Immune responses to stroke: mechanisms, modulation, and therapeutic potential.

Tissue Plasminogen Activator for Acute Ischemic Stroke

(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654 · see citing works

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

Nogueira, R. G., Jadhav, A. P., Haussen, D. C., Bonafé, A., Budzik, R. F., Bhuva, P., Yavagal, D. R., Ribó, M., Cognard, C., Hanel, R. A., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1706442 · Cited by 5,667 · see citing works

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

Albers, G. W., Marks, M. P., Kemp, S. M., Christensen, S., Tsai, J. P.-C., Ortega‐Gutiérrez, S., McTaggart, R., Torbey, M., Kim‐Tenser, M. A., Leslie‐Mazwi, T. M., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1713973 · Cited by 4,966 · see citing works

Pathobiology of ischaemic stroke: an integrated view

Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01401-0 · Cited by 3,943 · see citing works

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Johnson, C. O., Nguyen, M., Roth, G. A., Nichols, E. L., Alam, S., Abate, D., Abd-Allah, F., Abdelalim, A., Abraha, H. N., Abu-Rmeileh, N. M., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30034-1 · Cited by 3,324 · see citing works

Thresholds in cerebral ischemia - the ischemic penumbra.

Astrup, J., Siesjö, B. K., & Symon, L. (1981) · Stroke · doi:10.1161/01.str.12.6.723 · Cited by 2,820 · see citing works

The immunology of stroke: from mechanisms to translation

Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596 · see citing works

A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis.

Kappos, L., Radue, E., O'Connor, P., Polman, C., Hohlfeld, R., Calabresi, P., Selmaj, K., Agoropoulou, C., Leyk, M., Zhang-Auberson, L., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0909494 · Cited by 2,569 · see citing works

Endovascular Stroke Therapy Results Improve over Time: The ‘Learning Curve' at a New Comprehensive Stoke Center

Benardete, E. A., & Nair, A. K. (2015) · Cerebrovascular Diseases Extra · doi:10.1159/000370060 · Cited by 2,546 · see citing works

Genomic analysis of reactive astrogliosis

Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404 · see citing works

Global Burden of Stroke

Katan, M., & Luft, A. (2018) · Seminars in Neurology · doi:10.1055/s-0038-1649503 · Cited by 2,137 · cited 1× · see citing works

The Science of Stroke: Mechanisms in Search of Treatments

Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930 · see citing works

Ischaemic stroke

Campbell, B. C. V., Silva, D. A. D., Macleod, M. R., Coutts, S. B., Schwamm, L. H., Davis, S. M., & Donnan, G. A. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0118-8 · Cited by 1,858 · see citing works

Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis

Pendlebury, S. T., & Rothwell, P. M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70236-4 · Cited by 1,853 · see citing works

Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

Guilliams, M., Ginhoux, F., Jakubzick, C., Naik, S. H., Onai, N., Schraml, B. U., Segura, É., Tussiwand, R., & Yona, S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3712 · Cited by 1,802 · see citing works

Global, regional, and country-specific lifetime risks of stroke, 1990 and 2016

Collaborators, T. G. 2. L. R. O. S. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1804492 · Cited by 1,503 · see citing works

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

Hu, X.-M., Li, P.-Y., Guo, Y., Wang, H., Leak, R., Chen, S., Gao, Y.-Q., & Chen, J. (2012) · Stroke · doi:10.1161/strokeaha.112.659656 · Cited by 1,445 · see citing works

Organised inpatient (stroke unit) care for stroke

Collaboratio, S. U. T. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000197.pub2 · Cited by 1,315 · see citing works

C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206 · see citing works

Medical Complications After Stroke: A Multicenter Study

Langhorne, P., Stott, D. J., Robertson, L., MacDonald, J., Jones, L., McAlpine, C., Dick, F., Taylor, G. S., & Murray, G. (2000) · Stroke · doi:10.1161/01.str.31.6.1223 · Cited by 1,196 · see citing works

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

Benakis, C., Brea, D., Caballero, S., Faraco, G., Moore, J., Murphy, M., Sita, G., Racchumi, G., Ling, L., Pamer, E. G., et al. (2016) · Nature Medicine · doi:10.1038/nm.4068 · Cited by 1,114 · see citing works

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

Liesz, A., Suri-Payer, E., Veltkamp, C., Doerr, H., Sommer, C., Rivest, S., Giese, T., & Veltkamp, R. (2009) · Nature Medicine · doi:10.1038/nm.1927 · Cited by 1,059 · see citing works

Multiple Sclerosis: Current Knowledge and Future Outlook

Kamm, C. P., Uitdehaag, B. M. J., & Polman, C. H. (2014) · European Neurology · doi:10.1159/000360528 · Cited by 1,011 · see citing works

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossini, C., Cella, M., Barrow, A. D., Diamond, M. S., & Colonna, M. (2012) · Nature Immunology · doi:10.1038/ni.2360 · Cited by 1,011 · see citing works

Stroke-induced Immunodeficiency Promotes Spontaneous Bacterial Infections and Is Mediated by Sympathetic Activation Reversal by Poststroke T Helper Cell Type 1–like Immunostimulation

Prass, K., Meisel, C., Höflich, C., Braun, J., Halle, E., Wolf, T., Ruscher, K., Victorov, I. V., Priller, J., Dirnagl, U., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021098 · Cited by 927 · see citing works

The movers and shapers in immune privilege of the CNS

Engelhardt, B., Vajkoczy, P., & Weller, R. O. (2017) · Nature Immunology · doi:10.1038/ni.3666 · Cited by 893 · see citing works

Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain

Lalancette-Hébert, M., Gowing, G., Simard, A., Weng, Y. C., & Kriz, J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5360-06.2007 · Cited by 874 · see citing works

Decline in Cardiovascular Mortality

Mensah, G. A., Wei, G. S., Sorlie, P. D., Fine, L. J., Rosenberg, Y., Kaufmann, P. G., Mussolino, M. E., Hsu, L. L., Addou, E., Engelgau, M. M., et al. (2017) · Circulation Research · doi:10.1161/circresaha.116.309115 · Cited by 856 · see citing works

Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre

Toledo, J. B., Arnold, S. E., Raible, K., Brettschneider, J., Xie, S. X., Grossman, M., Monsell, S. E., Kukull, W. A., & Trojanowski, J. Q. (2013) · Brain · doi:10.1093/brain/awt188 · Cited by 849 · see citing works

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D. J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1999 · Cited by 842 · see citing works

Forecasting the Future of Stroke in the United States

Ovbiagele, B. I., Goldstein, L. B., Higashida, R. T., Howard, V. J., Johnston, S. C., Khavjou, O., Lackland, D. T., Lichtman, J. H., Mohl, S., Sacco, R. L., et al. (2013) · Stroke · doi:10.1161/str.0b013e31829734f2 · Cited by 834 · see citing works

Vascular Cognitive Impairment and Dementia

Iadecola, C., Duering, M., Hachinski, V., Joutel, A., Pendlebury, S. T., Schneider, J. A., & Dichgans, M. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.04.034 · Cited by 831 · see citing works

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

Singh, V., Roth, S., Llovera, G., Sadler, R., Garzetti, D., Stecher, B., Dichgans, M., & Liesz, A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1114-16.2016 · Cited by 800 · see citing works

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

Yang, Y. R., & Rosenberg, G. A. (2011) · Stroke · doi:10.1161/strokeaha.110.608257 · Cited by 795 · see citing works

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

Ito, M., Komai, K., Mise-Omata, S., Iizuka-Koga, M., Noguchi, Y., Kondo, T., Sakai, R., Matsuo, K., Nakayama, T., Yoshie, O., et al. (2019) · Nature · doi:10.1038/s41586-018-0824-5 · Cited by 784 · see citing works

Poststroke Depression: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

Towfighi, A., Ovbiagele, B. I., Husseini, N. E., Hackett, M. L., Jorge, R. E., D, B. M. K. M., Mitchell, P. H., Skolarus, L. E., Whooley, M. A., & Williams, L. S. (2016) · Stroke · doi:10.1161/str.0000000000000113 · Cited by 783 · see citing works

Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons.

del Zoppo, G. J., Schmid‐Schönbein, G. W., Mori, E., Copeland, B. R., & Chang, C.-H. (1991) · Stroke · doi:10.1161/01.str.22.10.1276 · Cited by 764 · see citing works

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

Knowland, D., Arac, A., Sekiguchi, K. J., Hsu, M., Lutz, S. E., Perrino, J., Steinberg, G. K., Barres, B. A., Nimmerjahn, A., & Agalliu, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.003 · Cited by 703 · see citing works

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

Shechter, R., Miller, O., Yovel, G., Rosenzweig, N., London, A., Ruckh, J., Kim, K.-W., Klein, E., Kalchenko, V., Bendel, P., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.012 · Cited by 683 · see citing works

Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

Hill, M. D., Goyal, M., Menon, B. K., Nogueira, R. G., McTaggart, R., Demchuk, A. M., Poppe, A. Y., Buck, B. H., Field, T. S., Dowlatshahi, D. D., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30258-0 · Cited by 652 · see citing works

Subarachnoid Hemorrhage

Lawton, M. T., & Vates, G. E. (2017) · New England Journal of Medicine · doi:10.1056/nejmcp1605827 · Cited by 640 · see citing works

Stroma-derived interleukin-34 controls the development and maintenance of Langerhans cells and the maintenance of microglia

Greter, M., Lelios, I., Pelczar, P., Hoeffel, G., Price, J., Leboeuf, M., Kündig, T. M., Frei, K., Ginhoux, F., Merad, M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.11.001 · Cited by 630 · see citing works

Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study

Pendlebury, S. T., & Rothwell, P. M. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30442-3 · Cited by 629 · see citing works

