., Zhen, W., Zhao, W., Zhou, X., Zhu, X., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231114 · Cited by 17
Apolipoprotein E4 Affects Topographical Changes in Hippocampal and Cortical Atrophy in Alzheimer's Disease Dementia: A Five-Year Longitudinal Study
Kim, Y. J., Cho, H., Kim, Y. J., Ki, C., Chung, S. J., Ye, B. S., Kim, H. J., Kim, J., Kim, S. T., Lee, K. H., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141773 · Cited by 18
Cardiovascular Risk and Hippocampal Thickness in Alzheimer’s Disease
Donix, M., Scharf, M., Marschner, K., Werner, A., Sauer, C., Gerner, A., Nees, J. A., Meyer, S., Donix, K. L., von Kummer, R., et al. (2013) · International Journal of Alzheimer s Disease · doi:10.1155/2013/108021 · Cited by 15
Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia
McKeever, A., Paris, A., Cullen, J., Hayes, L., Ritchie, C., Ritchie, K., Waldman, A., Wells, K., Busza, A., Carrière, I., et al. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-200238 · Cited by 15
The number of cysteine residues per mole in apolipoprotein E affects systematically synchronous neural interactions in women’s healthy brains
Leuthold, A. C., Mahan, M. Y., Stanwyck, J. J., Georgopoulos, A., & Georgopoulos, A. P. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3464-x · Cited by 16
Brainwide functional networks associated with anatomically- and functionally-defined hippocampal subfields using ultrahigh-resolution fMRI
Chang, W., Langella, S., Tang, Y., Ahmad, S., Zhang, H., Yap, P., Giovanello, K. S., & Lin, W. (2021) · Scientific Reports · doi:10.1038/s41598-021-90364-7 · Cited by 19
Vascular Risk Factors of Hippocampal Subfield Volumes in Persons without Dementia: The Medea 7T Study
Blom, K., Koek, H. L., Zwartbol, M. H. T., Ghaznawi, R., Kuijf, H. J., Witkamp, T. D., Hendrikse, J., Biessels, G. J., Geerlings, M. I., & on behalf of the UCC-SMART Study Group (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200159 · Cited by 15
The Prevalence of Mild Cognitive Impairment in a Convenience Sample of 202 Gulf War Veterans
Chao, L. L. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17197158 · Cited by 16
Genetic Influences on Hippocampal Subfields
Vilor‐Tejedor, N., Evans, T. E., Adams, H. H. H., Gónzalez‐de‐Echávarri, J. M., Molinuevo, J. L., Guigó, R., Gispert, J. D., & Operto, G. (2021) · Neurology Genetics · doi:10.1212/nxg.0000000000000591 · Cited by 12
Structural Brain Changes in Early‐Onset Alzheimer's Disease Subjects Using the LONI Pipeline Environment
Moon, S. W., Dinov, I. D., Hobel, S., Zamanyan, A., Choi, Y. C., Shi, R., Thompson, P. M., Toga, A. W., & Initiative, A. D. N. (2015) · Journal of Neuroimaging · doi:10.1111/jon.12252 · Cited by 13
Piecing it together: atrophy profiles of hippocampal subfields relate to cognitive impairment along the Alzheimer’s disease spectrum
Christopher‐Hayes, N. J., Embury, C. M., Wiesman, A. I., May, P. E., Schantell, M. D., Johnson, C. M., Wolfson, S. L., Murman, D. L., & Wilson, T. W. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1212197 · Cited by 13
The Role of MRI Biomarkers and Their Interactions with Cognitive Status and APOE ε4 in Nondemented Elderly Subjects
Liang, X., Yin, Z., Liu, R., Zhao, H., Wu, S., Lu, J., Zhao, Q., Wei, Y., Yang, Q., Zhu, B., et al. (2018) · Neurodegenerative Diseases · doi:10.1159/000495754 · Cited by 12
Nonlinear interaction between APOE ε4 allele load and age in the hippocampal surface of cognitively intact individuals
Martí‐Juan, G., Sanromà, G., Cacciaglia, R., Falcón, C., Operto, G., Molinuevo, J. L., Ballester, M. Á. G., Gispert, J. D., Piella, G., Initiative, T. A. D. N., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25202 · Cited by 12
Neurogenetic effects on cognition in aging brains: a window of opportunity for intervention?
Reinvang, I. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00143 · Cited by 13
Respective influence of beta-amyloid and APOE ε4 genotype on medial temporal lobe subregions in cognitively unimpaired older adults
de Florès, R., Demeilliez-Servouin, S., Kuhn, E., Chauveau, L., Landeau, B., Delcroix, N., Gonneaud, J., Vivien, D., & Chételat, G. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106127 · Cited by 10
Reduced plasticity and mild cognitive impairment-like deficits after entorhinal lesions in hAPP/APOE4 mice
Bott, J.-B., Cosquer, B., Héraud, C., Zerbinatti, C., Kelche, C. R., Cassel, J., & Mathis, C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.018 · Cited by 10
Microstructural mapping of dentate gyrus pathology in Alzheimer’s disease: A 16.4 Tesla MRI study
Shih, N., Kurniawan, N. D., Cabeen, R. P., Korobkova, L., Wong, E., Chui, H. C., Clark, K. A., Miller, C. A., Hawes, D., Jones, K. T., et al. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103318 · Cited by 8
Magnetic resonance imaging study of hippocampus structural alterations in post-traumatic stress disorder: a brief review (translated version).
