Cited by 145Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

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Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controls

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Tomasi, D., Volkow, N.D., Wang, G.J., Wang, R., Telang, F., Caparelli, E.C., Wong, C., Jayne, M., Fowler, J.S.·2011·NeuroImage

DOI 10.1016/j.neuroimage.2010.10.060PMC PMC3020254

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Abstract

Methylphenidate (MPH) is a stimulant drug that amplifies dopamineric and noradrenergic signaling in the brain, which is believed to underlie its cognition enhancing effects. However, the neurobiological effects by which MPH improves cognition are still poorly understood. Here, functional magnetic resonance imaging (fMRI) was used together with working memory (WM) and visual attention (VA) tasks to test the hypothesis that 20mg oral MPH would increase activation in the dorsal attention network (DAN) and deactivation in the default mode network (DMN) as well as improve performance during cognitive tasks in healthy men. The group of subjects that received MPH (MPH group; N=16) had higher activation than the group of subjects who received no medication (control group: N=16) in DAN regions (parietal and prefrontal cortex, regions increasingly activated with increased cognitive load) and had increased deactivation in the insula and posterior cingulate cortex (regions increasingly deactivated with increased cognitive load) and these effects did not differ for the VA and the WM tasks. These findings provide the first evidence that MPH enhances activation of the DAN whereas it alters DMN deactivation. This suggests that MPH (presumably by amplifying dopamine and noradrenergic signaling) modulates cognition in part through its effects on DAN and DMN.

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“…given the massive presence in DAT and NET expression in the motor cortex, while also being associated with indirect and down-stream effects modulated by responses of the prefrontal cortex (Lewis et al., 2001; Peterson et al., 2009; Schulz et al., 2012; Seneca et al., 2006; Tomasi et al., 2011).”

Authors: Tomasi, D., Volkow, N. D., Wang, G. J., Wang, R., Telang, F., Caparelli, E. C., Wong, C., Jayne, M., & Fowler, J. S.
Affiliations: National Institute on Alcohol Abuse and Alcoholism (US)
Brookhaven National Laboratory (US)
Corresponding author: Tomasi, D.
ORCID: Tomasi, D.
Volkow, N.D.
Wang, G.J.
Caparelli, E.C.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2011-02
Volume: 54
Issue: 4
Pages: 3101-3110
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2010.10.060
PMC: PMC3020254
OpenAlex: W2027473195
Cited by: 145
References: 51
Citations by year: 2026: 4 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 17 · 2015: 5 · 2014: 11 · 2013: 26 · 2012: 19
FWCI: 11.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (2RO1AA09481)
National Center for Research Resources (GCRC 5-MO1-RR-10710)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: methylphenidate, stimulants, cognitive enhancement, dorsal attention network, default mode network, brain deactivation, visual attention, working memory, cognitive load, parietal cortex, prefrontal cortex, insula, posterior cingulate cortex, dopamine, norepinephrine
MeSH terms: Adult, Central Nervous System Stimulants, Attention, Brain, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Methylphenidate, Photic Stimulation

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Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controls

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