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

Herisson, F., Frodermann, V., Courties, G., Rohde, D., Sun, Y., Vandoorne, K., Wojtkiewicz, G. R., Masson, G. S., Vinegoni, C., Kim, J., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0213-2 · Cited by 610 · see citing works

Toll-Like Receptor 4 Is Involved in Brain Damage and Inflammation After Experimental Stroke

Caso, J. R., Pradillo, J. M., Hurtado, O., Lorenzo, P. L., Moro, M. Á., & Lizasoaín, I. (2007) · Circulation · doi:10.1161/circulationaha.106.603431 · Cited by 606 · see citing works

Human cerebrospinal fluid central memory CD4 + T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin

Kivisäkk, P., Mahad, D., Callahan, M. K., Trebst, C., Tucky, B. H., Wei, T., Wu, L., Bækkevold, E. S., Lassmann, H., Staugaitis, S. M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1433000100 · Cited by 546 · see citing works

Experimental Stroke Induces Massive, Rapid Activation of the Peripheral Immune System

Offner, H., Subramanian, S., Parker, S. M., Afentoulis, M. E., Vandenbark, A. A., & Hurn, P. D. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600217 · Cited by 537 · see citing works

Subarachnoid Hemorrhage

(2016) · Elsevier eBooks · doi:10.1016/b978-0-323-44781-2.50273-4 · Cited by 535 · see citing works

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

Morrison, H. W., & Filosa, J. A. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-4 · Cited by 506 · see citing works

Organised inpatient (stroke unit) care for stroke

Stroke Unit Trialists' Collaboration (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000197.pub3 · Cited by 506 · see citing works

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

Perego, C., Fumagalli, S., & Simoni, M. G. D. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-174 · Cited by 504 · see citing works

Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat).

García, J. H., Liu, K. F., Yoshida, Y., Lian, J., Chen, S., & del Zoppo, G. J. (1994) · PubMed Central · Cited by 496 · see citing works

Interaction Between the Coagulation and Complement System

Amara, U., Rittirsch, D., Flierl, M. A., Brückner, U. B., Klos, A., Gebhard, F. T., Lambris, J. D., & Huber-Lang, M. S. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-78952-1_6 · Cited by 474 · see citing works

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

Cai, R., Pan, C., Ghasemigharagoz, A., Todorov, M. I., Förstera, B., Zhao, S., Bhatia, H. S., Parra-Damas, A., Mrowka, L., Theodorou, D., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0301-3 · Cited by 470 · see citing works

Translocation and dissemination of commensal bacteria in post-stroke infection

Stanley, D., Mason, L. J., Mackin, K. E., Srikhanta, Y. N., Lyras, D., Prakash, M. D., Nurgali, K., Venegas, A., Hill, M. D., Moore, R. J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4194 · Cited by 464 · see citing works

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

Gelderblom, M., Weymar, A., Bernreuther, C., Velden, J., Arunachalam, P., Steinbach, K., Orthey, E., Arumugam, T. V., Leypoldt, F., Simova, O., et al. (2012) · Blood · doi:10.1182/blood-2012-02-412726 · Cited by 457 · see citing works

A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

Emsley, H. C. A. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.054882 · Cited by 444 · see citing works

Functional Innervation of Hepatic iNKT Cells Is Immunosuppressive Following Stroke

Wong, C. H. Y., Jenne, C., Lee, W.-Y., Léger, C., & Kubes, P. (2011) · Science · doi:10.1126/science.1210301 · Cited by 424 · see citing works

Neutrophil recruitment to the brain in mouse and human ischemic stroke

Perez-de-Puig, I., Miró-Mur, F., Ferrer-Ferrer, M., Gelpi, E., Pedragosa, J., Justicia, C., Urra, X., Chamorro, A., & Planas, A. M. (2015) · Acta Neuropathologica · doi:10.1007/s00401-014-1381-0 · Cited by 420 · see citing works

Multifaceted interactions between adaptive immunity and the central nervous system

Kipnis, J. (2016) · Science · doi:10.1126/science.aag2638 · Cited by 376 · see citing works

Stroke and dementia risk: A systematic review and meta‐analysis

Kuźma, E., Lourida, I., Moore, S. F., Levine, D. A., Ukoumunne, O. C., & Llewellyn, D. J. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.06.3061 · Cited by 376 · see citing works

Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice

Schilling, M., Besselmann, M., Leonhard, C., Mueller, M., Ringelstein, E. B., & Kiefer, R. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00082-7 · Cited by 375 · see citing works

Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke

Kawabori, M., Kacimi, R., Kauppinen, T., Calosing, C., Kim, J. Y., Hsieh, C. L., Nakamura, M. C., & Yenari, M. A. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2620-14.2015 · Cited by 375 · see citing works

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

Houlden, A., Goldrick, M., Brough, D., Vizi, E. S., Lénárt, N., Martinecz, B., Roberts, I. S., & Dénes, Á. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.04.003 · Cited by 369 · see citing works

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation.

Kleinschnitz, C., Schwab, N., Kraft, P., Hagedorn, I., Dreykluft, A., Schwarz, T. J., Austinat, M., Nieswandt, B., Wiendl, H., & Stoll, G. (2010) · Blood · doi:10.1182/blood-2009-10-249078 · Cited by 361 · see citing works

Atrial fibrillation in stroke-free patients is associated with memory impairment and hippocampal atrophy

Knecht, S., Oelschläger, C., Duning, T., Lohmann, H., Albers, J., Stehling, C., Heindel, W. L., Breithardt, G., Berger, K., Ringelstein, E. B., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn341 · Cited by 356 · see citing works

T- and B-Cell-Deficient Mice with Experimental Stroke have Reduced Lesion Size and Inflammation

Hum, P. D., Subramanian, S., Parker, S. M., Afentoulis, M. E., Kaler, L. J., Vandenbark, A. A., & Offner, H. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600482 · Cited by 355 · see citing works

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

Wattananit, S., Tornero, D., Graubardt, N., Memanishvili, T., Monni, E., Tatarishvili, J., Miskinyte, G., Ge, R., Ahlenius, H., Lindvall, O., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4317-15.2016 · Cited by 354 · see citing works

Depletion of microglia exacerbates postischemic inflammation and brain injury

Jin, W.-N., Shi, S. X.-Y., Li, Z., Li, M., Wood, K., Gonzales, R. J., & Liu, Q. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17694185 · Cited by 351 · cited 1× · see citing works

N2 Neutrophils, Novel Players in Brain Inflammation After Stroke

Cuartero, M. I., Ballesteros, I., Moraga, A., Nombela, F., Vivancos, J., Hamilton, J. A., Corbí, A. L., Lizasoaín, I., & Moro, M. Á. (2013) · Stroke · doi:10.1161/strokeaha.113.002470 · Cited by 345 · see citing works

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

Faraco, G., Brea, D., Garcia-Bonilla, L., Wang, G., Racchumi, G., Chang, H., Buendia, I., Santisteban, M. M., Segarra, S. G., Koizumi, K., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0059-z · Cited by 343 · see citing works

B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke

Doyle, K. P., Quach, L. N., Solé, M., Axtell, R. C., Nguyen, T. V., Soler-Llavina, G. J., Jurado, S., Han, J., Steinman, L., Longo, F. M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4098-14.2015 · Cited by 338 · see citing works

Immune Signaling in Neurodegeneration

Hammond, T. R., Marsh, S. E., & Stevens, B. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.016 · Cited by 336 · see citing works

Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory

Ribeiro, M., Brigas, H. C., Temido-Ferreira, M., Pousinha, P. A., Regen, T., Santa, C., Coelho, J. E., Marques-Morgado, I., Valente, C. A., Omenetti, S., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aay5199 · Cited by 335 · see citing works

DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury

Liesz, A., Dalpke, A., Mracsko, E., Roth, S., Zhou, W., Yang, H., Na, S.-Y., Akhisaroglu, M., Fleming, T., Eigenbrod, T., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2439-14.2015 · Cited by 334 · see citing works

Cerebral Intraparenchymal Hemorrhage

Gross, B. A., Jankowitz, B. T., & Friedlander, R. M. (2019) · JAMA · doi:10.1001/jama.2019.2413 · Cited by 327 · see citing works

Gene Expression in Blood Changes Rapidly in Neutrophils and Monocytes after Ischemic Stroke in Humans: A Microarray Study

Tang, Y., Xu, H., Du, X. L., Lit, L., Walker, W. L., Lu, A., Ran, R., Gregg, J. P., Reilly, M., Pancioli, A., et al. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600264 · Cited by 326 · see citing works

Preventing dementia by preventing stroke: The Berlin Manifesto

Hachinski, V., Einhäupl, K. M., Ganten, D., Alladi, S., Brayne, C., Stephan, B. C. M., Sweeney, M. D., Zloković, B. V., Iturria‐Medina, Y., Iadecola, C., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.06.001 · Cited by 314 · see citing works

Thromboinflammation in Stroke Brain Damage

Meyer, S. F. D., Denorme, F., Langhauser, F., Geuß, E., Fluri, F., & Kleinschnitz, C. (2016) · Stroke · doi:10.1161/strokeaha.115.011238 · Cited by 313 · see citing works

Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke

Ren, X. S., Akiyoshi, K., Dziennis, S., Vandenbark, A. A., Herson, P. S., Hurn, P. D., & Offner, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1623-11.2011 · Cited by 298 · see citing works

Impact of an immune modulator fingolimod on acute ischemic stroke

Fu, Y., Zhang, N., Ren, L., Yan, Y., Sun, N., Li, Y.-J., Han, W., Xue, R., Liu, Q., Hao, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416166111 · Cited by 290 · see citing works

