Selective effects of aging on brain white matter microstructure: a diffusion tensor imaging tractography study
Abstract
We examined age-related changes in the cerebral white matter. Structural magnetic resonance images (MRIs) and diffusion tensor images (DTIs) were acquired from 69 healthy subjects aged 22-84 years. Quantitative DTI tractography was performed for nine different white matter tracts to determine tract volume, fractional anisotropy (FA), mean diffusivity (MD), axial, and radial diffusivities. We used automated and manual segmentation to determine volumes of gray matter (GM), white mater (WM), cerebrospinal fluid (CSF), and intracranial space. The results showed significant effects of aging on WM, GM, CSF volumes, and selective effects of aging on structural integrity of different white matter tracts. WM of the prefrontal region was the most vulnerable to aging, while temporal lobe connections, cingulum, and parieto-occipital commissural connections showed relative preservation with age. This study was cross-sectional, and therefore, additional longitudinal studies are needed to confirm our findings.
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In participants aged 22-84 years, FA values of the corpus callosum declined with aging only in the genu part, not in the body and splenium parts.
“FA values of the corpus callosum declined with aging only in the genu part while not in the body and splenium parts in participants aged 22–84 years (Michielse et al., 2010).”
From Quantitative mapping of the brain’s structural connectivity using diffusion MRI tractography: A review (2022) · cites this paper as Michielse et al., 2010
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- Authors
- Michielse, S., Coupland, N., Camicioli, R., Carter, R., Seres, P., Sabino, J., & Malykhin, N.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Malykhin, Nikolai
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 52
- Issue
- 4
- Pages
- 1190-1201
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2154288487
- Cited by
- 144
- References
- 4
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 15 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 11 · 2013: 14 · 2012: 10
- FWCI
- 10.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- brain aging, white matter microstructure, white matter tracts, fractional anisotropy, mean diffusivity, axial and radial diffusivity, tract volume, prefrontal white matter, cingulum, corpus callosum, gray matter volume, cerebrospinal fluid volume, intracranial space
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Brain, Female, Humans, Male, Middle Aged, Nerve Fibers, Myelinated, Diffusion Tensor Imaging
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