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Caffeine dose effect on activation-induced BOLD and CBF responses
Open accessAbstract
Caffeine is a popular psychostimulant, typically found in beverages. While low to intermediate doses of caffeine are associated with positive feelings and increased mental performance and alertness, high doses induce negative feelings such as insomnia, anxiety and nervousness. We investigate if this nonlinear dose-response is present for caffeine's effects on functional activation. Twenty-seven healthy subjects were assigned randomly to four different groups: saline, 1 mg/kg, 2.5 mg/kg and 5 mg/kg doses of caffeine. Simultaneous ASL/BOLD timeseries were collected both before and after an intravenous infusion of saline or caffeine and the task-induced CBF and BOLD percent changes were compared. The maximum increase in BOLD response was associated with the intermediate caffeine dose of 2.5 mg/kg, which increased BOLD response by 32.2% and 32.5% in motor and visual areas respectively. The maximum increase in CBF response was associated with the highest caffeine dose of 5 mg/kg. This difference could be related to a different density of A(1) and A(2A) adenosine receptors in the brain.
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A linear dose relationship exists between reductions in CBF and caffeine following doses of 1, 2.5 and 5 mg/kg caffeine.
“A linear dose relationship has been observed between reductions in CBF and caffeine following doses of 1, 2.5 and 5 mg/kg caffeine (Chen and Parrish 2009a).”
From A Double-Blind, Placebo-Controlled Study Evaluating the Effects of Caffeine and L-Theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood (2015) · cites this paper as Chen and Parrish 2009a
The Results report that resting CBF fell by 22%, 25%, and 32% after 1, 2.5, and 5 mg/kg caffeine, respectively, and the Discussion calls these decreases dose-dependent. The paper describes a linear trend for task-induced CBF responses, but does not establish that the reductions in resting CBF have a linear dose relationship. (LLM, conf=0.84)
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Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624 · cited 4×
“One should also note that these measurements were based on self report from subjects, and that beverage contents of caffeine are highly variable: a cup of coffee could contain anywhere between 40–180 mg of caffeine, depending on brewing method and duration (Fredholm et al., 1999), therefore the caffeine usage measurem…”
InfluentialOn the Use of Caffeine as a Contrast Booster for BOLD fMRI Studies
Mulderink, T. A., Gitelman, D. R., Mesulam, M.-M., & Parrish, T. B. (2002) · NeuroImage · doi:10.1006/nimg.2001.0973 · Cited by 164
Self-citationDietary Caffeine Consumption Modulates fMRI Measures
Laurienti, P. J., Field, A. S., Burdette, J. H., Maldjian, J. A., Yen, Y.-F., & Moody, D. M. (2002) · NeuroImage · doi:10.1006/nimg.2002.1237 · Cited by 136
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Research works printed but not linked: 26
- Bauer, 2003, In vivo imaging of adenosine A1 receptors in the human brain with [18F]CPFPX and positron emission tomography, NeuroImage, 19, 1760, 10.1016/S1053-8119(03)00241-6 · DOI
- Behzadi, 2005, An arteriolar compliance model of the cerebral blood flow response to neural stimulus, NeuroImage, 25, 1100, 10.1016/j.neuroimage.2004.12.057 · DOI
- Bendlin, 2007, Caffeine attenuates practice effects in word stem completion as measured by fMRI BOLD signal, Hum. Brain Mapp., 28, 654, 10.1002/hbm.20295 · DOI
- Cameron, 1990, Caffeine and human cerebral blood flow: a positron emission tomography study, Life Sci., 47, 1141, 10.1016/0024-3205(90)90174-P · DOI
- Chen, 1999, A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice, J. Neurosci., 19, 9192, 10.1523/JNEUROSCI.19-21-09192.1999 · DOI
- Dager, 2000, Brain imaging and the effects of caffeine and nicotine, Ann. Med., 32, 592, 10.3109/07853890009002029 · DOI
- Dager, 1999, Human brain metabolic response to caffeine and the effects of tolerance, Am. J. Psychiatry, 156, 229, 10.1176/ajp.156.2.229 · DOI
- Daly, 1998, Caffeine—an atypical drug of dependence, Drug Alcohol Depend., 51, 199, 10.1016/S0376-8716(98)00077-5 · DOI
- Field, 2003, Dietary caffeine consumption and withdrawal: confounding variables in quantitative cerebral perfusion studies?, Radiology, 227, 129, 10.1148/radiol.2271012173 · DOI · Paper page