Leukocyte Recruitment and Ischemic Brain Injury

Yilmaz, G., & Granger, D. (2009) · Neuromolecular medicine · doi:10.1007/s12017-009-8074-1 · Cited by 285 · see citing works

Macrophages prevent hemorrhagic infarct transformation in murine stroke models

Gliem, M., Mausberg, A. K., Lee, J., Simiantonakis, I., van Rooijen, N., Hartung, H., & Jander, S. (2012) · Annals of Neurology · doi:10.1002/ana.23529 · Cited by 284 · see citing works

Fingolimod for the Treatment of Intracerebral Hemorrhage

Fu, Y., Hao, J., Zhang, N., Ren, L., Sun, N., Li, Y.-J., Yan, Y., Huang, D., Yu, C., & Shi, F. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1065 · Cited by 278 · see citing works

Ischemic neurons recruit natural killer cells that accelerate brain infarction

Gan, Y. X., Liu, Q., Wu, W., Yin, J., Bai, X., Shen, R. Z., Wang, Y., Chen, J., Cava, A. L., Poursine‐Laurent, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315943111 · Cited by 275 · see citing works

Stroke incidence in young adults according to age, subtype, sex, and time trends

Ekker, M., Verhoeven, J., Vaartjes, I., van Nieuwenhuizen, K. M., Klijn, C., & de Leeuw, F. (2019) · Neurology · doi:10.1212/wnl.0000000000007533 · Cited by 273 · see citing works

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

Otxoa-de-Amezaga, A., Miró-Mur, F., Pedragosa, J., Gallizioli, M., Justicia, C., Gaja-Capdevila, N., Ruíz-Jaen, F., Salas-Perdomo, A., Bosch, A., Calvo, M., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-1954-4 · Cited by 258 · see citing works

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia

Llovera, G., Hofmann, K., Roth, S., Salas-Perdomo, A., Ferrer-Ferrer, M., Perego, C., Zanier, E. R., Mamrak, U., Rex, A., Party, H., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa9853 · Cited by 250 · see citing works

Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study

Lane, C. A., Barnes, J., Nicholas, J. M., Sudre, C. H., Cash, D. M., Parker, T. D., Malone, I. B., Lu, K., James, S.-N., Keshavan, A., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30228-5 · Cited by 247 · see citing works

ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro.

Steffen, B. J., Breier, G., Butcher, E. C., Schulz, M., & Engelhardt, B. (1996) · Europe PMC (PubMed Central) · Cited by 245 · see citing works

Neutrophil Cerebrovascular Transmigration Triggers Rapid Neurotoxicity through Release of Proteases Associated with Decondensed DNA

Allen, C., Thornton, P., Dénes, Á., McColl, B. W., Pierozynski, A., Monestier, M., Pinteaux, E., Rothwell, N. J., & Allan, S. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200409 · Cited by 245 · see citing works

Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells

Courties, G., Hérisson, F., Sager, H. B., Heidt, T., Ye, Y., Wei, Y., Sun, Y., Sévère, N., Dutta, P., Scharff, J., et al. (2014) · Circulation Research · doi:10.1161/circresaha.116.305207 · Cited by 240 · see citing works

Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain

Kim, S.-W., Lee, H., Lee, H., Kim, I., & Lee, J.-K. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0747-x · Cited by 237 · see citing works

Dietary salt promotes cognitive impairment through tau phosphorylation

Faraco, G., Hochrainer, K., Segarra, S. G., Schaeffer, S., Santisteban, M. M., Menon, A., Jiang, H., Holtzman, D. M., Anrather, J., & Iadecola, C. (2019) · Nature · doi:10.1038/s41586-019-1688-z · Cited by 236 · see citing works

Stroke risk profile, brain volume, and cognitive function

Seshadri, S. S., Wolf, P. A., Beiser, A., Elias, M. F., Au, R., Kase, C. S., D’Agostino, R. B., & DeCarli, C. S. (2004) · Neurology · doi:10.1212/01.wnl.0000142968.22691.70 · Cited by 230 · see citing works

The Neurology of the Immune System: Neural Reflexes Regulate Immunity

Rosas‐Ballina, M., & Tracey, K. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.039 · Cited by 226 · see citing works

Complement Component C3 Mediates Inflammatory Injury Following Focal Cerebral Ischemia

Mocco, J., Mack, W. J., Ducruet, A. F., Sosunov, S. A., Sughrue, M. E., Hassid, B. G., Nair, M. N., Laufer, I., Komotar, R. J., Claire, M. B. F. S., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000232544.90675.42 · Cited by 226 · see citing works

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

Enzmann, G., Mysiorek, C., Gorina, R., Cheng, Y.-J., Ghavampour, S., Hannocks, M.-J., Prinz, V., Dirnagl, U., Endres, M., Prinz, M., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1076-3 · Cited by 225 · see citing works

Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial

Elkins, J., Veltkamp, R., Montaner, J., Johnston, S. C., Singhal, A. B., Becker, K., Lansberg, M. G., Tang, W., Chang, I., Muralidharan, K., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30357-x · Cited by 224 · see citing works

Increased Cytokine Release from Peripheral Blood Cells after Acute Stroke

Ferrarese, C., Mascarucci, P., Zoia, C., Cavarretta, R., Frigo, M., Begni, B., Sarinella, F., Frattola, L., & Simoni, M. G. D. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199909000-00008 · Cited by 209 · see citing works

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke)

Smith, C. J., Hulme, S., Vail, A., Heal, C., Parry‐Jones, A., Scarth, S., Hopkins, K., Hoadley, M. E., Allan, S. M., Rothwell, N. J., et al. (2018) · Stroke · doi:10.1161/strokeaha.118.020750 · Cited by 200 · see citing works

Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke

Baron, J. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0002-2 · Cited by 197 · see citing works

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

Tang, Z., Gan, Y. X., Liu, Q., Yin, J., Liu, Q., Shi, J., & Shi, F. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-26 · Cited by 192 · see citing works

Mast Cells as Early Responders in the Regulation of Acute Blood–Brain Barrier Changes after Cerebral Ischemia and Hemorrhage

Lindsberg, P. J., Strbian, D., & Karjalainen‐Lindsberg, M. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.282 · Cited by 190 · see citing works

Role of Spleen-Derived Monocytes/Macrophages in Acute Ischemic Brain Injury

Kim, E., Yang, J., Beltran, C., & Cho, S. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.101 · Cited by 186 · see citing works

Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice

Crapser, J. D., Ritzel, R. M., Verna, R., Venna, V. R., Liu, F., Chauhan, A., Koellhoffer, E. C., Patel, A. R., Ricker, A., Maas, K. R., et al. (2016) · Aging · doi:10.18632/aging.100952 · Cited by 186 · see citing works

Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure

Firbank, M., Wiseman, R., Burton, E. J., Saxby, B. K., O'Brien, J. T., & Ford, G. A. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0238-4 · Cited by 184 · see citing works

Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association

Hinkle, J. L., Becker, K. J., Kim, J. S., Choi‐Kwon, S., Saban, K. L., McNair, N. D., & Mead, G. E. (2017) · Stroke · doi:10.1161/str.0000000000000132 · Cited by 184 · see citing works

Complement C1q Is Dramatically Up-Regulated in Brain Microglia in Response to Transient Global Cerebral Ischemia

Schäfer, M. K.-H., Schwaeble, W., Post, C., Salvati, P., Calabresi, M., Sim, R. B., Petry, F., Loos, M., & Weihe, E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.10.5446 · Cited by 172 · see citing works

Innate Control of Adaptive Immunity: Beyond the Three-Signal Paradigm

Jain, A., & Pasare, C. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602000 · Cited by 169 · see citing works

Brain-Derived Antigens in Lymphoid Tissue of Patients with Acute Stroke

Planas, A. M., Gómez-Choco, M. J., Urra, X., Gorina, R., Caballero, M., & Chamorro, Á. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102289 · Cited by 168 · see citing works

Time course of microglia activation and apoptosis in various brain regions after permanent focal cerebral ischemia in mice

Rupalla, K., ALLEGRINI, P. R., Sauer, D., & Wießner, C. (1998) · Acta Neuropathologica · doi:10.1007/s004010050878 · Cited by 168 · see citing works

Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice

Alawieh, A. M., Langley, E. F., & Tomlinson, S. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao6459 · Cited by 164 · see citing works

IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke

Bodhankar, S., Chen, Y., Vandenbark, A. A., Murphy, S. J., & Offner, H. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9413-3 · Cited by 163 · see citing works

Cerebral Hemorrhage in Carotid Artery Surgery

Bruetman, M. E., Fields, W. S., Crawford, E. S., & Debakey, M. E. (1963) · Archives of Neurology · doi:10.1001/archneur.1963.00460110026002 · Cited by 163 · see citing works

Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke

García‐Culebras, A., Durán‐Laforet, V., Peña‐Martínez, C., Moraga, A., Ballesteros, I., Cuartero, M. I., de la Parra, J., Palma-Tortosa, S., Hidalgo, A., Corbí, A. L., et al. (2019) · Stroke · doi:10.1161/strokeaha.119.025085 · Cited by 162 · see citing works

Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity

Liu, Q., Johnson, E. M., Lam, R. K., Wang, Q., Ye, H. B., Wilson, E. N., Minhas, P. S., Liu, L., Swarovski, M. S., Tran, S., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0421-2 · Cited by 159 · see citing works

Human cerebral infarct: a proposed histopathologic classification based on 137 cases

Mena, H., Cadavid, D., & Rushing, E. J. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0918-z · Cited by 156 · see citing works

Cerebral Mast Cells Regulate Early Ischemic Brain Swelling and Neutrophil Accumulation

Strbian, D., Karjalainen‐Lindsberg, M., Tatlisumak, T., & Lindsberg, P. J. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600228 · Cited by 153 · see citing works

