Directional patterns of cross frequency phase and amplitude coupling within the resting state mimic patterns of fMRI functional connectivity
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Functional imaging investigations into the brain's resting state interactions have yielded a wealth of insight into the intrinsic and dynamic neural architecture supporting cognition and behavior. Electrophysiological studies however have highlighted the fact that synchrony across large-scale cortical systems is composed of spontaneous interactions occurring at timescales beyond the traditional resolution of fMRI, a feature that limits the capacity of fMRI to draw inference on the true directional relationship between network nodes. To approach the question of directionality in resting state signals, we recorded resting state functional MRI (rsfMRI) and electrocorticography (ECoG) from four human subjects undergoing invasive epilepsy monitoring. Using a seed-point based approach, we employed phase-amplitude coupling (PAC) and biPhase Locking Values (bPLV), two measures of cross-frequency coupling (CFC) to explore both outgoing and incoming connections between the seed and all non-seed, site electrodes. We observed robust PAC between a wide range of low-frequency phase and high frequency amplitude estimates. However, significant bPLV, a CFC measure of phase-phase synchrony, was only observed at specific narrow low and high frequency bandwidths. Furthermore, the spatial patterns of outgoing PAC connectivity were most closely associated with the rsfMRI connectivity maps. Our results support the hypothesis that PAC is relatively ubiquitous phenomenon serving as a mechanism for coordinating high-frequency amplitudes across distant neuronal assemblies even in absence of overt task structure. Additionally, we demonstrate that the spatial distribution of a seed-point rsfMRI sensorimotor network is strikingly similar to specific patterns of directional PAC. Specifically, the high frequency activities of distal patches of cortex owning membership in a rsfMRI sensorimotor network were most likely to be entrained to the phase of a low frequency rhythm engendered from the neural populations at the seed-point, suggestive of greater directional coupling from the seed out to the site electrodes.
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Electrophysiological infraslow fluctuations are believed to coordinate large-scale intrinsic connectivity network organization and long-range information exchange.
“and are believed to coordinate large-scale ICN organization and long-range information exchange [68, 83–91].”
From Infraslow closed-loop brain training for anxiety and depression (ISAD): a protocol for a randomized, double-blind, sham-controlled pilot trial in adult females with internalizing disorders (2022) · cites this paper as [89]
The Introduction links electrophysiological infraslow oscillations to intrinsic networks, and the Discussion describes low-frequency phase–amplitude coupling as a possible mechanism for long-distance resting-state interactions. But the coordinating oscillations studied here are chiefly in the 1–10 Hz range; the paper does not establish that infraslow electrophysiological fluctuations specifically coordinate network organization or long-range exchange. (LLM, conf=0.86)
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- Authors
- Weaver, K. E., Wander, J. D., Ko, A. L., Casimo, K., Grabowski, T. J., Ojemann, J. G., & Darvas, F.
- Affiliations
- University of Washington (US)
- Corresponding author
- Weaver, Kurt E.
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 128
- Pages
- 238-251
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC4762762
- OpenAlex
- W2218504993
- Cited by
- 44
- References
- 52
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 5
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- NeuroImage (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5KOI NS065186-035, T32 656052, NS065186, NS012542)
- National Science Foundation (EEC-1028725)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- cross-frequency coupling, phase-amplitude coupling, resting-state functional connectivity, directional coupling, electrocorticography, sensorimotor network, neural entrainment, epilepsy monitoring
- MeSH terms
- Drug Resistant Epilepsy, Electrocorticography, Adolescent, Adult, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Synaptic Transmission, Rest, Young Adult
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