The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controls
Open accessAbstract
Methylphenidate (MPH) is a stimulant drug that amplifies dopamineric and noradrenergic signaling in the brain, which is believed to underlie its cognition enhancing effects. However, the neurobiological effects by which MPH improves cognition are still poorly understood. Here, functional magnetic resonance imaging (fMRI) was used together with working memory (WM) and visual attention (VA) tasks to test the hypothesis that 20mg oral MPH would increase activation in the dorsal attention network (DAN) and deactivation in the default mode network (DMN) as well as improve performance during cognitive tasks in healthy men. The group of subjects that received MPH (MPH group; N=16) had higher activation than the group of subjects who received no medication (control group: N=16) in DAN regions (parietal and prefrontal cortex, regions increasingly activated with increased cognitive load) and had increased deactivation in the insula and posterior cingulate cortex (regions increasingly deactivated with increased cognitive load) and these effects did not differ for the VA and the WM tasks. These findings provide the first evidence that MPH enhances activation of the DAN whereas it alters DMN deactivation. This suggests that MPH (presumably by amplifying dopamine and noradrenergic signaling) modulates cognition in part through its effects on DAN and DMN.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Taken together, both stimulants and nonstimulants may act on brain frontoparietal circuity to ameliorate the dysfunction of cognitive control and attention in ADHD individuals (Cubillo et al., 2014; Fu et al., 2022; Tomasi et al., 2011)”
From Overlapping and differential neuropharmacological mechanisms of stimulants and nonstimulants for attention-deficit/hyperactivity disorder: A comparative neuroimaging analysis (2024) · cites this paper as Tomasi et al., 2011
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Using fMRI, it has been shown that MPH increases activation of the parietal and prefrontal cortices and increases deactivation of the insula and posterior cingulate cortex during visual attention and working memory tasks (180).”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
A three-dimensional statistical analysis for CBF activation studies in human brain
Worsley, K. J., Evans, A. C., Marrett, S., & Neelin, P. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.127 · Cited by 2,036
Tracking multiple independent targets: evidence for a parallel tracking mechanism.
Pylyshyn, Z., & Storm, R. (1988) · Spatial Vision · doi:10.1163/156856888x00122 · Cited by 2,021
The Role of Working Memory in Visual Selective Attention
de Fockert, J. W., Rees, G., Frith, C. D., & Lavie, N. (2001) · Science · doi:10.1126/science.1056496 · Cited by 924
McCabe, S. E., Knight, J. R., Teter, C. J., & Wechsler, H. (2004) · Addiction · doi:10.1111/j.1360-0443.2005.00944.x · Cited by 880
Neurocognitive enhancement: what can we do and what should we do?
Farah, M. J., Illes, J., Cook-Deegan, R. M., Gardner, H., Kandel, E. R., King, P., Parens, E., Sahakian, B. J., & Wolpe, P. R. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1390 · Cited by 653
Functional connectivity density mapping
Tomasi, D. G., & Volkow, N. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001414107 · Cited by 645
Self-citationBerridge, C. W., Devilbiss, D. M., Andrzejewski, M. E., Arnsten, A. F. T., Kelley, A. E., Schmeichel, B., Hamilton, C., & Spencer, R. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.022 · Cited by 617
Cited by
Sorted by citations
Items 101–145 of 145
Vance, D. E. (2013) · ISRN Nursing · doi:10.1155/2013/297173 · Cited by 8
Adam, L. C., Repantis, D., Konrad, B. N., Dresler, M., & Kühn, S. (2021) · Brain and Cognition · doi:10.1016/j.bandc.2021.105802 · Cited by 6
The Over-prescription of Ritalin for Suspected Cases of ADHD
