DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212

Kim, Ju Young, Duan, Xin, Liu, Cindy Y., Jang, Mi-Hyeon, Guo, Junjie U., Pow-anpongkul, Nattapol, Kang, Eunchai, Song, Hongjun, Ming, Guo-li·2009·Neuron

DOI 10.1016/j.neuron.2009.08.008

Cited by (321)

Items 101–200 of 321

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Takashi Namba, Guo‐li Ming, Hongjun Song, Chikako Waga, Atsushi Enomoto, Kozo Kaibuchi, Shinichi Kohsaka, Shigeo Uchino · 2011 · Journal of Neurochemistry
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Nishantha Kumarasinghe, Natalie Jane Beveridge, Erin J. Gardiner, Rodney John Scott, Surangi G Yasawardene, Antoinette Perera, Jayan Mendis, Kanishka Suriyakumara, Ulrich Schall, Paul A. Tooney · 2013 · The International Journal of Neuropsychopharmacology
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Kathryn Waite, Britta Johanna Eickholt · 2010 · Current topics in microbiology and immunology
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Eunchai Kang, Danye Jiang, Yun Kyoung Ryu, Sanghee Lim, Minhye Kwak, Christy Gray, Michael Xu, Jun H. Choi, Sue Junn, Ji‐Eun Kim et al. · 2017 · PLoS Biology
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Margrith E. Mattmann, Sydney L. Stoops, Craig W. Lindsley · 2011 · Expert Opinion on Therapeutic Patents
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Qian Chen, Jeffrey H. Kogan, Adam K. Gross, Yuan Zhou, Noah M. Walton, Rick S. Shin, Carrie L Heusner, Shinichi Miyake, Katsunori Tajinda, Kouichi Tamura et al. · 2012 · European Journal of Neuroscience
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Wei Yung Ding, Jiawen Huang, Hongyan Wang · 2020 · PLoS Genetics
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Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development
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Role of Adult Hippocampal Neurogenesis in Cognition in Physiology and Disease: Pharmacological Targets and Biomarkers
Veronica Costa, Sebastian Lugert, Ravi Jagasia · 2015 · Handbook of experimental pharmacology
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Daniel Voskas, Ling Sunny Ling, James Robert Woodgett · 2010 · F1000 Biology Reports
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Mario O. Torres-Pérez, Ruth Ivonne Tellez-Ballesteros, Leonardo Ortíz‐López, Muhammad Ichwan, Nelly Maritza Vega‐Rivera, Mario Castro-García, Ariadna Gómez‐Sánchez, Gerd Kempermann, Gerardo Bernabé Ramírez-Rodríguez · 2015 · PLoS ONE
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Zhao, Qian, Li, Tao, Zhao, XinZhi, Huang, Ke, Wang, Ti, Li, ZhiQiang, Ji, Jue, Zeng, Zhen, Zhang, Zhao, Li, Kan et al. · 2013 · Schizophrenia Bulletin
DISC1 (Disrupted-in-Schizophrenia-1) Regulates Differentiation of Oligodendrocytes
Tsuyoshi Hattori, Shoko Shimizu, Yoshihisa Koyama, Hisayo Emoto, Yuji Matsumoto, Natsuko Kumamoto, Kohei Yamada, Hironori Takamura, Shinsuke Matsuzaki, Taiichi Katayama et al. · 2014 · PLoS ONE
Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity
Daisuke Tsuboi, Keisuke Kuroda, Motoki Tanaka, Takashi Namba, Yukihiko Iizuka, Shinichiro Taya, Tomoyasu Shinoda, Takao Hikita, Shinsuke Muraoka, Michiro Iizuka et al. · 2015 · Nature Neuroscience
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Areechun Sotthibundhu, Wilasinee Promjuntuek, Min Liu, Sanbing Shen, Parinya Noisa · 2018 · Cell and Tissue Research
