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A robust multi-shot scan strategy for high-resolution diffusion weighted MRI enabled by multiplexed sensitivity-encoding (MUSE)

Open access
Chen, Nan-kuei, Guidon, Arnaud, Chang, Hing-Chiu, Song, Allen W.·2013·NeuroImage

Abstract

Diffusion weighted magnetic resonance imaging (DWI) data have been mostly acquired with single-shot echo-planar imaging (EPI) to minimize motion induced artifacts. The spatial resolution, however, is inherently limited in single-shot EPI, even when the parallel imaging (usually at an acceleration factor of 2) is incorporated. Multi-shot acquisition strategies could potentially achieve higher spatial resolution and fidelity, but they are generally susceptible to motion-induced phase errors among excitations that are exacerbated by diffusion sensitizing gradients, rendering the reconstructed images unusable. It has been shown that shot-to-shot phase variations may be corrected using navigator echoes, but at the cost of imaging throughput. To address these challenges, a novel and robust multi-shot DWI technique, termed multiplexed sensitivity-encoding (MUSE), is developed here to reliably and inherently correct nonlinear shot-to-shot phase variations without the use of navigator echoes. The performance of the MUSE technique is confirmed experimentally in healthy adult volunteers on 3 Tesla MRI systems. This newly developed technique should prove highly valuable for mapping brain structures and connectivities at high spatial resolution for neuroscience studies.

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Metadata

Authors
Chen, N.-K., Guidon, A., Chang, H.-C., & Song, A. W.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2013-05
Volume
72
Pages
41-47
ISSN
1053-8119 (ISSN-L)
OpenAlex
W1972866249
Cited by
364
References
26
FWCI
8.79
Type
journal article
Language
en
Open access
green

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Chen, N.-K., Guidon, A., Chang, H.-C., & Song, A. W. (2013). A robust multi-shot scan strategy for high-resolution diffusion weighted MRI enabled by multiplexed sensitivity-encoding (MUSE). NeuroImage. https://doi.org/10.1016/j.neuroimage.2013.01.038

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