The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Dual Palmitoylation of NR2 Subunits Regulates NMDA Receptor Trafficking
Open accessAbstract
Modification of NMDA receptor function and trafficking contributes to the regulation of synaptic transmission and is important for several forms of synaptic plasticity. Here, we report that NMDA receptor subunits NR2A and NR2B have two distinct clusters of palmitoylation sites in their C-terminal region. Palmitoylation within the first cluster on a membrane proximal region increases tyrosine phosphorylation of tyrosine-based internalization motifs by Src family protein tyrosine kinases, leading to enhanced stable surface expression of NMDA receptors. In addition, palmitoylation of these sites regulates constitutive internalization of the NMDA receptor in developing neurons. In marked contrast, palmitoylation of the second cluster in the middle of C-terminus by distinct palmitoyl transferases causes receptors to accumulate in the Golgi apparatus and reduces receptor surface expression. These data suggest that regulated palmitoylation of NR2 subunits differentially modulate receptor trafficking and may be important for NMDA receptor dependent synaptic plasticity.
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The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
Lau, C. G., & Zukin, R. S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2153 · Cited by 1,159
Receptor trafficking and synaptic plasticity
Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046
The cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978
Self-citationPatterned Activity, Synaptic Convergence, and the NMDA Receptor in Developing Visual Pathways
Constantine-Paton, M., Cline, H. T., & Debski, E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.001021 · Cited by 784
Regulatory mechanisms of AMPA receptors in synaptic plasticity
Derkach, V. A., Oh, M. C., Guire, E. S., & Soderling, T. R. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2055 · Cited by 708
Molecular determinants of NMDA receptor internalization
Roche, K. W., Standley, S., McCallum, J., Dune Ly, C., Ehlers, M. D., & Wenthold, R. J. (2001) · Nature Neuroscience · doi:10.1038/90498 · Cited by 550
An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing
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Cited by
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
AMPARs and Synaptic Plasticity: The Last 25 Years
Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968
Self-citationGao, R., & Penzes, P. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303003028 · Cited by 516
Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders
Parsons, M. P., & Raymond, L. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.030 · Cited by 553
The intracellular dynamic of protein palmitoylation
Salaun, C., Greaves, J., & Chamberlain, L. H. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201008160 · Cited by 355
Metadata
- Authors
- Hayashi, T., Thomas, G. M., & Huganir, R. L.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 64
- Issue
- 2
- Pages
- 213-226
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2001679254
- Cited by
- 219
- References
- 12
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hayashi, T., Thomas, G. M., & Huganir, R. L. (2009). Dual Palmitoylation of NR2 Subunits Regulates NMDA Receptor Trafficking. Neuron. https://doi.org/10.1016/j.neuron.2009.08.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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