Inflammation, Autoimmunity, Infection, and Stroke

Parikh, N. S., Merkler, A. E., & Iadecola, C. (2020) · Stroke · doi:10.1161/strokeaha.119.024157 · Cited by 151 · see citing works

Brain dendritic cells in ischemic stroke: Time course, activation state, and origin

Felger, J. C., Abe, T., Kaunzner, U. W., Gottfried-Blackmore, A., Gal-Toth, J., McEwen, B. S., Iadecola, C., & Bulloch, K. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.11.002 · Cited by 148 · see citing works

Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome

Kes, V. B., Šimundić, A.-M., Nikolac, N., Topić, E., & Demarin, V. (2008) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2008.08.080 · Cited by 147 · see citing works

CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage

Pedragosa, J., Salas-Perdomo, A., Gallizioli, M., Cugota, R., Miró‐Mur, F., Briansó, F., Justicia, C., Pérez-Asensio, F. J., Márquez‐Kisinousky, L., Urra, X., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0581-6 · Cited by 147 · see citing works

A Rapid and Transient Peripheral Inflammatory Response Precedes Brain Inflammation after Experimental Stroke

Chapman, K. Z., Dale, V. Q., Dénes, Á., Bennett, G., Rothwell, N., Allan, S., & McColl, B. (2009) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2009.113 · Cited by 142 · see citing works

Genetically-Defined Deficiency of Mannose-Binding Lectin Is Associated with Protection after Experimental Stroke in Mice and Outcome in Human Stroke

Cervera, Á., Planas, A. M., Justicia, C., Urra, X., Jensenius, J. C., Torres, F., Lozano, F., & Chamorro, Á. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008433 · Cited by 141 · see citing works

Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke.

Frenkel, D., Huang, Z., Maron, R., Koldzic, D. N., Moskowitz, M., & Weiner, H. (2005) · Journal of Neurological Sciences · doi:10.1016/j.jns.2005.03.022 · Cited by 141 · see citing works

Novel Characterization of Monocyte-Derived Cell Populations in the Meninges and Choroid Plexus and Their Rates of Replenishment in Bone Marrow Chimeric Mice

Chinnery, H. R., Ruitenberg, M. J., & McMenamin, P. G. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181edbc1a · Cited by 140 · see citing works

Gastrointestinal complications after ischemic stroke

Camara-Lemarroy, C. R., Ibarra-Yruegas, B. E., & Góngora‐Rivera, F. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.08.027 · Cited by 139 · see citing works

Immature monocytes recruited to the ischemic mouse brain differentiate into macrophages with features of alternative activation

Miró‐Mur, F., Pérez-de-Puig, I., Ferrer-Ferrer, M., Urra, X., Justicia, C., Chamorro, Á., & Planas, A. M. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.010 · Cited by 133 · see citing works

Protease-activated receptor signalling by coagulation proteases in endothelial cells

Rezaie, A. R. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-02-0167 · Cited by 133 · see citing works

Inducible Nitric Oxide Synthase in Neutrophils and Endothelium Contributes to Ischemic Brain Injury in Mice

García‐Bonilla, L., Moore, J. M. R., Racchumi, G., Zhou, P., Butler, J. M., Iadecola, C., & Anrather, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400918 · Cited by 132 · see citing works

Delayed Administration of Interleukin-1 Receptor Antagonist Reduces Ischemic Brain Damage and Inflammation in Comorbid Rats

Pradillo, J. M., Dénes, Á., Greenhalgh, A. D., Boutin, H., Drake, C., McColl, B. W., Barton, E. C., Proctor, S. D., Russell, J. C., Rothwell, N. J., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.101 · Cited by 130 · see citing works

Abolition of aberrant neurogenesis ameliorates cognitive impairment after stroke in mice

Cuartero, M. I., de la Parra, J., Pérez-Ruiz, A., Bravo-Ferrer, I., Durán-Laforet, V., García-Culebras, A., García-Segura, J. M., Dhaliwal, J., Frankland, P. W., Lizasoain, I., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci120412 · Cited by 128 · see citing works

Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke

Yang, Y., Yang, L. Y., Orbán, L., Cuylear, D. L., Thompson, J., Simon, B. J., & Yang, Y. R. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.01.034 · Cited by 126 · see citing works

Racial and Ethnic Disparities in the Utilization of Thrombectomy for Acute Stroke

Rinaldo, L., Rabinstein, A. A., Cloft, H. J., Knudsen, J. M., Castilla, L. R., & Brinjikji, W. (2019) · Stroke · doi:10.1161/strokeaha.118.024651 · Cited by 126 · see citing works

Molecular Identification of the Ischemic Penumbra

Weinstein, P. R., Hong, S. M., & Sharp, F. R. (2004) · Stroke · doi:10.1161/01.str.0000144052.10644.ed · Cited by 125 · see citing works

Neutrophil elastase and neurovascular injury following focal stroke and reperfusion

Stowe, A. M., Adair-Kirk, T. L., Gonzales, E. R., Perez, R. S., Shah, A. R., Park, T. S., & Gidday, J. M. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.04.006 · Cited by 123 · see citing works

Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts

Zbesko, J. C., Nguyen, T. V., Yang, T., Frye, J. B., Hussain, O. M., Hayes, M. I., Chung, A. G., Day, W. A., Stepanovic, K., Krumberger, M., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.007 · Cited by 123 · see citing works

Brain-to-cervical lymph node signaling after stroke.

Esposito, E., Ahn, B. J., Shi, J., Nakamura, Y., Park, J. H., Mandeville, E. T., Yu, Z., Chan, S. J., Desai, R., Hayakawa, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13324-w · Cited by 123 · see citing works

Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain

García‐Bonilla, L., Faraco, G., Moore, J. M. R., Murphy, M., Racchumi, G., Srinivasan, J., Brea, D., Iadecola, C., & Anrather, J. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0750-0 · Cited by 119 · see citing works

Autoimmune Responses to the Brain After Stroke Are Associated With Worse Outcome

Becker, K. J., Kalil, A., Tanzi, P., Zierath, D. K., Savos, A. V., Gee, J. M., Hadwin, J., Carter, K. T., Shibata, D. K., & Cain, K. C. (2011) · Stroke · doi:10.1161/strokeaha.111.619593 · Cited by 116 · see citing works

Sensitization to Brain Antigens after Stroke is Augmented by Lipopolysaccharide

Becker, K. J., Kindrick, D. L., Lester, M. P., Shea, C., & Ye, Z. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600160 · Cited by 115 · see citing works

Activation of α-7 Nicotinic Acetylcholine Receptor Reduces Ischemic Stroke Injury through Reduction of Pro-Inflammatory Macrophages and Oxidative Stress

Han, Z., Shen, F., He, Y., Degos, V., Camus, M., Maze, M., Young, W. L., & Su, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105711 · Cited by 113 · see citing works

Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivors

Firbank, M., Burton, E. J., Barber, R., Stephens, S., Kenny, R. A., Ballard, C. G., Kalaria, R. N., & O'Brien, J. T. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.07.009 · Cited by 113 · see citing works

CCR2 deficiency in monocytes impairs angiogenesis and functional recovery after ischemic stroke in mice

Pedragosa, J., Miró‐Mur, F., Otxoa-de-Amezaga, A., Justicia, C., Ruíz-Jaén, F., Ponsaerts, P., Pasparakis, M., & Planas, A. M. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20909055 · Cited by 112 · see citing works

Autoimmunity After Ischemic Stroke and Brain Injury

Javidi, E., & Magnus, T. U. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00686 · Cited by 110 · see citing works

Serum cytokine and glucose levels as predictors of poststroke fatigue in acute ischemic stroke patients

Ormstad, H., Aass, H. C. D., Amthor, K.-F., Lund-Sørensen, N., & Sandvik, L. (2011) · Journal of Neurology · doi:10.1007/s00415-011-5962-8 · Cited by 109 · see citing works

Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: Comparisons to ischemic stroke, migraine, and Tourette syndrome

Du, X., Tang, Y., Xu, H., Lit, L., Walker, W. L., Ashwood, P., Gregg, J. P., & Sharp, F. R. (2006) · Genomics · doi:10.1016/j.ygeno.2006.02.003 · Cited by 107 · see citing works

A Concerted Appeal for International Cooperation in Preclinical Stroke Research

Dirnagl, U., Hakim, A. M., Macleod, M. R., Fisher, M., Howells, D. W., Allan, S. M., Steinberg, G. K., Planas, A. M., Boltze, J., Savitz, S. I., et al. (2013) · Stroke · doi:10.1161/strokeaha.113.000734 · Cited by 102 · see citing works

Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke

Engel, O., Akyüz, L., Gonçalves, A. C. D. C., Winek, K., Dames, C., Thielke, M., Herold, S., Böttcher, C., Priller, J., Volk, H., et al. (2015) · Stroke · doi:10.1161/strokeaha.115.008989 · Cited by 101 · see citing works

IL-23 (Interleukin-23)–Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke

Gelderblom, M., Gallizioli, M., Ludewig, P., Häußler, V., Arunachalam, P., Rissiek, B., Bernreuther, C., Glatzel, M., Korn, T., Arumugam, T. V., et al. (2017) · Stroke · doi:10.1161/strokeaha.117.019101 · Cited by 99 · see citing works

Rates and predictors of futile recanalization in patients undergoing endovascular treatment in a multicenter clinical trial

Hussein, H. M., Saleem, M. A., & Qureshi, A. I. (2018) · Neuroradiology · doi:10.1007/s00234-018-2016-2 · Cited by 99 · see citing works

Location of Neutrophils in Different Compartments of the Damaged Mouse Brain After Severe Ischemia/Reperfusion

