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Quantitative Mapping of a Digenic Behavioral Trait Implicates Globin Variation in C. elegans Sensory Behaviors
Open accessAbstract
Most heritable behavioral traits have a complex genetic basis, but few multigenic traits are understood at a molecular level. Here we show that the C. elegans strains N2 and CB4856 have opposite behavioral responses to simultaneous changes in environmental O2 and CO2. We identify two quantitative trait loci (QTL) that affect this trait, and map each QTL to a single-gene polymorphism. One gene, npr-1, encodes a previously described neuropeptide receptor whose high activity in N2 promotes CO2 avoidance. The second gene, glb-5, encodes a neuronal globin domain protein whose high activity in CB4856 modifies behavioral responses to O2 and combined O2/CO2 stimuli. glb-5 acts in O2–sensing neurons to increase O2-evoked calcium signals, implicating globins in sensory signaling. An analysis of wild C. elegans strains indicates that the N2 alleles of npr-1 and glb-5 arose recently in the same strain background, possibly as an adaptation to laboratory conditions.
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Cites
Yeast flocculation: what brewers should know
Verstrepen, K. J., Derdelinckx, G., Verachtert, H., & Delvaux, F. R. (2003) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-002-1200-8 · Cited by 345
Cited by
Rethinking the Emotional Brain
LeDoux, J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.004 · Cited by 1,594
“…innate behaviors related to survival functions such as defense, reproduction and arousal in invertebrates such as Drosophila (Wang et al., 2011; Lebestky et al., 2009; Dickson, 2008) and C. elegans (McGrath et al., 2009; Pirri and Alkema, 2012; Garrity et al., 2010; Bendesky et al. 2011).”
The natural history of Caenorhabditis elegans
Félix, M.-A., & Braendle, C. (2010) · Current Biology · doi:10.1016/j.cub.2010.09.050 · Cited by 458
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity
Andersen, E. C., Gerke, J. P., Shapiro, J. A., Crissman, J. R., Ghosh, R., Bloom, J. S., Félix, M.-A., & Kruglyak, L. (2012) · Nature Genetics · doi:10.1038/ng.1050 · Cited by 403
Self-citationA database of Caenorhabditis elegans behavioral phenotypes
Yemini, E., Jucikas, T., Grundy, L. J., Brown, A. E. X., & Schafer, W. R. (2013) · Nature Methods · doi:10.1038/nmeth.2560 · Cited by 310
CeNDR, the Caenorhabditis elegans natural diversity resource
Cook, D. E., Zdraljevic, S., Roberts, J. P., & Andersen, E. C. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw893 · Cited by 304
Metadata
- Authors
- McGrath, P. T., Rockman, M. V., Zimmer, M., Jang, H., Macosko, E. Z., Kruglyak, L., & Bargmann, C. I.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 61
- Issue
- 5
- Pages
- 692-699
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2157351849
- Cited by
- 241
- References
- 1
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- McGrath, P. T., Rockman, M. V., Zimmer, M., Jang, H., Macosko, E. Z., Kruglyak, L., & Bargmann, C. I. (2009). Quantitative Mapping of a Digenic Behavioral Trait Implicates Globin Variation in C. elegans Sensory Behaviors. Neuron. https://doi.org/10.1016/j.neuron.2009.02.012
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