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Aaron Topol, J A English, Erin K. Flaherty, Prashanth Rajarajan, Brigham J. Hartley, Sounak Gupta, Fiona A. Desland, Shijia Zhu, Troy Goff, L Friedman et al. · 2015 · Translational Psychiatry
Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: Impact of mouse models
Tatiana V. Lipina, John Roder · 2014 · Neuroscience & Biobehavioral Reviews
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Ci-Di Chen, Hu Li, Jennifer J. Liang, Kathryn M. Hixson, Ella Zeldich, Carmela R. Abraham · 2014 · Journal of Molecular Neuroscience
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Matteo Bergami, Benedikt Berninger · 2012 · Developmental Neurobiology
DISC1 regulates cell–cell adhesion, cell–matrix adhesion and neurite outgrowth
Tsuyoshi Hattori, Shoko Shimizu, Yoshihisa Koyama, K Yamada, Ryusuke Kuwahara, Natsuko Kumamoto, Shinsuke Matsuzaki, A Ito, Taiichi Katayama, M. Tohyama · 2010 · Molecular Psychiatry
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Sowmyalakshmí Rasika, Sandrine Passemard, Alain Verloès, Pierre Gressèns, Vincent El Ghouzzi · 2018 · Developmental Neuroscience
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Yue Li, Jian-Min Luo, Benson Wui-Man Lau, Guo‐qing Zheng, Shuping Fu, Tingting Wang, Heping Zeng, Kwok‐Fai So, Sookja Kim Chung, Yao Tong et al. · 2011 · PLoS ONE
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Hechen Bao, Juan Song · 2018 · Trends in Molecular Medicine
Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia
Eduard Bentea, Erica A. K. DePasquale, Sinead Marie O'Donovan, Courtney R. Sullivan, Micah S. Simmons, James H. Meador‐Woodruff, Ying Zhou, Chongchong Xu, Bing Bai, Junmin Peng et al. · 2019 · Molecular Omics
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Kei Ohara, Atsushi Enomoto, Takuya Kato, Takahiko Hashimoto, Mayu Isotani-Sakakibara, Naoya Asai, Maki Takagishi, Liang Weng, Masanori Nakayama, Takashi Watanabe et al. · 2012 · PLoS ONE
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Mikel Garcia‐Marcos, Patrick S. Kietrsunthorn, Yelena Pavlova, Michelle A. Adia, Pradipta Ghosh, Marilyn G. Farquhar · 2012 · Proceedings of the National Academy of Sciences
DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway
Rafael Flores, Yuki Hirota, Brian Armstrong, Akira Sawa, Toshifumi Tomoda · 2011 · Neuroscience Research
The rationale of targeting mammalian target of rapamycin for ischemic stroke
Zhao Zhong Chong, Qingqiang Yao, Hui‐Hua Li · 2013 · Cellular Signalling
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Mira Polajnar, Eva Žerovnik · 2014 · Journal of Cellular and Molecular Medicine
Brain Insulin-Like Growth Factor-I Directs the Transition from Stem Cells to Mature Neurons During Postnatal/Adult Hippocampal Neurogenesis
Vanesa Nieto‐Estévez, Carlos Omar Oueslati Morales, Lingling Li, James M. Pickel, Aixa V. Morales, Carlos Vicario‐Abejón · 2016 · Stem Cells
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Angelique Florentinus-Mefailoski, Peter Bowden, Philip Scheltens, Joep Killestein, Charlotte Elisabeth Teunissen, John G. Marshall · 2021 · Clinical Proteomics
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María del Rocío Pérez Baca, Eva Jacobs, Lies Vantomme, Pontus Leblanc, Elke Bogaert, Annelies Dheedene, Laurenz De Cock, Sadegheh Haghshenas, Aidin Foroutan, Michael A. Levy et al. · 2024 · The American Journal of Human Genetics
DISC1 knockdown impairs the tangential migration of cortical interneurons by affecting the actin cytoskeleton
