CoChat
Sign Up
Cited by 423Ultrasound Imaging and ElastographyAdvanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and Applications

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

The impact of aging and gender on brain viscoelasticity

Sack, Ingolf, Beierbach, Bernd, Wuerfel, Jens, Klatt, Dieter, Hamhaber, Uwe, Papazoglou, Sebastian, Martus, Peter, Braun, Jürgen·2009·NeuroImage
DOI 10.1016/j.neuroimage.2009.02.040
Open this paper in CoChat — free account

Abstract

Viscoelasticity is a sensitive measure of the microstructural constitution of soft biological tissue and is increasingly used as a diagnostic marker, e.g. in staging liver fibrosis or characterizing breast tumors. In this study, multifrequency magnetic resonance elastography was used to investigate the in vivo viscoelasticity of healthy human brain in 55 volunteers (23 females) ranging in age from 18 to 88 years. The application of four vibration frequencies in an acoustic range from 25 to 62.5 Hz revealed for the first time how physiological aging changes the global viscosity and elasticity of the brain. Using the rheological springpot model, viscosity and elasticity are combined in a parameter mu that describes the solid-fluid behavior of the tissue and a parameter alpha related to the tissue's microstructure. It is shown that the healthy adult brain undergoes steady parenchymal 'liquefaction' characterized by a continuous decline in mu of 0.8% per year (P<0.001), whereas alpha remains unchanged. Furthermore, significant sex differences were found with female brains being on average 9% more solid-like than their male counterparts rendering women more than a decade 'younger' than men with respect to brain mechanics (P=0.016). These results set the background for using cerebral multifrequency elastography in diagnosing subtle neurodegenerative processes not detectable by other diagnostic methods.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.neuroimage.2009.02.040

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 31 references

Research works printed but not linked: 2

  1. Klatt, 2008, Assessment of the solid–liquid behavior of the liver for the diagnosis of diffuse disease using magnetic resonance elastography, Röfo, 180, 1106
  2. Wuerfel, 2008, elastography reveals tissue degeneration in Multiple Sclerosis patients. In: Proceedings 16th Scientific Meeting, International Society for Magnetic Resonance in Medicine, Toronto, 1547

Cited by

Sorted by citations

See all 423

Related

Metadata

Authors
Sack, I., Beierbach, B., Wuerfel, J., Klatt, D., Hamhaber, U., Papazoglou, S., Martus, P., & Braun, J.
Affiliations
  • Charité – Universitätsmedizin Berlin (DE)
  • University of Lübeck (DE)
Corresponding author
Sack, Ingolf
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2009-07
Volume
46
Issue
3
Pages
652-657
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2009.02.040
OpenAlex
W2035928670
Cited by
423
References
31
Citations by year
2026: 19 · 2025: 22 · 2024: 26 · 2023: 26 · 2022: 29 · 2021: 30 · 2020: 27 · 2019: 26 · 2018: 25 · 2017: 30 · 2016: 23 · 2015: 20 · 2014: 17 · 2013: 25 · 2012: 28
FWCI
19.61
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
brain viscoelasticity, brain aging, sex differences, brain microstructure, brain tissue stiffness, neurodegeneration, healthy human brain
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Aging, Brain, Computer Simulation, Female, Hardness, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Models, Neurological, Sex Factors, Viscosity, Elasticity Imaging Techniques, Elastic Modulus, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review