Otxoa-de-Amezaga, A., Gallizioli, M., Pedragosa, J., Justicia, C., Miró‐Mur, F., Salas-Perdomo, A., Díaz-Marugán, L., Gunzer, M., & Planas, A. M. (2019) · Stroke · doi:10.1161/strokeaha.118.023837 · Cited by 99 · see citing works

Cognitive Decline After Stroke

Kliper, E., Bashat, D. B., Bornstein, N. M., Shenhar‐Tsarfaty, S., Hallevi, H., Auriel, E., Shopin, L., Bloch, S., Berliner, S. A., Giladi, N., et al. (2013) · Stroke · doi:10.1161/strokeaha.111.000536 · Cited by 98 · see citing works

Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke

Ge, R., Tornero, D., Hirota, M., Monni, E., Laterza, C., Lindvall, O., & Kokaia, Z. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0909-3 · Cited by 95 · see citing works

Strong complement activation after acute ischemic stroke is associated with unfavorable outcomes

Széplaki, G., Szegedi, R., Hirschberg, K., Gombos, T., Varga, L. Á., Karádi, I., Entz, L., Széplaki, Z., Garred, P., Prohászka, Z., et al. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.07.044 · Cited by 94 · see citing works

A role for spleen monocytes in post-ischemic brain inflammation and injury

Bao, Y., Kim, E., Bhosle, S., Mehta, H., & Cho, S. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-92 · Cited by 94 · see citing works

Mannose-Binding Lectin Deficiency Is Associated With Smaller Infarction Size and Favorable Outcome in Ischemic Stroke Patients

Osthoff, M. F., Mira, K., Fluri, F., Schüetz, P., Bingisser, R. M., Kappos, L., Steck, A. J., Engelter, S. T., Müeller, B., Christ‐Crain, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021338 · Cited by 91 · see citing works

Emulating Multicentre Clinical Stroke Trials: A New Paradigm for Studying Novel Interventions in Experimental Models of Stroke

Bath, P. M. W., Macleod, M. R., & Green, A. (2009) · International Journal of Stroke · doi:10.1111/j.1747-4949.2009.00386.x · Cited by 83 · see citing works

Multipotent Adult Progenitor Cells Enhance Recovery After Stroke by Modulating the Immune Response from the Spleen

Yang, B., Hamilton, J. A., Valenzuela, K. S., Bogaerts, A., Xi, X., Aronowski, J. A., Mays, R. W., & Savitz, S. I. (2017) · Stem Cells · doi:10.1002/stem.2600 · Cited by 83 · see citing works

Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System

Gauberti, M., Fournier, A. P., Docagne, F., Vivien, D., & de Lizarrondo, S. M. (2018) · Theranostics · doi:10.7150/thno.22662 · Cited by 83 · see citing works

Immunological observations on patients with acute cerebral vascular disease

Członkowska, A., Cyrta, B., & Korlak, J. (1979) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(79)90024-8 · Cited by 80 · see citing works

Cytokine changes in the pathophysiology of poststroke depression

Su, J., Chou, S., Tsai, C., & Hung, T. (2011) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2011.09.020 · Cited by 80 · see citing works

Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia: An unlikely role for cerebral blood flow

Ay, İ., Sorensen, A. G., & Ay, H. (2011) · Brain Research · doi:10.1016/j.brainres.2011.03.060 · Cited by 80 · see citing works

Splenectomy protects aged mice from injury after experimental stroke

Chauhan, A., Mamun, A. A., Spiegel, G., Harris, N., Zhu, L., & McCullough, L. D. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.022 · Cited by 79 · see citing works

A year-long immune profile of the systemic response in acute stroke survivors

Tsai, A. S., Berry, K., Beneyto, M. M., Gaudilliere, D. K., Ganio, E. A., Culos, A., Ghaemi, M. S., Choisy, B., Djebali, K., Einhaus, J. F., et al. (2019) · Brain · doi:10.1093/brain/awz022 · Cited by 79 · see citing works

Endogenous Protection from Ischemic Brain Injury by Preconditioned Monocytes

García‐Bonilla, L., Brea, D., Benakis, C., Lane, D., Murphy, M., Moore, J. M. R., Racchumi, G., Jiang, X., Iadecola, C., & Anrather, J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0324-18.2018 · Cited by 79 · see citing works

Endothelial CD36 Contributes to Postischemic Brain Injury by Promoting Neutrophil Activation via CSF3

Garcia-Bonilla, L., Racchumi, G., Murphy, M., Anrather, J., & Iadecola, C. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2980-15.2015 · Cited by 77 · see citing works

Stroke induces a rapid adaptive autoimmune response to novel neuronal antigens.

Ortega, S. B., Noorbhai, I., Poinsatte, K., Kong, X., Anderson, A. G., Monson, N. L., & Stowe, A. M. (2015) · PubMed · Cited by 76 · see citing works

Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia

Pradillo, J. M., Murray, K. N., Coutts, G., Moraga, A., Oroz-Gonjar, F., Boutin, H., Moro, M. Á., Lizasoaín, I., Rothwell, N. J., & Allan, S. M. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.013 · Cited by 76 · see citing works

Associations of cytokine gene polymorphisms with post-stroke depression

Kim, J., Stewart, R. J., Kim, S., Shin, I., Kim, J.-T., Park, M., Park, S.-W., Kim, Y., Cho, K.-H., & Yoon, J. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.588247 · Cited by 72 · see citing works

Tissue-Resident Ecto-5′ Nucleotidase (CD73) Regulates Leukocyte Trafficking in the Ischemic Brain

Petrovic‐Djergovic, D., Hyman, M. C., Ray, J. J., Bouïs, D., Visovatti, S., Hayasaki, T., & Pinsky, D. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1003671 · Cited by 70 · see citing works

The “inflammatory penumbra” in ischemic stroke: From clinical data to experimental evidence

Gauberti, M., de Lizarrondo, S. M., & Vivien, D. (2016) · European Stroke Journal · doi:10.1177/2396987316630249 · Cited by 69 · see citing works

Transient decrease in circulating dendritic cell precursors after acute stroke: potential recruitment into the brain

Yılmaz, A., Fuchs, T., Dietel, B., Altendorf, R., Cicha, I., Stumpf, C., Schellinger, P. D., Blümcke, I., Schwab, S., Daniel, W. G., et al. (2009) · Clinical Science · doi:10.1042/cs20090154 · Cited by 67 · see citing works

Thomas Willis Lecture: Is Translational Stroke Research Broken, and if So, How Can We Fix It?

Dirnagl, U. (2016) · Stroke · doi:10.1161/strokeaha.116.013244 · Cited by 61 · see citing works

Plasma proinflammatory and anti-inflammatory cytokine and catecholamine concentrations as predictors of neurological outcome in acute stroke patients

Oto, J., Suzue, A., Inui, D., Fukuta, Y., Hosotsubo, K. K., Torii, M., Nagahiro, S., & Nishimura, M. (2008) · Journal of Anesthesia · doi:10.1007/s00540-008-0639-x · Cited by 58 · see citing works

Ischemia-induced Neuronal Cell Death Is Mediated by Chemokine Receptor CX3CR1

Wang, J., Gan, Y., Han, P., Yin, J., Liu, Q., Ghanian, S., Gao, F., Gong, G., & Tang, Z. (2018) · Scientific Reports · doi:10.1038/s41598-017-18774-0 · Cited by 58 · see citing works

Importance of Preclinical Research in the Development of Neuroprotective Strategies for Ischemic Stroke

Neuhaus, A. A., Rabie, T., Sutherland, B. A., Papadakis, M., Hadley, G., Cai, R., & Buchan, A. M. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.6299 · Cited by 57 · see citing works

Evidence of Intrathecal Immunoglobulin Synthesis in Stroke

Prüß, H., Iggena, D., Baldinger, T., Prinz, V., Meisel, A., Endres, M., Dirnagl, U., & Schwab, J. M. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.3252 · Cited by 55 · see citing works

Antibodies to myelin basic protein are associated with cognitive decline after stroke

Becker, K. J., Tanzi, P. M., Zierath, D. K., & Buckwalter, M. S. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.04.001 · Cited by 55 · see citing works

Differential Affection of Intestinal Immune Cell Populations after Cerebral Ischemia in Mice

Schulte‐Herbrüggen, O., Quarcoo, D., Meisel, A., & Meisel, C. (2009) · NeuroImmunoModulation · doi:10.1159/000205514 · Cited by 52 · see citing works

Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism

Chung, A. G., Frye, J. B., Zbesko, J. C., Constantopoulos, E., Hayes, M. I., Figueroa, A. G., Becktel, D. A., Day, W. A., Konhilas, J. P., McKay, B. S., et al. (2018) · eNeuro · doi:10.1523/eneuro.0076-18.2018 · Cited by 50 · see citing works

Effect of vagus nerve stimulation during transient focal cerebral ischemia on chronic outcome in rats

Hiraki, T., Baker, W. B., & Greenberg, J. H. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22812 · Cited by 46 · see citing works

Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke

Huang, J., Hu, J., Chen, N., & Hu, M. (2012) · Journal of Critical Care · doi:10.1016/j.jcrc.2012.10.003 · Cited by 46 · see citing works

Brain drains: new insights into brain clearance pathways from lymphatic biology

Bower, N. I., & Hogan, B. M. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1634-9 · Cited by 44 · see citing works

Cellular-Immune Response to Myelin Protein: Absence in Multiple Sclerosis and Presence in Cerebrovascular Accidents*

Youngchaiyud, U., Coates, A. S., Whittingham, S., & Mackay, I. R. (1974) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1974.tb03233.x · Cited by 42 · see citing works

Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α

Orsini, F., Fumagalli, S., Császár, E., Tóth, K., Blasio, D. D., Zangari, R., Lénárt, N., Dénes, Á., & Simoni, M. G. D. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311058 · Cited by 40 · see citing works

Fostering reproducibility in industry-academia research

Jasny, B. R., Wigginton, N. S., Mcnutt, M. K., Bubela, T. M., Buck, S., Cook-Deegan, R. M., Gardner, T. S., Hanson, B., Hustad, C. M., Kiermer, V., et al. (2017) · Science · doi:10.1126/science.aan4906 · Cited by 35 · see citing works

Oligoclonal immunoglobulin G in acute subarachnoid hemorrhage and stroke

Tsementzis, S. A., Chao, S. W., Hitchcock, E. R., Gill, J. S., & Beevers, D. G. (1986) · Neurology · doi:10.1212/wnl.36.3.395 · Cited by 32 · see citing works

Insular Cortex Atrophy as an Independent Determinant of Disrupted Diurnal Rhythm of Ambulatory Blood Pressure in Elderly Hypertension

Nagai, M., Hoshide, S., Ishikawa, J., Shimada, K., & Kario, K. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.71 · Cited by 28 · see citing works

What Do Experimental Models Teach Us About Comorbidities in Stroke?