Wang, Z., & Xiao, Z. (2010) · PubMed · Cited by 7
Multimodal magnetic resonance imaging reveals distinct sensitivity of hippocampal subfields in asymptomatic stage of Alzheimer’s disease
Wu, J., Shahid, S. S., Lin, Q., Hone‐Blanchet, A., Smith, J. L., Risk, B. B., Bisht, A. S., Loring, D. W., Goldstein, F. C., Levey, A. I., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.901140 · Cited by 6
Apolipoprotein E ε4 Allele-Based Differences in Brain Volumes Are Largely Uniform Across Late Middle Aged and Older Hispanic/Latino- and Non-Hispanic/Latino Whites Without Dementia
Stickel, A. M., McKinnon, A. C., Matijevic, S., Grilli, M. D., Ruiz, J. M., & Ryan, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.627322 · Cited by 5
Hippocampal Subregions Volume and Texture for the Diagnosis of Mild Cognitive Impairment
Chu, T., Liu, Y., Gui, B., Zhang, Z., Zhang, G., Dong, F., Dong, J., & Lin, S. (2024) · Experimental Aging Research · doi:10.1080/0361073x.2024.2313940 · Cited by 4
The associations of the BDNF and APOE polymorphisms, hippocampal subfield volumes, and episodic memory performance across the lifespan
Malykhin, N. V., Travis, S. G., Fujiwara, E., Huang, Y., Camicioli, R. M., & Olsen, F. (2020) · Hippocampus · doi:10.1002/hipo.23217 · Cited by 4
The APOE gene and cognitive function in non-demented and Alzheimer's disease patients
Payton, A. (2009) · Reviews in Clinical Gerontology · doi:10.1017/s0959259809990268 · Cited by 3
Apolipoprotein ε4 modifies obesity-related atrophy in the hippocampal formation of cognitively healthy adults
Coad, B. M., Ghomroudi, P. A., Sims, R., Aggleton, J. P., Vann, S. D., & Metzler‐Baddeley, C. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.02.004 · Cited by 2
The Differential Effects of APOE ɛ4 on Cerebral Volumetric Structures in Different Lifespan in Community-Dwelling Populations
Tang, M., Su, N., Zhang, D., Dai, Y., Yao, M., Zhou, L., Cui, L., Zhang, S., Zhu, Y., & Ni, J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220834 · Cited by 2
Exposure to intermittent hypoxia impairs learning and memory ability in rats
Zhang, F., Tian, Z., Peng, S., Li, J., Yang, X., Mo, H., Tan, J., Yao, H., & Li, B. (2018) · Sleep and Biological Rhythms · doi:10.1007/s41105-018-0161-y · Cited by 2
T2 signal intensity and volume abnormalities of hippocampal subregions in patients with amnestic mild cognitive impairment by magnetic resonance imaging
Luo, Y., Cao, Z., Liu, Y., Wu, L., Shan, H., Liu, Y., Ma, T., Zhu, X., Zhou, D., Jiang, B., et al. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1083018 · Cited by 2
Effects of amyloid and APOE4 on medial temporal lobe subregions in cognitively unimpaired elderlyPreprint
de Florès, R., Demeilliez-Servouin, S., Kuhn, E., Chauveau, L., Landeau, B., Delcroix, N., Gonneaud, J., & Chételat, G. (2022) · medRxiv · doi:10.1101/2022.01.20.22269607 · Cited by 2
Decreased hippocampal neurite density in late-middle-aged adults following prenatal exposure to higher levels of maternal inflammation
Mohyee, R. A., Elliott, B. L., Pike, M. R., Smith, E., Kring, A. M., Olson, I. R., Breen, E. C., Cohn, B. A., Cirillo, P. M., Krigbaum, N. Y., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2420188122 · Cited by 1
Impact of apolipoprotein Ε4 (APOE ε4) on neuroimaging outcomes in cognitively healthy midlife adults: A systematic review
Davis, R., Wood, L., Wilkes, L., Chandler, H. L., Anderson, E. L., & Hiscox, L. V. (2026) · NeuroImage Clinical · doi:10.1016/j.nicl.2026.104035 · Cited by 1

Authors: Mueller, S. G., Schuff, N., Raptentsetsang, S., Elman, J., & Weiner, M. W.
Affiliations: San Francisco VA Medical Center (US)
Corresponding author: Mueller, S.G.
ORCID: Mueller, S.G.
Elman, J.
Weiner, M.W.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2008-08
Volume: 42
Issue: 1
Pages: 42-48
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2008.04.174
PMC: PMC2597377
OpenAlex: W2124461703
Cited by: 116
References: 45
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 8 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 11 · 2013: 9 · 2012: 9
FWCI: 7.79
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
National Institute on Aging (R01AG010897, P01AG012435)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: APOE ε4, Alzheimer's disease, hippocampal subfields, CA3, dentate gyrus, normal aging, entorhinal cortex, subiculum, CA1, regional selectivity
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Female, Hippocampus, Humans, Image Enhancement, Magnetic Resonance Imaging, Male, Middle Aged, Dentate Gyrus, Genetic Predisposition to Disease, Apolipoprotein E4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks