Caffeine induced changes in cerebral circulation.
Abstract
While the caffeine induced cerebral vasoconstriction is well documented, the effects of oral ingestion of the drug in a dose range comparable to the quantities in which it is usually consumed and the intensity and duration of the associated reduction in cerebral circulation are unknown. Cerebral blood flow was measured via the 133Xenon inhalation technique before and thirty and ninety minutes after the oral administration of 250 mg of caffeine or a placebo, under double-blind conditions. Caffeine ingestion was found to be associated with significant reductions in cerebral perfusion thirty and ninety minutes later. The placebo group showed no differences between the three sets of cerebral blood flow values.
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Caffeine has been shown to decrease cerebral blood flow.
“Earlier, Mathew et al. demonstrated that cerebral blood flow decreases with caffeine ingestion [13,40].”
From Central and peripheral effects of sustained caffeine use: tolerance is incomplete (2002) · cites this paper as [13]
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- Authors
- Mathew, R. J., & Wilson, W. H.
- Venue
- Stroke
- Published
- 1985-09
- Volume
- 16
- Issue
- 5
- Pages
- 814-817
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2125972553
- Cited by
- 142
- References
- 35
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 8 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 1 · 2012: 3
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Keywords
- caffeine, cerebral blood flow, cerebral vasoconstriction, cerebral perfusion
- MeSH terms
- Administration, Oral, Adult, Analysis of Variance, Brain, Caffeine, Cerebrovascular Circulation, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Male, Radionuclide Imaging, Vasoconstriction, Xenon Radioisotopes
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