Cho, S., & Yang, J. (2018) · Stroke · doi:10.1161/strokeaha.117.017793 · Cited by 27 · see citing works

Loss of neuronal CD200 contributed to microglial activation after acute cerebral ischemia in mice

Yang, Y., Zhang, X., Zhang, C., Chen, R., Li, L., He, J., Xie, Y., & Chen, Y. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.004 · Cited by 26 · see citing works

Stroke in young adults: Five new things.

Bhatt, N., Malik, A., & Chaturvedi, S. (2018) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000000522 · Cited by 25 · see citing works

Update in the Early Management and Reperfusion Strategies of Patients with Acute Ischemic Stroke

Mendez, A. A., Samaniego, E. A., Sheth, S. A., Dandapat, S., Hasan, D. M., Limaye, K. S., Hindman, B. J., Derdeyn, C. P., & Ortega‐Gutiérrez, S. (2018) · Critical Care Research and Practice · doi:10.1155/2018/9168731 · Cited by 23 · see citing works

Role of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke

Cisbani, G., Béhot, A. L., Plante, M.-M., Préfontaine, P., Lecordier, M., & Rivest, S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.03.008 · Cited by 22 · see citing works

CX3C chemokine receptor 1 deficiency modulates microglia morphology but does not affect lesion size and short-term deficits after experimental stroke

van der Maten, G., Henck, V., Wieloch, T. W., & Ruscher, K. (2017) · BMC Neuroscience · doi:10.1186/s12868-016-0325-0 · Cited by 20 · see citing works

Are researchers moving away from animal models as a result of poor clinical translation in the field of stroke? An analysis of opinion papers

Pound, P., & Ram, R. (2020) · BMJ Open Science · doi:10.1136/bmjos-2019-100041 · Cited by 20 · see citing works

Brain Atrophy Estimated from Structural Magnetic Resonance Imaging as a Marker of Large-Scale Network-Based Neurodegeneration in Aging and Stroke

Veldsman, M. (2017) · Geriatrics · doi:10.3390/geriatrics2040034 · Cited by 12 · see citing works

Mechanical thrombectomy and the future of acute stroke treatment

Dmytriw, A. A., Zhang, Y., & Pereira, V. M. (2019) · European Journal of Radiology · doi:10.1016/j.ejrad.2019.01.029 · Cited by 11 · see citing works

Intrathecal inflammation in young stroke

Süße, M., Hannich, M. J., Holbe, C., Ruhnau, J., von Sarnowski, B., & Dressel, A. (2019) · Acta Neurologica Scandinavica · doi:10.1111/ane.13094 · Cited by 9 · see citing works

Effects of COVID-19 on the Nervous System

Iadecola, C., Anrather, J., & Kamel, H. (2020) · Cell · doi:10.1016/j.cell.2020.08.028 · Cited by 663 · see citing works

Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke

Alsbrook, D. L., Napoli, M. D., Bhatia, K., Biller, J., Andalib, S., Hinduja, A., Rodrigues, R., Rodriguez, M., Sabbagh, S. Y., Selim, M. H., et al. (2023) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-023-01282-2 · Cited by 539 · see citing works

Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke

Endres, M., Moro, M. Á., Nolte, C. H., Dames, C., Buckwalter, M. S., & Meisel, A. (2022) · Circulation Research · doi:10.1161/circresaha.121.319994 · Cited by 347 · see citing works

Cerebral Intraparenchymal Hemorrhage

Gross, B. A., Jankowitz, B. T., & Friedlander, R. M. (2019) · JAMA · doi:10.1001/jama.2019.2413 · Cited by 327 · see citing works

Systemic inflammation after stroke: implications for post‐stroke comorbidities

Simats, A., & Liesz, A. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202216269 · Cited by 276 · see citing works

Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke

Li, C., Sun, G., Chen, B., Xu, L., Ye, Y., He, J., Bao, Z., Zhao, P., Miao, Z., Zhao, L., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105933 · Cited by 258 · see citing works

Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke

Elkind, M. S. V., Boehme, A. K., Smith, C. J., Meisel, A., & Buckwalter, M. S. (2020) · Stroke · doi:10.1161/strokeaha.120.030429 · Cited by 252 · see citing works

Immunodepression, Infections, and Functional Outcome in Ischemic Stroke

Westendorp, W. F., Dames, C., Nederkoorn, P. J., & Meisel, A. (2022) · Stroke · doi:10.1161/strokeaha.122.038867 · Cited by 234 · see citing works

Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke

García‐Bonilla, L., Shahanoor, Z., Sciortino, R. K., Nazarzoda, O., Racchumi, G., Iadecola, C., & Anrather, J. (2024) · Nature Immunology · doi:10.1038/s41590-023-01711-x · Cited by 217 · see citing works

Effect of bisphenol A on the neurological system: a review update

Costa, H. E., & Cairrão, E. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03614-0 · Cited by 214 · see citing works

Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes

Shi, Z., Yu, P., Lin, W., Chen, S., Hu, X., Chen, S., Cheng, J., Liu, Q., Yang, Y., Li, S., et al. (2023) · Neuron · doi:10.1016/j.neuron.2022.12.009 · Cited by 182 · see citing works

Age-related immune alterations and cerebrovascular inflammation

Finger, C. E., Moreno‐González, I., Gutiérrez, A., Moruno-Manchon, J. F., & McCullough, L. D. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01361-1 · Cited by 177 · see citing works

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

Zeng, J., Bao, T., Yang, K., Zhu, X., Wang, S., Xiang, W., Ge, A., Zeng, L., & Ge, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1047550 · Cited by 175 · see citing works

Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome

Honarpisheh, P., Bryan, R. M., & McCullough, L. D. (2022) · Circulation Research · doi:10.1161/circresaha.122.319983 · Cited by 173 · see citing works

Innate immune memory after brain injury drives inflammatory cardiac dysfunction

Simats, A., Zhang, S., Messerer, D., Chong, F., Beşkardeş, S., Chivukula, A. S., Cao, J., Besson‐Girard, S., Montellano, F. A., Morbach, C., et al. (2024) · Cell · doi:10.1016/j.cell.2024.06.028 · Cited by 155 · see citing works

Inflammation, Autoimmunity, Infection, and Stroke

Parikh, N. S., Merkler, A. E., & Iadecola, C. (2020) · Stroke · doi:10.1161/strokeaha.119.024157 · Cited by 151 · see citing works

Targeting pyroptosis as a preventive and therapeutic approach for stroke

Long, J., Sun, Y., Liu, S., Yang, S., Chen, C., Zhang, Z., Chu, S., Yang, Y., Pei, G., Lin, M., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01440-y · Cited by 153 · see citing works

Beyond the gut: decoding the gut–immune–brain axis in health and disease

Park, J. C., Chang, L., Kwon, H.-K., & Im, S.-H. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01333-3 · Cited by 149 · see citing works

Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair

Shichita, T., Ooboshi, H., & Yoshimura, A. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00690-0 · Cited by 145 · see citing works

The relationship between systemic inflammation index, systemic immune-inflammatory index, and inflammatory prognostic index and 90-day outcomes in acute ischemic stroke patients treated with intravenous thrombolysis

Ma, F., Li, L., Xu, L., Wu, J., Zhang, A., Liao, J., Chen, J., Li, Y., Li, L., Chen, Z., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02890-y · Cited by 138 · see citing works

Brain-spleen axis in health and diseases: A review and future perspective

Wei, Y., Wang, T., Liao, L., Fan, X., Chang, L., & Hashimoto, K. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.008 · Cited by 134 · see citing works

Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Stroke: A Systematic Review and Meta-Analysis

Li, W., Hou, M., Ding, Z., Liu, X., Shao, Y., & Li, X. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.686983 · Cited by 134 · see citing works

Role of microglia in stroke

Planas, A. M. (2024) · Glia · doi:10.1002/glia.24501 · Cited by 133 · see citing works

SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia

Olajide, O. A., Iwuanyanwu, V. U., Adegbola, O. D., & Al‐Hindawi, A. A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02593-6 · Cited by 124 · see citing works

The neurovascular unit and systemic biology in stroke — implications for translation and treatment

Tiedt, S., Buchan, A. M., Dichgans, M., Lizasoaín, I., Moro, M. Á., & Lo, E. H. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00703-z · Cited by 130 · see citing works

Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology

Gullotta, G. S., Feo, D. D., Friebel, E., Semerano, A., Scotti, G. M., Bergamaschi, A., Butti, E., Brambilla, E., Genchi, A., Capotondo, A., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01505-1 · Cited by 124 · see citing works

Decompression Sickness and Arterial Gas Embolism

Mitchell, S. J., Bennett, M. H., & Moon, R. E. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2116554 · Cited by 125 · see citing works

Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease

Derk, J., Jones, H. E., Como, C., Pawlikowski, B., & Siegenthaler, J. A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.703944 · Cited by 120 · see citing works

Inflammation, Oxidative Stress, Vascular Aging and Atherosclerotic Ischemic Stroke

Koutsaliaris, I. K., Moschonas, I. C., Pechlivani, L., Tsouka, A. N., & Tselepis, A. D. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210921161711 · Cited by 120 · see citing works

Association between dietary inflammatory index and Stroke in the US population: evidence from NHANES 1999–2018

Mao, Y., Weng, J., Xie, Q., Wu, L., Xuan, Y., Zhang, J., & Han, J. (2024) · BMC Public Health · doi:10.1186/s12889-023-17556-w · Cited by 119 · see citing works

Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke

Li, X., Lyu, J., Li, R., Jain, V., Shen, Y., del Águila, Á., Hoffmann, U., Sheng, H., & Yang, W. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02447-5 · Cited by 117 · see citing works

Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): Relevant signaling pathways and therapeutic strategies

Jin, J., Duan, J., Du, L., Xing, W., Peng, X., & Zhao, Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1027756 · Cited by 115 · see citing works

Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review

Holste, K. G., Xia, F., Ye, F., Keep, R. F., & Xi, G. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00324-0 · Cited by 113 · see citing works

TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury

Xia, Q., Zhan, G., Mao, M., Zhao, Y., & Li, X. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00734-y · Cited by 112 · see citing works

Immune dynamics in the CNS and its barriers during homeostasis and disease*

Buckley, M. W., & McGavern, D. B. (2022) · Immunological Reviews · doi:10.1111/imr.13066 · Cited by 97 · see citing works

Engineering CXCL12 Biomimetic Decoy‐Integrated Versatile Immunosuppressive Nanoparticle for Ischemic Stroke Therapy with Management of Overactivated Brain Immune Microenvironment

Shi, J., Yang, Y., Yin, N., Liu, C., Zhao, Y., Cheng, H., Zhou, T., Zhang, Z., & Zhang, K. (2021) · Small Methods · doi:10.1002/smtd.202101158 · Cited by 95 · see citing works

Cellular recovery after prolonged warm ischaemia of the whole body

Andrijević, D., Vrselja, Z., Lysyy, T., Zhang, S., Škarica, M., Spajic, A., Dellal, D., Thorn, S., Duckrow, R. B., Ma, S., et al. (2022) · Nature · doi:10.1038/s41586-022-05016-1 · Cited by 92 · see citing works

Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy

Beccari, S., Sierra-Torre, V., Valero, J., Pereira-Iglesias, M., García-Zaballa, M., Soria, F. N., De Las Heras-Garcia, L., Carretero-Guillen, A., Capetillo-Zarate, E., Domercq, M., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2165313 · Cited by 89 · see citing works

Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model

Cui, P., Lu, W., Wang, J., Wang, F., Zhang, X., Hou, X., Xu, F., Liang, Y., Chai, G., & Hao, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02705-0 · Cited by 89 · see citing works

The role of the ATP-adenosine axis in ischemic stroke

Schädlich, I. S., Winzer, R., Stabernack, J., Tolosa, E., Magnus, T. U., & Rissiek, B. (2023) · Seminars in Immunopathology · doi:10.1007/s00281-023-00987-3 · Cited by 89 · see citing works

Impact of aging and comorbidities on ischemic stroke outcomes in preclinical animal models: A translational perspective

Candelario‐Jalil, E., & Paul, S. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113494 · Cited by 89 · see citing works

Microglia–Astrocyte Interaction in Neural Development and Neural Pathogenesis

Sun, M., You, H., Hu, X., Luo, Y., Zhang, Z., Song, Y., An, J., & Lü, H. (2023) · Cells · doi:10.3390/cells12151942 · Cited by 88 · see citing works

Neuroinflammation, Stem Cells, and Stroke

Anthony, S., Cabantan, D., Monsour, M., & Borlongan, C. V. (2022) · Stroke · doi:10.1161/strokeaha.121.036948 · Cited by 87 · see citing works

Stroke affects intestinal immune cell trafficking to the central nervous system

Brea, D., Poon, C., Benakis, C., Lubitz, G. S., Murphy, M., Iadecola, C., & Anrather, J. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.05.008 · Cited by 81 · see citing works

Meningeal Lymphatics in Central Nervous System Diseases

Salvador, A. F., Abduljawad, N., & Kipnis, J. (2024) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-113023-103045 · Cited by 87 · see citing works

Immune regulation of the gut-brain axis and lung-brain axis involved in ischemic stroke

Xie, X., Wang, L., Dong, S., Ge, S., & Zhu, T. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.380869 · Cited by 85 · see citing works

Neutrophil–lymphocyte ratio in acute ischemic stroke: Immunopathology, management, and prognosis

Sharma, D., Spring, K. J., & Bhaskar, S. M. M. (2021) · Acta Neurologica Scandinavica · doi:10.1111/ane.13493 · Cited by 81 · see citing works

New Therapeutic Approaches to and Mechanisms of Ginsenoside Rg1 against Neurological Diseases

Sun, Y., Yang, Y., Liu, S., Yang, S., Chen, C., Lin, M., Zeng, Q., Long, J., Yao, J., Yi, F., et al. (2022) · Cells · doi:10.3390/cells11162529 · Cited by 81 · see citing works

Indole-3-propionic acid alleviates ischemic brain injury in a mouse middle cerebral artery occlusion model

Xie, Y., Zou, X., Han, J., Zhang, Z., Feng, Z., Ouyang, Q., Hua, S., Liu, Z., Li, C., Cai, Y., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114081 · Cited by 80 · see citing works

Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke

Duan, M., Xu, Y., Li, Y., Feng, H., & Chen, Y. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03101-y · Cited by 82 · see citing works

Role of lipocalin 2 in stroke

Zhao, R., Wei, P., Sun, X., Zhang, D., He, Q., Liu, J., Chang, J., Yang, Y. R., & Guo, Z. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106044 · Cited by 72 · see citing works

Exploration on neurobiological mechanisms of the central–peripheral–central closed-loop rehabilitation

Jia, J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.982881 · Cited by 73 · see citing works

Brain to periphery in acute ischemic stroke: Mechanisms and clinical significance

Cui, P., McCullough, L. D., & Hao, J. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100932 · Cited by 69 · see citing works

The Specific Role of Reactive Astrocytes in Stroke

Li, L., Zhou, J., Han, L., Wu, X., Shi, Y., Cui, W., Zhang, S., Hu, Q., Wang, J., Bai, H., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.850866 · Cited by 66 · see citing works

The Role of Osteopontin in Microglia Biology: Current Concepts and Future Perspectives

Rosmus, D.-D., Lange, C., Ludwig, F., Ajami, B., & Wieghofer, P. (2022) · Biomedicines · doi:10.3390/biomedicines10040840 · Cited by 68 · see citing works

Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications

Hochrainer, K., & Yang, W. (2022) · Circulation Research · doi:10.1161/circresaha.122.320110 · Cited by 62 · see citing works

Reactive Oxygen Species-Responsive Transformable and Triple-Targeting Butylphthalide Nanotherapy for Precision Treatment of Ischemic Stroke by Normalizing the Pathological Microenvironment

Yang, Q., Pu, W., Hu, K., Hu, Y., Feng, Z., Cai, J., Li, C., Li, L., Zhou, Z., & Zhang, J. (2023) · ACS Nano · doi:10.1021/acsnano.2c11363 · Cited by 62 · see citing works

PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke

Nakamura, A., Sakai, S., Taketomi, Y., Tsuyama, J., Miki, Y., Hara, Y., Arai, N., Sugiura, Y., Kawaji, H., Murakami, M., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.024 · Cited by 62 · see citing works

MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia

Infantino, R., Schiano, C., Luongo, L., Paino, S., Mansueto, G., Boccella, S., Guida, F., Ricciardi, F., Iannotta, M., Belardo, C., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105611 · Cited by 61 · see citing works

CX3CL1 inhibits NLRP3 inflammasome-induced microglial pyroptosis and improves neuronal function in mice with experimentally-induced ischemic stroke

Ge, Y., Wang, L., Wang, C., Chen, J., Dai, M., Yao, S., & Lin, Y. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120564 · Cited by 61 · see citing works

Inflammation and the Link to Vascular Brain Health: Timing Is Brain

Mun, K. T., & Hinman, J. D. (2022) · Stroke · doi:10.1161/strokeaha.121.032613 · Cited by 59 · see citing works

Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury

Zhang, X., Gong, P., Zhao, Y., Wan, T., Yuan, K., Xiong, Y., Wu, M., Zha, M., Li, Y., Jiang, T., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104275 · Cited by 60 · see citing works

Immune mechanisms and shared immune targets in neurodegenerative diseases

Weiner, H. L. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01046-7 · Cited by 63 · see citing works

Ferritinophagy and Ferroptosis in Cerebral Ischemia Reperfusion Injury

Liu, X., Xie, C., Wang, Y., Xiang, J., Chen, L., Yuan, J. Y., Chen, C., & Tian, H.-M. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04161-5 · Cited by 58 · see citing works

The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR

Zeng, S., Zhao, Z., Zheng, S., Wu, M., Song, X., Li, Y., Zheng, Y., Liu, B., Chen, L., Gao, C., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102058 · Cited by 58 · see citing works

Molecular Mechanisms of Neuroimmune Crosstalk in the Pathogenesis of Stroke

Choi, Y. H., Laaker, C. J., Hsu, M., Cismaru, P., Sándor, M., & Fábry, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179486 · Cited by 57 · see citing works

Systemic Inflammation Response Index as a Predictor of Stroke Risk in Elderly Patients with Hypertension: A Cohort Study