Chan, J. Y. C., Dennis, T. A., & MacLeod, M. A. (2012) · Revue interdisciplinaire des sciences de la santé - Interdisciplinary Journal of Health Sciences · doi:10.18192/riss-ijhs.v2i2.1519 · Cited by 6
Hill, J., Korponay, C. H., Salmeron, B. J., Ross, T. J., & Janes, A. C. (2024) · Human Brain Mapping · doi:10.1002/hbm.70086 · Cited by 4
Temperament and probabilistic predictive coding in visual-spatial attention
Lasaponara, S., Scozia, G., Lozito, S., Pinto, M., Conversi, D., Costanzi, M., Vriens, T., Silvetti, M., & Doricchi, F. (2023) · Cortex · doi:10.1016/j.cortex.2023.10.004 · Cited by 6
Peattie, A. R. D., Manktelow, A. E., Sahakian, B. J., Menon, D. K., & Stamatakis, E. A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13030771 · Cited by 6
Koloski, M. F., Terry, A., Lee, N., & Ramanathan, D. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1385502 · Cited by 5
Moeller, S. J., Konova, A. B., Tomasi, D. G., Parvaz, M. A., & Goldstein, R. Z. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4307-9 · Cited by 6
Self-citationNeuroimaging of sleep disorders
Nofzinger, E. A., Maquet, P., & Thorpy, M. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139088268.025 · Cited by 5
Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation
Tomasi, D. G., Manza, P., Demiral, Ş. B., Yan, W., Miller, K. B., Veenker, F., Zhao, J., Lildharrie, C., Yonga, M.-V., Abey, S. K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67477-y · Cited by 4
Self-citationVidor, M. V., Vitola, E. S., Bandeira, C. E., Martins, A. R., Tavares, M. E., Cupertino, R. B., Panzenhagen, A. C., da Silva, B. S., Falkenberg, I. G., Barreto, P. O., et al. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01805-z · Cited by 4
Richards, T., Morandini, H. A. E., & Rao, P. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.06.004 · Cited by 4
Catecholaminergic Modulation of Semantic Processing in Sentence Comprehension
Tan, Y., & Peter Hagoort, A. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa204 · Cited by 4
The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
Klomp, A., Tremoleda, J. L., Schrantee, A., Gsell, W., & Reneman, L. (2012) · Journal of Visualized Experiments · doi:10.3791/3956-v · Cited by 4
Cognitive-Enhancing Substances and the Developing Brain: Risks and Benefits
Urban, K. R., & Gao, W. (2021) · Contemporary clinical neuroscience · doi:10.1007/978-3-030-54564-2_29 · Cited by 2
Effect of Methylphenidate on Learning in Normal Population
Na, K., & Lee, S. I. (2012) · Journal of korean Academy of Child and Adolescent Psychiatry · doi:10.5765/jkacap.2012.23.2.49 · Cited by 3
CONTRIBUTION OF CATECHOLAMINES TO VISUAL WORKING MEMORY IN THE MACAQUE MONKEY
Oemisch, M. (2012) · QSpace (Queen's University Library) · Cited by 3
Hodzhev, Y., Yordanova, J., Diruf, M., Kratz, O., Moll, G. H., Kolev, V., & Heinrich, H. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0799-6 · Cited by 3
Links between socioeconomic disadvantage, neural function, and working memory in early childhood
Li, X., Lipschutz, R. S., Montero-Hernandez, S. A., Biekman, B. D., Shen, S., Montgomery, D. A., Perlman, S. B., Pollonini, L., & Bick, J. R. (2021) · Developmental Psychobiology · doi:10.1002/dev.22181 · Cited by 2
Longitudinal regression of covariance matrix outcomes
Zhao, Y., Caffo, B. S., & Luo, X. (2022) · Biostatistics · doi:10.1093/biostatistics/kxac045 · Cited by 2
Spencer, R. C., Martin, A. J., Devilbiss, D. M., & Berridge, C. W. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01738-6 · Cited by 2
Cognitive Development Considerations for Long-term Safety Exposures in Children
Pipan, M. E., Wang, P. P., & Penna, R. T. (2013) · Wiley eBooks · doi:10.1002/9781118312087.ch30 · Cited by 2
Mazzetti, C., ter Huurne, N., Buitelaar, J. K., & Jensen, O. B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.13.990929 · Cited by 2
Multidimensional decision making
Mills‐Finnerty, C. (2015) · doi:10.7282/t3b27x9r · Cited by 1
¿Estamos estudiando y tratando correctamente la esquizofrenia?
