The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity
Open accessAbstract
The nematode Caenorhabditis elegans is central to research in molecular, cell and developmental biology, but nearly all of this research has been conducted on a single strain of C. elegans. Little is known about the population genomic and evolutionary history of this species. We characterized C. elegans genetic variation using high-throughput selective sequencing of a worldwide collection of 200 wild strains and identified 41,188 SNPs. Notably, C. elegans genome variation is dominated by a set of commonly shared haplotypes on four of its six chromosomes, each spanning many megabases. Population genetic modeling showed that this pattern was generated by chromosome-scale selective sweeps that have reduced variation worldwide; at least one of these sweeps probably occurred in the last few hundred years. These sweeps, which we hypothesize to be a result of human activity, have drastically reshaped the global C. elegans population in the recent past.
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Cited by
Genomic signatures of selection at linked sites: unifying the disparity among species
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The Natural Biotic Environment of Caenorhabditis elegans
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Self-citationCaenorhabditis elegans responses to bacteria from its natural habitats
Samuel, B. S., Rowedder, H., Braendle, C., Félix, M.-A., & Ruvkun, G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607183113 · Cited by 409
Self-citationCeNDR, the Caenorhabditis elegans natural diversity resource
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Self-citationSpeciation and introgression between Mimulus nasutus and Mimulus guttatus
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Metadata
- Authors
- Andersen, E. C., Gerke, J. P., Shapiro, J. A., Crissman, J. R., Ghosh, R., Bloom, J. S., Félix, M.-A., & Kruglyak, L.
- Venue
- Nature Genetics
- Published
- 2012-01-29
- Volume
- 44
- Issue
- 3
- Pages
- 285-290
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2034742459
- Cited by
- 403
- References
- 40
- FWCI
- 21.08
- Type
- journal article
- Language
- en
- Open access
- green
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