The DOI matches its Crossref record; 78 of the 80 references it cites were found in a registry or an index.
Grey matter alterations associated with cannabis use: Results of a VBM study in heavy cannabis users and healthy controls
Abstract
Cannabis abuse is related to impairments in a broad range of cognitive functions. However, studies on cannabis abuse in relation to brain structure are sparse and results are inconsistent, probably due to differences in imaging methodology, severity of cannabis abuse, and use of other substances. The goal of the current MRI study was to investigate brain morphology related to current and lifetime severity of cannabis use and dependence in heavy cannabis users without intensive use of other illicit drugs. Voxel-based morphometry was used to assess differences in regional grey and white matter volume between 33 heavy cannabis users and 42 matched controls. Within heavy cannabis users, grey and white matter volume was correlated with measures of cannabis use and dependence. Analyses were focused a priori on the orbitofrontal cortex, anterior cingulate cortex, striatum, amygdala, hippocampus, and cerebellum, regions implicated in substance dependence and/or with high cannabinoid receptor-1 concentrations. Regional grey matter volume in the anterior cerebellum was larger in heavy cannabis users. Within the group of heavy cannabis users, grey matter volume in the amygdala and hippocampus correlated negatively with the amount of cannabis use or dependence. No associations were found between white matter volume and measures of cannabis use or dependence. These findings indicate that associations between heavy cannabis use and altered brain structure are complex. Differential patterns of structural changes for various cannabis use levels imply that alterations in brain structure are associated with specific characteristics of cannabis use and dependence.
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“Studies examining the relationship between cannabis abuse and white matter microstructure have yielded conflicting results (Cousijn et al., 2012).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Cousijn et al., 2012
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139
SAUNDERS, J. B., AASLAND, O. G., BABOR, T. F., DE LA FUENTE, J. R., & GRANT, M. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb02093.x · Cited by 13,597 · cited 6×
“Drug and alcohol use was controlled by excluding participants with an Alcohol Use Disorder Identification Test (AUDIT) score higher than 10 (Saunders et al., 1993), smoking more than 20 cigarettes a day, a positive urine screen for alcohol, amphetamines, benzodiazepines, opioids or cocaine, or…”
BackgroundMethodInfluentialThe Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738
A fast diffeomorphic image registration algorithm
Ashburner, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.007 · Cited by 8,122
Ashburner, J., & Friston, K. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.018 · Cited by 7,507
The mini international neuropsychiatric interview
Lecrubier, Y., Sheehan, D. V., Hergueta, T., & Weiller, E. (1998) · European Psychiatry · doi:10.1016/s0924-9338(99)80239-9 · Cited by 5,899
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340
Tracking neuronal fiber pathways in the living human brain
Conturo, T. E., Lori, N. F., Cull, T. S., Akbudak, E., Snyder, A. Z., Shimony, J. S., McKinstry, R. C., Burton, H., & Raichle, M. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10422 · Cited by 1,774
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Lower-Risk Cannabis Use Guidelines: A Comprehensive Update of Evidence and Recommendations
Fischer, B., Russell, C., Sabioni, P., van den Brink, W., Foll, B. L., Hall, W., Rehm, J. T., & Room, R. (2017) · American Journal of Public Health · doi:10.2105/ajph.2017.303818 · Cited by 474
Batalla, A., Bhattacharyya, S., Yücel, M., Fusar‐Poli, P., Crippa, J. A. S., Nogué, S., Torrens, M., Pujol, J., Farré, M., & Martín‐Santos, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055821 · Cited by 437
“(2011) [146] found a larger anterior cerebellum in cannabis users.”
BackgroundInfluentialLong-Term Effects of Cannabis on Brain Structure
Battistella, G., Fornari, E., Annoni, J., Chtioui, H., Dao, K., Fabritius, M. M., Favrat, B., Mall, J., Maeder, P. P., & Giroud, C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.67 · Cited by 348
“In Cousijn et al (2012), volume reduction in the amygdala and the hippocampus does not differ significantly between regular cannabis users and controls but still correlates with the amount of cannabis used and the severity of cannabis dependence, respectively.”
BackgroundResultInfluentialEffect of long-term cannabis use on axonal fibre connectivity
Zalesky, A., Solowij, N., Yücel, M., Lubman, D. I., Takagi, M., Harding, I. H., Lorenzetti, V., Wang, R., Searle, K., Pantelis, C., et al. (2012) · Brain · doi:10.1093/brain/aws136 · Cited by 340
“, 2002) and have been shown to be associated with brain structural alterations in a range of studies (Matochik et al., 2005; Yücel et al., 2008; Cousijn et al., 2012).”
BackgroundGABAergic mechanisms of hippocampal hyperactivity in schizophrenia
Heckers, S., & Konradi, C. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.041 · Cited by 277
“In particular, the early and heavy use of cannabis alters hippocampal structure (Cousijn et al., 2012).”
Background
Metadata
- Authors
- Cousijn, J., Wiers, R. W., Ridderinkhof, K. R., van den Brink, W., Veltman, D. J., & Goudriaan, A. E.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- University of Amsterdam (NL)
- Corresponding author
- Cousijn, Janna
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 59
- Issue
- 4
- Pages
- 3845-3851
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2064378998
- Cited by
- 287
- References
- 80
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 10 · 2023: 30 · 2022: 12 · 2021: 22 · 2020: 27 · 2019: 27 · 2018: 18 · 2017: 23 · 2016: 19 · 2015: 29 · 2014: 23 · 2013: 18 · 2012: 8
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Netherlands Organisation for Scientific Research–Health Research and Development, ZON-Mw
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- cannabis use, cannabis use disorder, heavy cannabis users, gray matter volume, white matter volume, brain structure, orbitofrontal cortex, anterior cingulate cortex, striatum, amygdala, hippocampus, cerebellum, CB1 receptor, substance dependence, cognitive impairment
- MeSH terms
- Adolescent, Adult, Brain, Marijuana Abuse, Female, Humans, Magnetic Resonance Imaging, Male, Organ Size, Severity of Illness Index, Young Adult, Neuroimaging
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