Swerdlow, N. R. (2011) · Psiquiatría Biológica · doi:10.1016/j.psiq.2011.10.010 · Cited by 1
Viedma, C. R. (2012) · Aula de infantil · Cited by 1
The brain at play: neural substrates of social play behaviour in adolescent rats
van Kerkhof, L. W. M. (2013) · Utrecht University Repository (Utrecht University) · Cited by 1
Cognitive and electrophysiological responses to dopaminergic manipulations
Linssen, A. M. W. (2013) · Research Publications (Maastricht University) · doi:10.26481/dis.20130118al · Cited by 1
Developmental Disorders of Attention
Cohen, R. A. (2013) · Springer eBooks · doi:10.1007/978-0-387-72639-7_18 · Cited by 1
Biernacki, K., Zhai, T., Hill, J., McConnell, E., Salmeron, B. J., Kaiser, R. H., & Janes, A. C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.30.679567 · Cited by 1
나경세, & 이소영 (2012) · Journal of korean Academy of Child and Adolescent Psychiatry
Albein‐Urios, N. (2013) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Methylphenidate and Cognitive Performance
Yechiam, E., & Agay, N. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800634-4.00068-8
Disconnection, network dysfunction and cognitive impairment after traumatic brain injury
Bonnelle, V. (2012) · Spiral (Imperial College London) · doi:10.25560/9782
Thurston, L. T. (2016) · QSpace (Queen's University Library)
More Focus, Less Growth? Exploring the association between growth deficits and ADHD medication
Zaza, A., Abrego, K., Gabra, M., & Champsi, A. (2017) · uO Research (University of Ottawa) · doi:10.20381/ruor-21352
(2016) · Wiley eBooks · doi:10.1002/9781394259472.refs
Altered dynamic functional connectivity of insular subdivisions among male cigarette smokers
Xie, A., Sun, Y., Chen, H., Li, L., Liu, P., Liao, Y., & Li, Y. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1353103
Neurobiology of Attention Deficit Hyperactivity Disorder
Faraone, S. V., & Radonjić, N. V. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_33 · Cited by 2
EEG-based network dynamics in cannabis and polydrug use: a directed transfer function approach
Binkowska, A. A., Kaszyńska, A. A., Kamiński, M., Blinowska, K. J., Czarny, J., Raczkowski, M., & Brzezicka, A. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06933-5
Functional neuroimaging of alerting medication effects
THOMAS, R. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139088268.054
Biernacki, K., Zhai, T., Hill, J., McConnell, E., Salmeron, B. J., Kaiser, R. H., & Janes, A. C. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-025-02318-6
Integrative Review of the Effects of Nonprescriptive Methylphenidate Use
Maciel, R. D. N., Oliveira, R. G. D., Bortolatto, C. F., & Brüning, C. A. (2026) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000002129
Blunted modulation of hierarchical brain organization in opioid use disorderPreprint
Tomasi, D. G., Manza, P., Demiral, Ş. B., Giddens, N. T., Belcher, A. M., Yan, W., Miller, K., Veenker, F., Lildharrie, C., Yonga, M.-V., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9889932/v1
Self-citationLi, L., Bo, T., Lopez, E. M., Gonzalez, M. R., Fernández‐del‐Olmo, M., Gurevich, T., Desojo, L. V., & Fogelson, N. (2026) · Clinical Neurophysiology Practice · doi:10.1016/j.cnp.2026.09.001
Metadata
- Authors
- Tomasi, D., Volkow, N. D., Wang, G. J., Wang, R., Telang, F., Caparelli, E. C., Wong, C., Jayne, M., & Fowler, J. S.
- Affiliations
- National Institute on Alcohol Abuse and Alcoholism (US)
- Brookhaven National Laboratory (US)
- Corresponding author
- Tomasi, D.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 54
- Issue
- 4
- Pages
- 3101-3110
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3020254
- OpenAlex
- W2027473195
- Cited by
- 145
- References
- 51
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 17 · 2015: 5 · 2014: 11 · 2013: 26 · 2012: 19
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (2RO1AA09481)
- National Center for Research Resources (GCRC 5-MO1-RR-10710)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- methylphenidate, stimulants, cognitive enhancement, dorsal attention network, default mode network, brain deactivation, visual attention, working memory, cognitive load, parietal cortex, prefrontal cortex, insula, posterior cingulate cortex, dopamine, norepinephrine
- MeSH terms
- Adult, Central Nervous System Stimulants, Attention, Brain, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Methylphenidate, Photic Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