- Kaplan, 1993, Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding, J. Pharmacol. Exp. Ther., 266, 1563, 10.1016/S0022-3565(25)39453-X · DOI
- Kaplan, 1997, Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans, J. Clin. Pharmacol., 37, 693, 10.1002/j.1552-4604.1997.tb04356.x · DOI
- Koppelstaetter, 2008, Does caffeine modulate verbal working memory processes? An fMRI study, NeuroImage, 39, 492, 10.1016/j.neuroimage.2007.08.037 · DOI · Paper page
- Laurienti, 2003, Relationship between caffeine-induced changes in resting cerebral perfusion and blood oxygenation level-dependent signal, AJNR Am. J. Neuroradiol., 24, 1607
- Li, 2002, How can we make BOLD contrast bolder?, AJNR Am. J. Neuroradiol., 23, 507
- Liau, 2008, Caffeine reduces the activation extent and contrast-to-noise ratio of the functional cerebral blood flow response but not the BOLD response, NeuroImage, 42, 296, 10.1016/j.neuroimage.2008.04.177 · DOI
- Liu, 2004, Caffeine alters the temporal dynamics of the visual BOLD response, NeuroImage, 23, 1402, 10.1016/j.neuroimage.2004.07.061 · DOI
- Luh, 1999, QUIPSS II with thin-slice TI1 periodic saturation: a method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling, Magn. Reson. Med., 41, 1246, 10.1002/(SICI)1522-2594(199906)41:6<1246::AID-MRM22>3.0.CO;2-N · DOI
- Luh, 2000, Comparison of simultaneously measured perfusion and BOLD signal increases during brain activation with T(1)-based tissue identification, Magn. Reson. Med., 44, 137, 10.1002/1522-2594(200007)44:1<137::AID-MRM20>3.0.CO;2-R · DOI
- Mathew, 1985, Caffeine induced changes in cerebral circulation, Stroke, 16, 814, 10.1161/01.STR.16.5.814 · DOI · Paper page
- Morton, 2002, Systemic theophylline augments the blood oxygen level-dependent response to forepaw stimulation in rats, AJNR Am. J. Neuroradiol., 23, 588
- Nehlig, 2000, Dose–response study of caffeine effects on cerebral functional activity with a specific focus on dependence, Brain Res., 858, 71, 10.1016/S0006-8993(99)02480-4 · DOI
- Ongini, 1997, Adenosine A2A receptors and neuroprotection, Ann. N.Y. Acad. Sci., 825, 30, 10.1111/j.1749-6632.1997.tb48412.x · DOI
- Perthen, 2008, Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: a calibrated BOLD fMRI study, NeuroImage, 40, 237, 10.1016/j.neuroimage.2007.10.049 · DOI · Paper page
- Varani, 2000, Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors: functional and biochemical aspects, Circulation, 102, 285, 10.1161/01.CIR.102.3.285 · DOI
- Wang, 2005, To smooth or not to smooth? ROC analysis of perfusion fMRI data, Magn. Reson. Imaging, 23, 75, 10.1016/j.mri.2004.11.009 · DOI
- Wong, 1997, Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling, NMR Biomed., 10, 237, 10.1002/(SICI)1099-1492(199706/08)10:4/5<237::AID-NBM475>3.0.CO;2-X · DOI
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Perthen, J. E., Lansing, A. E., Liau, J., Liu, T. T., & Buxton, R. B. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.049 · Cited by 162
Dodd, F. L., Kennedy, D. O., Riby, L. M., & Haskell-Ramsay, C. F. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3895-0 · Cited by 102
“A linear dose relationship has been observed between reductions in CBF and caffeine following doses of 1, 2.5 and 5mg/kg caffeine (Chen and Parrish 2009a).”
BackgroundMethodResultInfluentialKennedy, D. O., & Haskell, C. F. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2010.12.010 · Cited by 73
Shourav, M. K., Salsabila, S., Lee, J.-Y., & Kim, J. K. (2021) · Biomedical Optics Express · doi:10.1364/boe.431534 · Cited by 10
Metadata
- Authors
- Chen, Y., & Parrish, T. B.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Parrish, Todd B.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 46
- Issue
- 3
- Pages
- 577-583
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC2694217
- OpenAlex
- W2015511270
- Cited by
- 103
- References
- 3
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 11 · 2012: 18
- FWCI
- 9.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R01EB002449)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- caffeine, dose-response relationship, BOLD signal, cerebral blood flow, adenosine A1 receptor, adenosine A2A receptor, psychostimulants, functional brain activation, motor cortex, visual cortex, arterial spin labeling
- MeSH terms
- Adult, Central Nervous System Stimulants, Blood Flow Velocity, Brain Mapping, Caffeine, Cerebrovascular Circulation, Dose-Response Relationship, Drug, Evoked Potentials, Female, Humans, Male, Oxygen Consumption, Diffusion Magnetic Resonance Imaging
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