André Steinecke, Christin Gampe, Falk Nitzsche, J. Bolz · 2014 · Frontiers in Cellular Neuroscience
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Ajay Kumar Gupta, Thomas G. Schulze, Vijayaraj Nagarajan, Nirmala Akula, Winston Corona, X-y Jiang, N Hunter, Francis J. McMahon, S D Detera-Wadleigh · 2011 · The Pharmacogenomics Journal
Disc1 regulates both β‐catenin‐mediated and noncanonical Wnt signaling during vertebrate embryogenesis
Gianluca De Rienzo, Joshua A. Bishop, Yingwei Mao, Luyuan Pan, Taylur P. Ma, Cecilia B. Moens, Li‐Huei Tsai, Hazel L. Sive · 2011 · The FASEB Journal
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Qian Zhang, Yonghua Zhao, Youhua Xu, Zhenwei Chen, Naiwei Liu, Chien‐Chih Ke, Bowen Liu, Wei-Kang Wu · 2016 · Journal of Translational Medicine
Antipsychotic Drugs Activate the C. elegans Akt Pathway via the DAF-2 Insulin/IGF-1 Receptor
Kathrine R. Weeks, Donard S. Dwyer, Eric J. Aamodt · 2010 · ACS Chemical Neuroscience
The tumor-suppressor gene LZTS1 suppresses colorectal cancer proliferation through inhibition of the AKT–mTOR signaling pathway
Wei Zhou, Mei-Rong He, Hong‐Li Jiao, Liuqing He, Danling Deng, Juanjuan Cai, Zhiyuan Xiao, Yaping Ye, Yanqing Ding, Wenting Liao et al. · 2015 · Cancer Letters
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Laura Stappert, Frederike Klaus, Oliver Brüstle · 2018 · Frontiers in Neuroscience
Neural stem and progenitor cells in health and disease
Ian Ladran, Ngoc Tran, Aaron Topol, Kristen Brennand · 2013 · WIREs Systems Biology and Medicine
Inducible and Conditional Deletion of Extracellular Signal-regulated Kinase 5 Disrupts Adult Hippocampal Neurogenesis
Yung-Wei Pan, Junhui Zou, Wenbin Wang, Hiroyuki Sakagami, Michael G. Garelick, Glen M. Abel, Chay T. Kuo, Daniel R. Storm, Zhengui Xia · 2012 · Journal of Biological Chemistry
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T. NAKAI, Taku Nagai, Rui Wang, Shinnosuke Yamada, Keisuke Kuroda, Kozo Kaibuchi, Kiyofumi Yamada · 2014 · Neurochemistry International
Dendrite Development Regulated by the Schizophrenia-Associated Gene FEZ1 Involves the Ubiquitin Proteasome System
Yasuhito Watanabe, Konstantin Khodosevich, Hannah Monyer · 2014 · Cell Reports
mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons
Agnieszka Skalecka, Ewa Liszewska, Robert Bilinski, Christos G. Gkogkas, Arkady Khoutorsky, Anna R. Malik, Nahum Sonenberg, Jacek Jaworski · 2016 · Developmental Neurobiology
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Seokheon Hong, Jee Hyun Yi, Soonje Lee, Chang‐Hwan Park, Jong Hoon Ryu, Ki Soon Shin, Shin Jung Kang · 2019 · Cell Death and Disease
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Candi L. LaSarge, Victor Rodrigues Santos, Steve C. Danzer · 2015 · Neurobiology of Disease
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Ken‐ichiro Kubo, Kenji Tomita, Asuka Uto, Keisuke Kuroda, Saurav Seshadri, Jared A. Cohen, Kozo Kaibuchi, Atsushi Kamiya, Kazunori Nakajima · 2010 · Biochemical and Biophysical Research Communications
Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits
Lin Cui, Wei Sun, M. Yu, Nan Li, Li Guo, Hua-Ting Gu, Yu Zhou · 2016 · Molecular Brain
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Qian Wu, Yi Li, Bo Xiao · 2013 · Gene
Hippocampus remodeling by chronic stress accompanied by GR, proteasome and caspase-3 overexpression
Maxim Orlovsky, Victor Dosenko, Francesca Spiga, G. G. Skibo, Stafford Louis Lightman · 2014 · Brain Research
