Cerebral amyloid angiopathy-related cognitive impairment: the search for a specific neuropsychological pattern
Abstract
Cerebral amyloid angiopathy is diagnosed in stroke units after lobar intracerebral hemorrhage. CAA can also be diagnosed in memory clinics when patients are referred for cognitive impairment assessment, and may be a reason for admission to emergency or neurology departments because of rapidly progressive cognitive or neurological decline, or a transient focal neurological episode. CAA may even be observed in older community-dwelling individuals. Neuropsychological impairment in CAA has been described over the past 20 years. The symptoms most commonly reported are perceptual speed, episodic memory, semantic memory, attention and executive function, and global cognitive impairments. Psychiatric symptoms, such as personality changes, behavioral disturbances and depression, have been more recently described. CAA is also a risk factor for the development of dementia, and its relationship with Alzheimer's disease has been demonstrated in post-mortem studies. Yet, despite the increase in literature on CAA-related cognitive and psychiatric symptoms, the specific characteristics of symptoms in CAA are difficult to assess because of the substantial prevalence of comorbidities such as small vessel disease due to high blood pressure, Lewy body disease and, of course, AD, all of which act as important confounding factors. Also, within the entity of CAA itself, the additive and perhaps synergistic effects of each lesion on cognition remain to be assessed. In the present paper, the focus is on the latest evidence of neuropsychological impairment observed in CAA patients, and the emergence of a possible specific neuropsychological profile due to CAA is also discussed.
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Neuropathological examination of patient brains harboring APP duplications shows abundant plaque and tangle pathology as well as cerebral amyloid angiopathy (CAA).
“Neuropathological examination of patient brains harboring APP duplications show abundant plaque and tangle pathology as well cerebral amyloid angiopathy (CAA)”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [248]
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- Authors
- Planton, M., Raposo, N., Albucher, J.-F., & Pariente, J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Pariente, J.
- Venue
- Revue Neurologique
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 173
- Issue
- 9
- Pages
- 562-565
- ISSN
- 0035-3787 (ISSN-L)
- OpenAlex
- W2761588143
- Cited by
- 26
- References
- 25
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Revue Neurologique (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- cerebral amyloid angiopathy, cognitive impairment, neuropsychological profile, episodic memory, semantic memory, executive function, attention, perceptual speed, dementia, Alzheimer's disease, psychiatric symptoms, personality change, behavioral problems, depression, cerebral small vessel disease, Lewy body disease, comorbidities
- MeSH terms
- Alzheimer Disease, Humans, Neuropsychology, Cerebral Amyloid Angiopathy, Cognitive Dysfunction
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