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Cited by 298

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The behavioral and cognitive relevance of time-varying, dynamic changes in functional connectivity

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Cohen, Jessica R.·2018·NeuroImage
DOI 10.1016/j.neuroimage.2017.09.036
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Abstract

ABSTRACT Recent advances in neuroimaging methods and analysis have led to an expanding body of research that investigates how large‐scale brain network organization dynamically adapts to changes in one's environment, including both internal state changes and external stimulation. It is now possible to detect changes in functional connectivity that occur on the order of seconds, both during an unconstrained resting state and during the performance of constrained cognitive tasks. It is thought that these dynamic, time‐varying changes in functional connectivity, often referred to as dynamic functional connectivity (dFC), include features that are relevant to behavior and cognition. This review summarizes four aspects of the nascent literature directly testing that assumption: 1) how changes in functional network organization on the order of task blocks relate to differences in task demands and to cognitive ability; 2) how differences in dFC variability between different contexts relate to cognitive demands and behavioral performance; 3) how ongoing fluctuations in dFC impact perception and attention; and 4) how different patterns of dFC correspond to individual differences in cognition. The review ends by discussing promising directions for future research in this field. First, it comments on how dFC analyses can help to elucidate the mechanisms of healthy cognition. Next, it describes how dFC processes may be disrupted in disease, and how probing such dysfunction can increase understanding of neural etiology, as well as behavioral and cognitive impairments, observed in psychiatric and neurologic populations. Last, it considers the potential for computational models to uncover neuronal mechanisms of dFC, and how both healthy cognition and disease emerge from network dynamics. HighlightsA recent appreciation of dynamic functional connectivity (dFC) has emerged.This review probes recent examinations of the relationship between dFC and cognition.Promising directions include cognitive/clinical relevance and computational modeling.

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Cited by

Metadata

Authors
Cohen, J. R.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2018-10
Volume
180
Issue
Pt B
Pages
515-525
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2017.09.036
OpenAlex
W2759165456
Cited by
298
References
18
FWCI
9.02
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
National Institute of Mental Health (R00MH102349)

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