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Mirna Kvajo, Heather McKellar, Joseph A. Gogos · 2011 · Neuroscience
Progress in defining the biological causes of schizophrenia
Ben S. Pickard · 2011 · Expert Reviews in Molecular Medicine
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F. Zheng, Li-Fang Wang, Mei-Xiang Jia, W. Yue, Y. Ruan, Tian-Lan Lu, Jing Liu, Jun Li, Dai Zhang · 2011 · Behavioral and Brain Functions
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M. Hayashi, J. Guerreiro, Erik I. Charych, A. Kamiya, R. L. Barbosa, Mauricio F. M. Machado, J. D. Campeiro, Vitor Oliveira, A. Sawa, A. C. Camargo et al. · 2010 · Molecular and cellular neurosciences
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S. Eastwood, M. Walker, T. Hyde, J. Kleinman, Paul J. Harrison · 2010 · Human Molecular Genetics
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Andrey S. Trulioff, Alexander S. Ermakov, Yegor B. Malashichev · 2017 · Genes
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Anthony Leyme, Arthur Marivin, Lorena Pérez, Lien T. Nguyen, Mikel Garcia‐Marcos · 2015 · The Journal of Cell Biology
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Sneha B. Rao, Gregory W. Kirschen, Joanna Szczurkowska, Adrian Di Antonio, Jia Wang, Shaoyu Ge, Maya Shelly · 2017 · Journal of Neuroscience
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Ruyan Wu, Hailou Zhang, Wenda Xue, Zhilu Zou, Lu Cai, Baomei Xia, Wei Wang, Gang Chen · 2016 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
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Jing Xu, Yong-lan Du, Jing-wei Xu, Xiaoge Hu, Lin-fan Gu, Xiumao Li, Ping-hong Hu, Tailin Liao, Qiang-qiang Xia, Qi Sun et al. · 2019 · Frontiers in Cellular Neuroscience
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Fiona Limanaqi, Carla Letizia Busceti, Roberta Celli, Francesca Biagioni, Francesco Fornai · 2021 · Progress in Neurobiology
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Guo‐li Ming, Oliver Brüstle, Alysson Renato Muotri, Lorenz Studer, Marius Wernig, Kimberly M. Christian · 2011 · Journal of Neuroscience
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Penelope J Boyd, Vincent T. Cunliffe, Sudipto Roy, Jonathan Wood · 2015 · Biology Open
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Leonardo Ortíz‐López, Nelly Maritza Vega‐Rivera, Harish Babu, Gerardo Bernabé Ramírez-Rodríguez · 2016 · Neurotoxicity Research
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Eunchai Kang, Juan Song, Yu-Ting Lin, Jaesuk Park, Jennifer H. Lee, Qassim Hussani, Yan Gu, Shaoyu Ge, Weidong Li, Kuei‐Sen Hsu et al. · 2019 · Cell Reports
PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus
Travis C. Jackson, Jonathan D. Verrier, Susan L. Semple‐Rowland, Ashok Kumar, Thomas C. Foster · 2010 · Journal of Neurochemistry
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Guozhu Ye, Yajie Chen, Hongou Wang, Ting Ye, Yi Lin, Qiansheng Huang, Yulang Chi, Sijun Dong · 2016 · Scientific Reports
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Mitch R. Paro, Arijit R. Chakraborty, Sophia J. Angelo, Shyam Nambiar, Ketan R. Bulsara, Rajkumar Verma · 2022 · Reviews in the Neurosciences
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Shukun Wang, Qingli Liang, Huimin Qiao, Hong Li, Tianjin Shen, Fen Ji, Jianwei Jiao · 2016 · Development
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Emanuela Santini, Eric Klann · 2011 · Frontiers in Behavioral Neuroscience
Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-α
José Luis Nieto-González, Leonardo Gómez‐Sánchez, Fabiola Mavillard, Pedro Linares‐Clemente, Maria Rivero, Marina Valenzuela-Villatoro, José Luis Muñoz‐Bravo, Ricardo Pardal, Rafael Fernández‐Chacón · 2019 · Proceedings of the National Academy of Sciences
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Shigeo Miyata, Ryota Kumagaya, Toshikazu Kakizaki, Kazuyuki Fujihara, Kaori Wakamatsu, Yuchio Yanagawa · 2019 · Frontiers in Behavioral Neuroscience
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Coralie Berthoux, Al Mahdy Hamieh, Angelina Rogliardo, Emilie L Doucet, Camille Coudert, Fabrice Ango, Katarzyna Grychowska, Séverine Chaumont‐Dubel, Paweł Zajdel, Rafael J. Maldonado et al. · 2020 · EMBO Molecular Medicine
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Gerardo Bernabé Ramírez-Rodríguez, Harish Babu, Friederike Klempin, Olga Krylyshkina, Veerle Baekelandt, Rik Gijsbers, Zeger Debyser, Rupert W. Overall, Zeina Nicola, Klaus Fabel et al. · 2013 · Journal of Neuroscience
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Dayu Sun, Junhua Chen, Xiaohang Bao, Yulong Cai, Jinghui Zhao, Jing Huang, Wei Y. Huang, Xiaotang Fan, Haiwei Xu · 2014 · Molecular Neurobiology
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R. Norkett, Flavie Lesept, J. Kittler · 2020 · Frontiers in Cell and Developmental Biology
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Jonathan J. Sabbagh, Andrew S. Murtishaw, Monica M. Bolton, Chelcie F. Heaney, Michael A. Langhardt, Jefferson W. Kinney · 2013 · Neuroscience Letters
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Peter L. Jernigan, Richard S. Hoehn, Heike Grassmé, Michael J. Edwards, Christian P. Müller, Johannes Kornhuber, Erich Gulbins · 2015 · Neurosignals
The role of selective transport in neuronal polarization
Takashi Namba, Shinichi Nakamuta, Yasuhiro Funahashi, Kozo Kaibuchi · 2011 · Developmental Neurobiology
Activity-dependent signaling mechanisms regulating adult hippocampal neural stem cells and their progeny
Andrew Crowther, Juan Song · 2014 · Neuroscience Bulletin
Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1
Saul Kivimäe, P-M Martin, David Kapfhamer, Youlin Ruan, Ulrike Heberlein, John L.R. Rubenstein, Benjamin N. R. Cheyette · 2011 · Translational Psychiatry
Regulation of the cytoskeleton by Disrupted-in-Schizophrenia 1 (DISC1)
Qi Wang, Nicholas J. Brandon · 2011 · Molecular and Cellular Neuroscience
Genomics of schizophrenia and pharmacogenomics of antipsychotic drugs
Ramón Cacabelos, Pablo Cacabelos, Gjumrakch Aliev · 2013 · Open Journal of Psychiatry
The neurobiology of schizophrenia: new leads and avenues for treatment
Nicholas J. Bray, F. Markus Leweke, Shitij Kapur, Andreas Meyer‐Lindenberg · 2010 · Current Opinion in Neurobiology
Prophylactic Valproic Acid Treatment Prevents Schizophrenia-Related Behaviour in Disc1-L100P Mutant Mice
Tatiana V. Lipina, Fahmida Nipa Haque, Alexander McGirr, Paul Christopher Boutros, Thorsten Berger, Tak W. Mak, John Roder, Albert H.C. Wong · 2012 · PLoS ONE
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Fengping Dong, Joseph Mao, Miranda K. Chen, Joy Yoon, Yingwei Mao · 2021 · Molecular Brain
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Qian Wu, Wei-Ting Tang, Zhao-Hui Luo, Yi Li, Yi Shu, Zongwei Yue, Bo Xiao, Li Feng · 2017 · Frontiers in Cellular Neuroscience
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