DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212

AKT/PKB signaling: navigating downstream

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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Mechanisms and Functional Implications of Adult Neurogenesis

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ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM

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Neuregulin 1 and Susceptibility to Schizophrenia

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Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

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Adult neurogenesis and functional plasticity in neuronal circuits

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For the Long Run

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GABA regulates synaptic integration of newly generated neurons in the adult brain

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Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

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DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders

Kamiya, A., Sedlak, T. W., & Pletnikov, M. V. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00025 · Cited by 24

Evidence that Doublecortin Is Dispensable for the Development of Adult Born Neurons in Mice

Merz, K., & Lie, D. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062693 · Cited by 23

DISC1-mediated dysregulation of adult hippocampal neurogenesis in rats

Lee, H., Kang, E., GoodSmith, D., Yoon, D. Y., Song, H., Knierim, J. J., Ming, G., & Christian, K. M. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00093 · Cited by 22

Glycogen synthase kinase-3: The missing link to aberrant circuit function in disorders of cognitive dysfunction?

Manduca, J. D., Thériault, R.-K., & Perreault, M. L. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104819 · Cited by 22

Venlafaxine increases cell proliferation and regulates DISC1, PDE4B and NMDA receptor 2B expression in the hippocampus in chronic mild stress mice

Zhang, X., Li, X., Li, M., Ren, J., Yun, K., An, Y., Lin, L., & Zhang, H. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.02.044 · Cited by 24

DISC1 Ser704Cys impacts thalamic-prefrontal connectivity

Liu, B., Fan, L., Cui, Y. J., Zhang, X., Hou, B., Li, Y., Qin, W., Wang, D., Yu, C., & Jiang, T. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0640-5 · Cited by 22

Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age

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Role of Ash1l in Tourette syndrome and other neurodevelopmental disorders

Zhang, C., Xu, L., Zheng, X., Liu, S., & Che, F. (2020) · Developmental Neurobiology · doi:10.1002/dneu.22795 · Cited by 23

Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice

Shevelkin, A. V., Terrillion, C. E., Abazyan, B. N., Kajstura, T. J., Jouroukhin, Y., Rudow, G. L., Troncoso, J. C., Linden, D. J., & Pletnikov, M. V. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.04.008 · Cited by 21

Translating preclinical findings in clinically relevant new antipsychotic targets: focus on the glutamatergic postsynaptic density. Implications for treatment resistant schizophrenia

de Bartolomeis, A., Avagliano, C., Vellucci, L., D’Ambrosio, L., Manchia, M., D’Urso, G., Buonaguro, E. F., & Iasevoli, F. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.019 · Cited by 19

Neuroglial Advances: New Roles for Established Players

Verkhratsky, A., Li, B., Niu, J., Lin, S.-S., Su, Y., Jin, W., Li, Y., Jiang, S., Yi, C., Shi, F., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70080 · Cited by 19

Adult Neural Stem Cell Regulation by Small Non-coding RNAs: Physiological Significance and Pathological Implications

Penning, A., Tosoni, G., Abiega, O., Bielefeld, P., Gasperini, C., Tonelli, D. D. P., Fitzsimons, C. P., & Salta, E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.781434 · Cited by 23

Imaging microstructure with diffusion and susceptibility MR: neuronal density correlation in Disrupted‐in‐Schizophrenia‐1 mutant mice

Gong, N., Dibb, R., Pletnikov, M. V., Benner, E. J., & Liu, C. (2020) · NMR in Biomedicine · doi:10.1002/nbm.4365 · Cited by 20

Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit

Jaaro-Peled, H., Kumar, S., Hughes, D. N., Sumitomo, A., Kim, S.-H., Zoubovsky, S. P., Hirota-Tsuyada, Y., Zala, D., Bruyère, J., Katz, B. M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01389-3 · Cited by 19

Adolescent Isolation Interacts With DISC1 Point Mutation to Impair Adult Social Memory and Synaptic Functions in the Hippocampus

Li, N., Cui, L., Song, G., Guo, L., Gu, H., Cao, H., Li, G.-D., & Zhou, Y. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00238 · Cited by 17

Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system

Randall, A. D., Kurihara, M., Brandon, N. J., & Brown, J. T. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12500 · Cited by 15

Abnormal Behaviors and Developmental Disorder of Hippocampus in Zinc Finger Protein 521 (ZFP521) Mutant Mice

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Linking adult hippocampal neurogenesis with human physiology and disease

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Neural Stem Cell Dysfunction in Human Brain Disorders

Liszewska, E., & Jaworski, J. (2018) · Results and problems in cell differentiation · doi:10.1007/978-3-319-93485-3_13 · Cited by 15

How DISC1 regulates postnatal brain development: girdin gets in on the AKT.