Cai, X.-T., Song, S.-W., Hu, J.-L., Wang, L., Shen, D., Zhu, Q., Yang, W.-B., Luo, Q., Hong, J., & Li, N.-F. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s433190 · Cited by 53 · see citing works

Dynamic fibroblast–immune interactions shape recovery after brain injury

Ewing-Crystal, N. A., Mroz, N. M., Larpthaveesarp, A., Lizama, C. O., Pennington, R., Chiaranunt, P., Dennis, J. I., Chang, A. A., Merrill, E. D., Caryotakis, S. E., et al. (2025) · Nature · doi:10.1038/s41586-025-09449-2 · Cited by 56 · see citing works

Diabetes, stroke, and neuroresilience: looking beyond hyperglycemia

Krinock, M. J., & Singhal, N. S. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14583 · Cited by 56 · see citing works

Early peripheral blood gene expression associated with good and poor 90-day ischemic stroke outcomes

Amini, H., Knepp, B., Rodríguez, F., Jickling, G. C., Hull, H., Carmona-Mora, P., Bushnell, C., Ander, B. P., Sharp, F. R., & Stamova, B. S. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02680-y · Cited by 54 · see citing works

Targeting the JAK2-STAT3 pathway to inhibit cGAS-STING activation improves neuronal senescence after ischemic stroke

Zhang, W., Xu, M., Chen, F., Su, Y., Yu, M., Xing, L., Chang, Y. E., & Yan, T. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114474 · Cited by 54 · see citing works

The Implications of Microglial Regulation in Neuroplasticity-Dependent Stroke Recovery

Qiao, C., Liu, Z., & Qie, S. (2023) · Biomolecules · doi:10.3390/biom13030571 · Cited by 52 · see citing works

Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke

Hernandez, V. G., Lechtenberg, K. J., Peterson, T. C., Zhu, L., Lucas, T. A., Bradshaw, K. P., Owah, J. O., Dorsey, A. I., Gentles, A. J., & Buckwalter, M. S. (2023) · Glia · doi:10.1002/glia.24377 · Cited by 51 · see citing works

Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia

Žucha, D., Abaffy, P., Kirdajová, D., Jirák, D., Kubista, M., Anděrová, M., & Valihrach, L. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404203121 · Cited by 56 · see citing works

Central nervous system-associated macrophages modulate the immune response following stroke in aged mice

Levard, D., Seillier, C., Bellemain-Sagnard, M., Fournier, A. P., Lemarchand, E., Dembech, C., Riou, G., McDade, K., Smith, C., McQuaid, C., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01695-3 · Cited by 49 · see citing works

Single-cell analysis identifies Ifi27l2a as a gene regulator of microglial inflammation in the context of aging and stroke in mice

Kim, G. S., Harmon, E., Gutierrez, M. E. C., Kim, S., Vance, L., Burrous, H., Stephenson, J. M., Chauhan, A., Banerjee, A., Wise, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56847-1 · Cited by 49 · see citing works

Emerging prospects of extracellular vesicles for brain disease theranostics

Wang, R., Wang, X., Zhang, Y., Zhao, H., Cui, J., Li, J., & Di, L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.12.024 · Cited by 48 · see citing works

Systemic inflammation response index as a prognostic predictor in patients with acute ischemic stroke: A propensity score matching analysis

Dang, H., Mao, W., Wang, S., Sha, J., Lu, M., Cong, L., Meng, X., & Li, H. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2022.1049241 · Cited by 47 · see citing works

Time-dependent dual effect of microglia in ischemic stroke

Fan, P., Wang, S., Chu, S., & Chen, N. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105584 · Cited by 48 · see citing works

CD8+ T cells in brain injury and neurodegeneration

Zhang, Z., Duan, Z., & Cui, Y. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1281763 · Cited by 47 · see citing works

Ischemic stroke and infection: A brief update on mechanisms and potential therapies

Ghelani, D. P., Kim, H. A., Zhang, S. R., Drummond, G. R., Sobey, C. G., & Silva, T. M. D. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114768 · Cited by 46 · see citing works

Traditional Chinese medicine use in the pathophysiological processes of intracerebral hemorrhage and comparison with conventional therapy

Duan, T., Li, L., Yu, Y., Li, T., Han, R., Sun, X., Cui, Y., Liu, T., Wang, X., Wang, Y., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106200 · Cited by 46 · see citing works

Cerebral ischemia in the developing brain

Dietz, R. M., Dingman, A., & Herson, P. S. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221111600 · Cited by 46 · see citing works

Editing a gateway for cell therapy across the blood–brain barrier

Buil, B. A., Tackenberg, C., & Rust, R. (2022) · Brain · doi:10.1093/brain/awac393 · Cited by 46 · see citing works

Neuroinflammation and brain–peripheral interaction in ischemic stroke: A narrative review

Cheng, W., Zhao, Q. C., Li, C., & Xu, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1080737 · Cited by 47 · see citing works

Systemic inflammation response index as a clinical outcome evaluating tool and prognostic indicator for hospitalized stroke patients: a systematic review and meta-analysis

Huang, Y., Zhang, Y., Cui, F., An, Y.-H., Li, Z., & Yin, X.-S. (2023) · European journal of medical research · doi:10.1186/s40001-023-01446-3 · Cited by 46 · see citing works

B. glomerulata promotes neuroprotection against ischemic stroke by inhibiting apoptosis through the activation of PI3K/AKT/mTOR pathway

Xu, Z., Yang, L., Pi, P., Yi, Y., Tang, H., Zhang, Z., Xiong, H., Lei, B., Shi, Y., Li, J., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155817 · Cited by 46 · see citing works

Brain-targeting drug delivery systems.

Liu, P.-X., & Jiang, C. (2022) · Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1818 · Cited by 40 · see citing works

Evaluation of the Glymphatic System Using the DTI‐ALPS Index in Patients with Spontaneous Intracerebral Haemorrhage

Zhang, C., Sha, J., Cai, L., Xia, Y., Li, D., Zhao, H., Meng, C., & Xu, K. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2694316 · Cited by 44 · see citing works

Differences in the post-stroke innate immune response between young and old

Gallizioli, M., Arbaizar‐Rovirosa, M., Brea, D., & Planas, A. M. (2023) · Seminars in Immunopathology · doi:10.1007/s00281-023-00990-8 · Cited by 45 · see citing works

Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice

Bellut, M., Bieber, M., Kraft, P., Weber, A. N. R., Stoll, G., & Schuhmann, M. K. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02674-w · Cited by 43 · see citing works

CD11bhigh B Cells Increase after Stroke and Regulate Microglia

Korf, J. M., Honarpisheh, P., Mohan, E. C., Banerjee, A., Blasco-Conesa, M. P., Honarpisheh, P., Guzman, G. U., Khan, R., Ganesh, B. P., Hazen, A. L., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100884 · Cited by 43 · see citing works

The role of circulating cell-free DNA as an inflammatory mediator after stroke

Roth, S., Wernsdorf, S. R., & Liesz, A. (2023) · Seminars in Immunopathology · doi:10.1007/s00281-023-00993-5 · Cited by 43 · see citing works

Stroke in the Time of Circadian Medicine

Mergenthaler, P., Balami, J. S., Neuhaus, A. A., Mottahedin, A., Albers, G. W., Rothwell, P. M., Saver, J. L., Young, M. E., & Buchan, A. M. (2024) · Circulation Research · doi:10.1161/circresaha.124.323508 · Cited by 42 · see citing works

Relationship between circadian syndrome and stroke: A cross-sectional study of the national health and nutrition examination survey

Wang, Y., Yang, L., Zhang, Y., & Liu, J. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.946172 · Cited by 41 · see citing works

Macrophage and monocyte subsets in response to ischemic stroke

Blank-Stein, N., & Mass, E. (2023) · European Journal of Immunology · doi:10.1002/eji.202250233 · Cited by 40 · see citing works

Effects of Anthraquinones on Immune Responses and Inflammatory Diseases

Xin, D., Li, H., Zhou, S., Zhong, H., & Pu, W. (2022) · Molecules · doi:10.3390/molecules27123831 · Cited by 45 · see citing works

Glycolysis inhibition ameliorates brain injury after ischemic stroke by promoting the function of myeloid-derived suppressor cells

Yan, J., Li, A., Chen, X., Cao, K., Song, M., Guo, S., Li, Z., Huang, S., Li, Z., Xu, D., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106208 · Cited by 39 · see citing works

Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases

Wang, H., Liu, S., Sun, Y., Chen, C., Hu, Z., Li, Q., Long, J., Yan, Q., Liang, J., Lin, Y., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102472 · Cited by 39 · see citing works

Magnetic Field Driven Ceria Nanosystems for Mitochondria Targeted Therapy of Ischemic Stroke

Liao, J., He, W., Zhang, S., Wang, J., Cheng, H., Gong, L., Li, Y., Sun, Y., Lu, D., Zhang, C., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202423291 · Cited by 39 · see citing works

Emerging Targets for Modulation of Immune Response and Inflammation in Stroke

Thapa, K., Shivam, K., Khan, H., Kaur, A., Dua, K., Singh, S. K., & Singh, T. G. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03875-2 · Cited by 29 · see citing works

The immunology of stroke: from mechanisms to translation

Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596 · see citing works

The immunology of stroke: from mechanisms to translation. Nat Med 2011

Iadecola, C., & Anrather, J. (2016)

Brain-Immune Interactions and Ischemic Stroke

Iadecola, C. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.3590 · Cited by 203 · see citing works

The immunology of acute stroke

Chamorro, Á., Meisel, A., Planas, A. M., Urra, X., van de Beek, D., & Veltkamp, R. C. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.98 · Cited by 707 · see citing works