Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons

Frey, U.; Huang, Y.-Y.; Kandel, E. R.

doi:10.1126/science.8389057

Cited by 1,218Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurogenesis and neuroplasticity mechanisms

Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons

Frey, U., Huang, Y.-Y., Kandel, E. R.·1993·Science

DOI 10.1126/science.8389057

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Abstract

Hippocampal long-term potentiation (LTP) is thought to serve as an elementary mechanism for the establishment of certain forms of explicit memory in the mammalian brain. As is the case with behavioral memory, LTP in the CA1 region has stages: a short-term early potentiation lasting 1 to 3 hours, which is independent of protein synthesis, precedes a later, longer lasting stage (L-LTP), which requires protein synthesis. Inhibitors of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) blocked L-LTP, and analogs of cAMP induced a potentiation that blocked naturally induced L-LTP. The action of the cAMP analog was blocked by inhibitors of protein synthesis. Thus, activation of PKA may be a component of the mechanism that generates L-LTP.

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cAMP-mediated transcription is implicated in the late form of LTP in the Schaffer collateral, mossy fiber, and the medial perforant pathways.
“For example, cAMPmediated transcription is implicated in the late form of LTP in the Schaffer collateral, mossy fiber, and the medial perforant pathways (Frey et al., 1993;Impey et al., 1996;Abel et al., 1997).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Frey et al., 1993
Dopaminergic neurotransmission within the CA1 influences late phase LTP (L-LTP).
“Physiological evidence has indicated that dopaminergic neurotransmission within the CA1 influences late phase LTP (L-LTP)”
From Dopamine regulates aversive contextual learning and associated in vivo synaptic plasticity in the Hippocampus (2016) · cites this paper as Frey et al., 1993
L-LTP requires protein synthesis.
“a phenomenon that requires protein synthesis”
From Dopamine regulates aversive contextual learning and associated in vivo synaptic plasticity in the Hippocampus (2016) · cites this paper as Frey et al., 1993
L-LTP is thought to be a molecular mechanism underlying mnemonic consolidation in CA1 synapses.
“is thought to be a molecular mechanism underlying mnemonic consolidation in CA1 synapses”
From Dopamine regulates aversive contextual learning and associated in vivo synaptic plasticity in the Hippocampus (2016) · cites this paper as Frey et al., 1993
Late LTP is dependent on protein synthesis, whereas early LTP is not.
“LTP at these later times (termed late LTP) is dependent on protein synthesis, whereas the LTP at early times is not [13].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [13]

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Authors: Frey, U., Huang, Y.-Y., & Kandel, E. R.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Kandel, E. R.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1993-06-11
Volume: 260
Issue: 5114
Pages: 1661-1664
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.8389057
OpenAlex: W2051473177
Cited by: 1,218
References: 26
Citations by year: 2026: 6 · 2025: 13 · 2024: 24 · 2023: 10 · 2022: 14 · 2021: 31 · 2020: 20 · 2019: 28 · 2018: 29 · 2017: 29 · 2016: 24 · 2015: 40 · 2014: 37 · 2013: 43 · 2012: 47
FWCI: 19.01
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01gm032099-14)
National Institute of General Medical Sciences (GM 32099)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: long-term potentiation, CA1 pyramidal neurons, cyclic AMP, protein kinase A, protein synthesis, memory formation, cAMP analogs, PKA inhibitors
MeSH terms: Action Potentials, Cyclic AMP, Animals, Hippocampus, Male, Memory, Neurons, Protein Kinases, Time Factors, Second Messenger Systems, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Rats, In Vitro Techniques

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Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons

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