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The D2R-DISC1 protein complex and associated proteins are altered in schizophrenia and normalized with antipsychotic treatment

Wang, J.-J., Su, P., Yang, J., Xu, L.-H., Yuan, A.-H., Li, C.-B., Zhang, T.-H., Dong, F., Zhou, J.-J., Samsom, J. N., et al. (2022) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.210145 · Cited by 12

Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex

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Modelling disrupted-in-schizophrenia 1 loss of function in human neural progenitor cells: tools for molecular studies of human neurodevelopment and neuropsychiatric disorders

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Nigella sativa conserved hippocampal oxidative and neurogenic activities to salvage neuro-cognitive integrities in chlorpyrifos insult

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Neuronal Glypican4 promotes mossy fiber sprouting through the mTOR pathway after pilocarpine-induced status epilepticus in mice

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Interaction between DISC1 and CHL1 in regulation of neurite outgrowth

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An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration

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Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice

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Mammalian Target of Rapamycin-RhoA Signaling Impairments in Direct Striatal Projection Neurons Induce Altered Behaviors and Striatal Physiology in Mice

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Genomic analysis and selected molecular pathways in rare cancers

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IGF1-Stimulated Posttraumatic Hippocampal Remodeling Is Not Dependent on mTOR

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DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress

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DISC1 Protects Against Zika Virus Infection and Long-Term Neurological Damage Through AMPK-mTOR-Mediated Autophagy

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Co-Aggregation and Parallel Aggregation of Specific Proteins in Major Mental Illness

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Adult neural stem cells and schizophrenia

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Role of laminin-111 in neurotrophin-3 production of canine adipose-derived stem cells: Involvement of Akt, mTOR, and p70S6K

Park, S., Lee, Y. J., Han, H. J., & Kweon, O. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22686 · Cited by 9

Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus

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A recessive form of extreme macrocephaly and mild intellectual disability complements the spectrum of PTEN hamartoma tumour syndrome

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Ziprasidone triggers inflammasome signaling via PI3K-Akt-mTOR pathway to promote atrial fibrillation

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From Embryonic to Adult Neurogenesis in the Dentate Gyrus

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iTRAQ‐based proteomic analysis of the hippocampus of pentylenetetrazole‐kindled epileptic rats

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Pathological oligodendrocyte precursor cells revealed in human schizophrenic brains and trigger schizophrenia-like behaviors and synaptic defects in genetic animal modelPreprint

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Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons

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Susceptibility Genes for Schizophrenia: Mutant Models, Endophenotypes and Psychobiology

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The Immunoreactivity of PI3K/AKT Pathway After Prenatal Hypoxic Damage

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A computational biology approach to identify potential protein biomarkers and drug targets for sporadic amyotrophic lateral sclerosis

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The effect of deficient muscarinic signaling on commonly reported biochemical effects in schizophrenia and convergence with genetic susceptibility loci in explaining symptom dimensions of psychosis

Vakalopoulos, C. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00277 · Cited by 7

Switching DISC1 Function in Neurogenesis: Dixdc1 Selects DISC1 Binding Partners

Namba, T., & Kaibuchi, K. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.002 · Cited by 7

2009: Signaling Breakthroughs of the Year

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Application of reprogrammed patient cells to investigate the etiology of neurological and psychiatric disorders

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Translational control in neurovascular brain development

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Metabolic regulation of adult stem cell-derived neurons

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Lead Neurotoxicity on Human Neuroblastoma Cell Line SH-SY5Y is Mediated via Transcription Factor EGR1/Zif268 Induced Disrupted in Scherophernia-1 Activation

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Methylation pattern and mRNA expression of synapse-relevant genes in the MAM model of schizophrenia in the time-course of adolescence

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Insights into the mechanism of transcription factors in Pb2+-induced apoptosis

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Research Progress on Natural Compounds Exerting an Antidepressant Effect through Anti-inflammatory

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G protein-coupled estrogen receptor 1 deficiency impairs adult hippocampal neurogenesis in mice with schizophrenia

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Neurogenic hypothesis and psychiatric disorders

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mTOR, Autophagy, Aminoacidopathies, and Human Genetic Disorders

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Effect of physical activity on structural asymmetry of mouse hippocampus

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Duplication 2p16 is associated with perisylvian polymicrogyria

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Autism spectrum disorders

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PTEN Expression Regulates Gap Junction Connectivity in the Retina

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Integrative Roles of Dopamine Pathway and Calcium Channels Reveal a Link between Schizophrenia and Opioid Use Disorder

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Impaired Neurogenesis as a Risk Factor for Schizophrenia and Related Mental Diseases

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Early Postnatal Exposure to Midazolam Causes Lasting Histological and Neurobehavioral Deficits via Activation of the mTOR Pathway

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CRMP4 is required for the positioning and maturation of newly generated neurons in adult mouse hippocampus

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Quantification of a Neurological Protein in a Single Cell Without Amplification

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Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression

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Novel Targets for Drug Treatment in Psychiatry

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SRSF10 regulates migration of neural progenitor cells and granule cells and affects the formation of dentate gyrus during the development of mouse hippocampus

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Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signaling

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Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models

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Dual phosphorylation of DISC1 at Ser58 and Ser713 regulates polarization of cortical neurons via GSK3β

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Elevated calneuron-1, an accessory subunit of muscarinic receptors, induces frontotemporal dysconnectivity and schizophrenia-like deficits

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Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

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The New York Stem Cell Foundation: Fifth Annual Translational Stem Cell Research Conference

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Mechanisms for the differentiation of postnatal and adult neural stem cells: new insights and pathological issues based on the analysis of Girdin

Enomoto, A., Asai, N., & Takahashi, M. (2014) · Folia Pharmacologica Japonica · doi:10.1254/fpj.143.289 · Cited by 1

Modeling Gene–Gene Interactions in Schizophrenia

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Medicine

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