The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The Neurology of the Immune System: Neural Reflexes Regulate Immunity
Open accessAbstract
Parallel advances in neuroscience and immunology established the anatomical and cellular basis for bidirectional interactions between the nervous and immune systems. Like other physiological systems, the immune system—and the development of immunity—is modulated by neural reflexes. A prototypical example is the inflammatory reflex, comprised of an afferent arm that senses inflammation and an efferent arm, the cholinergic anti-inflammatory pathway, that inhibits innate immune responses. This mechanism is dependent on the α7 subunit of the nicotinic acetylcholine receptor, which inhibits NF-κB nuclear translocation and suppresses cytokine release by monocytes and macrophages. Here we summarize evidence showing that innate immunity is reflexive. Future advances will come from applying an integrative physiology approach that utilizes methods adapted from neuroscience and immunology.
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Cites
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228
Self-citationPhysiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563 · cited 1×
“This is the basis for the ‘‘cytokine theory of disease,’’ the paradigm that cytokines are necessary and sufficient for disease pathogenesis (Tracey, 2007).”
BackgroundSelf-citationCholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170
Self-citationTracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154 · cited 1×
“The answer stems from studies addressing the role of neural networks, which revealed that signals originating in the brain, and conveyed as action potentials transmitted in the vagus nerve, regulate cytokine production by the innate immune system (Tracey, 2009).”
BackgroundSelf-citationde Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., van Westerloo, D. J., Bennink, R. J., Berthoud, H.-R., Uematsu, S., Akira, S., van den Wijngaard, R. M., et al. (2005) · Nature Immunology · doi:10.1038/ni1229 · Cited by 1,074
Huston, J. M., Ochani, M., Rosas-Ballina, M., Liao, H., Ochani, K., Pavlov, V. A., Gallowitsch-Puerta, M., Ashok, M., Czura, C. J., Foxwell, B., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052362 · Cited by 683 · cited 1×
“Experiments addressing the anatomical basis of the cholinergic anti-inflammatory pathway indicated that the spleen is the target organ of the vagus nerve for controlling TNF production (Huston et al., 2006).”
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Self-citationThe Vagus Nerve and Nicotinic Receptors Modulate Experimental Pancreatitis Severity in Mice
van Westerloo, D. J., Giebelen, I. A., Florquin, S., Bruno, M. J., LaRosa, G. J., Ulloa, L., Tracey, K. J., & van der Poll, T. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.02.022 · Cited by 377
Self-citationGuarini, S., Altavilla, D., Cainazzo, M.-M., Giuliani, D., Bigiani, A., Marini, H., Squadrito, G., Minutoli, L., Bertolini, A., Marini, R., et al. (2003) · Circulation · doi:10.1161/01.cir.0000050627.90734.ed · Cited by 315 · cited 1×
“…and improving survival in experimental models of sepsis (Borovikova et al., 2000; Pavlov et al., 2007; Wang et al., 2004), hemorrhagic shock (Guarini et al., 2003), pancreatitis (van West- 28 Neuron 64, October 15, 2009 ª2009 Elsevier Inc. erloo et al., 2006), postoperative ileus (The et…”
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Iadecola, C., Buckwalter, M. S., & Anrather, J. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135530 · Cited by 853
Browning, K. N., & Travagli, R. A. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130055 · Cited by 541
Hypothalamic inflammation in obesity and metabolic disease
Jais, A., & Brüning, J. C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88878 · Cited by 474
Autonomic Nervous System and Immune System Interactions
Kenney, M. J., & Ganta, C. K. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130051 · Cited by 381
Mikita, J., Dubourdieu-Cassagno, N., Deloire, M. S., Vekris, A., Biran, M., Raffard, G., Brochet, B., Canron, M.-H., Franconi, J.-M., Boiziau, C., et al. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458510379243 · Cited by 358
Metadata
- Authors
- Rosas-Ballina, M., & Tracey, K. J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 64
- Issue
- 1
- Pages
- 28-32
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2038624273
- Cited by
- 226
- References
- 10
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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