The DOI matches its Crossref record; 106 of the 107 references it cites were found in a registry or an index.
The Hippocampal-VTA Loop: Controlling the Entry of Information into Long-Term Memory
Open accessAbstract
In this article we develop the concept that the hippocampus and the midbrain dopaminergic neurons of the ventral tegmental area (VTA) form a functional loop. Activation of the loop begins when the hippocampus detects newly arrived information that is not already stored in its long-term memory. The resulting novelty signal is conveyed through the subiculum, accumbens, and ventral pallidum to the VTA where it contributes (along with salience and goal information) to the novelty-dependent firing of these cells. In the upward arm of the loop, dopamine (DA) is released within the hippocampus; this produces an enhancement of LTP and learning. These findings support a model whereby the hippocampal-VTA loop regulates the entry of information into long-term memory.
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In the citing paper
“The hippocampus and substantia nigra (a basal ganglia structure) are central to novelty detection and reward evaluation of novelty (Bunzeck and Düzel, 2006; Lisman and Grace, 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Lisman and Grace, 2005
In the citing paper
“Although functional connections from the hippocampus activate VTA neurons (57)”
From Neuroanatomic differences associated with stress susceptibility and resilience (2016) · cites this paper as [57]
In the citing paper
“DA and ACh neurotransmission play critical roles in the regulation of memory via the ventral tegmental area and MSDB projections to the PFC-hippocampus-associated circuits”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Lisman and Grace, 2005
In the citing paper
“Our results thus provide novel insights into the relationship between midbrain dopaminergic neurons, encoding salient information about an environment9,10,16,19,20, and hippocampal assemblies, providing representations of space1-3, in modulating memory according to the value of the information to be remembered.”
From Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence (2014) · cites this paper as [10]
In the citing paper
“However the contribution of dopamine towards hippocampal neuronal dynamics associated with memory persistence remains to be identified10.”
From Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence (2014) · cites this paper as [10]
In the citing paper
“In line with earlier reports these data highlight the structural substrate by which midbrain-derived dopamine could modulate hippocampal dynamics10,15.”
From Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence (2014) · cites this paper as [10]
In the citing paper
“This VTA firing response to spatial novelty, which might be partially informed by hippocampal spatio-contextual inputs10,16, resulted in a higher fraction of action potentials discharged in bursts (interspike interval<50ms; novelty-induced burst ratio change=0.31±0.07, t156=4.31, P=2.9×10−5, paired t-test), a potentially suitable signal to in turn modulate hippocampal dynamics.”
From Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence (2014) · cites this paper as [10]
In the citing paper
“Importantly, the dopamine release depends on systems-level processes that include motivation and stimulus novelty [8]”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [8]
Citations
Cites
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Squire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680
The molecular basis of CaMKII function in synaptic and behavioural memory
Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860
Self-citationRecognition memory: What are the roles of the perirhinal cortex and hippocampus?
Brown, M. W., & Aggleton, J. P. (2001) · Nature reviews. Neuroscience · doi:10.1038/35049064 · Cited by 1,624
Neuronal Coding of Prediction Errors
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Schultz, W. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044563 · Cited by 1,303
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
Hirsch, E., Graybiel, A. M., & Agid, Y. A. (1988) · Nature · doi:10.1038/334345a0 · Cited by 1,301 · cited 1×
“However, there is c much less degeneration of the VTA, at least until late r stages of the disease (Hirsch et al., 1988), which may i account for why memory-related problems are not a s major factor in the early stages of the disease.”
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons
Frey, U., Huang, Y.-Y., & Kandel, E. R. (1993) · Science · doi:10.1126/science.8389057 · Cited by 1,218
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106
Self-citationResponses of monkey dopamine neurons during learning of behavioral reactions
Ljungberg, T., Apicella, P., & Schultz, W. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.1.145 · Cited by 987
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1 of the 107 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Mogenson, 1993, From motivation to action: A review of dopaminergic regulation of limbic to nucleus accumbens to ventral pallidum to pedunculopontine nucleus circuitries involved in limbic-motor integration, 193
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Ventral striatum dopamine release encodes unique properties of visual stimuli in mice
Gonzalez, L. S., Fisher, A. A., D'Souza, S. P., Cotella, E. M., Lang, R. A., & Robinson, J. E. (2023) · eLife · doi:10.7554/elife.85064 · Cited by 18
Mikus, N., Lamm, C., & Mathys, C. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.08.021 · Cited by 16
Dopaminergic influence over hippocampal synaptic plasticity and function
I Broussard, J. (2012) · Clinical and Experimental Pharmacology · doi:10.4172/2161-1459.1000e108 · Cited by 15
A probabilistic successor representation for context-dependent learning
Geerts, J. P., Gershman, S. J., Burgess, N., & Stachenfeld, K. L. (2024) · Psychological Review · doi:10.1037/rev0000414 · Cited by 14
Baldassarre, G., Santucci, V. G., Cartoni, E., & Caligiore, D. (2017) · Behavioral and Brain Sciences · doi:10.1017/s0140525x17000036 · Cited by 11
Replay to remember: a boost from dopamine
Ewell, L. A., & Leutgeb, S. (2014) · Nature Neuroscience · doi:10.1038/nn.3875 · Cited by 9
Evidence and implications of abnormal predictive coding in dementia
Kocagoncu, E., Klimovich-Gray, A., Hughes, L. E., & Rowe, J. B. (2021) · Brain · doi:10.1093/brain/awab254 · Cited by 3
Metadata
- Authors
- Lisman, J. E., & Grace, A. A.
- Affiliations
- Brandeis University (US)
- University of Pittsburgh (US)
- Corresponding author
- Lisman, John E.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 46
- Issue
- 5
- Pages
- 703-713
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2121007598
- Cited by
- 1,983
- References
- 107
- Citations by year
- 2026: 105 · 2025: 97 · 2024: 139 · 2023: 97 · 2022: 99 · 2021: 115 · 2020: 122 · 2019: 92 · 2018: 97 · 2017: 93 · 2016: 97 · 2015: 120 · 2014: 103 · 2013: 103 · 2012: 96
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2968 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- W. M. Keck Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, ventral tegmental area, dopamine, long-term memory consolidation, novelty detection, subiculum, ventral pallidum, accumbens, long-term potentiation, learning, salience, dopaminergic neurons
- MeSH terms
- Animals, Hippocampus, Humans, Memory, Nerve Net, Time Factors, Ventral Tegmental Area
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